Q97W45 - SULSO - GREMLIN Contacts

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Q97W45 - Uncharacterized protein

UniProt:	Q97W45	Sequences: MDKAQDSKPWSIRDLIPENHPRRESLLIREKLIEAMEKSILVPQGLIAHGRGECFDYLIGEKTQDFAEKAIEAAAATLLLAKTPTISVNGNMAALVPEGLIRLAEESNAKLEINLFYRDERREKAIAEVLYKGGAKEVLGVGEDASEVIPELFSQRRRVSPKGIYKADVVLLGLEDGDRTEALVKMGKKVIAIDINPLSRTSRTATITIVDNIIRAVPRLVEKVKELKSKSKEELEQIVFNYDNKTILAESLKFIANRLTQLSLSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	266 (242)
Sequences:	184 (128)
Seq/√Len:	8.2

HALSA - Q9HSG0
SULSO - Q97W45

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
75_A	220_L	6.007	1.00
19_N	153_F	4.916	0.99
81_A	169_V	4.726	0.99
242_Y	247_I	4.679	0.99
184_V	206_T	4.066	0.98
71_I	219_R	3.741	0.96
220_L	224_V	3.429	0.94
66_F	251_S	3.130	0.90
71_I	220_L	2.838	0.85
75_A	224_V	2.819	0.85
96_V	213_I	2.804	0.85
101_I	135_A	2.701	0.82
73_A	207_I	2.597	0.79
104_A	110_K	2.514	0.77
208_T	244_N	2.501	0.77
100_L	111_L	2.421	0.74
35_A	41_L	2.323	0.71
127_A	131_Y	2.253	0.69
77_T	189_K	2.241	0.68
202_S	208_T	2.153	0.65
154_S	180_T	2.147	0.65
77_T	207_I	2.058	0.61
93_A	130_L	2.000	0.59
80_L	235_L	1.998	0.59
235_L	239_V	1.960	0.57
148_V	157_R	1.937	0.56
111_L	135_A	1.929	0.56
83_T	132_K	1.891	0.54
235_L	238_I	1.871	0.54
236_E	240_F	1.856	0.53
83_T	110_K	1.804	0.51
165_Y	171_L	1.793	0.50
120_E	124_K	1.726	0.48
42_V	173_G	1.710	0.47
131_Y	213_I	1.682	0.46
106_E	228_K	1.640	0.44
96_V	212_N	1.631	0.44
217_V	221_V	1.551	0.40
171_L	193_I	1.548	0.40
59_I	151_E	1.524	0.39
231_S	234_E	1.524	0.39
155_Q	158_R	1.513	0.39
37_E	82_K	1.498	0.38
101_I	111_L	1.470	0.37
247_I	251_S	1.447	0.36
83_T	166_K	1.434	0.36
135_A	138_V	1.430	0.36
117_Y	155_Q	1.411	0.35
192_A	201_T	1.402	0.35
36_M	41_L	1.388	0.34
71_I	223_K	1.383	0.34
54_C	151_E	1.369	0.33
77_T	239_V	1.342	0.32
111_L	213_I	1.332	0.32
69_K	250_E	1.318	0.31
62_K	65_D	1.318	0.31
219_R	222_E	1.317	0.31
181_E	185_K	1.306	0.31
32_L	46_L	1.306	0.31
68_E	223_K	1.286	0.30
80_L	238_I	1.281	0.30
219_R	223_K	1.272	0.30
64_Q	254_F	1.247	0.29
59_I	255_I	1.244	0.29
73_A	238_I	1.236	0.29
76_A	235_L	1.234	0.29
40_I	154_S	1.211	0.28
96_V	138_V	1.208	0.28
149_I	182_A	1.204	0.28
42_V	154_S	1.199	0.27
96_V	111_L	1.198	0.27
30_E	33_I	1.198	0.27
123_E	145_A	1.194	0.27
131_Y	225_K	1.193	0.27
150_P	182_A	1.185	0.27
35_A	212_N	1.181	0.27
