LEU1 - SULSO - GREMLIN Contacts

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LEU1 - Probable 2-isopropylmalate synthase

UniProt:	Q97W36	Sequences: MIARKLADLGVDVIEAGFPASSEGEFIATRKIFEEIGDQVEVIGLSRSNKNDIDKTISTGISSIHLFIATSELHMKYKLKMTKEEVLNKIYESVKYAKDHGMIVEFSPEDATRTEEDFLFTAIRTAIEAGADRINIPDTVGTMHPFKYYDMIKKIVNFVGERIIVSVHCHNDFGLATANSLAGVYAGARQAHVTVNGIGERAGNASLEEVVMGIKKLLNYETNVKTWKLYEVSRFVAEMTGVPVPYFKAIVGDNAFGHESGIHVHGVIENPFTYEPISPEEVGNFRRLALGKHSGIHGLRKLLEEQGIYLSDDKLKIVLAEIKKLAESGNKVTVEDAKNIALKLMNS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	347 (336)
Sequences:	4949 (2436)
Seq/√Len:	132.9

ECOLI - LEU1 HOA
BACSU - LEU1 HMGCL
SULSO - LEU1 HOSA Q980Z1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
54_D	96_Y	3.625	1.00
265_H	269_E	3.514	1.00
149_Y	186_A	3.241	1.00
19_P	44_G	3.200	1.00
72_E	83_K	3.079	1.00
167_V	183_G	2.735	1.00
82_T	85_E	2.686	1.00
98_K	132_D	2.683	1.00
88_N	92_E	2.671	1.00
90_I	122_A	2.653	1.00
156_V	165_V	2.629	1.00
146_F	185_Y	2.610	1.00
7_A	40_V	2.601	1.00
123_I	134_I	2.595	1.00
153_K	157_N	2.518	1.00
7_A	39_Q	2.487	1.00
116_E	154_K	2.471	1.00
72_E	115_E	2.350	1.00
169_C	180_S	2.330	1.00
77_Y	270_N	2.292	1.00
184_V	191_A	2.245	1.00
50_K	92_E	2.239	1.00
81_M	89_K	2.235	1.00
278_S	281_E	2.184	1.00
84_E	121_T	2.184	1.00
91_Y	129_A	2.177	1.00
9_L	232_V	2.172	1.00
91_Y	95_K	2.144	1.00
304_E	309_Y	2.117	1.00
196_N	233_S	2.078	1.00
174_G	209_E	2.074	1.00
8_D	228_K	2.070	1.00
90_I	126_A	2.032	1.00
70_T	114_T	1.971	1.00
5_K	8_D	1.968	1.00
228_K	231_E	1.952	1.00
23_E	27_I	1.952	1.00
31_K	35_E	1.928	1.00
154_K	158_F	1.921	1.00
75_M	83_K	1.916	1.00
211_V	224_V	1.889	1.00
75_M	86_V	1.872	1.00
149_Y	185_Y	1.852	1.00
311_S	314_K	1.848	1.00
136_I	155_I	1.840	1.00
50_K	96_Y	1.818	1.00
50_K	54_D	1.814	1.00
91_Y	125_T	1.813	1.00
53_I	93_S	1.769	1.00
78_K	109_E	1.767	1.00
30_R	34_E	1.764	1.00
233_S	244_V	1.760	1.00
5_K	235_F	1.707	1.00
180_S	191_A	1.700	1.00
164_I	189_R	1.698	1.00
136_I	151_M	1.692	1.00
120_F	154_K	1.684	1.00
225_K	228_K	1.661	1.00
125_T	128_E	1.661	1.00
209_E	248_K	1.639	1.00
4_R	35_E	1.616	1.00
27_I	31_K	1.616	1.00
321_E	324_K	1.589	1.00
299_L	318_V	1.585	1.00
149_Y	153_K	1.581	1.00
324_K	328_S	1.577	1.00
153_K	186_A	1.545	1.00
124_R	160_G	1.541	1.00
300_R	304_E	1.527	1.00
84_E	88_N	1.518	1.00
70_T	122_A	1.513	1.00
330_N	336_D	1.509	1.00
87_L	122_A	1.506	1.00
165_V	188_A	1.499	1.00
83_K	118_F	1.493	1.00
81_M	85_E	1.490	1.00
106_F	122_A	1.488	1.00
275_E	286_R	1.484	1.00
148_Y	167_V	1.483	1.00
31_K	34_E	1.480	1.00
