GREMLIN Database
Q97W28 - Dihydropteroate synthase, putative
UniProt: Q97W28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 498 (470)
Sequences: 108 (91)
Seq/√Len: 4.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
409_A442_L4.2090.88
28_E56_A4.1660.87
152_L349_S3.6720.79
12_A16_S3.5660.77
29_I203_I3.4940.75
175_L275_P3.4130.74
439_G455_V3.0300.64
339_I352_V3.0100.63
174_V202_G2.9420.61
12_A31_V2.8710.59
306_G370_K2.7520.56
305_M338_L2.7370.55
381_D473_N2.6500.53
379_L470_L2.6250.52
142_T174_V2.5970.51
304_L338_L2.5870.51
188_K213_E2.5490.50
150_I338_L2.4700.48
381_D472_K2.4240.46
19_A466_I2.3940.45
12_A459_Y2.3870.45
2_K469_Q2.2730.42
204_D306_G2.2410.41
110_D290_G2.2170.40
280_P327_A2.2070.40
322_N339_I2.1830.39
154_I350_W2.1740.39
204_D370_K2.1640.39
2_K5_V2.1510.38
419_G466_I2.1030.37
86_E143_T2.0910.37
426_N469_Q2.0790.36
310_V465_E2.0580.36
33_N189_N2.0440.35
435_G465_E2.0440.35
142_T202_G1.9820.34
121_E124_R1.9820.34
82_K147_P1.9760.34
68_D191_V1.9610.33
175_L208_P1.9540.33
304_L340_M1.9460.33
105_T172_V1.9320.32
8_G37_A1.8950.31
89_D318_S1.8810.31
204_D315_D1.8800.31
103_L353_S1.8650.31
206_E337_L1.8640.31
38_S366_N1.8570.30
315_D382_K1.8520.30
90_L284_L1.8480.30
104_S371_D1.8290.30
404_D407_G1.8190.29
81_F426_N1.8150.29
307_I337_L1.8130.29
430_I442_L1.8130.29
170_V256_T1.8090.29
3_V321_M1.8050.29
40_M110_D1.7990.29
36_V442_L1.7980.29
267_G316_A1.7930.29
151_F172_V1.7910.29
268_F304_L1.7880.29
164_D221_F1.7520.28
160_F363_L1.7480.28
172_V245_A1.7480.28
29_I446_V1.7460.28
68_D362_A1.7300.27
89_D104_S1.7290.27
175_L211_L1.7280.27
170_V342_K1.7270.27
42_T142_T1.7080.27
82_K110_D1.7020.27
199_Y288_I1.6950.27
94_I233_L1.6900.26
263_A381_D1.6360.25
142_T146_P1.6310.25
202_G206_E1.6220.25
81_F244_V1.6140.25
260_V301_I1.6030.24
242_F304_L1.5940.24
33_N76_T1.5800.24
56_A441_E1.5790.24
94_I362_A1.5770.24
204_D382_K1.5560.23
89_D306_G1.5520.23
201_V321_M1.5380.23
46_A75_V1.5370.23
305_M477_D1.5230.23
103_L478_K1.5190.23
204_D313_L1.5160.23
85_E245_A1.5010.22
242_F457_I1.4930.22
308_L339_I1.4920.22
28_E173_V1.4900.22
322_N348_S1.4830.22
163_L194_L1.4810.22
271_L288_I1.4770.22
463_K472_K1.4650.22
6_V381_D1.4640.22
280_P397_R1.4610.21
152_L170_V1.4570.21
38_S76_T1.4540.21
5_V19_A1.4510.21
442_L457_I1.4500.21
110_D288_I1.4280.21
429_T438_I1.4250.21
104_S204_D1.4240.21
206_E245_A1.4240.21
353_S410_K1.4230.21
284_L329_A1.4170.21
440_R459_Y1.4170.21
65_V450_S1.4150.21
