GREMLIN Database
Q97W35 - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
UniProt: Q97W35 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (184)
Sequences: 214 (165)
Seq/√Len: 12.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_I107_I5.3891.00
100_V116_M4.1401.00
3_R125_V3.4430.98
5_W191_I3.3800.98
12_D15_I3.0770.96
10_E14_Y3.0390.96
23_L113_V2.9700.96
145_V195_I2.9620.95
66_D88_G2.6190.91
24_I121_P2.5060.89
43_A60_D2.4650.89
47_A160_M2.4370.88
3_R10_E2.3770.87
3_R14_Y2.2440.83
72_L77_I2.2350.83
6_F17_A2.1350.80
41_E154_K2.0700.78
64_A72_L2.0470.77
14_Y125_V2.0160.76
100_V110_L2.0130.76
20_L113_V2.0100.75
67_G88_G1.9840.74
63_I81_I1.9050.71
193_R197_E1.9050.71
82_I88_G1.9040.71
50_Q160_M1.8870.71
84_T127_P1.8810.70
84_T143_A1.7820.66
86_L100_V1.7780.66
5_W187_K1.7720.66
7_G151_K1.7240.63
5_W162_F1.6930.62
145_V198_Q1.6580.60
168_G182_S1.6150.58
73_V94_K1.5540.55
64_A69_A1.5480.55
8_F12_D1.5410.54
66_D157_L1.5330.54
83_V146_L1.5280.54
150_M190_E1.5210.53
91_T96_P1.5130.53
144_V196_I1.5060.53
119_V146_L1.5000.52
44_I151_K1.4800.51
49_P195_I1.4530.50
77_I107_I1.4420.49
8_F184_I1.4350.49
48_G71_Y1.4190.48
91_T95_N1.4050.48
162_F187_K1.4050.48
92_F95_N1.3600.45
62_I153_S1.3590.45
48_G160_M1.3420.44
44_I190_E1.3400.44
37_I63_I1.3180.43
23_L62_I1.3130.43
39_G76_G1.2860.42
20_L121_P1.2710.41
66_D82_I1.2630.40
20_L100_V1.2460.40
45_V67_G1.2300.39
43_A59_E1.2270.39
105_D199_V1.2100.38
42_I76_G1.1810.37
63_I83_V1.1810.37
4_S112_K1.1740.36
72_L198_Q1.1680.36
47_A168_G1.1640.36
82_I98_Y1.1630.36
79_P88_G1.1540.35
160_M191_I1.1420.35
32_E58_K1.1370.35
21_N130_R1.1150.34
144_V155_I1.1020.33
66_D87_D1.1020.33
47_A67_G1.1010.33
69_A96_P1.0990.33
29_D32_E1.0920.32
14_Y126_M1.0830.32
71_Y163_Q1.0720.32
82_I87_D1.0720.32
195_I199_V1.0620.31
23_L114_K1.0560.31
26_K32_E1.0530.31
67_G91_T1.0480.31
46_G162_F1.0430.30
4_S90_Q1.0360.30
3_R6_F1.0300.30
63_I79_P1.0280.30
64_A110_L1.0270.30
8_F14_Y1.0210.29
51_L76_G1.0070.29
37_I150_M1.0020.29
80_D147_A0.9930.28
20_L48_G0.9880.28
81_I121_P0.9700.27
47_A138_T0.9670.27
96_P109_L0.9410.26
144_V199_V0.9150.25
17_A99_V0.9070.25
4_S109_L0.8960.24
156_R163_Q0.8900.24
58_K83_V0.8880.24
63_I147_A0.8860.24
43_A158_Y0.8710.24
10_E125_V0.8700.24
50_Q163_Q0.8690.23
63_I134_Y0.8670.23
84_T100_V0.8660.23
157_L160_M0.8650.23
20_L119_V0.8520.23
95_N114_K0.8510.23
5_W196_I0.8490.23
66_D160_M0.8430.23
73_V116_M0.8410.22
22_Y111_H0.8360.22
88_G157_L0.8360.22
49_P145_V0.8310.22
9_K12_D0.8300.22
99_V121_P0.8240.22
2_I46_G0.8220.22
74_D116_M0.8180.22
44_I117_D0.8140.22
79_P134_Y0.8120.21
101_L159_A0.8090.21
82_I92_F0.8060.21
64_A76_G0.8050.21
49_P68_A0.8000.21
128_F131_L0.7990.21
182_S191_I0.7980.21
60_D143_A0.7970.21
95_N98_Y0.7880.21
44_I73_V0.7840.21
32_E35_E0.7820.20
102_A136_G0.7790.20
21_N160_M0.7780.20
32_E118_K0.7730.20
110_L186_R0.7730.20
152_A162_F0.7720.20
110_L147_A0.7650.20
69_A73_V0.7640.20
24_I134_Y0.7560.20
39_G42_I0.7520.19
52_D94_K0.7450.19
148_K191_I0.7440.19
69_A91_T0.7440.19
