Q97W26 - SULSO - GREMLIN Contacts

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Q97W26 - Inositol monophosphosphatase, putative (Imp3)

UniProt:	Q97W26	Sequences: MINLLNKVAIDATRYLNEIKNEKDLDKVIGFHAGDTTRVIDKKSEEYIFQLLNDTGLKFKFVSEESGVRVPSNSYDYVALIDPLDGSNNFVLGVPWYSISVAIYGKSSNSLLDSLGGFVSHISIDKIYSYDTSSAYLNGNPLKAEIIGNSPSNVVITYFDERGIDKILKVLSALKGYKIRSFGSASLDMILTCMGKAKLYFDIRGKLRNVDIAASANFCKRLNSIPSTLNGKEISSGIDDIYKIDEIIVSRDQSLMKNLYSIFS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	264 (228)
Sequences:	10099 (7141)
Seq/√Len:	472.9

ECOLI - SUHB CYSQ
BACSU - SUHB
HALSA - Q9HQ12
SULSO - Q97W26

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
219_C	224_S	4.016	1.00
120_S	127_I	3.371	1.00
77_Y	105_G	3.217	1.00
76_D	106_K	3.164	1.00
130_Y	133_S	2.928	1.00
216_A	220_K	2.790	1.00
134_S	221_R	2.738	1.00
121_H	124_I	2.602	1.00
8_V	51_L	2.590	1.00
11_D	51_L	2.378	1.00
156_I	197_A	2.332	1.00
15_Y	47_Y	2.310	1.00
13_T	120_S	2.202	1.00
228_T	232_K	2.151	1.00
113_D	131_D	2.119	1.00
77_Y	103_I	2.092	1.00
78_V	104_Y	2.089	1.00
97_Y	123_S	2.073	1.00
39_V	43_K	2.004	1.00
129_S	136_Y	1.989	1.00
46_E	50_Q	1.967	1.00
56_G	59_F	1.941	1.00
19_I	40_I	1.919	1.00
45_E	63_S	1.912	1.00
16_L	44_S	1.855	1.00
51_L	54_D	1.844	1.00
217_N	221_R	1.843	1.00
59_F	77_Y	1.842	1.00
105_G	115_L	1.838	1.00
117_G	217_N	1.832	1.00
80_L	104_Y	1.818	1.00
136_Y	141_P	1.799	1.00
137_L	194_M	1.766	1.00
104_Y	114_S	1.746	1.00
49_F	53_N	1.742	1.00
128_Y	194_M	1.706	1.00
28_V	31_F	1.642	1.00
29_I	42_K	1.628	1.00
49_F	61_F	1.625	1.00
47_Y	51_L	1.597	1.00
119_V	190_I	1.576	1.00
126_K	137_L	1.571	1.00
17_N	123_S	1.568	1.00
98_S	186_S	1.567	1.00
121_H	187_L	1.558	1.00
5_L	79_A	1.557	1.00
149_N	152_S	1.557	1.00
9_A	101_V	1.552	1.00
6_N	129_S	1.524	1.00
132_T	221_R	1.513	1.00
100_S	186_S	1.497	1.00
59_F	79_A	1.457	1.00
131_D	221_R	1.447	1.00
4_L	56_G	1.435	1.00
126_K	196_K	1.433	1.00
4_L	8_V	1.425	1.00
38_R	91_V	1.415	1.00
9_A	118_F	1.409	1.00
27_K	30_G	1.407	1.00
168_L	172_S	1.405	1.00
102_A	213_A	1.403	1.00
190_I	218_F	1.402	1.00
131_D	220_K	1.399	1.00
20_K	97_Y	1.399	1.00
76_D	105_G	1.398	1.00
4_L	55_T	1.396	1.00
113_D	220_K	1.393	1.00
15_Y	18_E	1.370	1.00
7_K	55_T	1.362	1.00
