GREMLIN Database
Q97W22 - Purine phosphoribosyltransferase (GpT-2)
UniProt: Q97W22 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (157)
Sequences: 4192 (2503)
Seq/√Len: 199.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_S134_F3.5961.00
118_M133_D3.5341.00
106_S110_T3.0151.00
88_K116_K2.8771.00
35_A44_A2.8241.00
15_A18_S2.6451.00
17_F50_L2.6441.00
8_S11_E2.6381.00
88_K115_A2.6011.00
85_E113_N2.3061.00
103_E107_N2.3031.00
15_A137_K2.3001.00
33_L48_S2.2751.00
30_P88_K2.1261.00
24_V52_D2.0981.00
36_V105_V2.0121.00
24_V53_L2.0101.00
9_W13_E1.8571.00
114_P117_V1.7811.00
26_S118_M1.7761.00
139_I142_W1.7631.00
124_L129_K1.7491.00
20_G24_V1.7271.00
33_L90_L1.7261.00
55_V87_K1.7231.00
96_A132_P1.7201.00
106_S119_T1.7191.00
66_S150_W1.6791.00
46_L49_D1.6521.00
25_K28_Y1.6461.00
124_L138_Q1.6451.00
46_L145_F1.5801.00
19_I136_Y1.5461.00
123_Y142_W1.5421.00
23_L47_L1.5261.00
13_E50_L1.5221.00
30_P115_A1.5141.00
36_V59_I1.4951.00
42_I48_S1.4241.00
33_L51_L1.4231.00
108_V112_F1.4141.00
126_P138_Q1.4141.00
41_I45_K1.3961.00
123_Y159_V1.3801.00
45_K49_D1.3801.00
35_A40_G1.3741.00
41_I56_I1.3691.00
9_W157_S1.3561.00
27_N116_K1.3481.00
10_D14_D1.3301.00
11_E14_D1.3221.00
78_S81_T1.3131.00
79_V112_F1.3111.00
15_A22_A1.2901.00
23_L51_L1.2831.00
18_S137_K1.2301.00
17_F21_E1.1951.00
20_G51_L1.1811.00
21_E25_K1.1781.00
27_N118_M1.1721.00
104_A107_N1.1681.00
22_A26_S1.1681.00
47_L92_V1.1591.00
127_W141_K1.1291.00
22_A25_K1.1251.00
132_P135_Y1.1171.00
42_I45_K1.1121.00
24_V51_L1.1061.00
86_G115_A1.1051.00
123_Y139_I1.0721.00
9_W50_L1.0561.00
16_V43_P1.0531.00
41_I58_Y1.0381.00
118_M134_F1.0261.00
93_D121_A1.0231.00
107_N110_T1.0151.00
19_I120_A1.0011.00
142_W147_W0.9941.00
7_P139_I0.9851.00
42_I49_D0.9821.00
57_R78_S0.9801.00
13_E46_L0.9791.00
61_I105_V0.9771.00
18_S22_A0.9700.99
21_E24_V0.9570.99
124_L135_Y0.9520.99
14_D18_S0.9510.99
32_V55_V0.9500.99
102_L119_T0.9270.99
32_V82_D0.9240.99
80_Y84_L0.9200.99
91_V106_S0.9190.99
23_L120_A0.9170.99
34_I80_Y0.9170.99
43_P120_A0.9170.99
71_E74_P0.9160.99
107_N111_M0.9140.99
38_T151_D0.9030.99
91_V109_I0.9020.99
128_S141_K0.8950.99
127_W140_D0.8930.99
108_V111_M0.8920.99
31_D87_K0.8790.99
48_S56_I0.8720.99
84_L114_P0.8660.99
41_I48_S0.8660.99
23_L90_L0.8650.99
119_T130_R0.8580.99
124_L128_S0.8460.99
96_A121_A0.8280.98
60_D78_S0.8250.98
124_L132_P0.8190.98
121_A135_Y0.8180.98
106_S130_R0.8150.98
93_D96_A0.8150.98
93_D119_T0.8150.98
32_V87_K0.8140.98
37_L41_I0.8020.98
120_A134_F0.8020.98
60_D77_R0.7980.98
55_V152_V0.7950.98
44_A56_I0.7920.98
33_L92_V0.7890.98
20_G50_L0.7790.98
64_Y97_D0.7780.98
