GREMLIN Database
Q97W27 - Thioredoxin reductase (TrxB-3)
UniProt: Q97W27 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (282)
Sequences: 60130 (42942)
Seq/√Len: 2557.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_A240_V3.9381.00
46_E91_I3.6331.00
156_V179_K3.2841.00
217_K226_V2.9841.00
215_E226_V2.8691.00
181_Y208_V2.7901.00
42_L88_L2.6121.00
17_D115_D2.6041.00
179_K206_E2.5411.00
226_V237_E2.4821.00
208_V236_K2.3031.00
224_Q237_E2.2901.00
18_V34_S2.2871.00
217_K224_Q2.2861.00
17_D40_K2.2741.00
214_K228_E2.2541.00
126_R250_D2.1941.00
30_A118_I2.1841.00
156_V241_N2.1601.00
103_V111_E2.1591.00
158_A183_I2.1351.00
197_E201_K2.1321.00
15_K113_K2.1281.00
212_V228_E2.1131.00
156_V181_Y2.1041.00
262_E270_K2.0991.00
16_F42_L2.0701.00
272_D276_R2.0691.00
100_D281_G2.0041.00
19_I44_I1.9721.00
214_K226_V1.9701.00
44_I112_F1.9681.00
229_N236_K1.8721.00
118_I312_A1.8601.00
94_K105_K1.8511.00
131_P215_E1.8231.00
217_K237_E1.8201.00
15_K115_D1.8081.00
105_K111_E1.8031.00
158_A225_V1.7741.00
97_N279_V1.7681.00
185_R212_V1.7641.00
224_Q239_N1.7601.00
19_I114_A1.7521.00
211_S229_N1.7351.00
181_Y206_E1.7331.00
116_S281_G1.7061.00
19_I104_V1.6541.00
17_D42_L1.6361.00
124_K252_P1.6251.00
183_I238_L1.6061.00
124_K250_D1.6031.00
103_V113_K1.6031.00
114_A117_V1.5831.00
214_K235_I1.5741.00
262_E278_S1.5701.00
156_V178_T1.5641.00
19_I112_F1.5631.00
211_S236_K1.5411.00
226_V235_I1.5261.00
264_D268_Y1.5161.00
26_A285_A1.5161.00
156_V239_N1.4981.00
228_E235_I1.4921.00
121_I288_C1.4831.00
155_R241_N1.4781.00
142_S146_V1.4671.00
218_G223_K1.4631.00
116_S283_F1.4251.00
143_Y146_V1.4181.00
68_Q71_D1.4081.00
187_D210_N1.4041.00
106_T112_F1.3981.00
116_S312_A1.3861.00
264_D290_S1.3771.00
227_V238_L1.3551.00
91_I107_K1.3481.00
96_E103_V1.3381.00
93_E105_K1.3301.00
31_A43_V1.3281.00
23_L45_G1.3251.00
96_E99_G1.3221.00
283_F311_S1.3171.00
208_V211_S1.3091.00
77_N81_E1.3011.00
135_E218_G1.2991.00
124_K254_D1.2921.00
227_V236_K1.2901.00
118_I285_A1.2871.00
19_I42_L1.2811.00
40_K86_P1.2811.00
216_I243_V1.2781.00
211_S227_V1.2741.00
264_D270_K1.2591.00
181_Y240_V1.2581.00
20_I27_A1.2331.00
93_E107_K1.2311.00
276_R280_P1.2241.00
309_A313_Y1.2241.00
37_Y313_Y1.2081.00
199_V202_K1.2041.00
222_V239_N1.1671.00
49_G52_L1.1651.00
33_Y310_T1.1621.00
18_V39_L1.1621.00
78_K82_K1.1601.00
305_G309_A1.1561.00
157_V173_L1.1541.00
94_K258_S1.1461.00
18_V118_I1.1441.00
79_H83_Y1.1351.00
271_V289_T1.1301.00
196_V200_K1.1241.00
162_G184_H1.1131.00
63_G66_E1.1121.00
96_E105_K1.1111.00
307_V311_S1.1061.00
129_G133_E1.1031.00
146_V149_A1.1021.00
157_V242_G1.1021.00
229_N235_I1.1001.00
26_A301_A1.0971.00
308_A312_A1.0951.00
269_I284_A1.0891.00
106_T110_G1.0891.00
184_H209_L1.0821.00
50_G53_T1.0791.00
33_Y36_R1.0741.00
199_V203_P1.0701.00
35_A85_V1.0671.00
183_I227_V1.0581.00
20_I31_A1.0431.00
181_Y238_L1.0371.00
51_Q54_E1.0321.00
153_K178_T1.0251.00
74_K78_K1.0241.00
154_N178_T1.0241.00
88_L112_F1.0181.00
167_L182_L1.0171.00
18_V116_S0.9991.00
120_G285_A0.9971.00