158_Q177_F1.4030.20
242_F268_F1.3990.20
42_T224_N1.3970.20
281_L466_I1.3910.20
39_L157_K1.3870.20
89_D370_K1.3820.20
169_N220_S1.3750.20
211_L219_A1.3690.20
180_G377_L1.3670.20
308_L342_K1.3640.20
455_V477_D1.3630.20
211_L303_I1.3610.20
169_N342_K1.3600.20
45_I147_P1.3590.19
170_V468_Y1.3560.19
172_V408_F1.3530.19
40_M81_F1.3490.19
3_V225_L1.3490.19
315_D370_K1.3460.19
306_G315_D1.3340.19
112_I431_K1.3310.19
37_A370_K1.3290.19
229_N310_V1.3250.19
119_I148_F1.3190.19
123_L286_S1.3150.19
181_H210_E1.3110.19
174_V338_L1.3110.19
139_I192_K1.3080.19
279_P302_P1.3070.19
74_E438_I1.3010.18
150_I305_M1.3000.18
31_V93_V1.2980.18
336_N349_S1.2970.18
393_V443_I1.2900.18
9_T58_Y1.2840.18
272_I325_L1.2730.18
294_V337_L1.2690.18
313_L370_K1.2640.18
74_E428_I1.2580.18
117_D433_K1.2570.18
117_D195_V1.2530.18
119_I273_A1.2520.18
280_P291_Y1.2500.18
162_K205_A1.2430.17
251_N450_S1.2430.17
85_E151_F1.2380.17
2_K328_I1.2330.17
32_L39_L1.2270.17
60_L331_E1.2220.17
309_N315_D1.2190.17
435_G474_Y1.2180.17
148_F338_L1.2160.17
177_F202_G1.2100.17
94_I438_I1.2090.17
40_M305_M1.2030.17
8_G87_A1.2000.17
213_E316_A1.1970.17
207_S281_L1.1970.17
390_N466_I1.1950.17
409_A457_I1.1920.17
138_G479_P1.1910.17
302_P477_D1.1830.16
29_I297_T1.1810.16
221_F437_S1.1810.16
341_E380_K1.1780.16
221_F307_I1.1700.16
279_P407_G1.1670.16
85_E111_K1.1660.16
230_F423_I1.1640.16
141_I211_L1.1590.16
239_E438_I1.1580.16
10_L36_V1.1510.16
90_L199_Y1.1480.16
85_E228_N1.1440.16
45_I133_S1.1370.16
72_V191_V1.1370.16
61_L214_G1.1370.16
441_E445_R1.1330.16
151_F304_L1.1330.16
456_Y476_Q1.1300.16
216_R386_R1.1300.16
334_I449_I1.1290.16
154_I319_I1.1240.15
62_P278_S1.1230.15
206_E223_F1.1220.15
257_I301_I1.1220.15
75_V303_I1.1210.15
224_N342_K1.1210.15
312_E320_G1.1200.15
163_L413_V1.1190.15
39_L42_T1.1190.15
104_S315_D1.1160.15
224_N308_L1.1120.15
73_E321_M1.1080.15
308_L352_V1.1020.15
20_K394_I1.0990.15
141_I187_V1.0950.15
45_I80_T1.0940.15
15_L29_I1.0920.15
127_E359_I1.0900.15
62_P90_L1.0800.15
42_T223_F1.0790.15
210_E410_K1.0770.15
318_S461_L1.0760.15
60_L276_V1.0750.15
194_L227_E1.0730.15
256_T342_K1.0720.15
313_L358_M1.0710.15
207_S210_E1.0690.15
36_V113_I1.0680.15
123_L394_I1.0670.15
87_A149_R1.0640.15
89_D204_D1.0630.15
244_V465_E1.0620.15
452_E477_D1.0580.14
49_L135_E1.0580.14
306_G313_L1.0500.14
36_V189_N1.0500.14
79_R140_K1.0420.14
151_F223_F1.0410.14
39_L174_V1.0410.14
3_V420_V1.0360.14
72_V81_F1.0310.14
45_I61_L1.0290.14
