GREMLIN Database
Q97W23 - Uncharacterized protein
UniProt: Q97W23 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (319)
Sequences: 3456 (2618)
Seq/√Len: 146.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_T114_H4.5351.00
311_S315_N3.3251.00
236_P274_P3.1211.00
231_S272_H2.7691.00
202_W206_Y2.7241.00
325_G328_D2.6491.00
238_A241_T2.6181.00
311_S345_Y2.5861.00
65_L263_S2.5101.00
92_T101_V2.4821.00
252_I256_S2.4201.00
106_F221_Y2.3061.00
66_V262_Y2.2611.00
228_D232_H2.2231.00
202_W208_L2.2151.00
93_V104_T2.1451.00
64_R218_D2.1391.00
323_I345_Y2.1161.00
308_Y312_T2.0621.00
67_L219_F2.0331.00
259_H264_F1.9711.00
232_H269_D1.9561.00
349_P355_F1.9511.00
94_F348_V1.9491.00
69_L102_L1.9181.00
208_L222_F1.9151.00
185_S189_H1.8911.00
109_L113_E1.8791.00
68_A264_F1.8741.00
162_Y165_E1.8361.00
158_H161_S1.8211.00
194_E197_T1.8151.00
63_N261_K1.8071.00
253_L257_Q1.7921.00
311_S325_G1.7861.00
210_Q214_Q1.7841.00
228_D372_H1.7571.00
332_L375_L1.7531.00
72_G272_H1.7361.00
205_F255_I1.7351.00
256_S264_F1.7281.00
204_A208_L1.7201.00
312_T315_N1.7151.00
157_P187_A1.6981.00
67_L267_T1.6971.00
296_Y305_R1.6971.00
234_Y240_P1.6941.00
70_F227_V1.6901.00
62_N263_S1.6851.00
227_V230_L1.6791.00
206_Y209_S1.6701.00
309_D312_T1.6481.00
302_I305_R1.6471.00
98_T102_L1.6361.00
66_V264_F1.6251.00
150_V158_H1.6191.00
71_D232_H1.6071.00
162_Y166_V1.5931.00
237_Y274_P1.5851.00
230_L244_S1.5571.00
239_E243_K1.5551.00
80_Q242_I1.5441.00
243_K247_D1.5361.00
203_D206_Y1.5341.00
192_S198_Y1.5191.00
67_L221_Y1.5161.00
208_L212_L1.5131.00
322_K350_T1.5131.00
151_P186_N1.5091.00
268_A383_P1.5081.00
195_S198_Y1.4941.00
303_F343_P1.4851.00
76_N378_E1.4651.00
312_T316_R1.4651.00
93_V101_V1.4541.00
226_D230_L1.4521.00
81_A245_A1.4261.00
174_I177_K1.4221.00
306_T344_D1.4191.00
308_Y311_S1.4191.00
93_V111_P1.4131.00
227_V248_I1.4011.00
153_S158_H1.3971.00
272_H370_G1.3861.00
249_L253_L1.3651.00
64_R216_T1.3641.00
123_S126_L1.3501.00
284_D317_K1.3491.00
102_L119_Y1.3401.00
206_Y212_L1.3351.00
154_S158_H1.3341.00
232_H372_H1.3321.00
192_S196_K1.3281.00
150_V155_S1.3261.00
280_I283_N1.3161.00
172_I175_V1.2921.00
310_V313_Y1.2891.00
55_N58_N1.2841.00
251_S254_E1.2761.00
90_I383_P1.2721.00
351_D378_E1.2701.00
228_D269_D1.2651.00
198_Y201_F1.2651.00
64_R262_Y1.2651.00
172_I176_P1.2641.00
71_D269_D1.2641.00
170_K174_I1.2591.00
209_S258_K1.2581.00
193_G196_K1.2581.00
236_P370_G1.2511.00
157_P165_E1.2511.00
99_S119_Y1.2511.00
206_Y254_E1.2471.00
150_V160_K1.2471.00
194_E200_N1.2461.00
315_N328_D1.2461.00
192_S200_N1.2441.00
94_F375_L1.2301.00