205_A	210_V	1.478	1.00
230_Y	284_N	1.476	1.00
301_K	304_E	1.474	1.00
91_Y	128_E	1.474	1.00
124_R	158_F	1.465	1.00
143_M	148_Y	1.464	1.00
300_R	312_D	1.441	1.00
54_D	100_H	1.439	1.00
303_L	341_A	1.415	1.00
83_K	115_E	1.409	1.00
94_V	104_V	1.400	1.00
54_D	58_S	1.389	1.00
113_R	147_K	1.380	1.00
267_V	287_R	1.377	1.00
87_L	121_T	1.375	1.00
259_E	291_G	1.374	1.00
152_I	165_V	1.373	1.00
211_V	226_T	1.370	1.00
27_I	30_R	1.369	1.00
44_G	56_T	1.363	1.00
325_L	332_V	1.362	1.00
72_E	76_K	1.361	1.00
41_E	103_I	1.361	1.00
302_L	305_E	1.353	1.00
108_P	123_I	1.345	1.00
319_L	323_K	1.345	1.00
318_V	340_I	1.343	1.00
195_V	236_V	1.336	1.00
296_I	316_K	1.335	1.00
320_A	324_K	1.318	1.00
150_D	154_K	1.306	1.00
19_P	29_T	1.302	1.00
72_E	75_M	1.294	1.00
96_Y	100_H	1.290	1.00
94_V	129_A	1.282	1.00
120_F	155_I	1.274	1.00
235_F	239_M	1.271	1.00
83_K	121_T	1.262	1.00
5_K	232_V	1.259	1.00
152_I	186_A	1.257	1.00
212_M	226_T	1.255	1.00
85_E	88_N	1.250	1.00
13_V	103_I	1.244	1.00
103_I	132_D	1.237	1.00
24_G	327_E	1.235	1.00
57_I	100_H	1.234	1.00
3_A	28_A	1.232	1.00
181_L	213_G	1.231	1.00
156_V	189_R	1.231	1.00
60_G	63_S	1.224	1.00
75_M	114_T	1.222	1.00
259_E	293_H	1.212	1.00
193_V	207_L	1.206	1.00
75_M	115_E	1.204	1.00
117_D	121_T	1.204	1.00
117_D	120_F	1.203	1.00
123_I	136_I	1.188	0.99
171_N	174_G	1.184	0.99
26_F	55_K	1.177	0.99
127_I	160_G	1.176	0.99
91_Y	126_A	1.175	0.99
152_I	155_I	1.175	0.99
112_T	143_M	1.174	0.99
152_I	167_V	1.174	0.99
127_I	163_I	1.169	0.99
138_D	179_N	1.166	0.99
230_Y	234_R	1.154	0.99
67_F	262_I	1.153	0.99
120_F	124_R	1.143	0.99
177_T	210_V	1.137	0.99
81_M	86_V	1.132	0.99
75_M	118_F	1.128	0.99
32_I	42_V	1.113	0.99
303_L	310_L	1.112	0.99
209_E	249_A	1.097	0.99
125_T	129_A	1.095	0.99
109_E	274_Y	1.094	0.99
120_F	158_F	1.093	0.99
180_S	210_V	1.090	0.99
116_E	151_M	1.088	0.99
180_S	205_A	1.085	0.99
215_K	221_E	1.079	0.99
182_A	186_A	1.072	0.99
12_D	223_N	1.062	0.99
87_L	125_T	1.058	0.99
55_K	58_S	1.056	0.99
5_K	228_K	1.034	0.98
193_V	211_V	1.027	0.98
84_E	87_L	1.024	0.98
20_A	51_N	1.021	0.98
110_D	113_R	1.020	0.98
301_K	305_E	1.018	0.98
124_R	128_E	1.017	0.98
47_R	52_D	1.016	0.98
95_K	129_A	1.015	0.98
127_I	134_I	1.013	0.98
68_I	106_F	1.006	0.98
46_S	56_T	0.999	0.98
317_I	320_A	0.998	0.98
171_N	249_A	0.986	0.98
316_K	320_A	0.986	0.98
80_K	269_E	0.983	0.98
61_I	102_M	0.979	0.98
97_A	104_V	0.978	0.98
215_K	281_E	0.972	0.98
92_E	96_Y	0.969	0.98
174_G	206_S	0.967	0.98
12_D	39_Q	0.962	0.98
182_A	185_Y	0.955	0.97
113_R	142_T	0.955	0.97
112_T	151_M	0.954	0.97