43_K191_V1.0280.14
102_Q431_K1.0260.14
5_V324_L1.0210.14
113_I477_D1.0040.14
74_E124_R1.0030.14
4_L337_L1.0020.14
197_Y321_M1.0000.14
2_K296_E1.0000.14
152_L213_E0.9990.14
66_Y214_G0.9980.14
306_G382_K0.9960.14
5_V354_Q0.9960.14
236_I239_E0.9810.13
36_V316_A0.9810.13
309_N382_K0.9780.13
94_I435_G0.9780.13
127_E246_P0.9770.13
321_M332_L0.9750.13
39_L205_A0.9750.13
275_P383_R0.9710.13
82_K472_K0.9710.13
142_T224_N0.9680.13
229_N244_V0.9670.13
56_A229_N0.9670.13
370_K382_K0.9650.13
466_I472_K0.9650.13
100_G106_T0.9640.13
150_I451_K0.9600.13
246_P481_F0.9590.13
49_L455_V0.9590.13
362_A479_P0.9570.13
91_P468_Y0.9530.13
324_L391_A0.9510.13
85_E278_S0.9470.13
165_R207_S0.9450.13
152_L233_L0.9440.13
359_I421_E0.9420.13
369_P372_I0.9410.13
37_A246_P0.9410.13
106_T261_K0.9380.13
202_G365_E0.9370.13
37_A204_D0.9300.13
109_A310_V0.9300.13
73_E141_I0.9290.13
437_S440_R0.9270.13
172_V336_N0.9270.13
222_V468_Y0.9270.13
290_G439_G0.9260.13
90_L106_T0.9260.13
2_K307_I0.9220.13
63_G341_E0.9200.13
4_L371_D0.9190.13
16_S31_V0.9190.13
256_T275_P0.9190.13
142_T155_D0.9160.13
119_I304_L0.9140.12
202_G352_V0.9130.12
204_D358_M0.9110.12
150_I356_T0.9070.12
74_E211_L0.9040.12
163_L469_Q0.9030.12
103_L264_K0.9010.12
163_L201_V0.9000.12
346_R471_D0.9000.12
100_G338_L0.8980.12
31_V384_R0.8970.12
89_D315_D0.8910.12
263_A353_S0.8910.12
39_L273_A0.8910.12
9_T436_L0.8890.12
154_I205_A0.8870.12
335_S454_A0.8820.12
79_R244_V0.8810.12
147_P210_E0.8810.12
83_G267_G0.8800.12
63_G456_Y0.8790.12
240_A451_K0.8790.12
340_M365_E0.8760.12
340_M367_R0.8750.12
64_L352_V0.8730.12
100_G434_D0.8720.12
300_D383_R0.8700.12
268_F359_I0.8690.12
209_R216_R0.8680.12
230_F400_E0.8660.12
62_P67_G0.8630.12
304_L336_N0.8620.12
59_I408_F0.8620.12
192_K201_V0.8610.12
318_S411_I0.8590.12
226_N241_A0.8580.12
9_T81_F0.8570.12
8_G352_V0.8570.12
11_A474_Y0.8570.12
302_P465_E0.8560.12
233_L242_F0.8530.12
175_L475_I0.8520.12
5_V321_M0.8520.12
369_P407_G0.8490.12
178_P214_G0.8490.12
430_I438_I0.8480.12
83_G108_S0.8470.12
358_M375_D0.8460.12
174_V367_R0.8450.12
62_P93_V0.8410.12
90_L185_D0.8400.12
155_D202_G0.8340.11
323_A329_A0.8330.11
38_S328_I0.8290.11
33_N48_N0.8280.11
101_I270_K0.8270.11
150_I304_L0.8250.11
42_T174_V0.8250.11
158_Q290_G0.8230.11
39_L142_T0.8220.11
60_L81_F0.8190.11
188_K270_K0.8170.11
224_N347_W0.8160.11
315_D373_G0.8150.11
333_G407_G0.8140.11
280_P440_R0.8110.11
58_Y79_R0.8110.11
183_D234_E0.8100.11
154_I162_K0.8090.11