194_E198_Y1.2271.00
275_V354_A1.2241.00
267_T383_P1.2211.00
202_W212_L1.2121.00
105_L267_T1.2081.00
115_S341_A1.2041.00
231_S241_T1.1851.00
122_F127_G1.1841.00
196_K199_V1.1741.00
309_D313_Y1.1711.00
232_H270_H1.1701.00
277_E353_R1.1651.00
53_C56_K1.1621.00
84_N87_A1.1461.00
320_S350_T1.1441.00
96_S380_F1.1410.99
89_K381_E1.1350.99
181_N186_N1.1340.99
158_H162_Y1.1290.99
68_A252_I1.1190.99
122_F126_L1.1180.99
330_E334_G1.1170.99
301_A305_R1.1130.99
149_S155_S1.1080.99
92_T96_S1.1080.99
170_K175_V1.1060.99
205_F209_S1.1030.99
98_T119_Y1.0980.99
70_F248_I1.0950.99
197_T201_F1.0900.99
131_N134_R1.0820.99
163_L169_K1.0760.99
205_F208_L1.0750.99
131_N135_Y1.0750.99
351_D380_F1.0730.99
314_L318_Y1.0690.99
302_I306_T1.0650.99
70_F73_L1.0620.99
171_T176_P1.0600.99
98_T269_D1.0580.99
110_T334_G1.0560.99
196_K201_F1.0510.99
326_K329_F1.0500.99
201_F208_L1.0450.99
70_F252_I1.0410.99
193_G198_Y1.0360.99
224_I255_I1.0310.99
275_V371_H1.0310.99
297_G300_R1.0300.99
287_L290_M1.0290.99
295_P304_L1.0280.99
193_G201_F1.0260.99
192_S201_F1.0240.99
283_N358_N1.0240.99
197_T200_N1.0170.99
171_T177_K1.0160.99
116_V121_T1.0120.99
311_S323_I0.9980.99
186_N189_H0.9980.99
73_L245_A0.9950.99
250_T253_L0.9930.99
146_I158_H0.9910.99
285_Q290_M0.9900.99
109_L149_S0.9820.98
68_A222_F0.9800.98
348_V374_G0.9750.98
161_S164_K0.9750.98
70_F266_I0.9730.98
208_L211_V0.9730.98
259_H262_Y0.9660.98
181_N187_A0.9660.98
329_F346_I0.9650.98
273_V351_D0.9640.98
99_S116_V0.9640.98
286_E289_N0.9620.98
63_N263_S0.9610.98
234_Y238_A0.9600.98
206_Y258_K0.9580.98
71_D270_H0.9580.98
123_S341_A0.9560.98
87_A385_V0.9550.98
182_T185_S0.9550.98
67_L265_L0.9520.98
157_P163_L0.9520.98
310_V345_Y0.9500.98
96_S373_G0.9500.98
150_V153_S0.9490.98
156_F165_E0.9450.98
243_K246_R0.9430.98
180_E185_S0.9360.98
202_W207_Q0.9360.98
210_Q213_Q0.9300.98
273_V380_F0.9270.98
227_V245_A0.9220.98
74_G77_V0.9200.98
94_F301_A0.9160.98
379_E382_I0.9140.98
64_R261_K0.9130.98
204_A222_F0.9120.98
196_K200_N0.9090.97
77_V272_H0.9090.97
296_Y302_I0.9080.97
104_T111_P0.9060.97
227_V244_S0.9060.97
173_S177_K0.9030.97
54_L57_M0.9010.97
192_S195_S0.8950.97
80_Q237_Y0.8930.97
254_E258_K0.8900.97
72_G231_S0.8890.97
195_S199_V0.8890.97
54_L58_N0.8860.97
95_P111_P0.8860.97
202_W205_F0.8850.97
163_L166_V0.8840.97
73_L227_V0.8830.97
76_N381_E0.8800.97
195_S200_N0.8780.97
311_S317_K0.8760.97
223_Y228_D0.8730.97
125_R340_T0.8670.97
325_G329_F0.8650.97
204_A207_Q0.8640.97
308_Y325_G0.8560.96
184_F187_A0.8550.96
91_T380_F0.8490.96
305_R343_P0.8450.96
201_F212_L0.8450.96
