GREMLIN Database
Q97W46 - Uncharacterized protein
UniProt: Q97W46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (218)
Sequences: 213 (162)
Seq/√Len: 10.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_G220_F4.0330.99
30_S151_A3.9580.99
26_K59_Y3.1360.96
39_I47_S3.0370.95
40_E46_K2.8020.92
226_Q230_S2.7650.91
166_G170_G2.7160.91
30_S52_L2.6150.89
114_L152_Q2.5860.88
27_V115_A2.5220.87
62_A115_A2.5180.87
49_S194_T2.4750.86
148_D194_T2.4450.85
49_S161_R2.4270.85
30_S53_T2.3560.83
52_L211_F2.2900.81
203_I207_L2.1270.76
30_S161_R2.1250.76
29_I35_W2.0610.73
160_Y211_F2.0220.72
52_L160_Y1.9300.68
62_A96_V1.8490.65
53_T151_A1.8410.64
62_A200_R1.8020.62
148_D161_R1.7970.62
25_I119_G1.7770.61
102_L112_I1.7600.61
85_L117_A1.7450.60
151_A161_R1.7200.59
143_G198_I1.7150.58
30_S49_S1.7060.58
133_N168_G1.7010.58
35_W59_Y1.7010.58
31_I49_S1.6980.58
211_F223_V1.6230.54
30_S194_T1.6120.54
37_P198_I1.5730.52
98_S102_L1.5700.52
161_R194_T1.5660.51
55_T60_I1.5530.51
35_W233_F1.5520.51
204_A207_L1.5490.51
29_I100_V1.5420.50
38_V164_A1.5420.50
32_S204_A1.5310.50
54_L237_Y1.5130.49
34_I204_A1.5060.49
184_I218_L1.5040.48
219_K222_E1.5030.48
148_D151_A1.4770.47
49_S148_D1.4650.47
130_D216_S1.4350.45
35_W101_P1.4200.44
40_E47_S1.3850.43
59_Y107_G1.3780.42
162_K230_S1.3750.42
30_S211_F1.3690.42
45_I137_L1.3650.42
34_I113_S1.3510.41
54_L161_R1.3380.41
219_K223_V1.3380.41
110_G142_S1.3200.40
43_N68_S1.3120.39
121_K131_A1.2990.39
56_L184_I1.2860.38
96_V112_I1.2690.37
30_S148_D1.2620.37
110_G171_E1.2580.37
190_S221_I1.2550.37
100_V231_L1.2540.37
86_K120_V1.2540.37
42_E87_K1.2380.36
60_I111_A1.2320.36
43_N214_N1.2170.35
152_Q207_L1.2160.35
107_G224_A1.2110.35
32_S161_R1.1960.34
54_L171_E1.1950.34
31_I161_R1.1840.34
106_Y186_S1.1840.34
189_I232_G1.1760.33
32_S49_S1.1730.33
34_I207_L1.1600.33
123_L196_S1.1580.33
198_I218_L1.1500.32
64_I94_L1.1440.32
106_Y233_F1.1360.32
118_L131_A1.1160.31
107_G114_L1.1070.30
175_I236_E1.1050.30
48_G161_R1.0970.30
96_V115_A1.0880.30
127_S215_P1.0830.30
50_I159_V1.0820.29
241_Y244_K1.0800.29
106_Y119_G1.0800.29
61_T95_S1.0740.29
131_A170_G1.0710.29
38_V140_V1.0640.29
39_I88_K1.0530.28
114_L132_V1.0500.28
44_L178_D1.0480.28
31_I58_P1.0440.28
29_I56_L1.0420.28
42_E178_D1.0390.28
214_N219_K1.0340.28
29_I107_G1.0330.28
42_E125_P1.0270.27
212_L215_P1.0200.27
57_E207_L1.0190.27
228_T234_S1.0140.27