21_V92_V0.9961.00
33_Y37_Y0.9931.00
42_L86_P0.9921.00
140_G146_V0.9891.00
216_I222_V0.9871.00
16_F19_I0.9841.00
42_L112_F0.9821.00
78_K81_E0.9811.00
218_G222_V0.9791.00
194_I197_E0.9731.00
97_N282_V0.9711.00
139_R142_S0.9691.00
219_D224_Q0.9641.00
37_Y310_T0.9621.00
142_S145_S0.9511.00
33_Y306_A0.9491.00
195_Y199_V0.9451.00
62_L65_I0.9441.00
157_V178_T0.9441.00
98_R103_V0.9401.00
144_C147_C0.9381.00
88_L110_G0.9371.00
16_F116_S0.9351.00
219_D223_K0.9321.00
171_E175_S0.9311.00
285_A308_A0.9301.00
44_I88_L0.9291.00
15_K40_K0.9251.00
76_F79_H0.9211.00
274_W311_S0.9191.00
227_V235_I0.9181.00
279_V282_V0.9151.00
174_S205_V0.9031.00
42_L114_A0.9021.00
188_T193_P0.9011.00
39_L313_Y0.9011.00
219_D222_V0.8981.00
222_V243_V0.8931.00
193_P197_E0.8931.00
21_V121_I0.8901.00
194_I198_T0.8861.00
170_A182_L0.8841.00
142_S147_C0.8841.00
44_I92_V0.8811.00
21_V119_L0.8801.00
145_S149_A0.8801.00
48_P52_L0.8791.00
32_L36_R0.8721.00
177_S180_V0.8711.00
172_I176_Y0.8711.00
47_T54_E0.8701.00
197_E209_L0.8701.00
211_S228_E0.8701.00
158_A238_L0.8671.00
49_G53_T0.8661.00
16_F40_K0.8591.00
275_M289_T0.8591.00
145_S148_D0.8571.00
160_I243_V0.8531.00
254_D257_K0.8511.00
159_V170_A0.8501.00
34_S309_A0.8471.00
139_R146_V0.8431.00
160_I247_I0.8421.00
171_E174_S0.8411.00
198_T201_K0.8401.00
269_I288_C0.8401.00
198_T202_K0.8381.00
17_D113_K0.8361.00
71_D74_K0.8351.00
284_A289_T0.8341.00
174_S179_K0.8331.00
27_A120_G0.8281.00
208_V238_L0.8211.00
275_M307_V0.8131.00
67_I71_D0.8081.00
34_S39_L0.8051.00
50_G54_E0.8021.00
118_I308_A0.8011.00
30_A285_A0.8001.00
123_V249_F0.8001.00
219_D239_N0.8001.00
144_C149_A0.7971.00
283_F312_A0.7881.00
139_R145_S0.7871.00
90_D108_R0.7871.00
47_T77_N0.7851.00
71_D75_V0.7791.00
271_V284_A0.7791.00
17_D39_L0.7771.00
48_P89_L0.7751.00
44_I106_T0.7661.00
135_E138_G0.7621.00
173_L176_Y0.7591.00
284_A288_C0.7591.00
138_G142_S0.7581.00
92_V104_V0.7581.00
23_L43_V0.7581.00
30_A305_G0.7571.00
52_L57_I0.7541.00
175_S203_P0.7531.00
132_G215_E0.7521.00
117_V282_V0.7521.00
90_D107_K0.7521.00
31_A41_T0.7511.00
275_M308_A0.7481.00
300_T304_Q0.7481.00
49_G54_E0.7411.00
140_G143_Y0.7411.00
143_Y147_C0.7381.00
289_T304_Q0.7371.00
31_A85_V0.7371.00
30_A308_A0.7371.00
189_F209_L0.7321.00
35_A41_T0.7321.00
75_V78_K0.7321.00
18_V312_A0.7271.00
138_G143_Y0.7231.00
47_T53_T0.7221.00
139_R143_Y0.7211.00
34_S41_T0.7171.00
143_Y148_D0.7161.00
301_A305_G0.7141.00
29_G33_Y0.7131.00
95_I117_V0.7131.00
80_I83_Y0.7121.00
213_V225_V0.7111.00
144_C148_D0.7081.00
271_V275_M0.7071.00
135_E139_R0.7061.00
270_K278_S0.7031.00
20_I30_A0.7031.00
99_G103_V0.6981.00
276_R311_S0.6981.00
160_I245_I0.6981.00
156_V222_V0.6981.00
308_A311_S0.6971.00
68_Q72_M0.6941.00
240_V243_V0.6921.00
158_A243_V0.6901.00
70_S74_K0.6861.00
16_F86_P0.6861.00
217_K220_K0.6841.00
306_A310_T0.6801.00
94_K97_N0.6791.00
48_P53_T0.6791.00
34_S312_A0.6791.00
139_R144_C0.6771.00
73_I77_N0.6761.00
29_G32_L0.6731.00
220_K237_E0.6731.00
35_A84_E0.6721.00
283_F308_A0.6701.00
188_T197_E0.6691.00
119_L288_C0.6661.00