126_K	194_M	1.348	1.00
16_L	84_L	1.342	1.00
48_I	81_I	1.331	1.00
81_I	101_V	1.318	1.00
155_V	199_L	1.310	1.00
16_L	97_Y	1.298	1.00
50_Q	54_D	1.293	1.00
79_A	103_I	1.285	1.00
6_N	10_I	1.284	1.00
17_N	97_Y	1.283	1.00
135_A	142_L	1.262	1.00
10_I	127_I	1.262	1.00
52_L	59_F	1.260	1.00
46_E	66_S	1.255	1.00
43_K	46_E	1.246	1.00
51_L	55_T	1.241	1.00
48_I	101_V	1.240	1.00
6_N	127_I	1.229	1.00
7_K	11_D	1.205	1.00
189_M	215_S	1.205	1.00
45_E	66_S	1.204	1.00
36_T	91_V	1.194	1.00
216_A	226_P	1.175	1.00
49_F	63_S	1.171	1.00
36_T	88_N	1.167	1.00
11_D	47_Y	1.158	1.00
220_K	233_E	1.155	1.00
191_L	196_K	1.147	1.00
45_E	49_F	1.136	1.00
94_V	182_F	1.122	1.00
115_L	131_D	1.110	1.00
169_K	173_A	1.109	1.00
18_E	22_E	1.097	1.00
16_L	40_I	1.097	1.00
114_S	217_N	1.073	1.00
62_V	80_L	1.072	1.00
15_Y	43_K	1.071	1.00
72_S	75_Y	1.065	1.00
170_V	174_L	1.064	1.00
145_E	198_K	1.064	1.00
187_L	191_L	1.056	1.00
49_F	66_S	1.053	1.00
42_K	46_E	1.049	1.00
8_V	47_Y	1.049	1.00
15_Y	19_I	1.043	1.00
103_I	116_G	1.042	1.00
19_I	43_K	1.038	1.00
80_L	213_A	1.037	1.00
170_V	173_A	1.026	1.00
102_A	114_S	1.026	1.00
129_S	139_G	1.020	1.00
169_K	172_S	1.018	1.00
14_R	18_E	1.015	1.00
7_K	51_L	1.010	1.00
120_S	125_D	1.010	1.00
185_A	207_L	1.003	1.00
135_A	221_R	1.002	1.00
189_M	219_C	0.999	1.00
8_V	48_I	0.993	1.00
114_S	216_A	0.976	1.00
41_D	65_E	0.970	1.00
4_L	52_L	0.967	1.00
165_D	169_K	0.960	1.00
11_D	14_R	0.959	1.00
135_A	218_F	0.954	1.00
62_V	78_V	0.952	1.00
38_R	87_S	0.947	1.00
77_Y	115_L	0.944	1.00
26_D	31_F	0.935	1.00
32_H	35_D	0.918	1.00
20_K	123_S	0.913	1.00
19_I	39_V	0.908	1.00
96_W	191_L	0.902	1.00
27_K	31_F	0.902	1.00
44_S	84_L	0.898	1.00
44_S	48_I	0.897	1.00
63_S	66_S	0.877	1.00
116_G	130_Y	0.869	1.00
31_F	35_D	0.867	1.00
52_L	56_G	0.865	1.00
10_I	125_D	0.865	1.00
103_I	115_L	0.865	1.00
89_N	180_R	0.865	1.00
20_K	93_G	0.864	1.00
119_V	218_F	0.864	1.00
142_L	194_M	0.859	1.00
128_Y	190_I	0.845	1.00
119_V	215_S	0.831	1.00
65_E	87_S	0.830	1.00
153_N	198_K	0.827	1.00
167_I	170_V	0.815	1.00
10_I	120_S	0.811	1.00
64_E	87_S	0.811	1.00
107_S	113_D	0.809	1.00
60_K	78_V	0.805	1.00
102_A	217_N	0.804	1.00
62_V	210_V	0.801	1.00
10_I	14_R	0.799	1.00
5_L	118_F	0.799	1.00
