Q97W23 - SULSO - GREMLIN Contacts

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Q97W23 - Uncharacterized protein

UniProt:	Q97W23	Sequences: MANTVIDNIDINLKINTYNLIANMDLILPDYSGENIYTLSCFVAEYLGVKRQCLNKMNLNVNNRLVLALFDGLGWNVFSQAGVNLKAKKITTVFPSTTSTVLTTLFTALTPAEHSVLGYNTFSKRLGGVVNTLRYTYPTVSDRDSIKDSVPFSSSFPHVKSYLKEVQDKKTISIVPKGIENTEFSNATHGASGESKTYVNFWDAFYQLSQVLQQDTYDFIYFYIPDVDTLSHRYGPYAEPTIKSARDILTSILEISQKHKKYSFLITADHGHVPVTETIIFNNDQELLNMLDVPPYGDSRAIFLRTRYDVSTYLNRKYVSLKIFGKSDFERLLGKINDITALPDYIAVPTDYRAFIFNFKDKDEYDKLKGHHGGLLQEEFEIPLVILNG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	389 (319)
Sequences:	3456 (2618)
Seq/√Len:	146.6

HALSA - Q9HSF0
SULSO - Q97W23

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
104_T	114_H	4.535	1.00
311_S	315_N	3.325	1.00
236_P	274_P	3.121	1.00
231_S	272_H	2.769	1.00
202_W	206_Y	2.724	1.00
325_G	328_D	2.649	1.00
238_A	241_T	2.618	1.00
311_S	345_Y	2.586	1.00
65_L	263_S	2.510	1.00
92_T	101_V	2.482	1.00
252_I	256_S	2.420	1.00
106_F	221_Y	2.306	1.00
66_V	262_Y	2.261	1.00
228_D	232_H	2.223	1.00
202_W	208_L	2.215	1.00
93_V	104_T	2.145	1.00
64_R	218_D	2.139	1.00
323_I	345_Y	2.116	1.00
308_Y	312_T	2.062	1.00
67_L	219_F	2.033	1.00
259_H	264_F	1.971	1.00
232_H	269_D	1.956	1.00
349_P	355_F	1.951	1.00
94_F	348_V	1.949	1.00
69_L	102_L	1.918	1.00
208_L	222_F	1.915	1.00
185_S	189_H	1.891	1.00
109_L	113_E	1.879	1.00
68_A	264_F	1.874	1.00
162_Y	165_E	1.836	1.00
158_H	161_S	1.821	1.00
194_E	197_T	1.815	1.00
63_N	261_K	1.807	1.00
253_L	257_Q	1.792	1.00
311_S	325_G	1.786	1.00
210_Q	214_Q	1.784	1.00
228_D	372_H	1.757	1.00
332_L	375_L	1.753	1.00
72_G	272_H	1.736	1.00
205_F	255_I	1.735	1.00
256_S	264_F	1.728	1.00
204_A	208_L	1.720	1.00
312_T	315_N	1.715	1.00
157_P	187_A	1.698	1.00
67_L	267_T	1.697	1.00
296_Y	305_R	1.697	1.00
234_Y	240_P	1.694	1.00
70_F	227_V	1.690	1.00
62_N	263_S	1.685	1.00
227_V	230_L	1.679	1.00
206_Y	209_S	1.670	1.00
309_D	312_T	1.648	1.00
302_I	305_R	1.647	1.00
98_T	102_L	1.636	1.00
66_V	264_F	1.625	1.00
150_V	158_H	1.619	1.00
71_D	232_H	1.607	1.00
162_Y	166_V	1.593	1.00
237_Y	274_P	1.585	1.00
230_L	244_S	1.557	1.00
239_E	243_K	1.555	1.00
80_Q	242_I	1.544	1.00
243_K	247_D	1.536	1.00
203_D	206_Y	1.534	1.00
192_S	198_Y	1.519	1.00
67_L	221_Y	1.516	1.00
208_L	212_L	1.513	1.00
322_K	350_T	1.513	1.00
151_P	186_N	1.509	1.00
268_A	383_P	1.508	1.00
195_S	198_Y	1.494	1.00
303_F	343_P	1.485	1.00
76_N	378_E	1.465	1.00
312_T	316_R	1.465	1.00
