Q97W41 - SULSO - GREMLIN Contacts

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Q97W41 - Uncharacterized protein

UniProt:	Q97W41	Sequences: MMLRTMIKKEILDLKRDRKLLLGTIVLPFVLLPLIGIILYASIAVSPPVIEIINYNQSNLPYIQIISNYITRNGGTVIYNNTNTSIVPDAVIIFPNDFNINASNISRQTFVYEKILISSNQEASNLVNNAIGYLSYTLVYNRIERLINSSNLQHVVNPDDVINPLLVKNFVVTITGRNASQSQANLSEMARIITLVLFPSATPVIFYVTDGIVGEKERKTLESLLASPISINSFIFSKVIIAVILGVLSSLGDILGIVIFSSLMSFTFGLPLSLSTPFILIVILTYLLAVLLTAALSVILLLALGGSMRNMQVINFLILSFGLIASFSALFINVANLQSPLNLVLLIPYEQLSLSLLYFVSGSTFVSLSLLLGVFAVCVIILIVSSRLFNSERLLLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	397 (354)
Sequences:	9663 (8140)
Seq/√Len:	432.6

ECOLI - YBHR YBHS YHHJ
BACSU - YHAP NATB YFIM YFIN YHGE
SULSO - Q97W41 Q7LY08

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
51_E	88_P	5.985	1.00
79_Y	91_V	5.315	1.00
285_T	355_S	4.655	1.00
97_D	101_N	4.212	1.00
82_T	88_P	3.936	1.00
7_I	244_I	3.553	1.00
6_M	237_S	3.525	1.00
8_K	12_L	3.493	1.00
81_N	85_S	3.424	1.00
7_I	240_I	3.105	1.00
83_N	91_V	3.065	1.00
230_S	233_S	2.721	1.00
82_T	87_V	2.664	1.00
80_N	84_T	2.633	1.00
368_L	372_L	2.613	1.00
251_L	283_I	2.482	1.00
52_I	63_I	2.437	1.00
255_L	259_I	2.435	1.00
10_E	238_K	2.429	1.00
54_N	61_P	2.400	1.00
372_L	376_A	2.360	1.00
55_Y	93_I	2.345	1.00
94_F	98_F	2.335	1.00
101_N	106_S	2.296	1.00
286_Y	352_L	2.252	1.00
289_A	352_L	2.247	1.00
299_I	384_V	2.216	1.00
78_I	82_T	2.201	1.00
56_N	99_N	2.092	1.00
292_L	378_C	2.079	1.00
376_A	380_I	2.069	1.00
291_L	378_C	2.025	1.00
54_N	57_Q	1.997	1.00
344_V	350_E	1.964	1.00
53_I	79_Y	1.925	1.00
354_L	370_L	1.852	1.00
288_L	375_F	1.840	1.00
130_A	134_L	1.783	1.00
12_L	16_R	1.765	1.00
281_I	359_F	1.740	1.00
334_V	344_V	1.738	1.00
345_L	351_Q	1.737	1.00
4_R	8_K	1.730	1.00
88_P	91_V	1.726	1.00
250_S	286_Y	1.718	1.00
243_V	287_L	1.718	1.00
58_S	61_P	1.696	1.00
109_T	114_K	1.689	1.00
295_A	378_C	1.680	1.00
47_P	73_N	1.677	1.00
285_T	371_L	1.668	1.00
345_L	350_E	1.667	1.00
11_I	248_L	1.660	1.00
187_S	190_A	1.654	1.00
289_A	293_T	1.642	1.00
215_E	238_K	1.617	1.00
243_V	291_L	1.613	1.00
51_E	82_T	1.611	1.00
49_V	75_G	1.595	1.00
12_L	15_K	1.592	1.00
369_S	373_G	1.585	1.00
246_G	290_V	1.579	1.00
387_R	391_S	1.570	1.00
135_S	139_V	1.566	1.00