25_S	53_E	1.169	0.26
33_I	44_Q	1.166	0.26
92_M	173_G	1.161	0.26
138_V	212_N	1.161	0.26
223_K	226_E	1.161	0.26
54_C	160_S	1.158	0.26
68_E	222_E	1.138	0.25
77_T	206_T	1.138	0.25
165_Y	193_I	1.126	0.25
23_R	180_T	1.122	0.25
75_A	221_V	1.118	0.25
59_I	186_M	1.097	0.24
19_N	151_E	1.095	0.24
72_E	223_K	1.080	0.24
71_I	224_V	1.078	0.24
40_I	186_M	1.073	0.23
75_A	223_K	1.068	0.23
35_A	205_A	1.055	0.23
167_A	170_V	1.051	0.23
161_P	180_T	1.051	0.23
96_V	217_V	1.049	0.23
232_K	236_E	1.047	0.23
106_E	221_V	1.039	0.22
150_P	186_M	1.039	0.22
92_M	100_L	1.037	0.22
107_S	224_V	1.029	0.22
217_V	220_L	1.025	0.22
220_L	223_K	1.016	0.22
72_E	239_V	1.012	0.22
220_L	226_E	1.012	0.22
105_E	136_K	1.012	0.22
44_Q	49_H	1.011	0.22
37_E	43_P	1.006	0.21
123_E	151_E	1.006	0.21
123_E	141_V	1.001	0.21
135_A	212_N	1.000	0.21
23_R	27_L	1.000	0.21
184_V	204_T	0.995	0.21
97_P	212_N	0.994	0.21
71_I	75_A	0.990	0.21
117_Y	180_T	0.983	0.21
97_P	135_A	0.981	0.21
63_T	71_I	0.977	0.21
142_G	157_R	0.977	0.21
47_I	224_V	0.976	0.21
107_S	110_K	0.960	0.20
162_K	208_T	0.955	0.20
62_K	254_F	0.953	0.20
26_L	39_S	0.950	0.20
118_R	206_T	0.947	0.20
32_L	40_I	0.943	0.20
67_A	113_I	0.930	0.19
75_A	78_L	0.929	0.19
63_T	219_R	0.927	0.19
141_V	158_R	0.927	0.19
36_M	180_T	0.927	0.19
33_I	117_Y	0.915	0.19
124_K	173_G	0.913	0.19
45_G	154_S	0.913	0.19
70_A	205_A	0.912	0.19
62_K	249_A	0.910	0.19
54_C	153_F	0.909	0.19
41_L	154_S	0.908	0.19
33_I	158_R	0.907	0.19
170_V	243_D	0.907	0.19
47_I	149_I	0.904	0.19
130_L	138_V	0.899	0.19
210_V	234_E	0.893	0.18
118_R	184_V	0.892	0.18
86_I	185_K	0.882	0.18
132_K	257_N	0.880	0.18
228_K	232_K	0.877	0.18
68_E	121_R	0.865	0.18
16_I	64_Q	0.861	0.18
180_T	205_A	0.860	0.18
31_K	131_Y	0.856	0.18
24_E	63_T	0.855	0.18
102_R	236_E	0.849	0.17
242_Y	245_K	0.849	0.17
40_I	106_E	0.841	0.17
78_L	202_S	0.839	0.17
134_G	163_G	0.836	0.17
152_L	186_M	0.832	0.17
49_H	73_A	0.829	0.17
86_I	214_I	0.829	0.17
143_E	160_S	0.828	0.17
15_L	249_A	0.825	0.17
150_P	158_R	0.824	0.17
96_V	144_D	0.822	0.17
42_V	49_H	0.821	0.17
33_I	208_T	0.820	0.17
36_M	226_E	0.819	0.17
110_K	132_K	0.818	0.17
128_E	241_N	0.817	0.17
192_A	204_T	0.815	0.17
38_K	125_A	0.814	0.17
100_L	249_A	0.813	0.17
142_G	151_E	0.811	0.16
254_F	258_R	0.809	0.16
124_K	180_T	0.808	0.16
151_E	157_R	0.804	0.16
54_C	130_L	0.803	0.16
160_S	212_N	0.802	0.16