93_V	101_V	1.454	1.00
226_D	230_L	1.452	1.00
81_A	245_A	1.426	1.00
174_I	177_K	1.422	1.00
306_T	344_D	1.419	1.00
308_Y	311_S	1.419	1.00
93_V	111_P	1.413	1.00
227_V	248_I	1.401	1.00
153_S	158_H	1.397	1.00
272_H	370_G	1.386	1.00
249_L	253_L	1.365	1.00
64_R	216_T	1.364	1.00
123_S	126_L	1.350	1.00
284_D	317_K	1.349	1.00
102_L	119_Y	1.340	1.00
206_Y	212_L	1.335	1.00
154_S	158_H	1.334	1.00
232_H	372_H	1.332	1.00
192_S	196_K	1.328	1.00
150_V	155_S	1.326	1.00
280_I	283_N	1.316	1.00
172_I	175_V	1.292	1.00
310_V	313_Y	1.289	1.00
55_N	58_N	1.284	1.00
251_S	254_E	1.276	1.00
90_I	383_P	1.272	1.00
351_D	378_E	1.270	1.00
228_D	269_D	1.265	1.00
198_Y	201_F	1.265	1.00
64_R	262_Y	1.265	1.00
172_I	176_P	1.264	1.00
71_D	269_D	1.264	1.00
170_K	174_I	1.259	1.00
209_S	258_K	1.258	1.00
193_G	196_K	1.258	1.00
236_P	370_G	1.251	1.00
157_P	165_E	1.251	1.00
99_S	119_Y	1.251	1.00
206_Y	254_E	1.247	1.00
150_V	160_K	1.247	1.00
194_E	200_N	1.246	1.00
315_N	328_D	1.246	1.00
192_S	200_N	1.244	1.00
94_F	375_L	1.230	1.00
194_E	198_Y	1.227	1.00
275_V	354_A	1.224	1.00
267_T	383_P	1.221	1.00
202_W	212_L	1.212	1.00
105_L	267_T	1.208	1.00
115_S	341_A	1.204	1.00
231_S	241_T	1.185	1.00
122_F	127_G	1.184	1.00
196_K	199_V	1.174	1.00
309_D	313_Y	1.171	1.00
232_H	270_H	1.170	1.00
277_E	353_R	1.165	1.00
53_C	56_K	1.162	1.00
84_N	87_A	1.146	1.00
320_S	350_T	1.144	1.00
96_S	380_F	1.141	0.99
89_K	381_E	1.135	0.99
181_N	186_N	1.134	0.99
158_H	162_Y	1.129	0.99
68_A	252_I	1.119	0.99
122_F	126_L	1.118	0.99
330_E	334_G	1.117	0.99
301_A	305_R	1.113	0.99
149_S	155_S	1.108	0.99
92_T	96_S	1.108	0.99
170_K	175_V	1.106	0.99
205_F	209_S	1.103	0.99
98_T	119_Y	1.098	0.99
70_F	248_I	1.095	0.99
197_T	201_F	1.090	0.99
131_N	134_R	1.082	0.99
163_L	169_K	1.076	0.99
205_F	208_L	1.075	0.99
131_N	135_Y	1.075	0.99
351_D	380_F	1.073	0.99
314_L	318_Y	1.069	0.99
302_I	306_T	1.065	0.99
70_F	73_L	1.062	0.99
171_T	176_P	1.060	0.99
98_T	269_D	1.058	0.99
110_T	334_G	1.056	0.99
196_K	201_F	1.051	0.99
326_K	329_F	1.050	0.99
201_F	208_L	1.045	0.99
70_F	252_I	1.041	0.99
193_G	198_Y	1.036	0.99
224_I	255_I	1.031	0.99
275_V	371_H	1.031	0.99
297_G	300_R	1.030	0.99
287_L	290_M	1.029	0.99
295_P	304_L	1.028	0.99
193_G	201_F	1.026	0.99
192_S	201_F	1.024	0.99
283_N	358_N	1.024	0.99
197_T	200_N	1.017	0.99
171_T	177_K	1.016	0.99
116_V	121_T	1.012	0.99
311_S	323_I	0.998	0.99
186_N	189_H	0.998	0.99
73_L	245_A	0.995	0.99
250_T	253_L	0.993	0.99
146_I	158_H	0.991	0.99
285_Q	290_M	0.990	0.99