81_N	84_T	1.557	1.00
296_L	318_I	1.532	1.00
188_E	191_R	1.527	1.00
54_N	58_S	1.524	1.00
199_P	203_P	1.516	1.00
58_S	99_N	1.514	1.00
55_Y	96_N	1.514	1.00
288_L	378_C	1.509	1.00
247_V	287_L	1.497	1.00
342_N	345_L	1.495	1.00
215_E	220_T	1.494	1.00
280_L	284_L	1.493	1.00
188_E	192_I	1.488	1.00
334_V	337_L	1.464	1.00
97_D	100_I	1.452	1.00
373_G	377_V	1.441	1.00
292_L	381_I	1.436	1.00
92_I	111_V	1.430	1.00
224_L	234_F	1.421	1.00
339_S	342_N	1.413	1.00
383_I	387_R	1.411	1.00
99_N	103_S	1.409	1.00
358_Y	364_T	1.403	1.00
65_I	68_N	1.402	1.00
192_I	195_L	1.399	1.00
288_L	371_L	1.399	1.00
232_N	386_S	1.395	1.00
93_I	112_Y	1.388	1.00
299_I	381_I	1.380	1.00
285_T	359_F	1.368	1.00
190_A	195_L	1.367	1.00
11_I	244_I	1.359	1.00
190_A	194_T	1.347	1.00
64_Q	67_S	1.346	1.00
78_I	81_N	1.328	1.00
254_I	286_Y	1.322	1.00
185_N	189_M	1.322	1.00
358_Y	362_G	1.321	1.00
347_I	350_E	1.314	1.00
255_L	258_V	1.304	1.00
198_F	204_V	1.301	1.00
350_E	354_L	1.294	1.00
303_A	388_L	1.293	1.00
351_Q	373_G	1.287	1.00
278_F	281_I	1.285	1.00
256_G	260_F	1.283	1.00
56_N	97_D	1.282	1.00
184_A	188_E	1.279	1.00
83_N	88_P	1.276	1.00
299_I	385_S	1.275	1.00
232_N	236_F	1.255	1.00
73_N	76_T	1.255	1.00
320_S	323_L	1.251	1.00
7_I	237_S	1.244	1.00
377_V	381_I	1.241	1.00
53_I	91_V	1.234	1.00
373_G	376_A	1.227	1.00
50_I	92_I	1.227	1.00
380_I	384_V	1.225	1.00
77_V	82_T	1.209	1.00
307_S	310_N	1.208	1.00
282_V	356_L	1.202	1.00
237_S	241_I	1.195	1.00
371_L	375_F	1.187	1.00
9_K	215_E	1.185	1.00
50_I	90_A	1.183	1.00
128_N	132_G	1.180	1.00
112_Y	115_I	1.179	1.00
61_P	99_N	1.174	1.00
326_S	329_A	1.174	1.00
188_E	195_L	1.174	1.00
60_L	99_N	1.172	1.00
6_M	229_I	1.157	1.00
233_S	237_S	1.157	1.00
141_N	144_E	1.156	1.00
4_R	7_I	1.156	1.00
351_Q	370_L	1.152	1.00
195_L	198_F	1.147	1.00
65_I	137_T	1.145	1.00
213_V	216_K	1.142	1.00
7_I	241_I	1.141	1.00
292_L	377_V	1.140	1.00
299_I	388_L	1.139	1.00
49_V	73_N	1.135	1.00
33_P	256_G	1.124	1.00
313_V	316_F	1.124	1.00
191_R	195_L	1.117	1.00
56_N	94_F	1.116	1.00
137_T	141_N	1.110	1.00
189_M	194_T	1.103	1.00
137_T	140_Y	1.097	1.00
337_L	342_N	1.097	1.00
190_A	193_I	1.094	1.00
317_L	321_F	1.091	1.00
124_S	128_N	1.090	1.00
365_F	369_S	1.085	1.00
184_A	191_R	1.081	1.00
290_V	294_A	1.077	1.00
244_I	248_L	1.076	1.00
