Q97W27 - SULSO - GREMLIN Contacts

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Q97W27 - Thioredoxin reductase (TrxB-3)

UniProt:	Q97W27	Sequences: MSLLPRTTSVKPGEKFDVIIVGLGPAAYGAALYSARYMLKTLVIGETPGGQLTEAGIVDDYLGLIEIQASDMIKVFNKHIEKYEVPVLLDIVEKIENRGDEFVVKTKRKGEFKADSVILGIGVKRRKLGVPGEQEFAGRGISYCSVCDAPLFKNRVVAVIGGGDSALEGAEILSSYSTKVYLIHRRDTFKAQPIYVETVKKKPNVEFVLNSVVKEIKGDKVVKQVVVENLKTGEIKELNVNGVFIEIGFDPPTDFAKSNGIETDTNGYIKVDEWMRTSVPGVFAAGDCTSAWLGFRQVITAVAQGAVAATSAYRYVTEKKGKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	323 (282)
Sequences:	60130 (42942)
Seq/√Len:	2557.2

ECOLI - AHPF STHA TRXB GSHR DLDH RCLA HCAD DHNA NORW PRET GLTD NIRB YGFT AEGA FADH YGFK
BACSU - DHNA TRXB FENR2 FENR1 DLDH2 DLDH1 YPDA DLDH3 YJLD CZCO YUMB YUTJ GLTB NASB NASD
HALSA - P82854 DLDH Q9HP48 Q9HSN0 Q9HR27 O54535
SULSO - Q97W27 Q97V69 Q97WE3 Q97VD9 Q97YT2 Q97XZ3 FENR Q97WG1 Q97Z19 Q97Z14 Q97VJ3 Q97Y24 Q97VQ4 Q97U72 Q980U1 Q97UV0 Q97ZB4 Q97UP4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
158_A	240_V	3.938	1.00
46_E	91_I	3.633	1.00
156_V	179_K	3.284	1.00
217_K	226_V	2.984	1.00
215_E	226_V	2.869	1.00
181_Y	208_V	2.790	1.00
42_L	88_L	2.612	1.00
17_D	115_D	2.604	1.00
179_K	206_E	2.541	1.00
226_V	237_E	2.482	1.00
208_V	236_K	2.303	1.00
224_Q	237_E	2.290	1.00
18_V	34_S	2.287	1.00
217_K	224_Q	2.286	1.00
17_D	40_K	2.274	1.00
214_K	228_E	2.254	1.00
126_R	250_D	2.194	1.00
30_A	118_I	2.184	1.00
156_V	241_N	2.160	1.00
103_V	111_E	2.159	1.00
158_A	183_I	2.135	1.00
197_E	201_K	2.132	1.00
15_K	113_K	2.128	1.00
212_V	228_E	2.113	1.00
156_V	181_Y	2.104	1.00
262_E	270_K	2.099	1.00
16_F	42_L	2.070	1.00
272_D	276_R	2.069	1.00
100_D	281_G	2.004	1.00
19_I	44_I	1.972	1.00
214_K	226_V	1.970	1.00
44_I	112_F	1.968	1.00
229_N	236_K	1.872	1.00
118_I	312_A	1.860	1.00
94_K	105_K	1.851	1.00
131_P	215_E	1.823	1.00
217_K	237_E	1.820	1.00
15_K	115_D	1.808	1.00
105_K	111_E	1.803	1.00
158_A	225_V	1.774	1.00
97_N	279_V	1.768	1.00
185_R	212_V	1.764	1.00
224_Q	239_N	1.760	1.00
19_I	114_A	1.752	1.00
211_S	229_N	1.735	1.00
181_Y	206_E	1.733	1.00
116_S	281_G	1.706	1.00
19_I	104_V	1.654	1.00
17_D	42_L	1.636	1.00
124_K	252_P	1.625	1.00
183_I	238_L	1.606	1.00
124_K	250_D	1.603	1.00
103_V	113_K	1.603	1.00
