GREMLIN Database
Q97W41 - Uncharacterized protein
UniProt: Q97W41 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (354)
Sequences: 9663 (8140)
Seq/√Len: 432.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_E88_P5.9851.00
79_Y91_V5.3151.00
285_T355_S4.6551.00
97_D101_N4.2121.00
82_T88_P3.9361.00
7_I244_I3.5531.00
6_M237_S3.5251.00
8_K12_L3.4931.00
81_N85_S3.4241.00
7_I240_I3.1051.00
83_N91_V3.0651.00
230_S233_S2.7211.00
82_T87_V2.6641.00
80_N84_T2.6331.00
368_L372_L2.6131.00
251_L283_I2.4821.00
52_I63_I2.4371.00
255_L259_I2.4351.00
10_E238_K2.4291.00
54_N61_P2.4001.00
372_L376_A2.3601.00
55_Y93_I2.3451.00
94_F98_F2.3351.00
101_N106_S2.2961.00
286_Y352_L2.2521.00
289_A352_L2.2471.00
299_I384_V2.2161.00
78_I82_T2.2011.00
56_N99_N2.0921.00
292_L378_C2.0791.00
376_A380_I2.0691.00
291_L378_C2.0251.00
54_N57_Q1.9971.00
344_V350_E1.9641.00
53_I79_Y1.9251.00
354_L370_L1.8521.00
288_L375_F1.8401.00
130_A134_L1.7831.00
12_L16_R1.7651.00
281_I359_F1.7401.00
334_V344_V1.7381.00
345_L351_Q1.7371.00
4_R8_K1.7301.00
88_P91_V1.7261.00
250_S286_Y1.7181.00
243_V287_L1.7181.00
58_S61_P1.6961.00
109_T114_K1.6891.00
295_A378_C1.6801.00
47_P73_N1.6771.00
285_T371_L1.6681.00
345_L350_E1.6671.00
11_I248_L1.6601.00
187_S190_A1.6541.00
289_A293_T1.6421.00
215_E238_K1.6171.00
243_V291_L1.6131.00
51_E82_T1.6111.00
49_V75_G1.5951.00
12_L15_K1.5921.00
369_S373_G1.5851.00
246_G290_V1.5791.00
387_R391_S1.5701.00
135_S139_V1.5661.00
81_N84_T1.5571.00
296_L318_I1.5321.00
188_E191_R1.5271.00
54_N58_S1.5241.00
199_P203_P1.5161.00
58_S99_N1.5141.00
55_Y96_N1.5141.00
288_L378_C1.5091.00
247_V287_L1.4971.00
342_N345_L1.4951.00
215_E220_T1.4941.00
280_L284_L1.4931.00
188_E192_I1.4881.00
334_V337_L1.4641.00
97_D100_I1.4521.00
373_G377_V1.4411.00
292_L381_I1.4361.00
92_I111_V1.4301.00
224_L234_F1.4211.00
339_S342_N1.4131.00
383_I387_R1.4111.00
99_N103_S1.4091.00
358_Y364_T1.4031.00
65_I68_N1.4021.00
192_I195_L1.3991.00
288_L371_L1.3991.00
232_N386_S1.3951.00
93_I112_Y1.3881.00
299_I381_I1.3801.00
285_T359_F1.3681.00
190_A195_L1.3671.00
11_I244_I1.3591.00
190_A194_T1.3471.00
64_Q67_S1.3461.00
78_I81_N1.3281.00
254_I286_Y1.3221.00
185_N189_M1.3221.00
358_Y362_G1.3211.00
347_I350_E1.3141.00
255_L258_V1.3041.00
198_F204_V1.3011.00
350_E354_L1.2941.00
303_A388_L1.2931.00
351_Q373_G1.2871.00
278_F281_I1.2851.00
256_G260_F1.2831.00
56_N97_D1.2821.00
184_A188_E1.2791.00
83_N88_P1.2761.00
299_I385_S1.2751.00
232_N236_F1.2551.00
73_N76_T1.2551.00
320_S323_L1.2511.00
7_I237_S1.2441.00
377_V381_I1.2411.00
53_I91_V1.2341.00
373_G376_A1.2271.00
50_I92_I1.2271.00
380_I384_V1.2251.00
77_V82_T1.2091.00
307_S310_N1.2081.00
282_V356_L1.2021.00
237_S241_I1.1951.00
371_L375_F1.1871.00
9_K215_E1.1851.00
50_I90_A1.1831.00
128_N132_G1.1801.00
112_Y115_I1.1791.00
