GREMLIN Database
Q97W24 - Phytoene dehydrogenase related protein
UniProt: Q97W24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 518 (438)
Sequences: 14428 (11246)
Seq/√Len: 537.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_D26_K4.3761.00
5_A281_A4.2521.00
77_K231_E4.0241.00
245_A250_V3.8981.00
28_A253_Y3.8701.00
3_D282_K3.7471.00
32_R257_E3.7071.00
36_V254_T3.6051.00
260_E272_K3.5731.00
16_T285_V3.3831.00
30_F279_I3.2431.00
286_S293_T3.0791.00
36_V242_K3.0701.00
262_L272_K2.9851.00
5_A30_F2.9841.00
272_K278_T2.9371.00
9_G36_V2.9261.00
34_E255_N2.8951.00
5_A279_I2.8341.00
501_G505_H2.7761.00
235_G239_Q2.7101.00
68_E71_L2.7051.00
411_M414_K2.6171.00
26_K251_E2.5961.00
5_A271_I2.5931.00
259_D274_K2.5681.00
257_E274_K2.5291.00
256_A273_L2.5291.00
236_E239_Q2.4491.00
273_L279_I2.4351.00
7_I286_S2.4251.00
242_K246_E2.3851.00
79_Y231_E2.3471.00
172_Q180_E2.3191.00
424_K431_K2.3171.00
30_F253_Y2.3001.00
242_K252_I2.2561.00
253_Y256_A2.2221.00
4_V25_L2.1971.00
68_E72_R2.1971.00
19_Y502_Y2.1711.00
44_E50_K2.1661.00
287_N486_C2.1571.00
283_I484_Y2.1121.00
3_D28_A2.0251.00
30_F281_A2.0001.00
12_N287_N1.9991.00
175_K179_D1.9751.00
23_A509_L1.9711.00
35_I41_V1.9671.00
285_V508_I1.9651.00
173_D176_S1.9451.00
424_K429_N1.9381.00
11_H496_V1.9261.00
269_E280_N1.9211.00
7_I288_A1.9151.00
105_K120_K1.9021.00
240_A243_R1.8831.00
264_K269_E1.8821.00
18_A244_S1.8771.00
42_T50_K1.8731.00
179_D188_K1.8611.00
417_E421_E1.8431.00
253_Y279_I1.7991.00
64_K502_Y1.7711.00
4_V283_I1.7591.00
19_Y506_V1.7581.00
19_Y22_K1.7411.00
17_A29_V1.7351.00
25_L509_L1.7341.00
261_V268_V1.7301.00
259_D272_K1.7261.00
268_V284_I1.7101.00
262_L278_T1.7041.00
256_A275_N1.6991.00
262_L269_E1.6781.00
28_A251_E1.6731.00
413_E417_E1.6651.00
288_A293_T1.6551.00
486_C504_A1.6441.00
269_E278_T1.5981.00
253_Y277_K1.5421.00
246_E249_G1.5301.00
36_V238_T1.5271.00
246_E251_E1.5211.00
258_V271_I1.5101.00
175_K204_S1.4901.00
3_D25_L1.4881.00
18_A22_K1.4801.00
49_I326_Y1.4761.00
100_S103_K1.4761.00
40_S238_T1.4731.00
328_E391_K1.4691.00
245_A252_I1.4671.00
30_F258_V1.4621.00
28_A279_I1.4611.00
239_Q243_R1.4431.00
283_I508_I1.4361.00
429_N432_P1.4301.00
246_E250_V1.4251.00
5_A28_A1.4221.00
268_V482_G1.4071.00
9_G29_V1.4061.00
127_D131_E1.3991.00
260_E299_R1.3841.00
29_V252_I1.3821.00
6_I17_A1.3751.00
503_N507_K1.3701.00
172_Q176_S1.3691.00
28_A281_A1.3671.00
4_V20_L1.3651.00
428_P431_K1.3641.00
328_E434_K1.3641.00
243_R246_E1.3541.00
36_V252_I1.3451.00
504_A507_K1.3451.00
13_G287_N1.3431.00
239_Q242_K1.3431.00
121_K125_F1.3381.00
416_A420_F1.3311.00
234_M496_V1.3241.00
64_K67_E1.3231.00
417_E431_K1.3001.00
288_A297_L1.2961.00
263_V268_V1.2881.00
327_L420_F1.2761.00
18_A241_L1.2731.00
65_I68_E1.2711.00
21_A250_V1.2691.00