109_L	149_S	0.982	0.98
68_A	222_F	0.980	0.98
348_V	374_G	0.975	0.98
161_S	164_K	0.975	0.98
70_F	266_I	0.973	0.98
208_L	211_V	0.973	0.98
259_H	262_Y	0.966	0.98
181_N	187_A	0.966	0.98
329_F	346_I	0.965	0.98
273_V	351_D	0.964	0.98
99_S	116_V	0.964	0.98
286_E	289_N	0.962	0.98
63_N	263_S	0.961	0.98
234_Y	238_A	0.960	0.98
206_Y	258_K	0.958	0.98
71_D	270_H	0.958	0.98
123_S	341_A	0.956	0.98
87_A	385_V	0.955	0.98
182_T	185_S	0.955	0.98
67_L	265_L	0.952	0.98
157_P	163_L	0.952	0.98
310_V	345_Y	0.950	0.98
96_S	373_G	0.950	0.98
150_V	153_S	0.949	0.98
156_F	165_E	0.945	0.98
243_K	246_R	0.943	0.98
180_E	185_S	0.936	0.98
202_W	207_Q	0.936	0.98
210_Q	213_Q	0.930	0.98
273_V	380_F	0.927	0.98
227_V	245_A	0.922	0.98
74_G	77_V	0.920	0.98
94_F	301_A	0.916	0.98
379_E	382_I	0.914	0.98
64_R	261_K	0.913	0.98
204_A	222_F	0.912	0.98
196_K	200_N	0.909	0.97
77_V	272_H	0.909	0.97
296_Y	302_I	0.908	0.97
104_T	111_P	0.906	0.97
227_V	244_S	0.906	0.97
173_S	177_K	0.903	0.97
54_L	57_M	0.901	0.97
192_S	195_S	0.895	0.97
80_Q	237_Y	0.893	0.97
254_E	258_K	0.890	0.97
72_G	231_S	0.889	0.97
195_S	199_V	0.889	0.97
54_L	58_N	0.886	0.97
95_P	111_P	0.886	0.97
202_W	205_F	0.885	0.97
163_L	166_V	0.884	0.97
73_L	227_V	0.883	0.97
76_N	381_E	0.880	0.97
195_S	200_N	0.878	0.97
311_S	317_K	0.876	0.97
223_Y	228_D	0.873	0.97
125_R	340_T	0.867	0.97
325_G	329_F	0.865	0.97
204_A	207_Q	0.864	0.97
308_Y	325_G	0.856	0.96
184_F	187_A	0.855	0.96
91_T	380_F	0.849	0.96
305_R	343_P	0.845	0.96
201_F	212_L	0.845	0.96
154_S	157_P	0.842	0.96
323_I	347_A	0.840	0.96
173_S	176_P	0.840	0.96
311_S	328_D	0.833	0.96
311_S	314_L	0.831	0.96
203_D	207_Q	0.824	0.96
170_K	173_S	0.824	0.96
212_L	218_D	0.823	0.95
374_G	379_E	0.822	0.95
313_Y	316_R	0.821	0.95
282_N	358_N	0.821	0.95
222_F	255_I	0.820	0.95
71_D	228_D	0.815	0.95
153_S	161_S	0.806	0.95
69_L	105_L	0.805	0.95
360_K	369_K	0.800	0.95
65_L	265_L	0.796	0.95
193_G	197_T	0.792	0.94
192_S	197_T	0.791	0.94
66_V	220_I	0.790	0.94
240_P	243_K	0.786	0.94
170_K	176_P	0.784	0.94
132_T	135_Y	0.784	0.94
229_T	233_R	0.779	0.94
324_F	330_E	0.770	0.94
155_S	162_Y	0.770	0.94
314_L	347_A	0.769	0.94
53_C	57_M	0.769	0.94
207_Q	210_Q	0.766	0.93
276_T	352_Y	0.764	0.93
98_T	228_D	0.763	0.93
268_A	382_I	0.761	0.93
176_P	179_I	0.761	0.93
124_K	344_D	0.760	0.93
97_T	118_G	0.759	0.93
66_V	212_L	0.759	0.93
212_L	220_I	0.757	0.93
71_D	372_H	0.757	0.93
98_T	232_H	0.757	0.93
331_R	334_G	0.756	0.93
281_F	347_A	0.756	0.93
