PANB - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PANB - 3-methyl-2-oxobutanoate hydroxymethyltransferase

UniProt:	Q97W44	Sequences: MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNVTMRDMISHTRAVARANPPQLIVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEIKDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQEEEQLIKDSLELEDAGVFSIVIENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEIISSAINQYIIDVKTNKFPEKQHYKERES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	267 (261)
Sequences:	3105 (1879)
Seq/√Len:	116.3

ECOLI - PANB
BACSU - PANB
HALSA - PANB
SULSO - PANB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_K	254_N	3.418	1.00
88_L	102_G	3.091	1.00
235_N	238_E	2.918	1.00
190_K	194_E	2.883	1.00
124_I	171_L	2.815	1.00
69_T	83_S	2.779	1.00
190_K	208_Y	2.658	1.00
233_Y	250_D	2.630	1.00
21_M	213_V	2.591	1.00
62_M	100_N	2.579	1.00
172_E	197_N	2.416	1.00
169_L	195_K	2.312	1.00
13_K	210_D	2.265	1.00
48_G	60_V	2.263	1.00
172_E	196_L	2.161	1.00
96_S	99_K	2.146	1.00
62_M	89_S	2.135	1.00
52_L	67_S	2.125	1.00
135_M	178_S	2.099	1.00
17_E	252_K	2.065	1.00
239_I	242_S	2.063	1.00
231_K	250_D	2.048	1.00
231_K	261_H	2.016	1.00
12_K	19_I	2.016	1.00
20_T	248_I	2.002	1.00
193_T	200_T	1.973	1.00
38_L	248_I	1.953	1.00
92_I	99_K	1.946	1.00
162_E	166_K	1.920	1.00
248_I	252_K	1.904	1.00
11_K	15_M	1.903	1.00
125_R	129_K	1.860	1.00
118_E	166_K	1.825	1.00
191_R	195_K	1.820	1.00
64_D	70_R	1.811	1.00
73_A	81_I	1.773	1.00
249_I	253_T	1.773	1.00
186_V	262_Y	1.758	1.00
234_V	239_I	1.751	1.00
135_M	177_F	1.724	1.00
242_S	246_Q	1.709	1.00
62_M	104_L	1.703	1.00
69_T	109_S	1.678	1.00
33_I	41_I	1.671	1.00
83_S	104_L	1.647	1.00
163_Q	167_D	1.643	1.00
33_I	244_I	1.640	1.00
157_T	160_E	1.636	1.00
85_M	100_N	1.614	1.00
34_S	79_Q	1.602	1.00
56_N	59_N	1.561	1.00
136_G	171_L	1.560	1.00
52_L	71_A	1.521	1.00
9_F	40_S	1.511	1.00
176_V	198_V	1.511	1.00
207_P	262_Y	1.510	1.00
41_I	76_N	1.505	1.00
226_T	232_S	1.502	1.00
165_I	191_R	1.498	1.00
258_E	261_H	1.496	1.00
40_S	213_V	1.493	1.00
29_T	216_I	1.469	1.00
169_L	172_E	1.466	1.00
63_R	103_L	1.462	1.00
154_I	160_E	1.460	1.00
250_D	255_K	1.447	1.00
97_A	123_I	1.446	1.00
12_K	17_E	1.445	1.00
69_T	107_A	1.440	1.00
232_S	235_N	1.417	1.00
238_E	242_S	1.412	1.00
104_L	107_A	1.393	1.00
136_G	176_V	1.391	1.00
85_M	101_A	1.362	1.00
111_A	177_F	1.359	1.00
172_E	198_V	1.340	1.00
40_S	135_M	1.317	1.00
21_M	40_S	1.317	1.00
179_I	196_L	1.306	1.00
171_L	176_V	1.303	1.00
92_I	96_S	1.286	1.00