39_A488_S1.2641.00
410_E414_K1.2601.00
421_E431_K1.2601.00
281_A284_I1.2481.00
416_A435_Y1.2481.00
289_D292_T1.2481.00
12_N486_C1.2461.00
67_E72_R1.2421.00
484_Y504_A1.2331.00
290_P489_G1.2261.00
30_F273_L1.2121.00
407_R410_E1.2071.00
30_F256_A1.2041.00
21_A27_V1.2021.00
484_Y508_I1.2021.00
12_N500_P1.1921.00
490_T503_N1.1911.00
44_E235_G1.1891.00
105_K109_E1.1801.00
441_L444_E1.1751.00
128_L131_E1.1631.00
418_I421_E1.1591.00
422_K425_E1.1591.00
18_A245_A1.1591.00
102_E105_K1.1571.00
420_F424_K1.1491.00
118_N121_K1.1451.00
261_V284_I1.1441.00
264_K280_N1.1431.00
273_L277_K1.1371.00
131_E134_D1.1361.00
43_E53_T1.1331.00
93_K186_E1.1311.00
20_L505_H1.1291.00
502_Y506_V1.1281.00
125_F128_L1.1271.00
103_K106_K1.1261.00
103_K107_E1.1221.00
292_T296_K1.1181.00
202_S205_T1.1171.00
65_I70_K1.1171.00
325_G420_F1.1161.00
256_A279_I1.1111.00
371_E425_E1.1071.00
230_V237_V1.1061.00
44_E48_S1.1061.00
127_D130_A1.1041.00
75_G78_V1.1041.00
6_I27_V1.1031.00
124_K127_D1.0991.00
267_R280_N1.0961.00
308_L312_R1.0871.00
98_W103_K1.0861.00
242_K254_T1.0851.00
438_L442_D1.0821.00
117_K121_K1.0821.00
490_T500_P1.0791.00
104_T107_E1.0701.00
345_A349_I1.0661.00
69_L72_R1.0651.00
273_L276_G1.0601.00
428_P432_P1.0581.00
283_I482_G1.0571.00
480_I483_L1.0561.00
232_G236_E1.0521.00
286_S483_L1.0501.00
64_K68_E1.0421.00
19_Y501_G1.0391.00
11_H40_S1.0361.00
261_V286_S1.0331.00
19_Y68_E1.0331.00
494_G499_A1.0321.00
414_K417_E1.0321.00
86_F96_Y1.0301.00
309_R312_R1.0281.00
3_D279_I1.0281.00
423_I427_A1.0251.00
263_V482_G1.0241.00
236_E240_A1.0201.00
21_A245_A1.0131.00
264_K267_R1.0111.00
484_Y507_K1.0101.00
400_Y403_Y1.0061.00
347_E350_M1.0021.00
495_G499_A0.9981.00
3_D280_N0.9961.00
9_G254_T0.9931.00
25_L28_A0.9931.00
346_S350_M0.9921.00
345_A348_L0.9921.00
421_E425_E0.9891.00
19_Y23_A0.9851.00
414_K418_I0.9771.00
49_I391_K0.9721.00
260_E300_N0.9661.00
67_E71_L0.9631.00
487_G500_P0.9621.00
106_K109_E0.9581.00
504_A508_I0.9571.00
172_Q177_L0.9561.00
28_A282_K0.9551.00
375_S378_I0.9551.00
475_D478_T0.9541.00
22_K71_L0.9521.00
128_L132_M0.9511.00
49_I388_P0.9511.00
412_K440_P0.9511.00
244_S247_H0.9461.00
423_I430_F0.9451.00
325_G396_I0.9431.00
416_A419_T0.9371.00
24_G27_V0.9361.00
259_D273_L0.9351.00
199_T203_P0.9311.00
416_A436_E0.9291.00
375_S379_Q0.9281.00
398_G419_T0.9241.00
121_K124_K0.9231.00
177_L181_Y0.9221.00
188_K192_A0.9211.00
421_E424_K0.9181.00
261_V271_I0.9181.00
441_L445_R0.9151.00
66_I69_L0.9111.00
98_W107_E0.9051.00
505_H508_I0.8991.00
130_A133_A0.8961.00
238_T242_K0.8931.00
373_W378_I0.8931.00
207_G210_Y0.8891.00
29_V245_A0.8871.00
397_F400_Y0.8871.00
374_L377_N0.8871.00
243_R247_H0.8861.00
33_R41_V0.8821.00
124_K128_L0.8811.00
256_A277_K0.8781.00
17_A250_V0.8771.00
66_I70_K0.8751.00