27_N90_L0.7780.98
59_I76_I0.7750.97
156_N160_P0.7750.97
5_H160_P0.7740.97
13_E49_D0.7740.97
15_A136_Y0.7670.97
64_Y125_K0.7520.97
97_D125_K0.7520.97
67_V70_T0.7520.97
37_L58_Y0.7390.97
16_V46_L0.7380.97
61_I77_R0.7370.97
59_I105_V0.7330.96
32_V89_V0.7310.96
22_A134_F0.7220.96
16_V47_L0.7100.96
100_E103_E0.7050.96
104_A108_V0.7030.96
11_E15_A0.7010.95
36_V104_A0.6980.95
16_V50_L0.6970.95
36_V40_G0.6970.95
12_I122_L0.6960.95
91_V119_T0.6910.95
9_W158_N0.6880.95
20_G47_L0.6710.94
7_P137_K0.6650.94
50_L157_S0.6630.94
61_I101_T0.6560.94
5_H8_S0.6560.94
33_L44_A0.6520.93
84_L89_V0.6440.93
27_N30_P0.6440.93
110_T117_V0.6390.93
55_V82_D0.6380.93
76_I108_V0.6380.93
31_D54_K0.6370.93
109_I114_P0.6360.93
89_V117_V0.6360.93
121_A124_L0.6300.92
153_V160_P0.6290.92
84_L117_V0.6260.92
16_V122_L0.6240.92
18_S21_E0.6190.91
84_L109_I0.6170.91
13_E17_F0.6160.91
63_F97_D0.6120.91
143_I153_V0.6120.91
32_V84_L0.6070.91
122_L159_V0.6060.91
27_N88_K0.5940.90
34_I109_I0.5940.90
61_I74_P0.5930.90
144_I148_D0.5920.90
67_V150_W0.5910.90
65_R68_G0.5900.89
76_I104_A0.5900.89
75_V81_T0.5780.88
63_F125_K0.5760.88
66_S69_K0.5760.88
23_L134_F0.5760.88
28_Y31_D0.5750.88
44_A92_V0.5750.88
65_R71_E0.5740.88
122_L137_K0.5700.88
38_T60_D0.5700.88
76_I79_V0.5680.88
119_T133_D0.5670.88
47_L51_L0.5610.87
152_V155_E0.5610.87
73_K104_A0.5570.87
21_E52_D0.5570.87
101_T105_V0.5560.86
103_E110_T0.5560.86
34_I57_R0.5530.86
6_I142_W0.5500.86
70_T98_T0.5500.86
26_S116_K0.5490.86
90_L134_F0.5490.86
65_R150_W0.5430.85
67_V71_E0.5420.85
63_F98_T0.5410.85
96_A128_S0.5370.85
66_S151_D0.5340.84
20_G23_L0.5340.84
144_I154_R0.5320.84
46_L50_L0.5300.84
106_S117_V0.5290.84
31_D152_V0.5270.83
149_K153_V0.5270.83
43_P92_V0.5250.83
70_T74_P0.5250.83
31_D88_K0.5220.83
7_P11_E0.5210.83
70_T100_E0.5190.83
39_G97_D0.5190.83
95_V139_I0.5190.83
40_G45_K0.5180.82
106_S133_D0.5160.82
127_W138_Q0.5160.82
34_I84_L0.5160.82
106_S131_I0.5140.82
40_G60_D0.5130.82
24_V54_K0.5120.82
39_G94_D0.5110.82
42_I46_L0.5110.82
128_S138_Q0.5100.81
31_D55_V0.5060.81
57_R82_D0.5040.81
91_V155_E0.5040.81
96_A102_L0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5bqpA 3 0.9553 100 0.289 Contact Map
3ozfA 4 0.9609 100 0.381 Contact Map
1tc1A 2 0.933 100 0.39 Contact Map
1fsgA 4 0.9553 100 0.393 Contact Map
2jbhA 4 0.9441 100 0.393 Contact Map
4raoA 4 0.9162 100 0.395 Contact Map
4trbA 2 0.9944 100 0.399 Contact Map
1pzmA 2 0.8603 100 0.4 Contact Map
4rqaA 3 0.905 100 0.4 Contact Map
4qyiA 3 0.9106 100 0.4 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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