GREMLIN Database
Q97W26 - Inositol monophosphosphatase, putative (Imp3)
UniProt: Q97W26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (228)
Sequences: 10099 (7141)
Seq/√Len: 472.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_C224_S4.0161.00
120_S127_I3.3711.00
77_Y105_G3.2171.00
76_D106_K3.1641.00
130_Y133_S2.9281.00
216_A220_K2.7901.00
134_S221_R2.7381.00
121_H124_I2.6021.00
8_V51_L2.5901.00
11_D51_L2.3781.00
156_I197_A2.3321.00
15_Y47_Y2.3101.00
13_T120_S2.2021.00
228_T232_K2.1511.00
113_D131_D2.1191.00
77_Y103_I2.0921.00
78_V104_Y2.0891.00
97_Y123_S2.0731.00
39_V43_K2.0041.00
129_S136_Y1.9891.00
46_E50_Q1.9671.00
56_G59_F1.9411.00
19_I40_I1.9191.00
45_E63_S1.9121.00
16_L44_S1.8551.00
51_L54_D1.8441.00
217_N221_R1.8431.00
59_F77_Y1.8421.00
105_G115_L1.8381.00
117_G217_N1.8321.00
80_L104_Y1.8181.00
136_Y141_P1.7991.00
137_L194_M1.7661.00
104_Y114_S1.7461.00
49_F53_N1.7421.00
128_Y194_M1.7061.00
28_V31_F1.6421.00
29_I42_K1.6281.00
49_F61_F1.6251.00
47_Y51_L1.5971.00
119_V190_I1.5761.00
126_K137_L1.5711.00
17_N123_S1.5681.00
98_S186_S1.5671.00
121_H187_L1.5581.00
5_L79_A1.5571.00
149_N152_S1.5571.00
9_A101_V1.5521.00
6_N129_S1.5241.00
132_T221_R1.5131.00
100_S186_S1.4971.00
59_F79_A1.4571.00
131_D221_R1.4471.00
4_L56_G1.4351.00
126_K196_K1.4331.00
4_L8_V1.4251.00
38_R91_V1.4151.00
9_A118_F1.4091.00
27_K30_G1.4071.00
168_L172_S1.4051.00
102_A213_A1.4031.00
190_I218_F1.4021.00
131_D220_K1.3991.00
20_K97_Y1.3991.00
76_D105_G1.3981.00
4_L55_T1.3961.00
113_D220_K1.3931.00
15_Y18_E1.3701.00
7_K55_T1.3621.00
126_K194_M1.3481.00
16_L84_L1.3421.00
48_I81_I1.3311.00
81_I101_V1.3181.00
155_V199_L1.3101.00
16_L97_Y1.2981.00
50_Q54_D1.2931.00
79_A103_I1.2851.00
6_N10_I1.2841.00
17_N97_Y1.2831.00
135_A142_L1.2621.00
10_I127_I1.2621.00
52_L59_F1.2601.00
46_E66_S1.2551.00
43_K46_E1.2461.00
51_L55_T1.2411.00
48_I101_V1.2401.00
6_N127_I1.2291.00
7_K11_D1.2051.00
189_M215_S1.2051.00
45_E66_S1.2041.00
36_T91_V1.1941.00
216_A226_P1.1751.00
49_F63_S1.1711.00
36_T88_N1.1671.00
11_D47_Y1.1581.00
220_K233_E1.1551.00
191_L196_K1.1471.00
45_E49_F1.1361.00
94_V182_F1.1221.00
115_L131_D1.1101.00
169_K173_A1.1091.00
18_E22_E1.0971.00
16_L40_I1.0971.00
114_S217_N1.0731.00
62_V80_L1.0721.00
15_Y43_K1.0711.00
72_S75_Y1.0651.00
170_V174_L1.0641.00
145_E198_K1.0641.00
187_L191_L1.0561.00
49_F66_S1.0531.00
42_K46_E1.0491.00
8_V47_Y1.0491.00
15_Y19_I1.0431.00
103_I116_G1.0421.00