292_L	374_V	1.073	1.00
109_T	116_L	1.073	1.00
318_I	322_G	1.063	1.00
235_I	386_S	1.062	1.00
49_V	89_D	1.059	1.00
340_P	343_L	1.045	1.00
208_V	211_G	1.032	1.00
310_N	313_V	1.031	1.00
11_I	241_I	1.017	1.00
295_A	381_I	1.016	1.00
209_T	311_M	1.010	1.00
198_F	352_L	1.006	1.00
51_E	91_V	1.005	1.00
319_L	323_L	0.994	1.00
114_K	117_I	0.994	1.00
220_T	223_S	0.985	1.00
127_V	130_A	0.984	1.00
280_L	283_I	0.983	1.00
126_L	130_A	0.979	1.00
135_S	138_L	0.977	1.00
131_I	135_S	0.976	1.00
334_V	342_N	0.969	1.00
201_A	204_V	0.963	1.00
201_A	205_I	0.963	1.00
57_Q	96_N	0.961	1.00
213_V	217_E	0.961	1.00
316_F	321_F	0.958	1.00
378_C	382_L	0.957	1.00
17_D	20_L	0.953	1.00
295_A	382_L	0.948	1.00
134_L	138_L	0.947	1.00
139_V	142_R	0.945	1.00
132_G	135_S	0.943	1.00
15_K	18_R	0.942	1.00
305_G	310_N	0.942	1.00
138_L	141_N	0.940	1.00
313_V	321_F	0.940	1.00
189_M	197_L	0.930	1.00
375_F	379_V	0.926	1.00
60_L	102_A	0.921	1.00
109_T	113_E	0.918	1.00
281_I	284_L	0.917	1.00
285_T	367_S	0.915	1.00
188_E	197_L	0.906	1.00
32_L	257_I	0.903	1.00
71_T	74_G	0.896	1.00
247_V	251_L	0.888	1.00
286_Y	356_L	0.886	1.00
198_F	201_A	0.874	1.00
369_S	372_L	0.870	1.00
133_Y	137_T	0.867	1.00
35_I	39_L	0.865	1.00
187_S	191_R	0.863	1.00
338_Q	342_N	0.859	1.00
32_L	36_G	0.858	1.00
22_L	26_V	0.852	1.00
239_V	291_L	0.850	1.00
358_Y	366_V	0.848	1.00
119_S	122_E	0.848	1.00
100_I	106_S	0.847	1.00
5_T	8_K	0.839	1.00
132_G	136_Y	0.837	1.00
186_L	189_M	0.836	1.00
109_T	115_I	0.834	1.00
188_E	194_T	0.830	1.00
136_Y	139_V	0.828	1.00
185_N	195_L	0.828	1.00
316_F	320_S	0.827	1.00
189_M	193_I	0.826	1.00
79_Y	82_T	0.826	1.00
166_L	169_N	0.825	1.00
194_T	197_L	0.820	1.00
37_I	260_F	0.820	1.00
184_A	187_S	0.817	1.00
239_V	295_A	0.815	1.00
118_S	121_Q	0.815	1.00
9_K	13_D	0.814	1.00
54_N	94_F	0.812	1.00
308_M	312_Q	0.812	1.00
80_N	114_K	0.810	1.00
189_M	195_L	0.808	1.00
185_N	188_E	0.808	1.00
33_P	37_I	0.806	1.00
195_L	200_S	0.806	1.00
11_I	15_K	0.805	1.00
158_P	162_I	0.804	1.00
323_L	328_S	0.803	1.00
189_M	192_I	0.802	1.00
170_F	174_I	0.800	1.00
186_L	194_T	0.800	1.00
67_S	74_G	0.800	1.00
142_R	145_R	0.799	1.00
51_E	77_V	0.799	1.00
54_N	63_I	0.799	1.00
254_I	282_V	0.798	1.00
308_M	315_N	0.798	1.00
366_V	369_S	0.797	1.00
