GREMLIN Database
Q97W37 - Uncharacterized protein
UniProt: Q97W37 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (181)
Sequences: 5002 (3345)
Seq/√Len: 248.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_V160_I3.6091.00
77_G94_S3.4951.00
99_Q105_K3.2081.00
149_I157_I3.0331.00
74_T99_Q2.8421.00
130_L154_P2.7401.00
78_I97_V2.6831.00
43_T108_H2.5601.00
143_K180_N2.3871.00
17_I39_L2.3711.00
140_I148_I2.3141.00
19_I43_T2.2921.00
97_V127_A2.2591.00
114_H151_K2.2501.00
131_L158_I2.2411.00
128_D155_K2.1931.00
76_K99_Q2.1521.00
106_I131_L2.1141.00
119_N123_E2.0941.00
2_V14_D2.0921.00
109_L133_P2.0151.00
136_G141_N2.0061.00
12_L16_R1.9961.00
24_G51_A1.9931.00
30_P33_D1.9141.00
11_V131_L1.9021.00
149_I154_P1.8611.00
78_I95_I1.8551.00
119_N151_K1.8171.00
41_L96_Y1.7431.00
41_L98_L1.7041.00
67_S74_T1.6921.00
175_E179_A1.6861.00
15_D101_S1.6701.00
147_E150_N1.6571.00
109_L132_I1.5721.00
176_E180_N1.5671.00
147_E151_K1.5531.00
69_T74_T1.5271.00
131_L160_I1.5261.00
3_L129_V1.4291.00
141_N144_E1.3991.00
39_L61_K1.3971.00
19_I98_L1.3961.00
134_I145_A1.3841.00
129_V158_I1.3781.00
122_K153_S1.3631.00
52_Y56_E1.3601.00
108_H160_I1.3411.00
19_I108_H1.3281.00
51_A54_I1.2831.00
41_L75_I1.2821.00
174_P177_F1.2631.00
6_F10_C1.2621.00
39_L63_N1.2511.00
4_K14_D1.2421.00
105_K127_A1.2281.00
75_I96_Y1.2181.00
6_F12_L1.2161.00
13_I19_I1.1981.00
97_V124_L1.1701.00
77_G96_Y1.1661.00
76_K124_L1.1491.00
180_N183_Y1.1381.00
109_L130_L1.1341.00
129_V156_I1.1271.00
18_L37_V1.1231.00
118_E148_I1.1151.00
10_C19_I1.1141.00
3_L11_V1.1091.00
39_L70_Y1.1051.00
13_I106_I1.0991.00
145_A157_I1.0941.00
40_I62_I1.0931.00
61_K65_Y1.0881.00
63_N96_Y1.0731.00
67_S76_K1.0661.00
95_I109_L1.0631.00
149_I181_L1.0551.00
6_F28_G1.0441.00
3_L131_L1.0381.00
66_G70_Y1.0361.00
137_V167_H1.0331.00
80_S95_I1.0321.00
23_D31_K1.0241.00
120_T123_E1.0151.00
44_H111_D1.0081.00
58_K61_K1.0071.00
132_I148_I1.0031.00
19_I41_L0.9961.00
146_L184_E0.9921.00
69_T72_N0.9911.00
16_R36_K0.9851.00
12_L37_V0.9751.00
132_I152_I0.9721.00
179_A183_Y0.9701.00
105_K125_Y0.9671.00
34_I37_V0.9521.00
104_K128_D0.9431.00
101_S104_K0.9361.00
176_E179_A0.9351.00
39_L75_I0.9321.00
168_Y172_D0.9291.00
172_D177_F0.9241.00
59_D65_Y0.9191.00
132_I140_I0.9131.00
22_H27_I0.9071.00
16_R38_D0.9061.00
23_D54_I0.9041.00
130_L152_I0.9011.00
178_L182_K0.8991.00
114_H147_E0.8931.00
107_V148_I0.8881.00
85_Y89_L0.8811.00
175_E178_L0.8741.00
156_I159_P0.8700.99
180_N184_E0.8690.99
17_I75_I0.8660.99
162_Y178_L0.8660.99
65_Y94_S0.8550.99
98_L106_I0.8540.99
67_S70_Y0.8530.99
12_L18_L0.8520.99
17_I73_Y0.8510.99
130_L149_I0.8470.99
41_L94_S0.8460.99
6_F23_D0.8430.99
80_S112_L0.8400.99
5_Y160_I0.8310.99
78_I107_V0.8240.99
95_I107_V0.8220.99
173_P176_E0.8220.99
46_H111_D0.8220.99
49_H111_D0.8220.99
97_V121_Y0.8180.99
150_N184_E0.8140.99
83_D88_K0.8140.99
15_D73_Y0.8100.99
45_D90_R0.8090.99
134_I162_Y0.8070.99
105_K128_D0.8060.99
16_R37_V0.8050.99
124_L127_A0.7970.99
10_C22_H0.7860.99