7_I258_V0.8721.00
42_T235_G0.8711.00
22_K244_S0.8701.00
230_V236_E0.8701.00
40_S55_A0.8681.00
257_E296_K0.8661.00
262_L300_N0.8651.00
309_R313_A0.8641.00
259_D262_L0.8641.00
184_T187_V0.8631.00
476_Y479_P0.8591.00
373_W376_I0.8581.00
440_P444_E0.8561.00
192_A203_P0.8551.00
130_A134_D0.8551.00
285_V484_Y0.8521.00
165_S168_R0.8521.00
304_E480_I0.8521.00
15_V241_L0.8511.00
440_P443_I0.8481.00
456_H460_T0.8481.00
401_L404_D0.8461.00
267_R481_R0.8441.00
506_V510_E0.8401.00
33_R450_N0.8391.00
26_K282_K0.8391.00
199_T206_P0.8381.00
17_A245_A0.8381.00
31_E254_T0.8351.00
263_V480_I0.8311.00
345_A350_M0.8311.00
6_I13_G0.8291.00
120_K123_V0.8271.00
347_E352_N0.8241.00
39_A54_G0.8241.00
438_L443_I0.8241.00
179_D184_T0.8241.00
494_G498_G0.8221.00
434_K437_V0.8201.00
64_K70_K0.8191.00
455_F461_P0.8191.00
223_V226_A0.8181.00
269_E272_K0.8181.00
396_I423_I0.8171.00
395_S398_G0.8161.00
104_T108_I0.8141.00
412_K416_A0.8141.00
185_D189_S0.8131.00
225_G228_G0.8131.00
15_V19_Y0.8111.00
371_E422_K0.8091.00
295_F312_R0.8091.00
258_V273_L0.8081.00
6_I285_V0.8081.00
433_I436_E0.8041.00
3_D281_A0.8021.00
25_L282_K0.8021.00
260_E298_L0.8001.00
11_H15_V0.7981.00
458_D461_P0.7971.00
305_E309_R0.7961.00
55_A234_M0.7951.00
422_K426_F0.7931.00
271_I284_I0.7921.00
15_V501_G0.7901.00
16_T501_G0.7901.00
14_L29_V0.7891.00
178_L192_A0.7881.00
200_F205_T0.7831.00
424_K432_P0.7831.00
21_A251_E0.7821.00
289_D450_N0.7811.00
120_K124_K0.7801.00
372_P378_I0.7791.00
420_F431_K0.7781.00
259_D275_N0.7721.00
413_E416_A0.7721.00
477_T507_K0.7711.00
126_W133_A0.7681.00
132_M135_F0.7631.00
213_A216_V0.7611.00
307_F479_P0.7611.00
439_T442_D0.7581.00
240_A244_S0.7551.00
70_K75_G0.7541.00
378_I381_S0.7531.00
203_P209_A0.7531.00
399_Q403_Y0.7491.00
288_A292_T0.7471.00
117_K120_K0.7461.00
71_L75_G0.7461.00
35_I235_G0.7461.00
11_H238_T0.7461.00
177_L208_T0.7451.00
373_W379_Q0.7421.00
67_E70_K0.7421.00
391_K434_K0.7421.00
284_I482_G0.7411.00
327_L433_I0.7321.00
459_M462_D0.7291.00
12_N499_A0.7291.00
102_E106_K0.7281.00
185_D188_K0.7281.00
75_G247_H0.7271.00
290_P311_V0.7231.00
183_E187_V0.7211.00
199_T207_G0.7201.00
184_T188_K0.7191.00
439_T444_E0.7181.00
11_H499_A0.7171.00
23_A506_V0.7131.00
374_L379_Q0.7111.00
372_P375_S0.7111.00
101_L105_K0.7101.00
193_E196_V0.7101.00
380_S392_F0.7091.00
33_R444_E0.7091.00
417_E420_F0.7051.00
460_T463_Q0.7051.00
326_Y391_K0.7051.00
326_Y434_K0.7031.00
165_S169_T0.7021.00
130_A136_F0.7021.00
16_T504_A0.7021.00
52_S234_M0.7001.00
129_F133_A0.6961.00
71_L247_H0.6911.00
345_A351_P0.6901.00
40_S496_V0.6891.00
127_D134_D0.6871.00
11_H241_L0.6851.00
344_I347_E0.6841.00
120_K125_F0.6841.00
267_R282_K0.6801.00
372_P376_I0.6801.00
418_I422_K0.6801.00
78_V81_K0.6791.00
439_T443_I0.6781.00
