GREMLIN Database
Q97W45 - Uncharacterized protein
UniProt: Q97W45 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (242)
Sequences: 184 (128)
Seq/√Len: 8.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_A220_L6.0071.00
19_N153_F4.9160.99
81_A169_V4.7260.99
242_Y247_I4.6790.99
184_V206_T4.0660.98
71_I219_R3.7410.96
220_L224_V3.4290.94
66_F251_S3.1300.90
71_I220_L2.8380.85
75_A224_V2.8190.85
96_V213_I2.8040.85
101_I135_A2.7010.82
73_A207_I2.5970.79
104_A110_K2.5140.77
208_T244_N2.5010.77
100_L111_L2.4210.74
35_A41_L2.3230.71
127_A131_Y2.2530.69
77_T189_K2.2410.68
202_S208_T2.1530.65
154_S180_T2.1470.65
77_T207_I2.0580.61
93_A130_L2.0000.59
80_L235_L1.9980.59
235_L239_V1.9600.57
148_V157_R1.9370.56
111_L135_A1.9290.56
83_T132_K1.8910.54
235_L238_I1.8710.54
236_E240_F1.8560.53
83_T110_K1.8040.51
165_Y171_L1.7930.50
120_E124_K1.7260.48
42_V173_G1.7100.47
131_Y213_I1.6820.46
106_E228_K1.6400.44
96_V212_N1.6310.44
217_V221_V1.5510.40
171_L193_I1.5480.40
59_I151_E1.5240.39
231_S234_E1.5240.39
155_Q158_R1.5130.39
37_E82_K1.4980.38
101_I111_L1.4700.37
247_I251_S1.4470.36
83_T166_K1.4340.36
135_A138_V1.4300.36
117_Y155_Q1.4110.35
192_A201_T1.4020.35
36_M41_L1.3880.34
71_I223_K1.3830.34
54_C151_E1.3690.33
77_T239_V1.3420.32
111_L213_I1.3320.32
69_K250_E1.3180.31
62_K65_D1.3180.31
219_R222_E1.3170.31
181_E185_K1.3060.31
32_L46_L1.3060.31
68_E223_K1.2860.30
80_L238_I1.2810.30
219_R223_K1.2720.30
64_Q254_F1.2470.29
59_I255_I1.2440.29
73_A238_I1.2360.29
76_A235_L1.2340.29
40_I154_S1.2110.28
96_V138_V1.2080.28
149_I182_A1.2040.28
42_V154_S1.1990.27
96_V111_L1.1980.27
30_E33_I1.1980.27
123_E145_A1.1940.27
131_Y225_K1.1930.27
150_P182_A1.1850.27
35_A212_N1.1810.27
25_S53_E1.1690.26
33_I44_Q1.1660.26
92_M173_G1.1610.26
138_V212_N1.1610.26
223_K226_E1.1610.26
54_C160_S1.1580.26
68_E222_E1.1380.25
77_T206_T1.1380.25
165_Y193_I1.1260.25
23_R180_T1.1220.25
75_A221_V1.1180.25
59_I186_M1.0970.24
19_N151_E1.0950.24
72_E223_K1.0800.24
71_I224_V1.0780.24
40_I186_M1.0730.23
75_A223_K1.0680.23
35_A205_A1.0550.23
167_A170_V1.0510.23
161_P180_T1.0510.23
96_V217_V1.0490.23
232_K236_E1.0470.23
106_E221_V1.0390.22
150_P186_M1.0390.22
92_M100_L1.0370.22
107_S224_V1.0290.22
217_V220_L1.0250.22
220_L223_K1.0160.22
72_E239_V1.0120.22
220_L226_E1.0120.22
105_E136_K1.0120.22
44_Q49_H1.0110.22
37_E43_P1.0060.21
123_E151_E1.0060.21
123_E141_V1.0010.21
135_A212_N1.0000.21
23_R27_L1.0000.21
184_V204_T0.9950.21
97_P212_N0.9940.21
71_I75_A0.9900.21
117_Y180_T0.9830.21
97_P135_A0.9810.21
63_T71_I0.9770.21
142_G157_R0.9770.21
47_I224_V0.9760.21
107_S110_K0.9600.20