172_D176_E0.7850.99
44_H161_H0.7840.99
173_P177_F0.7820.99
11_V158_I0.7800.99
10_C23_D0.7790.99
135_G139_T0.7790.99
132_I149_I0.7760.99
3_L158_I0.7740.99
142_F172_D0.7730.99
62_I65_Y0.7700.99
146_L150_N0.7700.99
9_S133_P0.7690.99
109_L112_L0.7580.99
15_D102_D0.7580.99
32_P57_Y0.7560.99
111_D161_H0.7550.99
31_K54_I0.7540.99
53_Q57_Y0.7540.99
65_Y96_Y0.7490.98
141_N145_A0.7490.98
31_K57_Y0.7460.98
4_K12_L0.7430.98
46_H49_H0.7410.98
44_H49_H0.7340.98
60_V65_Y0.7310.98
112_L118_E0.7250.98
85_Y88_K0.7210.98
154_P157_I0.7210.98
81_Y115_L0.7210.98
52_Y55_F0.7190.98
29_L34_I0.7180.98
50_N55_F0.7170.98
98_L101_S0.7080.98
116_L119_N0.6980.98
66_G69_T0.6970.98
9_S160_I0.6960.98
76_K125_Y0.6930.97
70_Y73_Y0.6920.97
117_E120_T0.6900.97
142_F146_L0.6890.97
122_K127_A0.6880.97
116_L120_T0.6700.97
159_P162_Y0.6660.97
45_D91_G0.6590.97
138_I141_N0.6540.96
43_T96_Y0.6460.96
87_G90_R0.6450.96
136_G172_D0.6420.96
133_P141_N0.6370.96
146_L180_N0.6350.96
15_D104_K0.6320.96
37_V55_F0.6280.96
5_Y162_Y0.6250.95
114_H118_E0.6240.95
146_L181_L0.6240.95
106_I129_V0.6230.95
126_G155_K0.6220.95
112_L140_I0.6160.95
144_E147_E0.6130.95
136_G167_H0.6090.95
118_E121_Y0.6070.95
179_A182_K0.6050.95
108_H133_P0.6020.94
49_H161_H0.5990.94
29_L33_D0.5970.94
61_K64_F0.5950.94
182_K185_I0.5950.94
63_N70_Y0.5950.94
42_V50_N0.5940.94
83_D89_L0.5910.94
55_F62_I0.5910.94
59_D63_N0.5900.94
83_D91_G0.5890.94
13_I17_I0.5870.94
59_D62_I0.5860.94
108_H131_L0.5830.93
165_K168_Y0.5820.93
97_V105_K0.5820.93
127_A130_L0.5740.93
122_K130_L0.5720.93
105_K126_G0.5720.93
75_I98_L0.5700.93
181_L185_I0.5700.93
59_D64_F0.5700.93
8_H47_Y0.5680.92
97_V107_V0.5660.92
48_D161_H0.5620.92
142_F176_E0.5620.92
107_V152_I0.5620.92
137_V144_E0.5600.92
44_H48_D0.5600.92
146_L157_I0.5570.92
134_I159_P0.5560.92
104_K129_V0.5470.91
64_F96_Y0.5470.91
79_K92_E0.5460.91
157_I181_L0.5430.91
163_W169_M0.5430.91
15_D103_G0.5410.91
5_Y163_W0.5410.91
148_I152_I0.5400.91
138_I169_M0.5400.91
177_F181_L0.5400.91
36_K58_K0.5370.90
98_L108_H0.5320.90
12_L29_L0.5320.90
133_P145_A0.5320.90
6_F158_I0.5310.90
84_K91_G0.5300.90
15_D98_L0.5280.90
174_P178_L0.5270.89
163_W168_Y0.5230.89
138_I180_N0.5180.89
79_K121_Y0.5150.88
44_H82_H0.5150.88
166_G169_M0.5110.88
137_V177_F0.5100.88
97_V125_Y0.5090.88
58_K63_N0.5080.88
5_Y11_V0.5060.87
81_Y113_G0.5040.87
58_K62_I0.5040.87
37_V58_K0.5030.87
63_N75_I0.5030.87
146_L185_I0.5020.87
80_S107_V0.5020.87
150_N153_S0.5010.87
45_D50_N0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qn9A 2 0.9716 100 0.438 Contact Map
3rpcA 2 0.9384 100 0.459 Contact Map
1vjnA 1 0.9005 100 0.504 Contact Map
3bv6A 5 0.9858 100 0.524 Contact Map
4jo0A 2 0.9336 100 0.544 Contact Map
2wylA 5 0.9668 100 0.549 Contact Map
3kl7A 1 0.8531 100 0.555 Contact Map
2cbnA 2 0.8815 99.9 0.615 Contact Map
1zkpA 2 0.872 99.9 0.628 Contact Map
1y44A 2 0.8957 99.9 0.631 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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