71_E95_S1.0100.27
84_I137_L1.0070.27
137_L141_L1.0060.27
73_N225_Q1.0030.26
133_N166_G0.9890.26
72_F98_S0.9880.26
55_T160_Y0.9860.26
114_L157_G0.9740.25
33_G160_Y0.9620.25
173_E176_N0.9570.25
37_P62_A0.9530.25
119_G123_L0.9450.24
151_A168_G0.9410.24
198_I230_S0.9400.24
23_V202_E0.9360.24
37_P189_I0.9330.24
32_S113_S0.9260.24
127_S212_L0.9180.23
125_P232_G0.9140.23
210_D226_Q0.9120.23
166_G193_P0.9100.23
104_Y162_K0.9090.23
121_K190_S0.8980.23
70_I232_G0.8920.23
49_S151_A0.8900.22
31_I151_A0.8840.22
202_E205_L0.8830.22
138_S242_R0.8810.22
189_I237_Y0.8770.22
35_W112_I0.8770.22
208_I223_V0.8740.22
110_G186_S0.8710.22
132_V153_Y0.8670.22
110_G152_Q0.8660.22
25_I187_Q0.8660.22
196_S206_K0.8590.21
56_L189_I0.8590.21
85_L125_P0.8580.21
135_A149_V0.8550.21
88_K164_A0.8540.21
94_L176_N0.8530.21
26_K34_I0.8500.21
56_L231_L0.8470.21
26_K35_W0.8460.21
31_I213_K0.8440.21
119_G187_Q0.8390.21
218_L222_E0.8280.20
61_T210_D0.8250.20
28_P103_G0.8230.20
141_L212_L0.8200.20
85_L94_L0.8170.20
92_Y149_V0.8140.20
116_Y173_E0.8070.20
64_I119_G0.8040.20
26_K54_L0.8030.20
29_I59_Y0.8010.20
64_I95_S0.7980.20
102_L220_F0.7940.19
167_L211_F0.7930.19
33_G224_A0.7930.19
24_E196_S0.7920.19
62_A120_V0.7900.19
113_S167_L0.7860.19
214_N229_S0.7860.19
73_N208_I0.7850.19
54_L163_K0.7830.19
82_Y186_S0.7780.19
240_S244_K0.7760.19
62_A201_S0.7750.19
164_A232_G0.7750.19
205_L228_T0.7710.19
163_K171_E0.7630.18
170_G214_N0.7630.18
213_K220_F0.7630.18
84_I88_K0.7590.18
81_N153_Y0.7580.18
96_V102_L0.7530.18
73_N152_Q0.7510.18
61_T97_Y0.7490.18
34_I221_I0.7480.18
214_N243_K0.7480.18
59_Y204_A0.7480.18
54_L196_S0.7460.18
67_G73_N0.7450.18
129_E216_S0.7420.18
30_S167_L0.7370.18
208_I215_P0.7360.18
35_W197_I0.7360.18
159_V175_I0.7360.18
81_N140_V0.7340.18
216_S220_F0.7340.18
46_K218_L0.7300.18
175_I220_F0.7260.17
36_Y50_I0.7250.17
87_K218_L0.7180.17
55_T102_L0.7170.17
173_E204_A0.7150.17
68_S210_D0.7070.17
23_V198_I0.7070.17
131_A189_I0.7030.17
128_E228_T0.6990.17
47_S164_A0.6990.17
143_G148_D0.6990.17
55_T142_S0.6950.17
105_G109_S0.6940.17
109_S145_G0.6940.17
105_G145_G0.6940.17
51_G105_G0.6940.17
51_G109_S0.6940.17
51_G145_G0.6940.17
104_Y189_I0.6940.17
104_Y188_P0.6850.16
82_Y112_I0.6830.16
111_A126_I0.6720.16
46_K171_E0.6710.16
76_E218_L0.6700.16
150_I170_G0.6680.16
73_N215_P0.6670.16
62_A113_S0.6640.16
175_I211_F0.6600.16
108_L115_A0.6570.16