171_N	176_A	0.952	0.97
124_R	159_V	0.948	0.97
300_R	315_L	0.948	0.97
302_L	334_V	0.947	0.97
90_I	125_T	0.944	0.97
78_K	265_H	0.938	0.97
146_F	150_D	0.934	0.97
37_G	60_G	0.933	0.97
256_F	282_V	0.925	0.97
11_V	224_V	0.925	0.97
48_S	93_S	0.923	0.97
154_K	157_N	0.918	0.97
29_T	44_G	0.913	0.97
174_G	249_A	0.909	0.97
310_L	318_V	0.909	0.97
107_S	137_P	0.906	0.97
69_A	74_H	0.904	0.96
73_L	77_Y	0.904	0.96
5_K	231_E	0.898	0.96
198_I	242_V	0.898	0.96
74_H	110_D	0.894	0.96
69_A	110_D	0.893	0.96
175_L	181_L	0.893	0.96
177_T	205_A	0.884	0.96
4_R	37_G	0.878	0.96
72_E	114_T	0.872	0.96
148_Y	169_C	0.864	0.95
146_F	149_Y	0.862	0.95
78_K	274_Y	0.861	0.95
69_A	109_E	0.860	0.95
78_K	273_T	0.860	0.95
299_L	315_L	0.858	0.95
75_M	81_M	0.857	0.95
117_D	154_K	0.855	0.95
24_G	292_K	0.855	0.95
79_L	109_E	0.854	0.95
312_D	315_L	0.852	0.95
103_I	133_R	0.851	0.95
246_Y	253_D	0.848	0.95
16_A	29_T	0.845	0.95
63_S	103_I	0.844	0.95
26_F	58_S	0.843	0.95
79_L	274_Y	0.842	0.95
122_A	126_A	0.840	0.95
105_E	135_N	0.835	0.95
150_D	153_K	0.831	0.94
121_T	125_T	0.830	0.94
299_L	319_L	0.825	0.94
180_S	193_V	0.824	0.94
43_I	63_S	0.820	0.94
123_I	155_I	0.819	0.94
41_E	62_S	0.817	0.94
95_K	99_D	0.816	0.94
57_I	62_S	0.815	0.94
65_H	107_S	0.814	0.94
149_Y	182_A	0.811	0.94
314_K	317_I	0.811	0.94
169_C	183_G	0.804	0.93
105_E	166_S	0.800	0.93
124_R	127_I	0.799	0.93
144_H	185_Y	0.788	0.93
23_E	55_K	0.782	0.92
206_S	248_K	0.780	0.92
325_L	328_S	0.779	0.92
85_E	89_K	0.779	0.92
21_S	293_H	0.771	0.92
12_D	224_V	0.771	0.92
325_L	340_I	0.770	0.92
232_V	236_V	0.770	0.92
65_H	135_N	0.769	0.92
65_H	105_E	0.769	0.92
155_I	165_V	0.768	0.92
335_E	339_N	0.765	0.92
177_T	209_E	0.764	0.91
206_S	209_E	0.764	0.91
7_A	37_G	0.763	0.91
126_A	131_A	0.762	0.91
280_E	285_F	0.761	0.91
321_E	325_L	0.758	0.91
234_R	238_E	0.758	0.91
87_L	118_F	0.756	0.91
105_E	190_Q	0.748	0.91
105_E	192_H	0.748	0.91
117_D	158_F	0.746	0.90
118_F	122_A	0.746	0.90
177_T	180_S	0.742	0.90
96_Y	99_D	0.742	0.90
215_K	224_V	0.740	0.90
18_F	45_L	0.738	0.90
9_L	229_L	0.737	0.90
45_L	135_N	0.735	0.90
264_V	298_G	0.733	0.90
208_E	248_K	0.730	0.90
233_S	251_V	0.730	0.90
195_V	232_V	0.729	0.89
237_A	243_P	0.729	0.89
8_D	231_E	0.727	0.89
76_K	80_K	0.727	0.89
144_H	218_L	0.726	0.89
20_A	55_K	0.724	0.89
44_G	61_I	0.723	0.89
146_F	182_A	0.722	0.89
317_I	321_E	0.722	0.89
152_I	188_A	0.718	0.89
57_I	102_M	0.717	0.89
280_E	286_R	0.715	0.89
89_K	93_S	0.715	0.89
87_L	91_Y	0.714	0.88
45_L	107_S	0.713	0.88
289_A	293_H	0.711	0.88
73_L	273_T	0.705	0.88
29_T	42_V	0.702	0.88