19_I43_K1.0381.00
80_L213_A1.0371.00
170_V173_A1.0261.00
102_A114_S1.0261.00
129_S139_G1.0201.00
169_K172_S1.0181.00
14_R18_E1.0151.00
7_K51_L1.0101.00
120_S125_D1.0101.00
185_A207_L1.0031.00
135_A221_R1.0021.00
189_M219_C0.9991.00
8_V48_I0.9931.00
114_S216_A0.9761.00
41_D65_E0.9701.00
4_L52_L0.9671.00
165_D169_K0.9601.00
11_D14_R0.9591.00
135_A218_F0.9541.00
62_V78_V0.9521.00
38_R87_S0.9471.00
77_Y115_L0.9441.00
26_D31_F0.9351.00
32_H35_D0.9181.00
20_K123_S0.9131.00
19_I39_V0.9081.00
96_W191_L0.9021.00
27_K31_F0.9021.00
44_S84_L0.8981.00
44_S48_I0.8971.00
63_S66_S0.8771.00
116_G130_Y0.8691.00
31_F35_D0.8671.00
52_L56_G0.8651.00
10_I125_D0.8651.00
103_I115_L0.8651.00
89_N180_R0.8651.00
20_K93_G0.8641.00
119_V218_F0.8641.00
142_L194_M0.8591.00
128_Y190_I0.8451.00
119_V215_S0.8311.00
65_E87_S0.8301.00
153_N198_K0.8271.00
167_I170_V0.8151.00
10_I120_S0.8111.00
64_E87_S0.8111.00
107_S113_D0.8091.00
60_K78_V0.8051.00
102_A217_N0.8041.00
62_V210_V0.8011.00
10_I14_R0.7991.00
5_L118_F0.7991.00
100_S214_A0.7981.00
41_D87_S0.7971.00
100_S119_V0.7951.00
207_L212_I0.7941.00
17_N125_D0.7921.00
228_T231_G0.7911.00
164_I167_I0.7911.00
192_T197_A0.7881.00
131_D217_N0.7881.00
6_N118_F0.7821.00
137_L140_N0.7721.00
12_A47_Y0.7721.00
12_A44_S0.7701.00
45_E67_G0.7701.00
134_S141_P0.7641.00
144_A224_S0.7641.00
166_K169_K0.7611.00
106_K113_D0.7581.00
235_S238_I0.7571.00
102_A117_G0.7561.00
16_L90_F0.7551.00
15_Y44_S0.7551.00
158_Y161_E0.7501.00
189_M226_P0.7491.00
100_S215_S0.7471.00
131_D134_S0.7451.00
56_G79_A0.7431.00
113_D233_E0.7391.00
167_I171_L0.7381.00
156_I188_D0.7371.00
185_A202_D0.7361.00
104_Y213_A0.7351.00
143_K146_I0.7321.00
52_L103_I0.7301.00
150_S153_N0.7301.00
44_S99_I0.7291.00
219_C226_P0.7221.00
39_V42_K0.7181.00
41_D64_E0.7161.00
147_I153_N0.7151.00
105_G113_D0.7141.00
215_S218_F0.7131.00
98_S184_S0.7101.00
137_L196_K0.7081.00
216_A236_S0.7061.00
24_D27_K0.7051.00
69_R72_S0.7041.00
49_F67_G0.7011.00
43_K47_Y0.6991.00
41_D82_D0.6991.00
160_D163_G0.6991.00
193_C218_F0.6991.00
19_I22_E0.6981.00
40_I90_F0.6951.00
65_E82_D0.6951.00
82_D87_S0.6911.00
10_I13_T0.6901.00
130_Y221_R0.6861.00
121_H128_Y0.6831.00
98_S121_H0.6821.00
220_K225_I0.6791.00
101_V118_F0.6791.00
7_K10_I0.6741.00
180_R183_G0.6731.00
159_F162_R0.6701.00
92_L177_Y0.6671.00
47_Y50_Q0.6631.00
64_E211_D0.6621.00
5_L59_F0.6611.00
98_S187_L0.6591.00
40_I44_S0.6571.00
5_L116_G0.6531.00
144_A222_L0.6521.00
184_S188_D0.6501.00