154_S157_P0.8420.96
323_I347_A0.8400.96
173_S176_P0.8400.96
311_S328_D0.8330.96
311_S314_L0.8310.96
203_D207_Q0.8240.96
170_K173_S0.8240.96
212_L218_D0.8230.95
374_G379_E0.8220.95
313_Y316_R0.8210.95
282_N358_N0.8210.95
222_F255_I0.8200.95
71_D228_D0.8150.95
153_S161_S0.8060.95
69_L105_L0.8050.95
360_K369_K0.8000.95
65_L265_L0.7960.95
193_G197_T0.7920.94
192_S197_T0.7910.94
66_V220_I0.7900.94
240_P243_K0.7860.94
170_K176_P0.7840.94
132_T135_Y0.7840.94
229_T233_R0.7790.94
324_F330_E0.7700.94
155_S162_Y0.7700.94
314_L347_A0.7690.94
53_C57_M0.7690.94
207_Q210_Q0.7660.93
276_T352_Y0.7640.93
98_T228_D0.7630.93
268_A382_I0.7610.93
176_P179_I0.7610.93
124_K344_D0.7600.93
97_T118_G0.7590.93
66_V212_L0.7590.93
212_L220_I0.7570.93
71_D372_H0.7570.93
98_T232_H0.7570.93
331_R334_G0.7560.93
281_F347_A0.7560.93
77_V231_S0.7550.93
182_T189_H0.7550.93
313_Y317_K0.7550.93
157_P162_Y0.7540.93
276_T353_R0.7530.93
297_G303_F0.7510.93
217_Y220_I0.7480.93
179_I184_F0.7410.92
117_L342_L0.7380.92
110_T113_E0.7360.92
148_D339_I0.7360.92
288_L291_L0.7340.92
236_P369_K0.7340.92
56_K59_L0.7340.92
321_L350_T0.7340.92
254_E257_Q0.7280.92
239_E242_I0.7260.91
53_C60_N0.7250.91
130_V134_R0.7240.91
179_I182_T0.7240.91
179_I185_S0.7210.91
96_S374_G0.7200.91
306_T310_V0.7170.91
186_N192_S0.7160.91
324_F375_L0.7160.91
79_S86_K0.7160.91
150_V161_S0.7150.91
98_T270_H0.7120.91
301_A306_T0.7030.90
57_M60_N0.7000.90
62_N218_D0.6970.90
182_T188_T0.6960.90
170_K179_I0.6950.90
175_V178_G0.6950.90
174_I179_I0.6940.90
278_T356_I0.6930.89
70_F226_D0.6910.89
75_W380_F0.6850.89
230_L241_T0.6820.89
200_N203_D0.6810.89
78_F386_I0.6810.89
180_E189_H0.6800.89
198_Y204_A0.6780.88
146_I149_S0.6760.88
202_W211_V0.6750.88
117_L121_T0.6740.88
64_R217_Y0.6690.88
98_T115_S0.6680.88
153_S157_P0.6670.88
299_S303_F0.6660.88
322_K328_D0.6660.88
183_E187_A0.6650.87
293_V296_Y0.6620.87
99_S102_L0.6620.87
187_A191_A0.6590.87
79_S83_V0.6560.87
75_W89_K0.6540.87
73_L77_V0.6540.87
292_D307_R0.6510.86
181_N185_S0.6480.86
89_K382_I0.6480.86
183_E186_N0.6480.86
70_F230_L0.6450.86
265_L386_I0.6450.86
184_F188_T0.6440.86
326_K330_E0.6430.86
297_G305_R0.6400.85
84_N88_K0.6390.85
268_A271_G0.6380.85
152_F158_H0.6370.85
334_G338_D0.6350.85
310_V323_I0.6340.85
193_G204_A0.6340.85
193_G199_V0.6320.85
202_W209_S0.6320.85
90_I384_L0.6310.85
300_R303_F0.6300.85
69_L100_T0.6300.85
119_Y232_H0.6290.84
277_E352_Y0.6280.84
81_A242_I0.6260.84
67_L105_L0.6250.84
84_N89_K0.6250.84
192_S199_V0.6250.84
308_Y347_A0.6230.84
320_S323_I0.6220.84
203_D208_L0.6200.84
208_L220_I0.6180.83