61_P99_N1.1741.00
326_S329_A1.1741.00
188_E195_L1.1741.00
60_L99_N1.1721.00
6_M229_I1.1571.00
233_S237_S1.1571.00
141_N144_E1.1561.00
4_R7_I1.1561.00
351_Q370_L1.1521.00
195_L198_F1.1471.00
65_I137_T1.1451.00
213_V216_K1.1421.00
7_I241_I1.1411.00
292_L377_V1.1401.00
299_I388_L1.1391.00
49_V73_N1.1351.00
33_P256_G1.1241.00
313_V316_F1.1241.00
191_R195_L1.1171.00
56_N94_F1.1161.00
137_T141_N1.1101.00
189_M194_T1.1031.00
137_T140_Y1.0971.00
337_L342_N1.0971.00
190_A193_I1.0941.00
317_L321_F1.0911.00
124_S128_N1.0901.00
365_F369_S1.0851.00
184_A191_R1.0811.00
290_V294_A1.0771.00
244_I248_L1.0761.00
292_L374_V1.0731.00
109_T116_L1.0731.00
318_I322_G1.0631.00
235_I386_S1.0621.00
49_V89_D1.0591.00
340_P343_L1.0451.00
208_V211_G1.0321.00
310_N313_V1.0311.00
11_I241_I1.0171.00
295_A381_I1.0161.00
209_T311_M1.0101.00
198_F352_L1.0061.00
51_E91_V1.0051.00
319_L323_L0.9941.00
114_K117_I0.9941.00
220_T223_S0.9851.00
127_V130_A0.9841.00
280_L283_I0.9831.00
126_L130_A0.9791.00
135_S138_L0.9771.00
131_I135_S0.9761.00
334_V342_N0.9691.00
201_A204_V0.9631.00
201_A205_I0.9631.00
57_Q96_N0.9611.00
213_V217_E0.9611.00
316_F321_F0.9581.00
378_C382_L0.9571.00
17_D20_L0.9531.00
295_A382_L0.9481.00
134_L138_L0.9471.00
139_V142_R0.9451.00
132_G135_S0.9431.00
15_K18_R0.9421.00
305_G310_N0.9421.00
138_L141_N0.9401.00
313_V321_F0.9401.00
189_M197_L0.9301.00
375_F379_V0.9261.00
60_L102_A0.9211.00
109_T113_E0.9181.00
281_I284_L0.9171.00
285_T367_S0.9151.00
188_E197_L0.9061.00
32_L257_I0.9031.00
71_T74_G0.8961.00
247_V251_L0.8881.00
286_Y356_L0.8861.00
198_F201_A0.8741.00
369_S372_L0.8701.00
133_Y137_T0.8671.00
35_I39_L0.8651.00
187_S191_R0.8631.00
338_Q342_N0.8591.00
32_L36_G0.8581.00
22_L26_V0.8521.00
239_V291_L0.8501.00
358_Y366_V0.8481.00
119_S122_E0.8481.00
100_I106_S0.8471.00
5_T8_K0.8391.00
132_G136_Y0.8371.00
186_L189_M0.8361.00
109_T115_I0.8341.00
188_E194_T0.8301.00
136_Y139_V0.8281.00
185_N195_L0.8281.00
316_F320_S0.8271.00
189_M193_I0.8261.00
79_Y82_T0.8261.00
166_L169_N0.8251.00
194_T197_L0.8201.00
37_I260_F0.8201.00
184_A187_S0.8171.00
239_V295_A0.8151.00
118_S121_Q0.8151.00
9_K13_D0.8141.00
54_N94_F0.8121.00
308_M312_Q0.8121.00
80_N114_K0.8101.00
189_M195_L0.8081.00
185_N188_E0.8081.00
33_P37_I0.8061.00
195_L200_S0.8061.00
11_I15_K0.8051.00
158_P162_I0.8041.00
323_L328_S0.8031.00
189_M192_I0.8021.00
170_F174_I0.8001.00
186_L194_T0.8001.00
67_S74_G0.8001.00
142_R145_R0.7991.00
51_E77_V0.7991.00
54_N63_I0.7991.00
254_I282_V0.7981.00
308_M315_N0.7981.00
366_V369_S0.7971.00
370_L374_V0.7931.00
372_L375_F0.7921.00
69_Y72_R0.7921.00
80_N91_V0.7901.00
319_L322_G0.7891.00
338_Q341_L0.7851.00
36_G39_L0.7811.00
190_A197_L0.7791.00
120_N126_L0.7791.00
310_N317_L0.7791.00
71_T75_G0.7751.00
77_V88_P0.7731.00
384_V387_R0.7711.00
381_I385_S0.7701.00