162_K208_T0.9550.20
62_K254_F0.9530.20
26_L39_S0.9500.20
118_R206_T0.9470.20
32_L40_I0.9430.20
67_A113_I0.9300.19
75_A78_L0.9290.19
63_T219_R0.9270.19
141_V158_R0.9270.19
36_M180_T0.9270.19
33_I117_Y0.9150.19
124_K173_G0.9130.19
45_G154_S0.9130.19
70_A205_A0.9120.19
62_K249_A0.9100.19
54_C153_F0.9090.19
41_L154_S0.9080.19
33_I158_R0.9070.19
170_V243_D0.9070.19
47_I149_I0.9040.19
130_L138_V0.8990.19
210_V234_E0.8930.18
118_R184_V0.8920.18
86_I185_K0.8820.18
132_K257_N0.8800.18
228_K232_K0.8770.18
68_E121_R0.8650.18
16_I64_Q0.8610.18
180_T205_A0.8600.18
31_K131_Y0.8560.18
24_E63_T0.8550.18
102_R236_E0.8490.17
242_Y245_K0.8490.17
40_I106_E0.8410.17
78_L202_S0.8390.17
134_G163_G0.8360.17
152_L186_M0.8320.17
49_H73_A0.8290.17
86_I214_I0.8290.17
143_E160_S0.8280.17
15_L249_A0.8250.17
150_P158_R0.8240.17
96_V144_D0.8220.17
42_V49_H0.8210.17
33_I208_T0.8200.17
36_M226_E0.8190.17
110_K132_K0.8180.17
128_E241_N0.8170.17
192_A204_T0.8150.17
38_K125_A0.8140.17
100_L249_A0.8130.17
142_G151_E0.8110.16
254_F258_R0.8090.16
124_K180_T0.8080.16
151_E157_R0.8040.16
54_C130_L0.8030.16
160_S212_N0.8020.16
19_N117_Y0.7990.16
63_T218_P0.7980.16
230_K236_E0.7970.16
44_Q205_A0.7960.16
41_L97_P0.7950.16
149_I158_R0.7880.16
232_K239_V0.7880.16
28_I54_C0.7870.16
180_T190_V0.7870.16
41_L205_A0.7860.16
41_L44_Q0.7780.16
92_M172_L0.7750.16
67_A70_A0.7740.16
68_E219_R0.7700.16
137_E180_T0.7690.16
19_N155_Q0.7670.16
39_S187_G0.7660.15
189_K206_T0.7650.15
66_F242_Y0.7630.15
124_K203_R0.7540.15
41_L113_I0.7530.15
30_E190_V0.7490.15
83_T256_A0.7470.15
190_V201_T0.7460.15
68_E71_I0.7430.15
65_D119_D0.7410.15
133_G184_V0.7390.15
202_S216_A0.7380.15
101_I138_V0.7360.15
65_D242_Y0.7350.15
130_L135_A0.7340.15
193_I254_F0.7270.15
79_L227_L0.7270.15
115_L118_R0.7250.15
131_Y137_E0.7230.15
80_L239_V0.7220.15
17_P205_A0.7200.15
97_P159_V0.7120.14
130_L212_N0.7110.14
47_I213_I0.7100.14
47_I181_E0.7060.14
77_T184_V0.7050.14
107_S121_R0.7050.14
124_K214_I0.7040.14
70_A167_A0.7030.14
88_V232_K0.7030.14
92_M149_I0.7020.14
169_V246_T0.7000.14
28_I162_K0.6990.14
238_I247_I0.6970.14
42_V104_A0.6950.14
233_E257_N0.6900.14
105_E144_D0.6840.14
120_E143_E0.6830.14
83_T125_A0.6830.14
81_A246_T0.6830.14
82_K245_K0.6820.14
36_M117_Y0.6810.14
243_D246_T0.6800.14
82_K240_F0.6800.14
127_A138_V0.6760.14
210_V244_N0.6760.14
32_L189_K0.6730.14
207_I239_V0.6700.14
111_L217_V0.6670.13
18_E173_G0.6650.13
97_P109_A0.6640.13
28_I154_S0.6630.13
159_V255_I0.6630.13
135_A189_K0.6610.13
19_N23_R0.6600.13
16_I231_S0.6600.13
47_I158_R0.6600.13
98_E249_A0.6600.13
66_F254_F0.6590.13
33_I190_V0.6590.13
