GREMLIN Database
Q97W30 - Uncharacterized protein
UniProt: Q97W30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (114)
Sequences: 2510 (1530)
Seq/√Len: 143.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_D31_T3.4921.00
40_G49_V3.2111.00
124_K134_I3.0761.00
122_L134_I2.8571.00
39_E121_I2.5501.00
35_N124_K2.5461.00
65_E110_D2.4851.00
105_I109_K2.4321.00
66_W106_E2.3071.00
17_Y70_L2.1651.00
34_V125_I2.1611.00
27_I70_L2.1541.00
108_A135_I2.0401.00
61_E114_K1.9211.00
36_V59_I1.9051.00
12_M16_H1.8861.00
60_K64_Q1.8621.00
15_A70_L1.8401.00
9_G35_N1.8251.00
66_W107_I1.7931.00
38_V50_V1.7791.00
9_G33_I1.7711.00
38_V55_L1.7541.00
104_G123_L1.7151.00
37_E122_L1.7071.00
35_N126_Y1.6991.00
36_V111_I1.6201.00
105_I135_I1.5981.00
23_A53_N1.5901.00
102_Y105_I1.5641.00
7_I37_E1.5111.00
32_Y100_A1.4341.00
31_T129_K1.3771.00
106_E110_D1.3641.00
26_Q69_K1.3371.00
91_K94_D1.2961.00
12_M34_V1.2761.00
47_G102_Y1.2661.00
124_K132_Y1.2231.00
33_I129_K1.1851.00
37_E124_K1.1510.99
61_E64_Q1.1410.99
51_D54_L1.1260.99
33_I126_Y1.0660.99
11_T130_D1.0410.99
37_E121_I1.0410.99
100_A103_I1.0290.99
54_L57_K1.0230.99
53_N56_K1.0230.99
48_F99_T1.0210.99
125_I133_A1.0200.99
25_S99_T1.0040.99
104_G133_A1.0030.99
15_A27_I0.9980.99
11_T31_T0.9880.98
126_Y132_Y0.9870.98
12_M15_A0.9850.98
6_G16_H0.9800.98
40_G43_N0.9790.98
50_V54_L0.9760.98
110_D113_L0.9620.98
107_I111_I0.9610.98
6_G12_M0.9410.98
6_G23_A0.9370.98
57_K61_E0.9360.98
59_I63_I0.9300.98
109_K112_Y0.8950.97
39_E119_Y0.8930.97
43_N46_S0.8900.97
14_S17_Y0.8840.97
104_G125_I0.8690.96
112_Y116_N0.8670.96
10_I18_T0.8330.95
7_I132_Y0.8250.95
90_Y94_D0.8210.95
20_S46_S0.8160.95
31_T126_Y0.8160.95
52_F131_S0.8150.95
66_W110_D0.8120.95
66_W103_I0.8110.95
21_S25_S0.8100.95
71_I91_K0.8070.95
14_S71_I0.8030.95
8_E12_M0.7990.94
96_P106_E0.7810.94
24_D52_F0.7760.93
42_V105_I0.7650.93
8_E130_D0.7650.93
97_F100_A0.7540.92
108_A112_Y0.7530.92
7_I124_K0.7490.92
92_V95_A0.7380.92
100_A133_A0.7330.91
52_F56_K0.7320.91
96_P102_Y0.7240.91
65_E92_V0.7210.91
10_I59_I0.7150.90
15_A20_S0.7130.90
14_S32_Y0.7020.90
107_I123_L0.6990.89
34_V59_I0.6840.88
50_V55_L0.6840.88
16_H24_D0.6780.88
66_W92_V0.6770.88
72_I98_P0.6720.87
114_K117_K0.6620.87
24_D68_H0.6510.86
6_G15_A0.6460.85
108_A123_L0.6450.85
55_L115_L0.6450.85
100_A131_S0.6430.85
100_A129_K0.6430.85
103_I107_I0.6420.85
108_A120_R0.6420.85
62_T65_E0.6380.85
105_I108_A0.6340.84
8_E131_S0.6330.84
56_K60_K0.6320.84
113_L117_K0.6310.84
58_I115_L0.6270.84
100_A127_E0.6200.83
32_Y131_S0.6160.82
72_I91_K0.6150.82
9_G14_S0.6120.82
6_G9_G0.6120.82
58_I114_K0.6090.82
106_E109_K0.6000.81
28_H127_E0.5970.80
50_V58_I0.5950.80
13_D129_K0.5920.80
10_I63_I0.5920.80
61_E110_D0.5900.80
11_T14_S0.5890.80
62_T107_I0.5880.79
111_I120_R0.5830.79
97_F102_Y0.5780.78
107_I125_I0.5760.78
20_S25_S0.5750.78
92_V96_P0.5750.78
8_E16_H0.5750.78
24_D127_E0.5710.77
110_D118_K0.5700.77
7_I134_I0.5650.77
113_L120_R0.5610.76
16_H23_A0.5530.75
109_K113_L0.5510.75
112_Y117_K0.5490.75
17_Y25_S0.5490.75
48_F69_K0.5390.73
13_D16_H0.5390.73
11_T129_K0.5350.73
116_N119_Y0.5340.73
42_V46_S0.5310.72
71_I94_D0.5280.72
108_A128_G0.5270.72
57_K60_K0.5260.72
54_L118_K0.5250.71
43_N47_G0.5210.71
92_V106_E0.5210.71
42_V47_G0.5160.70
93_I98_P0.5150.70
32_Y128_G0.5120.70
15_A128_G0.5110.69
36_V123_L0.5090.69
98_P106_E0.5080.69
90_Y93_I0.5070.69
45_K58_I0.5070.69
69_K73_P0.5060.69
31_T128_G0.5050.69
17_Y27_I0.5030.68
43_N49_V0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d7jA 4 0.8841 100 0.22 Contact Map
1b66A 4 0.8913 100 0.231 Contact Map
1y13A 5 0.9928 100 0.233 Contact Map
2obaA 4 0.8551 100 0.234 Contact Map
2g64A 4 0.8913 100 0.235 Contact Map
3jygA 4 0.971 100 0.237 Contact Map
3lx3A 4 0.9928 100 0.238 Contact Map
4ntkA 4 0.8551 100 0.248 Contact Map
2dj6A 3 0.8261 100 0.269 Contact Map
1sqlA 5 0.7536 12.3 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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