307_F310_R0.6771.00
201_A205_T0.6771.00
6_I29_V0.6731.00
374_L378_I0.6721.00
25_L283_I0.6701.00
192_A196_V0.6691.00
40_S234_M0.6661.00
299_R302_E0.6611.00
454_I457_L0.6601.00
442_D445_R0.6601.00
267_R482_G0.6601.00
286_S485_L0.6601.00
412_K415_I0.6601.00
18_A71_L0.6601.00
83_P86_F0.6571.00
56_Y395_S0.6571.00
81_K84_G0.6571.00
290_P314_L0.6551.00
372_P422_K0.6541.00
65_I71_L0.6541.00
242_K250_V0.6541.00
30_F271_I0.6531.00
455_F459_M0.6531.00
325_G416_A0.6521.00
182_F191_L0.6521.00
415_I438_L0.6481.00
505_H509_L0.6471.00
326_Y435_Y0.6461.00
199_T210_Y0.6441.00
212_L215_H0.6441.00
182_F186_E0.6431.00
283_I286_S0.6421.00
257_E449_I0.6421.00
193_E197_V0.6421.00
130_A135_F0.6421.00
289_D489_G0.6411.00
372_P379_Q0.6401.00
344_I348_L0.6381.00
486_C501_G0.6371.00
14_L238_T0.6341.00
259_D276_G0.6341.00
102_E120_K0.6331.00
346_S349_I0.6321.00
176_S180_E0.6311.00
62_R497_T0.6291.00
200_F203_P0.6281.00
299_R303_L0.6281.00
75_G243_R0.6271.00
133_A136_F0.6271.00
457_L461_P0.6261.00
329_E332_D0.6251.00
373_W422_K0.6231.00
125_F132_M0.6211.00
29_V36_V0.6201.00
466_F469_P0.6201.00
203_P206_P0.6191.00
136_F140_P0.6181.00
100_S104_T0.6171.00
4_V508_I0.6171.00
134_D139_N0.6171.00
66_I71_L0.6171.00
179_D204_S0.6161.00
327_L394_F0.6161.00
34_E254_T0.6151.00
80_L228_G0.6141.00
91_N186_E0.6131.00
170_F173_D0.6131.00
344_I349_I0.6131.00
65_I69_L0.6131.00
285_V504_A0.6131.00
321_F437_V0.6121.00
350_M353_M0.6091.00
65_I72_R0.6091.00
132_M136_F0.6081.00
189_S193_E0.6071.00
42_T52_S0.6051.00
330_L392_F0.6051.00
398_G403_Y0.6011.00
128_L133_A0.6011.00
14_L245_A0.6011.00
51_V324_V0.6001.00
329_E392_F0.6001.00
94_K97_I0.5991.00
175_K192_A0.5991.00
214_H217_I0.5971.00
122_W126_W0.5971.00
129_F132_M0.5971.00
56_Y377_N0.5961.00
42_T233_G0.5951.00
232_G383_D0.5941.00
224_K227_W0.5931.00
188_K193_E0.5931.00
304_E308_L0.5891.00
478_T485_L0.5880.99
5_A284_I0.5880.99
196_V202_S0.5870.99
239_Q246_E0.5870.99
407_R411_M0.5870.99
436_E440_P0.5870.99
398_G401_L0.5860.99
435_Y441_L0.5850.99
455_F488_S0.5850.99
256_A276_G0.5830.99
135_F139_N0.5810.99
452_G455_F0.5810.99
18_A250_V0.5810.99
236_E243_R0.5800.99
298_L302_E0.5800.99
82_D86_F0.5800.99
122_W125_F0.5780.99
349_I352_N0.5770.99
227_W230_V0.5760.99
82_D85_L0.5760.99
67_E502_Y0.5760.99
183_E186_E0.5760.99
327_L332_D0.5760.99
101_L104_T0.5750.99
96_Y99_S0.5740.99
45_L326_Y0.5740.99
39_A449_I0.5730.99
223_V227_W0.5730.99
282_K482_G0.5730.99
261_V297_L0.5720.99
41_V53_T0.5710.99
201_A204_S0.5710.99
134_D138_L0.5690.99
178_L188_K0.5680.99
383_D386_V0.5680.99
291_K316_N0.5680.99
323_I419_T0.5680.99
263_V266_G0.5680.99
44_E47_P0.5670.99
166_F170_F0.5670.99
406_K409_D0.5650.99
320_S454_I0.5650.99
45_L436_E0.5640.99
15_V65_I0.5630.99
387_A390_G0.5630.99