77_V	231_S	0.755	0.93
182_T	189_H	0.755	0.93
313_Y	317_K	0.755	0.93
157_P	162_Y	0.754	0.93
276_T	353_R	0.753	0.93
297_G	303_F	0.751	0.93
217_Y	220_I	0.748	0.93
179_I	184_F	0.741	0.92
117_L	342_L	0.738	0.92
110_T	113_E	0.736	0.92
148_D	339_I	0.736	0.92
288_L	291_L	0.734	0.92
236_P	369_K	0.734	0.92
56_K	59_L	0.734	0.92
321_L	350_T	0.734	0.92
254_E	257_Q	0.728	0.92
239_E	242_I	0.726	0.91
53_C	60_N	0.725	0.91
130_V	134_R	0.724	0.91
179_I	182_T	0.724	0.91
179_I	185_S	0.721	0.91
96_S	374_G	0.720	0.91
306_T	310_V	0.717	0.91
186_N	192_S	0.716	0.91
324_F	375_L	0.716	0.91
79_S	86_K	0.716	0.91
150_V	161_S	0.715	0.91
98_T	270_H	0.712	0.91
301_A	306_T	0.703	0.90
57_M	60_N	0.700	0.90
62_N	218_D	0.697	0.90
182_T	188_T	0.696	0.90
170_K	179_I	0.695	0.90
175_V	178_G	0.695	0.90
174_I	179_I	0.694	0.90
278_T	356_I	0.693	0.89
70_F	226_D	0.691	0.89
75_W	380_F	0.685	0.89
230_L	241_T	0.682	0.89
200_N	203_D	0.681	0.89
78_F	386_I	0.681	0.89
180_E	189_H	0.680	0.89
198_Y	204_A	0.678	0.88
146_I	149_S	0.676	0.88
202_W	211_V	0.675	0.88
117_L	121_T	0.674	0.88
64_R	217_Y	0.669	0.88
98_T	115_S	0.668	0.88
153_S	157_P	0.667	0.88
299_S	303_F	0.666	0.88
322_K	328_D	0.666	0.88
183_E	187_A	0.665	0.87
293_V	296_Y	0.662	0.87
99_S	102_L	0.662	0.87
187_A	191_A	0.659	0.87
79_S	83_V	0.656	0.87
75_W	89_K	0.654	0.87
73_L	77_V	0.654	0.87
292_D	307_R	0.651	0.86
181_N	185_S	0.648	0.86
89_K	382_I	0.648	0.86
183_E	186_N	0.648	0.86
70_F	230_L	0.645	0.86
265_L	386_I	0.645	0.86
184_F	188_T	0.644	0.86
326_K	330_E	0.643	0.86
297_G	305_R	0.640	0.85
84_N	88_K	0.639	0.85
268_A	271_G	0.638	0.85
152_F	158_H	0.637	0.85
334_G	338_D	0.635	0.85
310_V	323_I	0.634	0.85
193_G	204_A	0.634	0.85
193_G	199_V	0.632	0.85
202_W	209_S	0.632	0.85
90_I	384_L	0.631	0.85
300_R	303_F	0.630	0.85
69_L	100_T	0.630	0.85
119_Y	232_H	0.629	0.84
277_E	352_Y	0.628	0.84
81_A	242_I	0.626	0.84
67_L	105_L	0.625	0.84
84_N	89_K	0.625	0.84
192_S	199_V	0.625	0.84
308_Y	347_A	0.623	0.84
320_S	323_I	0.622	0.84
203_D	208_L	0.620	0.84
208_L	220_I	0.618	0.83
122_F	129_V	0.618	0.83
185_S	188_T	0.615	0.83
73_L	384_L	0.615	0.83
202_W	247_D	0.615	0.83
324_F	347_A	0.612	0.83
67_L	106_F	0.609	0.82
171_T	174_I	0.608	0.82
97_T	371_H	0.604	0.82
325_G	345_Y	0.600	0.82
173_S	178_G	0.598	0.81
284_D	313_Y	0.597	0.81
204_A	211_V	0.593	0.81
374_G	382_I	0.592	0.81
146_I	153_S	0.591	0.81
163_L	218_D	0.590	0.80
184_F	189_H	0.587	0.80
354_A	371_H	0.586	0.80
65_L	84_N	0.585	0.80
82_G	242_I	0.583	0.80