279_I283_I0.7671.00
192_I196_V0.7661.00
36_G261_S0.7661.00
205_I297_S0.7661.00
7_I11_I0.7631.00
9_K12_L0.7581.00
93_I114_K0.7571.00
193_I196_V0.7541.00
187_S195_L0.7541.00
311_M315_N0.7531.00
326_S330_L0.7511.00
10_E241_I0.7501.00
83_N86_I0.7491.00
185_N190_A0.7471.00
312_Q316_F0.7471.00
109_T112_Y0.7461.00
128_N131_I0.7461.00
90_A123_A0.7451.00
296_L381_I0.7421.00
61_P94_F0.7361.00
125_N129_N0.7331.00
67_S76_T0.7301.00
31_L35_I0.7301.00
281_I371_L0.7301.00
72_R75_G0.7271.00
309_R313_V0.7271.00
358_Y370_L0.7261.00
141_N145_R0.7261.00
123_A126_L0.7261.00
240_I244_I0.7251.00
125_N130_A0.7241.00
334_V350_E0.7211.00
215_E219_K0.7191.00
367_S370_L0.7181.00
367_S371_L0.7181.00
219_K228_P0.7171.00
136_Y140_Y0.7161.00
277_P359_F0.7141.00
333_N337_L0.7121.00
221_L234_F0.7111.00
344_V347_I0.7091.00
281_I367_S0.7051.00
80_N112_Y0.7031.00
189_M196_V0.7031.00
365_F368_L0.7021.00
54_N99_N0.7021.00
249_S253_D0.7011.00
355_S358_Y0.7001.00
32_L35_I0.7001.00
186_L195_L0.6991.00
243_V294_A0.6981.00
298_V385_S0.6971.00
134_L137_T0.6961.00
214_G217_E0.6941.00
163_N166_L0.6921.00
74_G77_V0.6911.00
351_Q354_L0.6911.00
329_A333_N0.6901.00
251_L254_I0.6901.00
359_F367_S0.6891.00
190_A196_V0.6871.00
133_Y136_Y0.6841.00
355_S359_F0.6841.00
277_P363_S0.6821.00
188_E193_I0.6791.00
312_Q323_L0.6781.00
346_L377_V0.6781.00
38_I42_S0.6771.00
288_L374_V0.6771.00
327_F341_L0.6761.00
191_R196_V0.6751.00
14_L245_L0.6741.00
239_V294_A0.6731.00
126_L134_L0.6721.00
216_K221_L0.6721.00
5_T9_K0.6691.00
131_I134_L0.6681.00
62_Y98_F0.6671.00
310_N323_L0.6641.00
60_L103_S0.6641.00
66_I127_V0.6631.00
194_T199_P0.6621.00
200_S204_V0.6611.00
210_D308_M0.6591.00
281_I285_T0.6570.99
312_Q315_N0.6570.99
165_L169_N0.6560.99
299_I303_A0.6560.99
122_E126_L0.6550.99
186_L191_R0.6540.99
204_V207_Y0.6540.99
62_Y94_F0.6530.99
33_P36_G0.6530.99
337_L340_P0.6500.99
243_V247_V0.6470.99
310_N314_I0.6470.99
37_I42_S0.6470.99
354_L358_Y0.6460.99
352_L355_S0.6460.99
113_E124_S0.6450.99
139_V143_I0.6450.99
236_F240_I0.6440.99
37_I40_Y0.6420.99
283_I286_Y0.6400.99
6_M234_F0.6380.99
121_Q124_S0.6370.99
188_E200_S0.6360.99
229_I233_S0.6360.99
305_G314_I0.6340.99
92_I109_T0.6340.99
28_P38_I0.6340.99
185_N194_T0.6320.99
120_N124_S0.6310.99
184_A189_M0.6300.99
186_L190_A0.6270.99
317_L320_S0.6270.99
294_A298_V0.6230.99
258_V262_S0.6220.99
351_Q377_V0.6210.99
308_M323_L0.6190.99
79_Y90_A0.6180.99
64_Q168_K0.6180.99
326_S332_I0.6170.99
318_I321_F0.6160.99
140_Y144_E0.6150.99
329_A344_V0.6110.99
199_P202_T0.6100.99
343_L347_I0.6090.99
50_I74_G0.6090.99
375_F378_C0.6070.99
191_R198_F0.6040.99
28_P32_L0.6020.99
218_R222_E0.6010.99
307_S312_Q0.6000.99
196_V199_P0.6000.99
328_S333_N0.5980.99
302_L305_G0.5960.99
167_V170_F0.5950.99
378_C381_I0.5940.99
63_I67_S0.5920.99
129_N133_Y0.5920.99