122_F129_V0.6180.83
185_S188_T0.6150.83
73_L384_L0.6150.83
202_W247_D0.6150.83
324_F347_A0.6120.83
67_L106_F0.6090.82
171_T174_I0.6080.82
97_T371_H0.6040.82
325_G345_Y0.6000.82
173_S178_G0.5980.81
284_D313_Y0.5970.81
204_A211_V0.5930.81
374_G382_I0.5920.81
146_I153_S0.5910.81
163_L218_D0.5900.80
184_F189_H0.5870.80
354_A371_H0.5860.80
65_L84_N0.5850.80
82_G242_I0.5830.80
132_T137_Y0.5820.80
146_I150_V0.5820.80
153_S162_Y0.5820.80
91_T382_I0.5810.79
273_V370_G0.5800.79
331_R337_N0.5790.79
178_G189_H0.5790.79
56_K61_V0.5770.79
97_T100_T0.5760.79
236_P241_T0.5730.79
234_Y241_T0.5710.78
303_F306_T0.5710.78
194_E199_V0.5680.78
244_S247_D0.5640.77
269_D272_H0.5640.77
296_Y299_S0.5640.77
296_Y300_R0.5630.77
123_S130_V0.5620.77
326_K342_L0.5610.77
223_Y232_H0.5610.77
308_Y313_Y0.5590.77
227_V272_H0.5590.77
255_I258_K0.5580.77
268_A348_V0.5570.77
80_Q238_A0.5540.76
219_F278_T0.5540.76
116_V295_P0.5520.76
69_L99_S0.5510.76
175_V179_I0.5500.76
295_P345_Y0.5500.76
290_M310_V0.5490.76
198_Y202_W0.5490.76
122_F292_D0.5480.75
103_T116_V0.5460.75
154_S184_F0.5450.75
300_R305_R0.5450.75
179_I189_H0.5440.75
53_C58_N0.5440.75
121_T132_T0.5410.75
193_G200_N0.5400.74
299_S305_R0.5400.74
242_I246_R0.5390.74
204_A212_L0.5390.74
153_S156_F0.5390.74
142_D150_V0.5380.74
66_V259_H0.5370.74
269_D372_H0.5370.74
201_F224_I0.5370.74
72_G271_G0.5350.74
54_L60_N0.5340.74
153_S163_L0.5330.73
205_F254_E0.5330.73
374_G383_P0.5330.73
173_S183_E0.5300.73
313_Y318_Y0.5290.73
315_N318_Y0.5290.73
247_D250_T0.5280.73
102_L232_H0.5270.73
180_E186_N0.5260.72
195_S201_F0.5220.72
157_P164_K0.5220.72
233_R347_A0.5210.72
350_T353_R0.5190.71
98_T227_V0.5190.71
119_Y372_H0.5190.71
281_F284_D0.5180.71
119_Y228_D0.5180.71
66_V366_D0.5170.71
171_T175_V0.5160.71
169_K172_I0.5150.71
157_P160_K0.5120.70
285_Q289_N0.5100.70
91_T377_Q0.5100.70
65_L218_D0.5090.70
172_I178_G0.5090.70
173_S189_H0.5080.70
156_F166_V0.5060.70
202_W254_E0.5060.70
56_K60_N0.5060.70
158_H165_E0.5030.69
322_K375_L0.5030.69
116_V130_V0.5010.69
231_S370_G0.5000.69
349_P353_R0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3szyA 1 0.8175 100 0.478 Contact Map
1ei6A 2 0.8123 100 0.481 Contact Map
4lr2A 1 0.7866 100 0.496 Contact Map
3q3qA 2 0.838 100 0.512 Contact Map
2gsoA 1 0.7969 100 0.52 Contact Map
3nkqA 1 0.892 100 0.529 Contact Map
4gtwA 1 0.8432 100 0.54 Contact Map
2w5vA 2 0.6787 99.8 0.771 Contact Map
4fdiA 2 0.6581 99.7 0.783 Contact Map
2qzuA 2 0.6452 99.7 0.787 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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