100_S	214_A	0.798	1.00
41_D	87_S	0.797	1.00
100_S	119_V	0.795	1.00
207_L	212_I	0.794	1.00
17_N	125_D	0.792	1.00
228_T	231_G	0.791	1.00
164_I	167_I	0.791	1.00
192_T	197_A	0.788	1.00
131_D	217_N	0.788	1.00
6_N	118_F	0.782	1.00
137_L	140_N	0.772	1.00
12_A	47_Y	0.772	1.00
12_A	44_S	0.770	1.00
45_E	67_G	0.770	1.00
134_S	141_P	0.764	1.00
144_A	224_S	0.764	1.00
166_K	169_K	0.761	1.00
106_K	113_D	0.758	1.00
235_S	238_I	0.757	1.00
102_A	117_G	0.756	1.00
16_L	90_F	0.755	1.00
15_Y	44_S	0.755	1.00
158_Y	161_E	0.750	1.00
189_M	226_P	0.749	1.00
100_S	215_S	0.747	1.00
131_D	134_S	0.745	1.00
56_G	79_A	0.743	1.00
113_D	233_E	0.739	1.00
167_I	171_L	0.738	1.00
156_I	188_D	0.737	1.00
185_A	202_D	0.736	1.00
104_Y	213_A	0.735	1.00
143_K	146_I	0.732	1.00
52_L	103_I	0.730	1.00
150_S	153_N	0.730	1.00
44_S	99_I	0.729	1.00
219_C	226_P	0.722	1.00
39_V	42_K	0.718	1.00
41_D	64_E	0.716	1.00
147_I	153_N	0.715	1.00
105_G	113_D	0.714	1.00
215_S	218_F	0.713	1.00
98_S	184_S	0.710	1.00
137_L	196_K	0.708	1.00
216_A	236_S	0.706	1.00
24_D	27_K	0.705	1.00
69_R	72_S	0.704	1.00
49_F	67_G	0.701	1.00
43_K	47_Y	0.699	1.00
41_D	82_D	0.699	1.00
160_D	163_G	0.699	1.00
193_C	218_F	0.699	1.00
19_I	22_E	0.698	1.00
40_I	90_F	0.695	1.00
65_E	82_D	0.695	1.00
82_D	87_S	0.691	1.00
10_I	13_T	0.690	1.00
130_Y	221_R	0.686	1.00
121_H	128_Y	0.683	1.00
98_S	121_H	0.682	1.00
220_K	225_I	0.679	1.00
101_V	118_F	0.679	1.00
7_K	10_I	0.674	1.00
180_R	183_G	0.673	1.00
159_F	162_R	0.670	1.00
92_L	177_Y	0.667	1.00
47_Y	50_Q	0.663	1.00
64_E	211_D	0.662	1.00
5_L	59_F	0.661	1.00
98_S	187_L	0.659	1.00
40_I	44_S	0.657	1.00
5_L	116_G	0.653	1.00
144_A	222_L	0.652	1.00
184_S	188_D	0.650	1.00
88_N	92_L	0.646	1.00
126_K	138_N	0.643	1.00
9_A	99_I	0.642	1.00
165_D	168_L	0.641	1.00
78_V	107_S	0.640	1.00
53_N	69_R	0.636	1.00
15_Y	40_I	0.633	1.00
8_V	12_A	0.633	1.00
121_H	126_K	0.632	1.00
212_I	234_I	0.632	1.00
145_E	148_G	0.629	1.00
227_S	231_G	0.629	1.00
133_S	221_R	0.627	0.99
79_A	116_G	0.618	0.99
88_N	154_V	0.612	0.99
184_S	187_L	0.611	0.99
147_I	198_K	0.611	0.99
118_F	127_I	0.609	0.99
12_A	99_I	0.603	0.99
62_V	68_V	0.602	0.99
64_E	82_D	0.601	0.99
8_V	55_T	0.600	0.99
41_D	211_D	0.599	0.99
154_V	178_K	0.595	0.99