19_N	117_Y	0.799	0.16
63_T	218_P	0.798	0.16
230_K	236_E	0.797	0.16
44_Q	205_A	0.796	0.16
41_L	97_P	0.795	0.16
149_I	158_R	0.788	0.16
232_K	239_V	0.788	0.16
28_I	54_C	0.787	0.16
180_T	190_V	0.787	0.16
41_L	205_A	0.786	0.16
41_L	44_Q	0.778	0.16
92_M	172_L	0.775	0.16
67_A	70_A	0.774	0.16
68_E	219_R	0.770	0.16
137_E	180_T	0.769	0.16
19_N	155_Q	0.767	0.16
39_S	187_G	0.766	0.15
189_K	206_T	0.765	0.15
66_F	242_Y	0.763	0.15
124_K	203_R	0.754	0.15
41_L	113_I	0.753	0.15
30_E	190_V	0.749	0.15
83_T	256_A	0.747	0.15
190_V	201_T	0.746	0.15
68_E	71_I	0.743	0.15
65_D	119_D	0.741	0.15
133_G	184_V	0.739	0.15
202_S	216_A	0.738	0.15
101_I	138_V	0.736	0.15
65_D	242_Y	0.735	0.15
130_L	135_A	0.734	0.15
193_I	254_F	0.727	0.15
79_L	227_L	0.727	0.15
115_L	118_R	0.725	0.15
131_Y	137_E	0.723	0.15
80_L	239_V	0.722	0.15
17_P	205_A	0.720	0.15
97_P	159_V	0.712	0.14
130_L	212_N	0.711	0.14
47_I	213_I	0.710	0.14
47_I	181_E	0.706	0.14
77_T	184_V	0.705	0.14
107_S	121_R	0.705	0.14
124_K	214_I	0.704	0.14
70_A	167_A	0.703	0.14
88_V	232_K	0.703	0.14
92_M	149_I	0.702	0.14
169_V	246_T	0.700	0.14
28_I	162_K	0.699	0.14
238_I	247_I	0.697	0.14
42_V	104_A	0.695	0.14
233_E	257_N	0.690	0.14
105_E	144_D	0.684	0.14
120_E	143_E	0.683	0.14
83_T	125_A	0.683	0.14
81_A	246_T	0.683	0.14
82_K	245_K	0.682	0.14
36_M	117_Y	0.681	0.14
243_D	246_T	0.680	0.14
82_K	240_F	0.680	0.14
127_A	138_V	0.676	0.14
210_V	244_N	0.676	0.14
32_L	189_K	0.673	0.14
207_I	239_V	0.670	0.14
111_L	217_V	0.667	0.13
18_E	173_G	0.665	0.13
97_P	109_A	0.664	0.13
28_I	154_S	0.663	0.13
159_V	255_I	0.663	0.13
135_A	189_K	0.661	0.13
19_N	23_R	0.660	0.13
16_I	231_S	0.660	0.13
47_I	158_R	0.660	0.13
98_E	249_A	0.660	0.13
66_F	254_F	0.659	0.13
33_I	190_V	0.659	0.13
59_I	228_K	0.659	0.13
34_E	242_Y	0.657	0.13
110_K	139_L	0.655	0.13
44_Q	109_A	0.653	0.13
85_T	206_T	0.653	0.13
161_P	245_K	0.652	0.13
99_G	181_E	0.644	0.13
97_P	133_G	0.643	0.13
100_L	104_A	0.641	0.13
79_L	235_L	0.636	0.13
173_G	198_L	0.633	0.13
144_D	186_M	0.630	0.13
145_A	207_I	0.629	0.13
180_T	242_Y	0.628	0.13
31_K	132_K	0.626	0.13
73_A	213_I	0.625	0.13
47_I	53_E	0.624	0.13
92_M	150_P	0.623	0.13
92_M	189_K	0.623	0.13
159_V	212_N	0.622	0.13
66_F	173_G	0.618	0.13
46_L	53_E	0.616	0.12
154_S	202_S	0.616	0.12
151_E	212_N	0.615	0.12
44_Q	47_I	0.611	0.12
88_V	120_E	0.611	0.12
30_E	201_T	0.609	0.12