370_L	374_V	0.793	1.00
372_L	375_F	0.792	1.00
69_Y	72_R	0.792	1.00
80_N	91_V	0.790	1.00
319_L	322_G	0.789	1.00
338_Q	341_L	0.785	1.00
36_G	39_L	0.781	1.00
190_A	197_L	0.779	1.00
120_N	126_L	0.779	1.00
310_N	317_L	0.779	1.00
71_T	75_G	0.775	1.00
77_V	88_P	0.773	1.00
384_V	387_R	0.771	1.00
381_I	385_S	0.770	1.00
279_I	283_I	0.767	1.00
192_I	196_V	0.766	1.00
36_G	261_S	0.766	1.00
205_I	297_S	0.766	1.00
7_I	11_I	0.763	1.00
9_K	12_L	0.758	1.00
93_I	114_K	0.757	1.00
193_I	196_V	0.754	1.00
187_S	195_L	0.754	1.00
311_M	315_N	0.753	1.00
326_S	330_L	0.751	1.00
10_E	241_I	0.750	1.00
83_N	86_I	0.749	1.00
185_N	190_A	0.747	1.00
312_Q	316_F	0.747	1.00
109_T	112_Y	0.746	1.00
128_N	131_I	0.746	1.00
90_A	123_A	0.745	1.00
296_L	381_I	0.742	1.00
61_P	94_F	0.736	1.00
125_N	129_N	0.733	1.00
67_S	76_T	0.730	1.00
31_L	35_I	0.730	1.00
281_I	371_L	0.730	1.00
72_R	75_G	0.727	1.00
309_R	313_V	0.727	1.00
358_Y	370_L	0.726	1.00
141_N	145_R	0.726	1.00
123_A	126_L	0.726	1.00
240_I	244_I	0.725	1.00
125_N	130_A	0.724	1.00
334_V	350_E	0.721	1.00
215_E	219_K	0.719	1.00
367_S	370_L	0.718	1.00
367_S	371_L	0.718	1.00
219_K	228_P	0.717	1.00
136_Y	140_Y	0.716	1.00
277_P	359_F	0.714	1.00
333_N	337_L	0.712	1.00
221_L	234_F	0.711	1.00
344_V	347_I	0.709	1.00
281_I	367_S	0.705	1.00
80_N	112_Y	0.703	1.00
189_M	196_V	0.703	1.00
365_F	368_L	0.702	1.00
54_N	99_N	0.702	1.00
249_S	253_D	0.701	1.00
355_S	358_Y	0.700	1.00
32_L	35_I	0.700	1.00
186_L	195_L	0.699	1.00
243_V	294_A	0.698	1.00
298_V	385_S	0.697	1.00
134_L	137_T	0.696	1.00
214_G	217_E	0.694	1.00
163_N	166_L	0.692	1.00
74_G	77_V	0.691	1.00
351_Q	354_L	0.691	1.00
329_A	333_N	0.690	1.00
251_L	254_I	0.690	1.00
359_F	367_S	0.689	1.00
190_A	196_V	0.687	1.00
133_Y	136_Y	0.684	1.00
355_S	359_F	0.684	1.00
277_P	363_S	0.682	1.00
188_E	193_I	0.679	1.00
312_Q	323_L	0.678	1.00
346_L	377_V	0.678	1.00
38_I	42_S	0.677	1.00
288_L	374_V	0.677	1.00
327_F	341_L	0.676	1.00
191_R	196_V	0.675	1.00
14_L	245_L	0.674	1.00
239_V	294_A	0.673	1.00
126_L	134_L	0.672	1.00
216_K	221_L	0.672	1.00
5_T	9_K	0.669	1.00
131_I	134_L	0.668	1.00
62_Y	98_F	0.667	1.00
310_N	323_L	0.664	1.00
60_L	103_S	0.664	1.00
66_I	127_V	0.663	1.00
194_T	199_P	0.662	1.00
200_S	204_V	0.661	1.00
210_D	308_M	0.659	1.00