19_I71_Y0.7430.19
26_K110_L0.7390.19
51_L86_L0.7330.19
13_D133_L0.7310.19
131_L134_Y0.7300.19
6_F189_L0.7300.19
17_A79_P0.7260.19
113_V119_V0.7200.18
40_R150_M0.7180.18
42_I147_A0.7150.18
13_D136_G0.7140.18
144_V160_M0.7140.18
148_K195_I0.7130.18
8_F115_E0.7110.18
67_G87_D0.7090.18
122_N132_R0.7070.18
30_E37_I0.7070.18
155_I160_M0.7050.18
61_V115_E0.7040.18
82_I96_P0.7040.18
65_A102_A0.6880.18
98_Y125_V0.6830.17
100_V104_G0.6810.17
47_A68_A0.6800.17
2_I162_F0.6780.17
48_G100_V0.6760.17
116_M158_Y0.6710.17
133_L145_V0.6690.17
168_G191_I0.6680.17
65_A136_G0.6660.17
51_L72_L0.6650.17
63_I143_A0.6620.17
108_N162_F0.6560.17
5_W8_F0.6550.17
8_F33_L0.6550.17
2_I133_L0.6530.17
65_A157_L0.6530.17
9_K98_Y0.6510.16
76_G147_A0.6510.16
20_L87_D0.6500.16
75_I163_Q0.6490.16
2_I95_N0.6440.16
30_E78_V0.6440.16
70_N160_M0.6360.16
62_I147_A0.6300.16
16_S127_P0.6290.16
93_P149_Y0.6280.16
90_Q94_K0.6250.16
4_S120_I0.6240.16
156_R198_Q0.6200.16
74_D125_V0.6180.16
7_G18_S0.6160.16
122_N126_M0.6120.15
3_R122_N0.6110.15
42_I131_L0.6080.15
101_L116_M0.6080.15
63_I190_E0.6000.15
38_K120_I0.5950.15
62_I76_G0.5910.15
127_P131_L0.5860.15
133_L136_G0.5820.15
8_F196_I0.5820.15
89_L115_E0.5790.15
40_R57_L0.5730.14
154_K167_V0.5730.14
191_I194_M0.5710.14
20_L24_I0.5700.14
40_R63_I0.5680.14
160_M168_G0.5680.14
43_A47_A0.5670.14
10_E123_S0.5660.14
113_V149_Y0.5650.14
26_K96_P0.5620.14
184_I189_L0.5600.14
97_I120_I0.5600.14
65_A133_L0.5590.14
18_S155_I0.5570.14
18_S154_K0.5550.14
44_I184_I0.5540.14
90_Q166_I0.5530.14
75_I191_I0.5510.14
84_T126_M0.5500.14
98_Y155_I0.5490.14
29_D80_D0.5490.14
6_F146_L0.5480.14
163_Q198_Q0.5480.14
130_R150_M0.5480.14
22_Y33_L0.5460.14
20_L88_G0.5460.14
19_I77_I0.5450.14
49_P86_L0.5440.14
18_S128_F0.5400.14
82_I167_V0.5380.14
38_K107_I0.5380.14
40_R115_E0.5340.13
48_G81_I0.5340.13
167_V192_A0.5310.13
64_A87_D0.5310.13
45_V69_A0.5300.13
16_S26_K0.5270.13
2_I23_L0.5240.13
138_T143_A0.5240.13
3_R110_L0.5220.13
14_Y29_D0.5190.13
49_P162_F0.5190.13
9_K40_R0.5180.13
67_G148_K0.5170.13
48_G163_Q0.5160.13
145_V199_V0.5140.13
23_L149_Y0.5130.13
56_K62_I0.5130.13
23_L96_P0.5120.13
153_S156_R0.5100.13
67_G96_P0.5080.13
130_R190_E0.5070.13
70_N128_F0.5040.13
88_G136_G0.5040.13
129_G184_I0.5010.13
133_L159_A0.5010.13
85_D188_K0.5000.13
139_D188_K0.5000.13
85_D185_K0.5000.13
85_D142_R0.5000.13
139_D142_R0.5000.13
85_D106_N0.5000.13
85_D140_G0.5000.13
85_D103_H0.5000.13
85_D139_D0.5000.13
185_K188_K0.5000.13
103_H185_K0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ro7A 3 0.7549 99.8 0.775 Contact Map
2p2vA 3 0.799 99.7 0.781 Contact Map
2wqqA 1 0.7059 99.6 0.798 Contact Map
3melA 2 0.6471 99.5 0.82 Contact Map
3l8mA 5 0.6029 99.4 0.821 Contact Map
3ihkA 3 0.6324 99.4 0.823 Contact Map
3lm8A 2 0.6225 99.3 0.832 Contact Map
3cq9A 2 0.6373 99.3 0.833 Contact Map
2omkA 2 0.6961 99.3 0.835 Contact Map
3k94A 2 0.6127 99.2 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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