220_L	240_I	1.275	0.99
83_S	107_A	1.260	0.99
94_V	123_I	1.257	0.99
141_T	148_L	1.254	0.99
35_N	241_S	1.251	0.99
169_L	196_L	1.250	0.99
126_A	130_A	1.249	0.99
66_I	104_L	1.249	0.99
158_K	162_E	1.248	0.99
138_I	181_I	1.244	0.99
138_I	164_L	1.240	0.99
136_G	180_V	1.239	0.99
22_L	219_L	1.227	0.99
110_D	146_L	1.223	0.99
179_I	200_T	1.212	0.99
3_K	110_D	1.194	0.99
125_R	173_D	1.191	0.99
10_I	14_S	1.184	0.99
118_E	167_D	1.179	0.99
82_V	180_V	1.174	0.99
33_I	216_I	1.172	0.99
70_R	74_R	1.172	0.99
48_G	54_Y	1.156	0.99
4_V	39_D	1.149	0.99
92_I	95_K	1.147	0.99
34_S	78_P	1.143	0.99
19_I	211_G	1.140	0.99
90_Y	114_L	1.128	0.99
186_V	208_Y	1.117	0.99
54_Y	74_R	1.108	0.99
54_Y	59_N	1.105	0.98
122_D	125_R	1.104	0.98
181_I	184_T	1.104	0.98
98_V	126_A	1.103	0.98
83_S	109_S	1.102	0.98
82_V	135_M	1.099	0.98
76_N	81_I	1.098	0.98
20_T	252_K	1.097	0.98
216_I	220_L	1.095	0.98
245_N	249_I	1.093	0.98
4_V	8_D	1.088	0.98
179_I	198_V	1.082	0.98
200_T	209_C	1.081	0.98
128_V	176_V	1.081	0.98
241_S	245_N	1.075	0.98
96_S	100_N	1.069	0.98
193_T	209_C	1.068	0.98
7_R	152_R	1.066	0.98
220_L	236_L	1.064	0.98
94_V	126_A	1.061	0.98
155_G	192_I	1.054	0.98
34_S	77_P	1.039	0.98
183_N	263_K	1.037	0.98
82_V	111_A	1.035	0.98
93_D	96_S	1.007	0.97
40_S	82_V	1.004	0.97
186_V	207_P	1.002	0.97
258_E	262_Y	0.998	0.97
119_E	163_Q	0.997	0.97
47_L	68_H	0.987	0.97
54_Y	64_D	0.984	0.97
8_D	11_K	0.976	0.97
140_L	183_N	0.976	0.97
189_A	209_C	0.975	0.97
4_V	78_P	0.975	0.97
20_T	38_L	0.972	0.97
98_V	127_I	0.962	0.96
85_M	89_S	0.961	0.96
161_E	188_I	0.961	0.96
121_K	167_D	0.960	0.96
103_L	107_A	0.956	0.96
166_K	170_E	0.947	0.96
48_G	64_D	0.945	0.96
167_D	170_E	0.945	0.96
28_P	222_L	0.942	0.96
63_R	66_I	0.941	0.96
51_V	217_H	0.941	0.96
64_D	67_S	0.939	0.96
28_P	51_V	0.927	0.95
246_Q	249_I	0.925	0.95
119_E	129_K	0.925	0.95
246_Q	250_D	0.924	0.95
32_I	244_I	0.917	0.95
193_T	210_D	0.916	0.95
121_K	170_E	0.911	0.95
59_N	106_K	0.904	0.95
95_K	99_K	0.903	0.95
160_E	163_Q	0.899	0.95
145_F	150_G	0.898	0.95
90_Y	97_A	0.894	0.95
181_I	192_I	0.893	0.94
207_P	254_N	0.886	0.94
191_R	194_E	0.884	0.94
98_V	130_A	0.884	0.94
148_L	183_N	0.882	0.94
80_L	111_A	0.882	0.94
120_I	123_I	0.876	0.94
22_L	33_I	0.871	0.94
105_V	133_P	0.870	0.94
128_V	177_F	0.869	0.94
22_L	38_L	0.868	0.94
237_K	241_S	0.867	0.94
62_M	65_M	0.866	0.94
19_I	39_D	0.866	0.94
91_E	106_K	0.861	0.93
180_V	198_V	0.858	0.93
73_A	76_N	0.854	0.93
47_L	60_V	0.852	0.93
41_I	81_I	0.851	0.93
66_I	103_L	0.842	0.93
236_L	240_I	0.841	0.93