197_L205_I0.5910.99
189_M204_V0.5880.99
308_M322_G0.5860.99
349_Y353_S0.5860.99
124_S130_A0.5850.99
91_V112_Y0.5840.99
219_K222_E0.5840.99
228_P231_I0.5830.99
125_N128_N0.5830.99
90_A127_V0.5820.99
317_L323_L0.5790.99
316_F319_L0.5790.99
374_V377_V0.5790.99
193_I203_P0.5780.99
70_I73_N0.5780.99
127_V131_I0.5760.99
195_L204_V0.5750.99
186_L193_I0.5730.99
229_I234_F0.5720.99
380_I383_I0.5710.99
171_V174_I0.5700.99
300_L314_I0.5650.98
120_N123_A0.5640.98
330_L353_S0.5630.98
379_V383_I0.5620.98
82_T85_S0.5610.98
70_I75_G0.5600.98
366_V370_L0.5600.98
208_V214_G0.5590.98
93_I110_F0.5580.98
312_Q320_S0.5570.98
190_A201_A0.5570.98
208_V294_A0.5560.98
251_L279_I0.5560.98
34_L38_I0.5550.98
239_V243_V0.5550.98
322_G347_I0.5540.98
224_L238_K0.5530.98
216_K219_K0.5530.98
209_T213_V0.5530.98
387_R390_N0.5520.98
144_E159_D0.5510.98
326_S331_F0.5500.98
235_I385_S0.5500.98
10_E234_F0.5490.98
192_I197_L0.5490.98
31_L36_G0.5490.98
40_Y43_I0.5460.98
69_Y74_G0.5460.98
308_M314_I0.5460.98
194_T198_F0.5450.98
18_R21_L0.5420.98
217_E220_T0.5420.98
194_T206_F0.5410.98
315_N323_L0.5400.98
125_N134_L0.5400.98
355_S370_L0.5390.98
191_R357_L0.5390.98
356_L359_F0.5390.98
239_V298_V0.5380.98
308_M311_M0.5380.98
317_L322_G0.5380.98
309_R322_G0.5370.98
382_L386_S0.5370.98
313_V322_G0.5370.98
209_T212_I0.5360.98
52_I74_G0.5340.98
295_A298_V0.5340.98
332_I336_N0.5340.98
211_G238_K0.5330.98
197_L204_V0.5330.98
165_L172_V0.5330.98
191_R197_L0.5330.98
76_T82_T0.5310.98
113_E117_I0.5300.98
186_L192_I0.5290.98
11_I159_D0.5280.98
370_L373_G0.5280.98
309_R317_L0.5280.98
224_L227_S0.5250.98
62_Y65_I0.5240.98
101_N105_I0.5220.97
34_L37_I0.5210.97
304_L307_S0.5200.97
24_T27_L0.5200.97
53_I93_I0.5180.97
323_L349_Y0.5180.97
14_L24_T0.5180.97
281_I368_L0.5180.97
329_A332_I0.5170.97
300_L315_N0.5170.97
355_S371_L0.5170.97
118_S122_E0.5170.97
321_F349_Y0.5150.97
23_G28_P0.5140.97
299_I304_L0.5130.97
216_K220_T0.5130.97
200_S203_P0.5130.97
223_S227_S0.5120.97
215_E221_L0.5120.97
59_N99_N0.5110.97
309_R312_Q0.5110.97
159_D162_I0.5100.97
10_E14_L0.5100.97
168_K171_V0.5090.97
355_S367_S0.5070.97
246_G294_A0.5070.97
26_V30_V0.5070.97
315_N322_G0.5060.97
211_G242_A0.5050.97
381_I384_V0.5040.97
211_G214_G0.5040.97
191_R203_P0.5010.97
63_I66_I0.5010.97
109_T117_I0.5000.97
213_V308_M0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cniA 2 0.3375 99.3 0.78 Contact Map
2p0sA 2 0.3098 98.1 0.855 Contact Map
2wswA 3 0.4156 11 0.957 Contact Map
3ktoA 3 0.2746 8.4 0.959 Contact Map
4q7eA 2 0.2872 6.6 0.961 Contact Map
2y7iA 2 0.3652 6 0.962 Contact Map
4mldA 2 0.2821 5 0.963 Contact Map
3cg0A 4 0.2846 4.8 0.964 Contact Map
2pl1A 2 0.2771 4.7 0.964 Contact Map
4igaA 1 0.262 4.7 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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