195_K198_I0.6460.15
118_L242_R0.6420.15
32_S35_W0.6420.15
110_G230_S0.6380.15
64_I180_S0.6370.15
158_L237_Y0.6350.15
129_E173_E0.6340.15
115_A139_D0.6340.15
98_S152_Q0.6320.15
110_G138_S0.6290.15
184_I236_E0.6280.15
50_I104_Y0.6280.15
43_N130_D0.6270.15
53_T167_L0.6270.15
159_V163_K0.6230.15
26_K161_R0.6210.15
83_E86_K0.6190.15
108_L143_G0.6180.15
198_I228_T0.6170.15
103_G220_F0.6170.15
58_P99_E0.6160.15
87_K141_L0.6130.15
190_S208_I0.6120.15
82_Y86_K0.6110.14
107_G157_G0.6110.14
211_F221_I0.6110.14
29_I119_G0.6100.14
58_P100_V0.6100.14
107_G227_F0.6090.14
86_K151_A0.6090.14
196_S221_I0.6090.14
60_I190_S0.6050.14
117_A203_I0.6030.14
72_F102_L0.6020.14
49_S165_G0.5980.14
73_N222_E0.5960.14
79_L96_V0.5910.14
31_I200_R0.5910.14
136_H146_L0.5900.14
94_L117_A0.5900.14
26_K101_P0.5890.14
119_G197_I0.5880.14
174_V214_N0.5860.14
97_Y129_E0.5850.14
151_A242_R0.5840.14
139_D148_D0.5830.14
162_K173_E0.5800.14
31_I194_T0.5800.14
35_W106_Y0.5780.14
92_Y123_L0.5740.14
163_K212_L0.5730.14
27_V56_L0.5700.14
128_E164_A0.5690.14
65_R75_I0.5650.13
159_V162_K0.5650.13
70_I73_N0.5640.13
117_A206_K0.5640.13
39_I198_I0.5610.13
171_E174_V0.5560.13
139_D194_T0.5560.13
111_A157_G0.5550.13
56_L140_V0.5540.13
210_D230_S0.5540.13
50_I129_E0.5530.13
30_S223_V0.5510.13
68_S99_E0.5500.13
32_S193_P0.5450.13
76_E238_P0.5420.13
60_I172_V0.5380.13
31_I143_G0.5370.13
33_G164_A0.5360.13
35_W157_G0.5330.13
121_K204_A0.5330.13
44_L240_S0.5330.13
135_A147_G0.5320.13
104_Y199_K0.5300.13
214_N234_S0.5300.13
78_Q173_E0.5290.13
216_S228_T0.5230.13
76_E122_E0.5230.13
190_S231_L0.5230.13
45_I213_K0.5220.12
104_Y170_G0.5210.12
103_G224_A0.5210.12
65_R178_D0.5210.12
121_K126_I0.5200.12
36_Y205_L0.5170.12
190_S211_F0.5160.12
193_P220_F0.5130.12
115_A221_I0.5070.12
73_N114_L0.5050.12
66_N102_L0.5040.12
27_V81_N0.5020.12
106_Y111_A0.5010.12
113_S129_E0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pyfA 1 0.8708 99.6 0.821 Contact Map
4n3oA 2 0.8893 99.6 0.821 Contact Map
3k85A 3 0.8118 99.6 0.821 Contact Map
4hacA 2 0.8967 99.6 0.825 Contact Map
2hfsA 1 0.9077 99.6 0.826 Contact Map
3gonA 1 0.893 99.6 0.827 Contact Map
1uekA 1 0.8303 99.5 0.834 Contact Map
3k17A 3 0.893 99.5 0.834 Contact Map
4rpfA 2 0.8782 99.5 0.835 Contact Map
2oi2A 2 0.8524 99.5 0.837 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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