170_V	201_F	0.593	0.99
28_V	42_K	0.593	0.99
96_W	187_L	0.593	0.99
18_E	21_N	0.593	0.99
12_A	16_L	0.592	0.99
200_Y	207_L	0.592	0.99
65_E	211_D	0.591	0.99
13_T	17_N	0.589	0.99
212_I	216_A	0.587	0.99
119_V	214_A	0.583	0.99
219_C	249_V	0.581	0.99
188_D	200_Y	0.580	0.99
83_P	87_S	0.580	0.99
52_L	79_A	0.578	0.99
44_S	47_Y	0.578	0.99
104_Y	209_N	0.577	0.99
80_L	114_S	0.576	0.99
96_W	182_F	0.575	0.99
168_L	173_A	0.575	0.99
8_V	11_D	0.568	0.99
6_N	139_G	0.566	0.99
85_D	211_D	0.566	0.99
202_D	207_L	0.565	0.99
126_K	191_L	0.564	0.99
209_N	237_G	0.562	0.99
236_S	239_D	0.562	0.99
99_I	118_F	0.561	0.99
95_P	124_I	0.558	0.99
167_I	174_L	0.558	0.99
80_L	102_A	0.557	0.99
158_Y	163_G	0.557	0.99
37_T	45_E	0.556	0.99
189_M	192_T	0.555	0.99
62_V	209_N	0.554	0.99
14_R	17_N	0.550	0.99
98_S	119_V	0.548	0.99
181_S	188_D	0.547	0.99
142_L	222_L	0.546	0.99
135_A	222_L	0.546	0.99
166_K	173_A	0.542	0.99
4_L	51_L	0.541	0.99
19_I	84_L	0.540	0.98
188_D	197_A	0.540	0.98
9_A	120_S	0.539	0.98
218_F	222_L	0.538	0.98
183_G	202_D	0.538	0.98
42_K	66_S	0.538	0.98
87_S	211_D	0.536	0.98
64_E	83_P	0.534	0.98
20_K	95_P	0.533	0.98
178_K	181_S	0.532	0.98
13_T	127_I	0.532	0.98
19_I	90_F	0.531	0.98
31_F	38_R	0.530	0.98
65_E	83_P	0.527	0.98
220_K	226_P	0.526	0.98
114_S	213_A	0.523	0.98
22_E	39_V	0.518	0.98
72_S	237_G	0.513	0.98
52_L	55_T	0.511	0.98
117_G	214_A	0.511	0.98
11_D	15_Y	0.511	0.98
41_D	83_P	0.510	0.98
89_N	183_G	0.509	0.98
119_V	186_S	0.509	0.98
27_K	39_V	0.508	0.98
17_N	122_I	0.507	0.98
48_I	51_L	0.507	0.98
137_L	142_L	0.506	0.98
60_K	75_Y	0.506	0.98
61_F	81_I	0.506	0.98
26_D	29_I	0.505	0.98
64_E	85_D	0.504	0.98
225_I	233_E	0.503	0.98
53_N	58_K	0.503	0.98
37_T	42_K	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4n81A	2	0.9242	100	0.1	Contact Map
2pcrA	3	0.8523	100	0.116	Contact Map
3t0jA	3	0.9242	100	0.121	Contact Map
2fvzA	2	0.875	100	0.123	Contact Map
3lv0A	2	0.9356	100	0.127	Contact Map
2qflA	1	0.9432	100	0.128	Contact Map
4i3yA	2	0.928	100	0.128	Contact Map
2p3nA	4	0.9167	100	0.129	Contact Map
2bjiA	2	0.947	100	0.131	Contact Map
1g0hA	2	0.9356	100	0.136	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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