114_A	117_V	1.583	1.00
214_K	235_I	1.574	1.00
262_E	278_S	1.570	1.00
156_V	178_T	1.564	1.00
19_I	112_F	1.563	1.00
211_S	236_K	1.541	1.00
226_V	235_I	1.526	1.00
264_D	268_Y	1.516	1.00
26_A	285_A	1.516	1.00
156_V	239_N	1.498	1.00
228_E	235_I	1.492	1.00
121_I	288_C	1.483	1.00
155_R	241_N	1.478	1.00
142_S	146_V	1.467	1.00
218_G	223_K	1.463	1.00
116_S	283_F	1.425	1.00
143_Y	146_V	1.418	1.00
68_Q	71_D	1.408	1.00
187_D	210_N	1.404	1.00
106_T	112_F	1.398	1.00
116_S	312_A	1.386	1.00
264_D	290_S	1.377	1.00
227_V	238_L	1.355	1.00
91_I	107_K	1.348	1.00
96_E	103_V	1.338	1.00
93_E	105_K	1.330	1.00
31_A	43_V	1.328	1.00
23_L	45_G	1.325	1.00
96_E	99_G	1.322	1.00
283_F	311_S	1.317	1.00
208_V	211_S	1.309	1.00
77_N	81_E	1.301	1.00
135_E	218_G	1.299	1.00
124_K	254_D	1.292	1.00
227_V	236_K	1.290	1.00
118_I	285_A	1.287	1.00
19_I	42_L	1.281	1.00
40_K	86_P	1.281	1.00
216_I	243_V	1.278	1.00
211_S	227_V	1.274	1.00
264_D	270_K	1.259	1.00
181_Y	240_V	1.258	1.00
20_I	27_A	1.233	1.00
93_E	107_K	1.231	1.00
276_R	280_P	1.224	1.00
309_A	313_Y	1.224	1.00
37_Y	313_Y	1.208	1.00
199_V	202_K	1.204	1.00
222_V	239_N	1.167	1.00
49_G	52_L	1.165	1.00
33_Y	310_T	1.162	1.00
18_V	39_L	1.162	1.00
78_K	82_K	1.160	1.00
305_G	309_A	1.156	1.00
157_V	173_L	1.154	1.00
94_K	258_S	1.146	1.00
18_V	118_I	1.144	1.00
79_H	83_Y	1.135	1.00
271_V	289_T	1.130	1.00
196_V	200_K	1.124	1.00
162_G	184_H	1.113	1.00
63_G	66_E	1.112	1.00
96_E	105_K	1.111	1.00
307_V	311_S	1.106	1.00
129_G	133_E	1.103	1.00
146_V	149_A	1.102	1.00
157_V	242_G	1.102	1.00
229_N	235_I	1.100	1.00
26_A	301_A	1.097	1.00
308_A	312_A	1.095	1.00
269_I	284_A	1.089	1.00
106_T	110_G	1.089	1.00
184_H	209_L	1.082	1.00
50_G	53_T	1.079	1.00
33_Y	36_R	1.074	1.00
199_V	203_P	1.070	1.00
35_A	85_V	1.067	1.00
183_I	227_V	1.058	1.00
20_I	31_A	1.043	1.00
181_Y	238_L	1.037	1.00
51_Q	54_E	1.032	1.00
153_K	178_T	1.025	1.00
74_K	78_K	1.024	1.00
154_N	178_T	1.024	1.00
88_L	112_F	1.018	1.00
167_L	182_L	1.017	1.00
18_V	116_S	0.999	1.00
120_G	285_A	0.997	1.00
21_V	92_V	0.996	1.00
33_Y	37_Y	0.993	1.00
42_L	86_P	0.992	1.00
140_G	146_V	0.989	1.00
216_I	222_V	0.987	1.00
16_F	19_I	0.984	1.00
42_L	112_F	0.982	1.00
78_K	81_E	0.981	1.00
218_G	222_V	0.979	1.00
194_I	197_E	0.973	1.00