102_R	137_E	0.607	0.12
160_S	224_V	0.605	0.12
204_T	246_T	0.605	0.12
27_L	248_L	0.605	0.12
136_K	232_K	0.604	0.12
152_L	208_T	0.604	0.12
65_D	253_K	0.603	0.12
145_A	165_Y	0.603	0.12
108_N	189_K	0.602	0.12
30_E	208_T	0.597	0.12
62_K	225_K	0.597	0.12
138_V	151_E	0.595	0.12
37_E	232_K	0.585	0.12
145_A	198_L	0.585	0.12
62_K	100_L	0.583	0.12
80_L	108_N	0.581	0.12
123_E	184_V	0.578	0.12
32_L	111_L	0.578	0.12
65_D	241_N	0.578	0.12
20_H	29_R	0.578	0.12
22_R	29_R	0.578	0.12
21_P	29_R	0.578	0.12
54_C	66_F	0.578	0.12
47_I	150_P	0.576	0.12
144_D	162_K	0.572	0.12
18_E	27_L	0.572	0.12
72_E	245_K	0.571	0.12
77_T	203_R	0.570	0.12
78_L	107_S	0.567	0.12
30_E	180_T	0.566	0.12
71_I	216_A	0.566	0.12
38_K	171_L	0.565	0.12
245_K	252_L	0.565	0.12
136_K	203_R	0.565	0.12
15_L	23_R	0.564	0.12
104_A	139_L	0.563	0.12
63_T	193_I	0.562	0.12
244_N	248_L	0.561	0.12
33_I	201_T	0.560	0.12
18_E	23_R	0.559	0.11
17_P	126_I	0.558	0.11
113_I	254_F	0.557	0.11
225_K	257_N	0.553	0.11
206_T	227_L	0.552	0.11
67_A	171_L	0.551	0.11
76_A	80_L	0.550	0.11
96_V	237_Q	0.548	0.11
47_I	218_P	0.547	0.11
104_A	151_E	0.547	0.11
41_L	180_T	0.545	0.11
39_S	119_D	0.542	0.11
42_V	117_Y	0.542	0.11
17_P	32_L	0.540	0.11
161_P	165_Y	0.539	0.11
83_T	133_G	0.538	0.11
34_E	250_E	0.538	0.11
75_A	103_L	0.533	0.11
161_P	252_L	0.531	0.11
35_A	113_I	0.530	0.11
108_N	225_K	0.527	0.11
226_E	235_L	0.526	0.11
58_L	118_R	0.525	0.11
216_A	227_L	0.523	0.11
96_V	160_S	0.523	0.11
33_I	159_V	0.521	0.11
47_I	193_I	0.520	0.11
166_K	219_R	0.518	0.11
30_E	205_A	0.517	0.11
86_I	192_A	0.517	0.11
80_L	209_I	0.516	0.11
107_S	257_N	0.516	0.11
15_L	202_S	0.514	0.11
33_I	101_I	0.513	0.11
16_I	142_G	0.510	0.11
213_I	216_A	0.509	0.11
84_P	108_N	0.508	0.11
16_I	165_Y	0.507	0.11
79_L	107_S	0.504	0.11
94_A	186_M	0.501	0.11
157_R	212_N	0.500	0.11
18_E	158_R	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mb0A	2	0.9436	100	0.064	Contact Map
3cf4G	2	0.6053	94.3	0.953	Contact Map
1ytlA	1	0.5414	89.2	0.96	Contact Map
2x7jA	4	0.9098	88.8	0.96	Contact Map
2q28A	4	0.8609	88.1	0.96	Contact Map
1q6zA	4	0.8534	86.9	0.961	Contact Map
4q9dA	4	0.8571	86	0.962	Contact Map
2c31A	4	0.8609	85.8	0.962	Contact Map
4rjjA	5	0.8346	84.7	0.962	Contact Map
3eyaA	5	0.8835	84.3	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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