206_E236_K0.6651.00
138_G144_C0.6621.00
196_V199_V0.6621.00
107_K110_G0.6621.00
156_V240_V0.6621.00
169_G172_I0.6601.00
303_A306_A0.6591.00
303_A307_V0.6561.00
127_K134_Q0.6561.00
263_T270_K0.6541.00
74_K77_N0.6521.00
216_I225_V0.6521.00
160_I213_V0.6491.00
195_Y198_T0.6461.00
133_E245_I0.6461.00
276_R281_G0.6441.00
69_A73_I0.6431.00
127_K245_I0.6421.00
174_S203_P0.6421.00
32_L83_Y0.6401.00
20_I120_G0.6381.00
155_R178_T0.6381.00
277_T284_A0.6371.00
140_G144_C0.6371.00
140_G245_I0.6351.00
254_D258_S0.6311.00
166_A184_H0.6291.00
76_F80_I0.6261.00
172_I175_S0.6241.00
47_T52_L0.6231.00
276_R283_F0.6211.00
45_G89_L0.6211.00
27_A31_A0.6211.00
130_V133_E0.6201.00
16_F115_D0.6191.00
142_S148_D0.6191.00
138_G146_V0.6181.00
44_I114_A0.6181.00
208_V227_V0.6151.00
139_R147_C0.6141.00
142_S149_A0.6121.00
183_I208_V0.6081.00
62_L66_E0.6051.00
310_T314_R0.6041.00
193_P196_V0.6031.00
128_L245_I0.6011.00
54_E58_V0.6011.00
132_G135_E0.5991.00
105_K109_K0.5981.00
140_G145_S0.5981.00
142_S242_G0.5981.00
270_K273_E0.5971.00
67_I70_S0.5941.00
141_I147_C0.5931.00
80_I85_V0.5931.00
184_H189_F0.5931.00
184_H191_A0.5921.00
276_R279_V0.5911.00
35_A40_K0.5901.00
17_D112_F0.5891.00
92_V106_T0.5891.00
43_V87_V0.5881.00
169_G246_E0.5861.00
48_P51_Q0.5811.00
127_K133_E0.5761.00
297_Q300_T0.5751.00
275_M311_S0.5741.00
121_I255_F0.5731.00
155_R242_G0.5731.00
174_S204_N0.5731.00
29_G302_V0.5721.00
253_T263_T0.5721.00
93_E96_E0.5711.00
47_T50_G0.5691.00
222_V241_N0.5671.00
142_S150_P0.5651.00
30_A309_A0.5641.00
290_S304_Q0.5631.00
304_Q308_A0.5621.00
302_V306_A0.5601.00
54_E57_I0.5561.00
79_H82_K0.5551.00
72_M75_V0.5541.00
143_Y149_A0.5541.00
257_K263_T0.5481.00
295_F300_T0.5461.00
135_E140_G0.5461.00
256_A259_N0.5461.00
119_L282_V0.5451.00
296_R300_T0.5451.00
184_H187_D0.5421.00
106_T109_K0.5411.00
156_V238_L0.5401.00
299_I302_V0.5391.00
159_V166_A0.5371.00
170_A205_V0.5361.00
20_I43_V0.5351.00
170_A180_V0.5351.00
285_A305_G0.5341.00
39_L312_A0.5281.00
75_V79_H0.5281.00
169_G244_F0.5271.00
17_D114_A0.5251.00
64_L67_I0.5241.00
162_G189_F0.5231.00
311_S314_R0.5211.00
287_D301_A0.5211.00
39_L115_D0.5211.00
138_G147_C0.5201.00
29_G305_G0.5181.00
139_R149_A0.5161.00
140_G147_C0.5141.00
119_L255_F0.5111.00
206_E209_L0.5101.00
271_V274_W0.5101.00
26_A120_G0.5061.00
77_N89_L0.5061.00
200_K207_F0.5061.00
216_I223_K0.5051.00
35_A86_P0.5051.00
298_V301_A0.5041.00
183_I211_S0.5041.00
94_K117_V0.5031.00
20_I41_T0.5031.00
129_G134_Q0.5011.00
158_A181_Y0.5011.00
80_I87_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f8dA 2 0.9598 100 0.199 Contact Map
2q7vA 2 0.9505 100 0.239 Contact Map
2a87A 2 0.9598 100 0.248 Contact Map
2q0lA 2 0.935 100 0.25 Contact Map
4up3A 2 0.935 100 0.25 Contact Map
3ctyA 2 0.9381 100 0.25 Contact Map
1fl2A 2 0.9412 100 0.257 Contact Map
1vdcA 2 0.9412 100 0.264 Contact Map
3r9uA 2 0.935 100 0.267 Contact Map
4jnqA 2 0.9443 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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