281_I	285_T	0.657	0.99
312_Q	315_N	0.657	0.99
165_L	169_N	0.656	0.99
299_I	303_A	0.656	0.99
122_E	126_L	0.655	0.99
186_L	191_R	0.654	0.99
204_V	207_Y	0.654	0.99
62_Y	94_F	0.653	0.99
33_P	36_G	0.653	0.99
337_L	340_P	0.650	0.99
243_V	247_V	0.647	0.99
310_N	314_I	0.647	0.99
37_I	42_S	0.647	0.99
354_L	358_Y	0.646	0.99
352_L	355_S	0.646	0.99
113_E	124_S	0.645	0.99
139_V	143_I	0.645	0.99
236_F	240_I	0.644	0.99
37_I	40_Y	0.642	0.99
283_I	286_Y	0.640	0.99
6_M	234_F	0.638	0.99
121_Q	124_S	0.637	0.99
188_E	200_S	0.636	0.99
229_I	233_S	0.636	0.99
305_G	314_I	0.634	0.99
92_I	109_T	0.634	0.99
28_P	38_I	0.634	0.99
185_N	194_T	0.632	0.99
120_N	124_S	0.631	0.99
184_A	189_M	0.630	0.99
186_L	190_A	0.627	0.99
317_L	320_S	0.627	0.99
294_A	298_V	0.623	0.99
258_V	262_S	0.622	0.99
351_Q	377_V	0.621	0.99
308_M	323_L	0.619	0.99
79_Y	90_A	0.618	0.99
64_Q	168_K	0.618	0.99
326_S	332_I	0.617	0.99
318_I	321_F	0.616	0.99
140_Y	144_E	0.615	0.99
329_A	344_V	0.611	0.99
199_P	202_T	0.610	0.99
343_L	347_I	0.609	0.99
50_I	74_G	0.609	0.99
375_F	378_C	0.607	0.99
191_R	198_F	0.604	0.99
28_P	32_L	0.602	0.99
218_R	222_E	0.601	0.99
307_S	312_Q	0.600	0.99
196_V	199_P	0.600	0.99
328_S	333_N	0.598	0.99
302_L	305_G	0.596	0.99
167_V	170_F	0.595	0.99
378_C	381_I	0.594	0.99
63_I	67_S	0.592	0.99
129_N	133_Y	0.592	0.99
197_L	205_I	0.591	0.99
189_M	204_V	0.588	0.99
308_M	322_G	0.586	0.99
349_Y	353_S	0.586	0.99
124_S	130_A	0.585	0.99
91_V	112_Y	0.584	0.99
219_K	222_E	0.584	0.99
228_P	231_I	0.583	0.99
125_N	128_N	0.583	0.99
90_A	127_V	0.582	0.99
317_L	323_L	0.579	0.99
316_F	319_L	0.579	0.99
374_V	377_V	0.579	0.99
193_I	203_P	0.578	0.99
70_I	73_N	0.578	0.99
127_V	131_I	0.576	0.99
195_L	204_V	0.575	0.99
186_L	193_I	0.573	0.99
229_I	234_F	0.572	0.99
380_I	383_I	0.571	0.99
171_V	174_I	0.570	0.99
300_L	314_I	0.565	0.98
120_N	123_A	0.564	0.98
330_L	353_S	0.563	0.98
379_V	383_I	0.562	0.98
82_T	85_S	0.561	0.98
70_I	75_G	0.560	0.98
366_V	370_L	0.560	0.98
208_V	214_G	0.559	0.98
93_I	110_F	0.558	0.98
312_Q	320_S	0.557	0.98
190_A	201_A	0.557	0.98
208_V	294_A	0.556	0.98
251_L	279_I	0.556	0.98
34_L	38_I	0.555	0.98
239_V	243_V	0.555	0.98
322_G	347_I	0.554	0.98
224_L	238_K	0.553	0.98
216_K	219_K	0.553	0.98
209_T	213_V	0.553	0.98