199_T202_S0.5630.99
78_V228_G0.5620.99
35_I239_Q0.5620.99
128_L136_F0.5610.99
55_A496_V0.5600.99
417_E435_Y0.5600.99
323_I416_A0.5590.99
396_I400_Y0.5590.99
18_A69_L0.5570.99
76_L79_Y0.5570.99
9_G242_K0.5570.99
438_L441_L0.5570.99
323_I437_V0.5550.99
460_T464_L0.5550.99
251_E254_T0.5520.99
400_Y404_D0.5520.99
9_G14_L0.5520.99
491_H503_N0.5510.99
395_S399_Q0.5510.99
325_G430_F0.5500.99
201_A206_P0.5490.99
200_F207_G0.5490.99
293_T297_L0.5480.99
69_L230_V0.5480.99
392_F395_S0.5470.99
388_P391_K0.5470.99
503_N506_V0.5460.99
408_N412_K0.5450.99
410_E415_I0.5450.99
263_V483_L0.5440.99
328_E433_I0.5440.99
178_L182_F0.5440.99
52_S56_Y0.5430.99
486_C500_P0.5430.99
397_F401_L0.5420.99
330_L334_G0.5410.99
135_F138_L0.5410.99
41_V439_T0.5400.99
285_V486_C0.5400.99
52_S57_V0.5400.99
263_V267_R0.5390.99
387_A391_K0.5390.99
22_K68_E0.5380.99
329_E335_N0.5380.99
123_V127_D0.5380.99
21_A246_E0.5380.99
415_I419_T0.5380.99
323_I396_I0.5370.99
436_E441_L0.5370.99
186_E190_A0.5350.99
507_K510_E0.5350.99
456_H489_G0.5340.99
104_T109_E0.5340.99
98_W101_L0.5330.99
233_G236_E0.5320.99
131_E135_F0.5320.99
20_L508_I0.5320.99
77_K232_G0.5310.99
415_I418_I0.5310.99
205_T209_A0.5300.99
321_F415_I0.5300.99
10_G13_G0.5290.99
293_T485_L0.5290.99
136_F139_N0.5290.99
178_L191_L0.5280.99
399_Q402_V0.5280.99
55_A59_S0.5260.99
121_K128_L0.5240.99
406_K410_E0.5240.99
393_S397_F0.5220.99
126_W130_A0.5220.99
434_K438_L0.5220.99
119_Y122_W0.5210.99
35_I254_T0.5200.99
343_H346_S0.5170.99
327_L333_F0.5170.99
452_G460_T0.5160.99
164_L167_L0.5160.99
80_L99_S0.5150.99
347_E351_P0.5140.99
190_A193_E0.5130.99
27_V250_V0.5130.99
118_N182_F0.5120.99
182_F187_V0.5110.99
292_T295_F0.5110.99
163_A166_F0.5110.99
453_N458_D0.5110.99
9_G31_E0.5080.99
200_F206_P0.5070.99
304_E307_F0.5070.99
307_F311_V0.5070.99
77_K80_L0.5070.99
416_A437_V0.5070.99
120_K127_D0.5060.98
452_G456_H0.5060.98
213_A217_I0.5060.98
134_D137_M0.5060.98
97_I100_S0.5060.98
348_L351_P0.5060.98
128_L134_D0.5060.98
51_V393_S0.5050.98
328_E432_P0.5040.98
6_I10_G0.5030.98
435_Y438_L0.5030.98
125_F181_Y0.5030.98
212_L216_V0.5020.98
125_F129_F0.5020.98
258_V297_L0.5020.98
257_E292_T0.5010.98
52_S235_G0.5010.98
122_W128_L0.5000.98
450_N453_N0.5000.98
437_V441_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dgkA 1 0.7568 100 0.346 Contact Map
2yg5A 2 0.8359 100 0.376 Contact Map
4i59A 1 0.8359 100 0.381 Contact Map
4repA 1 0.9247 100 0.398 Contact Map
1s3eA 2 0.8533 100 0.408 Contact Map
2vvmA 2 0.8436 100 0.415 Contact Map
3i6dA 1 0.7915 100 0.425 Contact Map
2ivdA 1 0.8166 100 0.427 Contact Map
1b37A 4 0.832 100 0.434 Contact Map
1sezA 3 0.832 100 0.434 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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