59_I228_K0.6590.13
34_E242_Y0.6570.13
110_K139_L0.6550.13
44_Q109_A0.6530.13
85_T206_T0.6530.13
161_P245_K0.6520.13
99_G181_E0.6440.13
97_P133_G0.6430.13
100_L104_A0.6410.13
79_L235_L0.6360.13
173_G198_L0.6330.13
144_D186_M0.6300.13
145_A207_I0.6290.13
180_T242_Y0.6280.13
31_K132_K0.6260.13
73_A213_I0.6250.13
47_I53_E0.6240.13
92_M150_P0.6230.13
92_M189_K0.6230.13
159_V212_N0.6220.13
66_F173_G0.6180.13
46_L53_E0.6160.12
154_S202_S0.6160.12
151_E212_N0.6150.12
44_Q47_I0.6110.12
88_V120_E0.6110.12
30_E201_T0.6090.12
102_R137_E0.6070.12
160_S224_V0.6050.12
204_T246_T0.6050.12
27_L248_L0.6050.12
136_K232_K0.6040.12
152_L208_T0.6040.12
65_D253_K0.6030.12
145_A165_Y0.6030.12
108_N189_K0.6020.12
30_E208_T0.5970.12
62_K225_K0.5970.12
138_V151_E0.5950.12
37_E232_K0.5850.12
145_A198_L0.5850.12
62_K100_L0.5830.12
80_L108_N0.5810.12
123_E184_V0.5780.12
32_L111_L0.5780.12
65_D241_N0.5780.12
20_H29_R0.5780.12
22_R29_R0.5780.12
21_P29_R0.5780.12
54_C66_F0.5780.12
47_I150_P0.5760.12
144_D162_K0.5720.12
18_E27_L0.5720.12
72_E245_K0.5710.12
77_T203_R0.5700.12
78_L107_S0.5670.12
30_E180_T0.5660.12
71_I216_A0.5660.12
38_K171_L0.5650.12
245_K252_L0.5650.12
136_K203_R0.5650.12
15_L23_R0.5640.12
104_A139_L0.5630.12
63_T193_I0.5620.12
244_N248_L0.5610.12
33_I201_T0.5600.12
18_E23_R0.5590.11
17_P126_I0.5580.11
113_I254_F0.5570.11
225_K257_N0.5530.11
206_T227_L0.5520.11
67_A171_L0.5510.11
76_A80_L0.5500.11
96_V237_Q0.5480.11
47_I218_P0.5470.11
104_A151_E0.5470.11
41_L180_T0.5450.11
39_S119_D0.5420.11
42_V117_Y0.5420.11
17_P32_L0.5400.11
161_P165_Y0.5390.11
83_T133_G0.5380.11
34_E250_E0.5380.11
75_A103_L0.5330.11
161_P252_L0.5310.11
35_A113_I0.5300.11
108_N225_K0.5270.11
226_E235_L0.5260.11
58_L118_R0.5250.11
216_A227_L0.5230.11
96_V160_S0.5230.11
33_I159_V0.5210.11
47_I193_I0.5200.11
166_K219_R0.5180.11
30_E205_A0.5170.11
86_I192_A0.5170.11
80_L209_I0.5160.11
107_S257_N0.5160.11
15_L202_S0.5140.11
33_I101_I0.5130.11
16_I142_G0.5100.11
213_I216_A0.5090.11
84_P108_N0.5080.11
16_I165_Y0.5070.11
79_L107_S0.5040.11
94_A186_M0.5010.11
157_R212_N0.5000.11
18_E158_R0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mb0A 2 0.9436 100 0.064 Contact Map
3cf4G 2 0.6053 94.3 0.953 Contact Map
1ytlA 1 0.5414 89.2 0.96 Contact Map
2x7jA 4 0.9098 88.8 0.96 Contact Map
2q28A 4 0.8609 88.1 0.96 Contact Map
1q6zA 4 0.8534 86.9 0.961 Contact Map
4q9dA 4 0.8571 86 0.962 Contact Map
2c31A 4 0.8609 85.8 0.962 Contact Map
4rjjA 5 0.8346 84.7 0.962 Contact Map
3eyaA 5 0.8835 84.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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