16_S366_N0.8080.11
172_V449_I0.8070.11
104_S306_G0.8060.11
380_K461_L0.8050.11
229_N273_A0.8050.11
45_I146_P0.8040.11
163_L446_V0.8040.11
254_E392_D0.8030.11
28_E441_E0.8030.11
62_P110_D0.8020.11
406_T470_L0.8020.11
219_A462_A0.8020.11
399_I463_K0.7950.11
293_Y296_E0.7950.11
203_I435_G0.7940.11
394_I415_E0.7940.11
87_A142_T0.7940.11
158_Q202_G0.7940.11
223_F304_L0.7900.11
34_Y265_Q0.7880.11
430_I446_V0.7880.11
126_M452_E0.7870.11
264_K301_I0.7870.11
58_Y90_L0.7870.11
381_D410_K0.7860.11
437_S445_R0.7840.11
45_I65_V0.7840.11
217_A402_E0.7840.11
204_D309_N0.7830.11
146_P174_V0.7820.11
108_S303_I0.7820.11
5_V108_S0.7800.11
6_V340_M0.7800.11
43_K94_I0.7800.11
263_A270_K0.7790.11
27_V192_K0.7790.11
257_I298_L0.7780.11
446_V451_K0.7780.11
123_L130_A0.7780.11
5_V316_A0.7770.11
460_E464_A0.7760.11
453_H464_A0.7760.11
453_H460_E0.7760.11
253_G389_F0.7740.11
261_K328_I0.7740.11
11_A82_K0.7720.11
125_K270_K0.7720.11
169_N224_N0.7710.11
205_A294_V0.7690.11
344_K380_K0.7680.11
353_S394_I0.7640.11
264_K416_D0.7610.11
39_L440_R0.7590.11
374_I393_V0.7580.11
191_V195_V0.7580.11
150_I408_F0.7580.11
175_L411_I0.7570.11
167_R416_D0.7550.11
157_K383_R0.7530.11
210_E252_R0.7520.11
137_N141_I0.7510.11
142_T339_I0.7510.11
195_V362_A0.7500.11
141_I212_K0.7480.10
55_D379_L0.7480.10
192_K296_E0.7470.10
19_A375_D0.7460.10
292_K438_I0.7460.10
3_V348_S0.7450.10
204_D308_L0.7430.10
5_V73_E0.7410.10
69_A143_T0.7410.10
201_V288_I0.7400.10
207_S276_V0.7400.10
169_N349_S0.7390.10
174_V308_L0.7390.10
45_I247_F0.7370.10
334_I433_K0.7360.10
165_R345_T0.7360.10
102_Q154_I0.7350.10
192_K428_I0.7340.10
33_N311_T0.7330.10
8_G370_K0.7330.10
18_V413_V0.7330.10
223_F361_V0.7320.10
162_K436_L0.7320.10
153_E312_E0.7320.10
104_S382_K0.7290.10
163_L333_G0.7290.10
146_P149_R0.7260.10
59_I241_A0.7240.10
60_L394_I0.7220.10
81_F139_I0.7220.10
85_E110_D0.7220.10
179_V290_G0.7220.10
59_I194_L0.7210.10
116_M258_D0.7200.10
311_T322_N0.7190.10
118_N258_D0.7190.10
84_T152_L0.7170.10
83_G470_L0.7160.10
127_E477_D0.7140.10
160_F394_I0.7130.10
417_G433_K0.7120.10
89_D176_G0.7110.10
12_A116_M0.7090.10
156_N263_A0.7080.10
75_V452_E0.7080.10
31_V39_L0.7070.10
176_G287_S0.7070.10
136_I353_S0.7070.10
191_V217_A0.7070.10
31_V157_K0.7070.10
371_D382_K0.7050.10
34_Y47_E0.7020.10
127_E302_P0.7010.10
123_L305_M0.7010.10
21_N185_D0.7000.10
193_Q433_K0.6980.10
82_K146_P0.6970.10
163_L441_E0.6970.10
83_G311_T0.6960.10
302_P362_A0.6940.10