97_N	282_V	0.971	1.00
139_R	142_S	0.969	1.00
219_D	224_Q	0.964	1.00
37_Y	310_T	0.962	1.00
142_S	145_S	0.951	1.00
33_Y	306_A	0.949	1.00
195_Y	199_V	0.945	1.00
62_L	65_I	0.944	1.00
157_V	178_T	0.944	1.00
98_R	103_V	0.940	1.00
144_C	147_C	0.938	1.00
88_L	110_G	0.937	1.00
16_F	116_S	0.935	1.00
219_D	223_K	0.932	1.00
171_E	175_S	0.931	1.00
285_A	308_A	0.930	1.00
44_I	88_L	0.929	1.00
15_K	40_K	0.925	1.00
76_F	79_H	0.921	1.00
274_W	311_S	0.919	1.00
227_V	235_I	0.918	1.00
279_V	282_V	0.915	1.00
174_S	205_V	0.903	1.00
42_L	114_A	0.902	1.00
188_T	193_P	0.901	1.00
39_L	313_Y	0.901	1.00
219_D	222_V	0.898	1.00
222_V	243_V	0.893	1.00
193_P	197_E	0.893	1.00
21_V	121_I	0.890	1.00
194_I	198_T	0.886	1.00
170_A	182_L	0.884	1.00
142_S	147_C	0.884	1.00
44_I	92_V	0.881	1.00
21_V	119_L	0.880	1.00
145_S	149_A	0.880	1.00
48_P	52_L	0.879	1.00
32_L	36_R	0.872	1.00
177_S	180_V	0.871	1.00
172_I	176_Y	0.871	1.00
47_T	54_E	0.870	1.00
197_E	209_L	0.870	1.00
211_S	228_E	0.870	1.00
158_A	238_L	0.867	1.00
49_G	53_T	0.866	1.00
16_F	40_K	0.859	1.00
275_M	289_T	0.859	1.00
145_S	148_D	0.857	1.00
160_I	243_V	0.853	1.00
254_D	257_K	0.851	1.00
159_V	170_A	0.850	1.00
34_S	309_A	0.847	1.00
139_R	146_V	0.843	1.00
160_I	247_I	0.842	1.00
171_E	174_S	0.841	1.00
198_T	201_K	0.840	1.00
269_I	288_C	0.840	1.00
198_T	202_K	0.838	1.00
17_D	113_K	0.836	1.00
71_D	74_K	0.835	1.00
284_A	289_T	0.834	1.00
174_S	179_K	0.833	1.00
27_A	120_G	0.828	1.00
208_V	238_L	0.821	1.00
275_M	307_V	0.813	1.00
67_I	71_D	0.808	1.00
34_S	39_L	0.805	1.00
50_G	54_E	0.802	1.00
118_I	308_A	0.801	1.00
30_A	285_A	0.800	1.00
123_V	249_F	0.800	1.00
219_D	239_N	0.800	1.00
144_C	149_A	0.797	1.00
283_F	312_A	0.788	1.00
139_R	145_S	0.787	1.00
90_D	108_R	0.787	1.00
47_T	77_N	0.785	1.00
71_D	75_V	0.779	1.00
271_V	284_A	0.779	1.00
17_D	39_L	0.777	1.00
48_P	89_L	0.775	1.00
44_I	106_T	0.766	1.00
135_E	138_G	0.762	1.00
173_L	176_Y	0.759	1.00
284_A	288_C	0.759	1.00
138_G	142_S	0.758	1.00
92_V	104_V	0.758	1.00
23_L	43_V	0.758	1.00
30_A	305_G	0.757	1.00
52_L	57_I	0.754	1.00
175_S	203_P	0.753	1.00
132_G	215_E	0.752	1.00
117_V	282_V	0.752	1.00
90_D	107_K	0.752	1.00
31_A	41_T	0.751	1.00
275_M	308_A	0.748	1.00
300_T	304_Q	0.748	1.00
49_G	54_E	0.741	1.00