88_N92_L0.6461.00
126_K138_N0.6431.00
9_A99_I0.6421.00
165_D168_L0.6411.00
78_V107_S0.6401.00
53_N69_R0.6361.00
15_Y40_I0.6331.00
8_V12_A0.6331.00
121_H126_K0.6321.00
212_I234_I0.6321.00
145_E148_G0.6291.00
227_S231_G0.6291.00
133_S221_R0.6270.99
79_A116_G0.6180.99
88_N154_V0.6120.99
184_S187_L0.6110.99
147_I198_K0.6110.99
118_F127_I0.6090.99
12_A99_I0.6030.99
62_V68_V0.6020.99
64_E82_D0.6010.99
8_V55_T0.6000.99
41_D211_D0.5990.99
154_V178_K0.5950.99
170_V201_F0.5930.99
28_V42_K0.5930.99
96_W187_L0.5930.99
18_E21_N0.5930.99
12_A16_L0.5920.99
200_Y207_L0.5920.99
65_E211_D0.5910.99
13_T17_N0.5890.99
212_I216_A0.5870.99
119_V214_A0.5830.99
219_C249_V0.5810.99
188_D200_Y0.5800.99
83_P87_S0.5800.99
52_L79_A0.5780.99
44_S47_Y0.5780.99
104_Y209_N0.5770.99
80_L114_S0.5760.99
96_W182_F0.5750.99
168_L173_A0.5750.99
8_V11_D0.5680.99
6_N139_G0.5660.99
85_D211_D0.5660.99
202_D207_L0.5650.99
126_K191_L0.5640.99
209_N237_G0.5620.99
236_S239_D0.5620.99
99_I118_F0.5610.99
95_P124_I0.5580.99
167_I174_L0.5580.99
80_L102_A0.5570.99
158_Y163_G0.5570.99
37_T45_E0.5560.99
189_M192_T0.5550.99
62_V209_N0.5540.99
14_R17_N0.5500.99
98_S119_V0.5480.99
181_S188_D0.5470.99
142_L222_L0.5460.99
135_A222_L0.5460.99
166_K173_A0.5420.99
4_L51_L0.5410.99
19_I84_L0.5400.98
188_D197_A0.5400.98
9_A120_S0.5390.98
218_F222_L0.5380.98
183_G202_D0.5380.98
42_K66_S0.5380.98
87_S211_D0.5360.98
64_E83_P0.5340.98
20_K95_P0.5330.98
178_K181_S0.5320.98
13_T127_I0.5320.98
19_I90_F0.5310.98
31_F38_R0.5300.98
65_E83_P0.5270.98
220_K226_P0.5260.98
114_S213_A0.5230.98
22_E39_V0.5180.98
72_S237_G0.5130.98
52_L55_T0.5110.98
117_G214_A0.5110.98
11_D15_Y0.5110.98
41_D83_P0.5100.98
89_N183_G0.5090.98
119_V186_S0.5090.98
27_K39_V0.5080.98
17_N122_I0.5070.98
48_I51_L0.5070.98
137_L142_L0.5060.98
60_K75_Y0.5060.98
61_F81_I0.5060.98
26_D29_I0.5050.98
64_E85_D0.5040.98
225_I233_E0.5030.98
53_N58_K0.5030.98
37_T42_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n81A 2 0.9242 100 0.1 Contact Map
2pcrA 3 0.8523 100 0.116 Contact Map
3t0jA 3 0.9242 100 0.121 Contact Map
2fvzA 2 0.875 100 0.123 Contact Map
3lv0A 2 0.9356 100 0.127 Contact Map
2qflA 1 0.9432 100 0.128 Contact Map
4i3yA 2 0.928 100 0.128 Contact Map
2p3nA 4 0.9167 100 0.129 Contact Map
2bjiA 2 0.947 100 0.131 Contact Map
1g0hA 2 0.9356 100 0.136 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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