92_E	95_K	0.699	0.87
268_I	301_K	0.698	0.87
32_I	35_E	0.698	0.87
48_S	66_L	0.698	0.87
3_A	32_I	0.698	0.87
230_Y	253_D	0.695	0.87
133_R	164_I	0.692	0.87
57_I	101_G	0.692	0.87
26_F	59_T	0.692	0.87
138_D	141_G	0.688	0.87
17_G	29_T	0.687	0.87
14_I	40_V	0.686	0.86
136_I	152_I	0.684	0.86
64_I	101_G	0.683	0.86
26_F	30_R	0.681	0.86
242_V	245_P	0.680	0.86
215_K	222_T	0.680	0.86
123_I	159_V	0.678	0.86
271_P	286_R	0.672	0.85
13_V	43_I	0.671	0.85
175_L	213_G	0.670	0.85
245_P	249_A	0.667	0.85
94_V	126_A	0.667	0.85
212_M	281_E	0.666	0.85
155_I	159_V	0.662	0.84
270_N	273_T	0.661	0.84
108_P	119_L	0.660	0.84
198_I	240_T	0.658	0.84
116_E	150_D	0.656	0.84
18_F	262_I	0.654	0.84
107_S	135_N	0.654	0.84
39_Q	60_G	0.651	0.83
185_Y	218_L	0.651	0.83
229_L	287_R	0.651	0.83
69_A	106_F	0.651	0.83
41_E	61_I	0.650	0.83
258_H	263_H	0.650	0.83
61_I	101_G	0.648	0.83
236_V	240_T	0.647	0.83
142_T	276_P	0.647	0.83
308_I	338_K	0.647	0.83
73_L	270_N	0.645	0.83
112_T	136_I	0.643	0.83
303_L	337_A	0.643	0.83
261_G	295_G	0.641	0.83
43_I	46_S	0.641	0.83
213_G	250_I	0.641	0.83
195_V	208_E	0.640	0.82
70_T	108_P	0.640	0.82
80_K	265_H	0.640	0.82
335_E	338_K	0.638	0.82
148_Y	152_I	0.636	0.82
303_L	308_I	0.635	0.82
67_F	107_S	0.635	0.82
172_D	201_R	0.632	0.82
71_S	74_H	0.630	0.81
284_N	287_R	0.629	0.81
196_N	236_V	0.629	0.81
66_L	93_S	0.629	0.81
33_F	60_G	0.628	0.81
166_S	192_H	0.627	0.81
88_N	91_Y	0.626	0.81
207_L	229_L	0.624	0.81
21_S	292_K	0.621	0.80
4_R	7_A	0.620	0.80
245_P	248_K	0.617	0.80
69_A	79_L	0.616	0.80
181_L	218_L	0.616	0.80
302_L	306_Q	0.614	0.80
234_R	253_D	0.613	0.80
312_D	316_K	0.611	0.79
61_I	64_I	0.610	0.79
11_V	211_V	0.609	0.79
184_V	214_I	0.608	0.79
108_P	134_I	0.607	0.79
194_T	207_L	0.607	0.79
217_L	220_Y	0.606	0.79
246_Y	254_N	0.604	0.79
46_S	67_F	0.604	0.79
264_V	294_S	0.604	0.79
82_T	88_N	0.602	0.78
69_A	107_S	0.601	0.78
112_T	148_Y	0.599	0.78
41_E	63_S	0.599	0.78
128_E	160_G	0.599	0.78
151_M	155_I	0.598	0.78
66_L	94_V	0.598	0.78
156_V	159_V	0.598	0.78
236_V	239_M	0.596	0.78
143_M	147_K	0.595	0.78
76_K	82_T	0.595	0.78
297_H	301_K	0.592	0.77
108_P	136_I	0.592	0.77
69_A	78_K	0.589	0.77
69_A	86_V	0.586	0.77
9_L	211_V	0.586	0.77
56_T	64_I	0.585	0.76
313_D	316_K	0.585	0.76
326_A	332_V	0.585	0.76
64_I	102_M	0.584	0.76
310_L	315_L	0.583	0.76
122_A	241_G	0.583	0.76
191_A	210_V	0.582	0.76
121_T	124_R	0.582	0.76
53_I	96_Y	0.580	0.76
299_L	337_A	0.580	0.76
89_K	92_E	0.579	0.76
93_S	126_A	0.578	0.76
24_G	27_I	0.578	0.76
171_N	245_P	0.576	0.75
127_I	159_V	0.574	0.75
72_E	118_F	0.573	0.75