140_G	143_Y	0.741	1.00
143_Y	147_C	0.738	1.00
289_T	304_Q	0.737	1.00
31_A	85_V	0.737	1.00
30_A	308_A	0.737	1.00
189_F	209_L	0.732	1.00
35_A	41_T	0.732	1.00
75_V	78_K	0.732	1.00
18_V	312_A	0.727	1.00
138_G	143_Y	0.723	1.00
47_T	53_T	0.722	1.00
139_R	143_Y	0.721	1.00
34_S	41_T	0.717	1.00
143_Y	148_D	0.716	1.00
301_A	305_G	0.714	1.00
29_G	33_Y	0.713	1.00
95_I	117_V	0.713	1.00
80_I	83_Y	0.712	1.00
213_V	225_V	0.711	1.00
144_C	148_D	0.708	1.00
271_V	275_M	0.707	1.00
135_E	139_R	0.706	1.00
270_K	278_S	0.703	1.00
20_I	30_A	0.703	1.00
99_G	103_V	0.698	1.00
276_R	311_S	0.698	1.00
160_I	245_I	0.698	1.00
156_V	222_V	0.698	1.00
308_A	311_S	0.697	1.00
68_Q	72_M	0.694	1.00
240_V	243_V	0.692	1.00
158_A	243_V	0.690	1.00
70_S	74_K	0.686	1.00
16_F	86_P	0.686	1.00
217_K	220_K	0.684	1.00
306_A	310_T	0.680	1.00
94_K	97_N	0.679	1.00
48_P	53_T	0.679	1.00
34_S	312_A	0.679	1.00
139_R	144_C	0.677	1.00
73_I	77_N	0.676	1.00
29_G	32_L	0.673	1.00
220_K	237_E	0.673	1.00
35_A	84_E	0.672	1.00
283_F	308_A	0.670	1.00
188_T	197_E	0.669	1.00
119_L	288_C	0.666	1.00
206_E	236_K	0.665	1.00
138_G	144_C	0.662	1.00
196_V	199_V	0.662	1.00
107_K	110_G	0.662	1.00
156_V	240_V	0.662	1.00
169_G	172_I	0.660	1.00
303_A	306_A	0.659	1.00
303_A	307_V	0.656	1.00
127_K	134_Q	0.656	1.00
263_T	270_K	0.654	1.00
74_K	77_N	0.652	1.00
216_I	225_V	0.652	1.00
160_I	213_V	0.649	1.00
195_Y	198_T	0.646	1.00
133_E	245_I	0.646	1.00
276_R	281_G	0.644	1.00
69_A	73_I	0.643	1.00
127_K	245_I	0.642	1.00
174_S	203_P	0.642	1.00
32_L	83_Y	0.640	1.00
20_I	120_G	0.638	1.00
155_R	178_T	0.638	1.00
277_T	284_A	0.637	1.00
140_G	144_C	0.637	1.00
140_G	245_I	0.635	1.00
254_D	258_S	0.631	1.00
166_A	184_H	0.629	1.00
76_F	80_I	0.626	1.00
172_I	175_S	0.624	1.00
47_T	52_L	0.623	1.00
276_R	283_F	0.621	1.00
45_G	89_L	0.621	1.00
27_A	31_A	0.621	1.00
130_V	133_E	0.620	1.00
16_F	115_D	0.619	1.00
142_S	148_D	0.619	1.00
138_G	146_V	0.618	1.00
44_I	114_A	0.618	1.00
208_V	227_V	0.615	1.00
139_R	147_C	0.614	1.00
142_S	149_A	0.612	1.00
183_I	208_V	0.608	1.00
62_L	66_E	0.605	1.00
310_T	314_R	0.604	1.00
193_P	196_V	0.603	1.00
128_L	245_I	0.601	1.00
54_E	58_V	0.601	1.00
132_G	135_E	0.599	1.00
105_K	109_K	0.598	1.00
140_G	145_S	0.598	1.00
142_S	242_G	0.598	1.00