387_R	390_N	0.552	0.98
144_E	159_D	0.551	0.98
326_S	331_F	0.550	0.98
235_I	385_S	0.550	0.98
10_E	234_F	0.549	0.98
192_I	197_L	0.549	0.98
31_L	36_G	0.549	0.98
40_Y	43_I	0.546	0.98
69_Y	74_G	0.546	0.98
308_M	314_I	0.546	0.98
194_T	198_F	0.545	0.98
18_R	21_L	0.542	0.98
217_E	220_T	0.542	0.98
194_T	206_F	0.541	0.98
315_N	323_L	0.540	0.98
125_N	134_L	0.540	0.98
355_S	370_L	0.539	0.98
191_R	357_L	0.539	0.98
356_L	359_F	0.539	0.98
239_V	298_V	0.538	0.98
308_M	311_M	0.538	0.98
317_L	322_G	0.538	0.98
309_R	322_G	0.537	0.98
382_L	386_S	0.537	0.98
313_V	322_G	0.537	0.98
209_T	212_I	0.536	0.98
52_I	74_G	0.534	0.98
295_A	298_V	0.534	0.98
332_I	336_N	0.534	0.98
211_G	238_K	0.533	0.98
197_L	204_V	0.533	0.98
165_L	172_V	0.533	0.98
191_R	197_L	0.533	0.98
76_T	82_T	0.531	0.98
113_E	117_I	0.530	0.98
186_L	192_I	0.529	0.98
11_I	159_D	0.528	0.98
370_L	373_G	0.528	0.98
309_R	317_L	0.528	0.98
224_L	227_S	0.525	0.98
62_Y	65_I	0.524	0.98
101_N	105_I	0.522	0.97
34_L	37_I	0.521	0.97
304_L	307_S	0.520	0.97
24_T	27_L	0.520	0.97
53_I	93_I	0.518	0.97
323_L	349_Y	0.518	0.97
14_L	24_T	0.518	0.97
281_I	368_L	0.518	0.97
329_A	332_I	0.517	0.97
300_L	315_N	0.517	0.97
355_S	371_L	0.517	0.97
118_S	122_E	0.517	0.97
321_F	349_Y	0.515	0.97
23_G	28_P	0.514	0.97
299_I	304_L	0.513	0.97
216_K	220_T	0.513	0.97
200_S	203_P	0.513	0.97
223_S	227_S	0.512	0.97
215_E	221_L	0.512	0.97
59_N	99_N	0.511	0.97
309_R	312_Q	0.511	0.97
159_D	162_I	0.510	0.97
10_E	14_L	0.510	0.97
168_K	171_V	0.509	0.97
355_S	367_S	0.507	0.97
246_G	294_A	0.507	0.97
26_V	30_V	0.507	0.97
315_N	322_G	0.506	0.97
211_G	242_A	0.505	0.97
381_I	384_V	0.504	0.97
211_G	214_G	0.504	0.97
191_R	203_P	0.501	0.97
63_I	66_I	0.501	0.97
109_T	117_I	0.500	0.97
213_V	308_M	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3cniA	2	0.3375	99.3	0.78	Contact Map
2p0sA	2	0.3098	98.1	0.855	Contact Map
2wswA	3	0.4156	11	0.957	Contact Map
3ktoA	3	0.2746	8.4	0.959	Contact Map
4q7eA	2	0.2872	6.6	0.961	Contact Map
2y7iA	2	0.3652	6	0.962	Contact Map
4mldA	2	0.2821	5	0.963	Contact Map
3cg0A	4	0.2846	4.8	0.964	Contact Map
2pl1A	2	0.2771	4.7	0.964	Contact Map
4igaA	1	0.262	4.7	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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