29_T	33_F	0.573	0.75
109_E	263_H	0.571	0.75
66_L	97_A	0.569	0.74
196_N	251_V	0.565	0.74
6_L	14_I	0.564	0.74
332_V	336_D	0.562	0.74
259_E	292_K	0.562	0.74
16_A	42_V	0.562	0.74
75_M	82_T	0.556	0.73
133_R	190_Q	0.556	0.73
84_E	118_F	0.555	0.73
116_E	120_F	0.555	0.73
67_F	106_F	0.555	0.73
51_N	54_D	0.554	0.73
69_A	114_T	0.552	0.72
23_E	324_K	0.551	0.72
169_C	205_A	0.550	0.72
83_K	114_T	0.550	0.72
167_V	184_V	0.550	0.72
74_H	273_T	0.549	0.72
120_F	159_V	0.548	0.72
263_H	274_Y	0.548	0.72
94_V	106_F	0.544	0.71
45_L	204_N	0.543	0.71
4_R	31_K	0.543	0.71
94_V	125_T	0.543	0.71
266_G	274_Y	0.542	0.71
212_M	277_I	0.540	0.71
230_Y	285_F	0.538	0.70
208_E	212_M	0.538	0.70
306_Q	334_V	0.537	0.70
180_S	184_V	0.537	0.70
90_I	106_F	0.536	0.70
25_E	292_K	0.536	0.70
218_L	221_E	0.535	0.70
202_A	255_A	0.533	0.70
111_A	119_L	0.533	0.70
177_T	193_V	0.533	0.70
115_E	118_F	0.532	0.69
212_M	250_I	0.532	0.69
120_F	160_G	0.532	0.69
298_G	302_L	0.531	0.69
325_L	336_D	0.530	0.69
94_V	131_A	0.530	0.69
258_H	275_E	0.530	0.69
74_H	113_R	0.528	0.69
173_F	276_P	0.528	0.69
64_I	97_A	0.527	0.69
73_L	272_F	0.527	0.69
18_F	22_S	0.525	0.68
214_I	218_L	0.524	0.68
292_K	323_K	0.522	0.68
105_E	133_R	0.520	0.68
26_F	29_T	0.519	0.68
133_R	162_R	0.519	0.68
269_E	300_R	0.518	0.67
60_G	102_M	0.518	0.67
184_V	220_Y	0.518	0.67
245_P	267_V	0.517	0.67
150_D	185_Y	0.517	0.67
171_N	206_S	0.517	0.67
135_N	192_H	0.517	0.67
140_V	276_P	0.517	0.67
32_I	37_G	0.516	0.67
91_Y	122_A	0.514	0.67
74_H	78_K	0.514	0.67
290_L	322_I	0.514	0.67
7_A	35_E	0.513	0.67
233_S	253_D	0.512	0.67
178_A	182_A	0.512	0.67
185_Y	220_Y	0.511	0.66
62_S	102_M	0.511	0.66
135_N	166_S	0.510	0.66
68_I	79_L	0.510	0.66
123_I	151_M	0.509	0.66
51_N	55_K	0.509	0.66
171_N	228_K	0.507	0.66
279_P	287_R	0.504	0.65
147_K	150_D	0.504	0.65
7_A	42_V	0.503	0.65
112_T	116_E	0.503	0.65
196_N	244_V	0.502	0.65
226_T	281_E	0.502	0.65
68_I	86_V	0.502	0.65
115_E	120_F	0.502	0.65
299_L	322_I	0.502	0.65
173_F	213_G	0.501	0.65
262_I	273_T	0.500	0.65
141_G	179_N	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ov4A	2	0.9625	100	0.153	Contact Map
2ztjA	2	0.804	100	0.169	Contact Map
3ivsA	2	0.9366	100	0.19	Contact Map
3hq1A	2	0.9625	100	0.196	Contact Map
3rmjA	2	0.781	100	0.207	Contact Map
3bleA	2	0.7839	100	0.302	Contact Map
3eegA	2	0.6945	100	0.355	Contact Map
2qf7A	4	0.9481	100	0.431	Contact Map
4qshA	4	0.8646	100	0.448	Contact Map
2cw6A	5	0.7147	100	0.465	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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