132_T	137_Y	0.582	0.80
146_I	150_V	0.582	0.80
153_S	162_Y	0.582	0.80
91_T	382_I	0.581	0.79
273_V	370_G	0.580	0.79
331_R	337_N	0.579	0.79
178_G	189_H	0.579	0.79
56_K	61_V	0.577	0.79
97_T	100_T	0.576	0.79
236_P	241_T	0.573	0.79
234_Y	241_T	0.571	0.78
303_F	306_T	0.571	0.78
194_E	199_V	0.568	0.78
244_S	247_D	0.564	0.77
269_D	272_H	0.564	0.77
296_Y	299_S	0.564	0.77
296_Y	300_R	0.563	0.77
123_S	130_V	0.562	0.77
326_K	342_L	0.561	0.77
223_Y	232_H	0.561	0.77
308_Y	313_Y	0.559	0.77
227_V	272_H	0.559	0.77
255_I	258_K	0.558	0.77
268_A	348_V	0.557	0.77
80_Q	238_A	0.554	0.76
219_F	278_T	0.554	0.76
116_V	295_P	0.552	0.76
69_L	99_S	0.551	0.76
175_V	179_I	0.550	0.76
295_P	345_Y	0.550	0.76
290_M	310_V	0.549	0.76
198_Y	202_W	0.549	0.76
122_F	292_D	0.548	0.75
103_T	116_V	0.546	0.75
154_S	184_F	0.545	0.75
300_R	305_R	0.545	0.75
179_I	189_H	0.544	0.75
53_C	58_N	0.544	0.75
121_T	132_T	0.541	0.75
193_G	200_N	0.540	0.74
299_S	305_R	0.540	0.74
242_I	246_R	0.539	0.74
204_A	212_L	0.539	0.74
153_S	156_F	0.539	0.74
142_D	150_V	0.538	0.74
66_V	259_H	0.537	0.74
269_D	372_H	0.537	0.74
201_F	224_I	0.537	0.74
72_G	271_G	0.535	0.74
54_L	60_N	0.534	0.74
153_S	163_L	0.533	0.73
205_F	254_E	0.533	0.73
374_G	383_P	0.533	0.73
173_S	183_E	0.530	0.73
313_Y	318_Y	0.529	0.73
315_N	318_Y	0.529	0.73
247_D	250_T	0.528	0.73
102_L	232_H	0.527	0.73
180_E	186_N	0.526	0.72
195_S	201_F	0.522	0.72
157_P	164_K	0.522	0.72
233_R	347_A	0.521	0.72
350_T	353_R	0.519	0.71
98_T	227_V	0.519	0.71
119_Y	372_H	0.519	0.71
281_F	284_D	0.518	0.71
119_Y	228_D	0.518	0.71
66_V	366_D	0.517	0.71
171_T	175_V	0.516	0.71
169_K	172_I	0.515	0.71
157_P	160_K	0.512	0.70
285_Q	289_N	0.510	0.70
91_T	377_Q	0.510	0.70
65_L	218_D	0.509	0.70
172_I	178_G	0.509	0.70
173_S	189_H	0.508	0.70
156_F	166_V	0.506	0.70
202_W	254_E	0.506	0.70
56_K	60_N	0.506	0.70
158_H	165_E	0.503	0.69
322_K	375_L	0.503	0.69
116_V	130_V	0.501	0.69
231_S	370_G	0.500	0.69
349_P	353_R	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3szyA	1	0.8175	100	0.478	Contact Map
1ei6A	2	0.8123	100	0.481	Contact Map
4lr2A	1	0.7866	100	0.496	Contact Map
3q3qA	2	0.838	100	0.512	Contact Map
2gsoA	1	0.7969	100	0.52	Contact Map
3nkqA	1	0.892	100	0.529	Contact Map
4gtwA	1	0.8432	100	0.54	Contact Map
2w5vA	2	0.6787	99.8	0.771	Contact Map
4fdiA	2	0.6581	99.7	0.783	Contact Map
2qzuA	2	0.6452	99.7	0.787	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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