11_A218_G0.6930.10
150_I466_I0.6930.10
80_T83_G0.6890.10
274_D287_S0.6880.10
201_V211_L0.6880.10
59_I348_S0.6880.10
168_K478_K0.6880.10
210_E481_F0.6850.10
58_Y81_F0.6850.10
244_V313_L0.6850.10
103_L354_Q0.6820.10
257_I293_Y0.6800.10
292_K296_E0.6780.10
436_L462_A0.6780.10
149_R210_E0.6780.10
225_L263_A0.6770.10
82_K112_I0.6760.10
307_I375_D0.6730.10
466_I477_D0.6720.10
246_P370_K0.6720.10
68_D477_D0.6710.10
183_D189_N0.6700.10
330_G359_I0.6700.10
89_D382_K0.6690.10
410_K470_L0.6690.10
39_L459_Y0.6650.10
315_D358_M0.6620.10
288_I332_L0.6620.10
203_I465_E0.6610.10
38_S261_K0.6580.10
166_I201_V0.6580.10
165_R401_P0.6550.09
124_R235_E0.6530.09
93_V215_V0.6530.09
134_F141_I0.6520.09
222_V431_K0.6490.09
65_V226_N0.6480.09
102_Q276_V0.6480.09
103_L420_V0.6460.09
209_R233_L0.6460.09
40_M291_Y0.6460.09
468_Y471_D0.6460.09
69_A472_K0.6450.09
147_P425_K0.6450.09
272_I444_R0.6450.09
289_I296_E0.6440.09
86_E149_R0.6440.09
313_L382_K0.6420.09
184_L471_D0.6420.09
154_I300_D0.6410.09
287_S458_G0.6410.09
87_A352_V0.6400.09
282_R368_L0.6390.09
199_Y203_I0.6380.09
372_I385_F0.6370.09
149_R247_F0.6370.09
61_L431_K0.6320.09
42_T342_K0.6320.09
63_G476_Q0.6320.09
229_N313_L0.6320.09
379_L415_E0.6310.09
62_P83_G0.6300.09
22_I101_I0.6280.09
49_L191_V0.6280.09
160_F352_V0.6260.09
204_D246_P0.6250.09
365_E447_K0.6250.09
45_I154_I0.6250.09
39_L339_I0.6210.09
178_P276_V0.6200.09
117_D232_E0.6200.09
9_T280_P0.6190.09
375_D472_K0.6180.09
139_I210_E0.6170.09
16_S62_P0.6170.09
9_T55_D0.6170.09
306_G381_D0.6170.09
94_I241_A0.6150.09
401_P450_S0.6140.09
441_E479_P0.6120.09
147_P207_S0.6120.09
42_T459_Y0.6110.09
148_F229_N0.6100.09
161_E198_G0.6080.09
257_I297_T0.6070.09
2_K118_N0.6060.09
66_Y178_P0.6060.09
70_K393_V0.6040.09
32_L75_V0.6020.09
348_S411_I0.6010.09
374_I410_K0.6000.09
36_V291_Y0.6000.09
220_S224_N0.6000.09
82_K425_K0.5990.09
321_M471_D0.5980.09
205_A260_V0.5980.09
253_G470_L0.5970.09
52_T271_L0.5960.09
418_F471_D0.5960.09
140_K212_K0.5950.09
62_P108_S0.5940.09
353_S357_K0.5940.09
219_A469_Q0.5920.09
204_D224_N0.5900.09
104_S345_T0.5900.09
169_N256_T0.5890.09
16_S239_E0.5890.09
55_D399_I0.5880.09
340_M465_E0.5870.09
358_M370_K0.5860.09
82_K381_D0.5860.09
66_Y469_Q0.5860.09
239_E442_L0.5840.09
139_I179_V0.5840.09
36_V183_D0.5830.09
442_L447_K0.5820.09
370_K381_D0.5820.09
223_F246_P0.5810.09
11_A68_D0.5810.09
61_L197_Y0.5800.09
43_K49_L0.5800.09
124_R161_E0.5790.09
219_A424_G0.5790.09
148_F205_A0.5790.09