165_I	195_K	0.841	0.93
242_S	245_N	0.838	0.92
162_E	191_R	0.837	0.92
165_I	169_L	0.834	0.92
28_P	217_H	0.833	0.92
39_D	252_K	0.832	0.92
31_K	35_N	0.826	0.92
224_E	237_K	0.823	0.92
155_G	164_L	0.823	0.92
118_E	170_E	0.816	0.91
233_Y	243_A	0.814	0.91
70_R	73_A	0.811	0.91
214_L	229_F	0.808	0.91
52_L	64_D	0.804	0.91
235_N	239_I	0.803	0.91
185_Y	205_A	0.793	0.90
118_E	163_Q	0.792	0.90
153_T	228_Y	0.792	0.90
117_G	121_K	0.790	0.90
81_I	110_D	0.789	0.90
94_V	122_D	0.787	0.90
67_S	71_A	0.785	0.90
236_L	239_I	0.785	0.90
29_T	217_H	0.784	0.90
111_A	135_M	0.782	0.90
47_L	52_L	0.780	0.89
9_F	177_F	0.775	0.89
61_T	64_D	0.774	0.89
234_V	243_A	0.772	0.89
153_T	263_K	0.769	0.89
89_S	106_K	0.768	0.89
171_L	179_I	0.765	0.88
183_N	228_Y	0.764	0.88
98_V	102_G	0.762	0.88
12_K	252_K	0.761	0.88
34_S	76_N	0.758	0.88
36_T	241_S	0.757	0.88
4_V	9_F	0.756	0.88
22_L	244_I	0.755	0.88
66_I	107_A	0.753	0.88
216_I	244_I	0.750	0.87
73_A	110_D	0.743	0.87
32_I	237_K	0.742	0.87
20_T	39_D	0.742	0.87
229_F	261_H	0.735	0.86
39_D	211_G	0.734	0.86
19_I	40_S	0.731	0.86
27_Y	31_K	0.730	0.86
250_D	253_T	0.729	0.86
176_V	179_I	0.725	0.86
233_Y	255_K	0.723	0.86
65_M	83_S	0.716	0.85
194_E	208_Y	0.715	0.85
185_Y	188_I	0.712	0.85
62_M	66_I	0.709	0.84
91_E	97_A	0.707	0.84
161_E	191_R	0.704	0.84
95_K	126_A	0.699	0.84
170_E	173_D	0.693	0.83
29_T	240_I	0.693	0.83
123_I	126_A	0.693	0.83
136_G	179_I	0.692	0.83
148_L	154_I	0.691	0.83
22_L	216_I	0.683	0.82
169_L	173_D	0.683	0.82
73_A	107_A	0.682	0.82
66_I	69_T	0.682	0.82
102_G	106_K	0.678	0.82
256_F	263_K	0.675	0.81
31_K	237_K	0.674	0.81
93_D	123_I	0.674	0.81
186_V	259_K	0.673	0.81
150_G	154_I	0.673	0.81
140_L	151_F	0.670	0.81
47_L	67_S	0.669	0.81
12_K	39_D	0.668	0.81
88_L	98_V	0.666	0.81
55_T	59_N	0.662	0.80
10_I	197_N	0.661	0.80
118_E	121_K	0.658	0.80
138_I	179_I	0.656	0.80
58_L	106_K	0.656	0.80
166_K	169_L	0.655	0.79
170_E	174_A	0.655	0.79
231_K	255_K	0.652	0.79
217_H	222_L	0.651	0.79
181_I	200_T	0.647	0.79
94_V	97_A	0.646	0.79
49_M	227_P	0.646	0.79
221_G	226_T	0.646	0.79
153_T	183_N	0.644	0.78
112_V	134_V	0.642	0.78
48_G	61_T	0.641	0.78
90_Y	100_N	0.641	0.78
227_P	230_A	0.639	0.78
123_I	127_I	0.637	0.78
6_I	177_F	0.631	0.77
231_K	258_E	0.630	0.77
230_A	263_K	0.628	0.77
30_A	76_N	0.628	0.77
70_R	107_A	0.627	0.76
25_Y	51_V	0.625	0.76
85_M	90_Y	0.625	0.76
40_S	80_L	0.623	0.76
128_V	147_R	0.622	0.76
114_L	127_I	0.622	0.76
21_M	30_A	0.621	0.76
26_D	29_T	0.616	0.75
196_L	200_T	0.609	0.74
66_I	70_R	0.609	0.74