270_K	273_E	0.597	1.00
67_I	70_S	0.594	1.00
141_I	147_C	0.593	1.00
80_I	85_V	0.593	1.00
184_H	189_F	0.593	1.00
184_H	191_A	0.592	1.00
276_R	279_V	0.591	1.00
35_A	40_K	0.590	1.00
17_D	112_F	0.589	1.00
92_V	106_T	0.589	1.00
43_V	87_V	0.588	1.00
169_G	246_E	0.586	1.00
48_P	51_Q	0.581	1.00
127_K	133_E	0.576	1.00
297_Q	300_T	0.575	1.00
275_M	311_S	0.574	1.00
121_I	255_F	0.573	1.00
155_R	242_G	0.573	1.00
174_S	204_N	0.573	1.00
29_G	302_V	0.572	1.00
253_T	263_T	0.572	1.00
93_E	96_E	0.571	1.00
47_T	50_G	0.569	1.00
222_V	241_N	0.567	1.00
142_S	150_P	0.565	1.00
30_A	309_A	0.564	1.00
290_S	304_Q	0.563	1.00
304_Q	308_A	0.562	1.00
302_V	306_A	0.560	1.00
54_E	57_I	0.556	1.00
79_H	82_K	0.555	1.00
72_M	75_V	0.554	1.00
143_Y	149_A	0.554	1.00
257_K	263_T	0.548	1.00
295_F	300_T	0.546	1.00
135_E	140_G	0.546	1.00
256_A	259_N	0.546	1.00
119_L	282_V	0.545	1.00
296_R	300_T	0.545	1.00
184_H	187_D	0.542	1.00
106_T	109_K	0.541	1.00
156_V	238_L	0.540	1.00
299_I	302_V	0.539	1.00
159_V	166_A	0.537	1.00
170_A	205_V	0.536	1.00
20_I	43_V	0.535	1.00
170_A	180_V	0.535	1.00
285_A	305_G	0.534	1.00
39_L	312_A	0.528	1.00
75_V	79_H	0.528	1.00
169_G	244_F	0.527	1.00
17_D	114_A	0.525	1.00
64_L	67_I	0.524	1.00
162_G	189_F	0.523	1.00
311_S	314_R	0.521	1.00
287_D	301_A	0.521	1.00
39_L	115_D	0.521	1.00
138_G	147_C	0.520	1.00
29_G	305_G	0.518	1.00
139_R	149_A	0.516	1.00
140_G	147_C	0.514	1.00
119_L	255_F	0.511	1.00
206_E	209_L	0.510	1.00
271_V	274_W	0.510	1.00
26_A	120_G	0.506	1.00
77_N	89_L	0.506	1.00
200_K	207_F	0.506	1.00
216_I	223_K	0.505	1.00
35_A	86_P	0.505	1.00
298_V	301_A	0.504	1.00
183_I	211_S	0.504	1.00
94_K	117_V	0.503	1.00
20_I	41_T	0.503	1.00
129_G	134_Q	0.501	1.00
158_A	181_Y	0.501	1.00
80_I	87_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3f8dA	2	0.9598	100	0.199	Contact Map
2q7vA	2	0.9505	100	0.239	Contact Map
2a87A	2	0.9598	100	0.248	Contact Map
2q0lA	2	0.935	100	0.25	Contact Map
4up3A	2	0.935	100	0.25	Contact Map
3ctyA	2	0.9381	100	0.25	Contact Map
1fl2A	2	0.9412	100	0.257	Contact Map
1vdcA	2	0.9412	100	0.264	Contact Map
3r9uA	2	0.935	100	0.267	Contact Map
4jnqA	2	0.9443	100	0.27	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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