275_P371_D0.5790.09
56_A163_L0.5780.09
152_L156_N0.5780.09
374_I430_I0.5770.09
69_A80_T0.5770.09
45_I149_R0.5760.09
278_S345_T0.5750.09
58_Y211_L0.5740.09
214_G478_K0.5740.09
187_V329_A0.5730.09
317_D351_E0.5730.09
268_F305_M0.5710.09
268_F324_L0.5690.09
124_R128_E0.5690.09
87_A174_V0.5690.09
202_G308_L0.5680.09
229_N465_E0.5670.09
188_K296_E0.5660.09
222_V428_I0.5650.09
354_Q357_K0.5650.09
259_L304_L0.5640.09
93_V468_Y0.5630.09
233_L304_L0.5620.09
40_M66_Y0.5610.09
341_E456_Y0.5600.09
60_L365_E0.5590.09
157_K339_I0.5580.09
15_L27_V0.5580.09
368_L478_K0.5570.09
75_V427_K0.5560.09
91_P212_K0.5550.09
61_L65_V0.5540.09
156_N224_N0.5530.09
342_K347_W0.5530.09
70_K94_I0.5500.08
192_K217_A0.5490.08
82_K149_R0.5490.08
69_A82_K0.5490.08
128_E444_R0.5490.08
295_R379_L0.5460.08
62_P218_G0.5460.08
126_M241_A0.5450.08
142_T308_L0.5430.08
156_N347_W0.5410.08
302_P407_G0.5400.08
63_G380_K0.5400.08
204_D373_G0.5390.08
404_D449_I0.5380.08
292_K390_N0.5380.08
77_G267_G0.5370.08
51_Q102_Q0.5370.08
181_H207_S0.5360.08
153_E176_G0.5350.08
280_P324_L0.5340.08
164_D415_E0.5340.08
120_E372_I0.5330.08
33_N68_D0.5310.08
116_M231_E0.5300.08
318_S467_A0.5290.08
42_T308_L0.5290.08
37_A306_G0.5280.08
27_V259_L0.5280.08
441_E481_F0.5270.08
123_L448_D0.5270.08
407_G449_I0.5250.08
43_K123_L0.5240.08
147_P181_H0.5220.08
98_K273_A0.5210.08
57_D63_G0.5190.08
97_L105_T0.5180.08
375_D423_I0.5180.08
240_A437_S0.5170.08
136_I264_K0.5170.08
202_G340_M0.5160.08
27_V236_I0.5160.08
33_N79_R0.5150.08
113_I455_V0.5150.08
161_E400_E0.5120.08
116_M285_V0.5120.08
88_W449_I0.5120.08
272_I440_R0.5120.08
304_L408_F0.5110.08
147_P252_R0.5100.08
184_L357_K0.5090.08
68_D72_V0.5090.08
80_T210_E0.5090.08
148_F339_I0.5080.08
327_A359_I0.5080.08
335_S353_S0.5070.08
17_E397_R0.5060.08
12_A435_G0.5050.08
140_K259_L0.5040.08
151_F408_F0.5040.08
260_V294_V0.5040.08
398_R429_T0.5030.08
84_T90_L0.5010.08
73_E77_G0.5010.08
127_E408_F0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4s39A 2 0.6265 100 0.815 Contact Map
4mwaA 4 0.4558 100 0.834 Contact Map
3noyA 2 0.5924 100 0.846 Contact Map
2yciX 2 0.4699 100 0.847 Contact Map
4o1eA 2 0.4679 100 0.852 Contact Map
4cczA 1 0.6667 100 0.855 Contact Map
3k13A 1 0.4699 100 0.859 Contact Map
2dqwA 2 0.4297 100 0.859 Contact Map
1f6yA 2 0.4458 100 0.86 Contact Map
2y5sA 2 0.4578 99.9 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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