183_N	223_S	0.605	0.74
5_T	140_L	0.604	0.74
116_G	167_D	0.604	0.74
192_I	195_K	0.603	0.74
6_I	10_I	0.601	0.73
11_K	14_S	0.601	0.73
29_T	220_L	0.600	0.73
121_K	174_A	0.600	0.73
161_E	185_Y	0.599	0.73
102_G	132_I	0.598	0.73
58_L	144_R	0.594	0.73
40_S	178_S	0.594	0.73
221_G	232_S	0.593	0.72
259_K	262_Y	0.593	0.72
164_L	188_I	0.592	0.72
73_A	77_P	0.592	0.72
30_A	41_I	0.591	0.72
85_M	104_L	0.591	0.72
147_R	177_F	0.590	0.72
240_I	244_I	0.587	0.72
151_F	227_P	0.584	0.71
94_V	98_V	0.584	0.71
114_L	120_I	0.583	0.71
180_V	196_L	0.583	0.71
100_N	104_L	0.582	0.71
72_V	81_I	0.581	0.71
151_F	183_N	0.581	0.71
51_V	71_A	0.578	0.70
122_D	129_K	0.578	0.70
19_I	201_I	0.576	0.70
223_S	226_T	0.574	0.70
181_I	189_A	0.574	0.70
138_I	155_G	0.572	0.70
36_T	245_N	0.569	0.69
8_D	12_K	0.568	0.69
128_V	174_A	0.566	0.69
201_I	211_G	0.566	0.69
169_L	197_N	0.564	0.69
82_V	178_S	0.564	0.69
9_F	12_K	0.563	0.68
141_T	144_R	0.561	0.68
101_A	132_I	0.561	0.68
131_G	147_R	0.559	0.68
27_Y	75_A	0.559	0.68
117_G	123_I	0.555	0.67
233_Y	236_L	0.553	0.67
203_I	213_V	0.551	0.67
87_F	131_G	0.550	0.67
184_T	200_T	0.549	0.67
58_L	145_F	0.547	0.66
219_L	230_A	0.545	0.66
200_T	210_D	0.542	0.66
105_V	127_I	0.539	0.65
24_A	43_V	0.539	0.65
8_D	49_M	0.539	0.65
145_F	151_F	0.538	0.65
24_A	33_I	0.534	0.64
154_I	263_K	0.532	0.64
12_K	15_M	0.531	0.64
127_I	130_A	0.531	0.64
35_N	245_N	0.528	0.64
9_F	19_I	0.526	0.63
124_I	136_G	0.525	0.63
21_M	82_V	0.524	0.63
19_I	199_P	0.520	0.62
154_I	185_Y	0.519	0.62
193_T	208_Y	0.517	0.62
98_V	123_I	0.517	0.62
26_D	217_H	0.517	0.62
35_N	237_K	0.517	0.62
124_I	176_V	0.516	0.62
184_T	188_I	0.516	0.62
24_A	30_A	0.515	0.62
24_A	41_I	0.514	0.62
60_V	64_D	0.513	0.61
250_D	261_H	0.512	0.61
216_I	222_L	0.511	0.61
62_M	103_L	0.510	0.61
43_V	83_S	0.510	0.61
165_I	192_I	0.508	0.61
31_K	224_E	0.507	0.60
58_L	149_G	0.506	0.60
105_V	108_G	0.506	0.60
244_I	248_I	0.506	0.60
153_T	185_Y	0.505	0.60
249_I	255_K	0.504	0.60
118_E	129_K	0.504	0.60
4_V	79_Q	0.504	0.60
164_L	192_I	0.504	0.60
117_G	180_V	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1o66A	3	0.9326	100	0.219	Contact Map
1m3uA	4	0.9775	100	0.227	Contact Map
1oy0A	4	0.9213	100	0.239	Contact Map
3vavA	4	0.9813	100	0.248	Contact Map
4lsbA	2	0.8989	100	0.542	Contact Map
4mg4A	4	0.8839	100	0.603	Contact Map
3lyeA	4	0.8989	100	0.618	Contact Map
2qiwA	2	0.8764	100	0.624	Contact Map
3eooA	4	0.9026	100	0.631	Contact Map
1xg4A	4	0.9101	100	0.634	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.