GREMLIN Database
Q97W20 - Lactoylglutathione lyase (Glyoxalase I), putative
UniProt: Q97W20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (129)
Sequences: 5211 (2634)
Seq/√Len: 231.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_K25_N4.2951.00
98_E102_A3.4171.00
97_L107_L3.2921.00
99_E103_K3.2841.00
106_Q127_K3.1921.00
92_D95_R3.1191.00
15_N18_E2.4011.00
101_T110_T2.3951.00
100_L105_L2.1961.00
5_N89_K2.0881.00
4_E91_S1.9851.00
74_K77_K1.9571.00
4_E89_K1.9021.00
97_L101_T1.8921.00
85_H135_E1.7661.00
51_E56_S1.7341.00
36_L43_K1.7031.00
14_G81_Q1.6941.00
73_A77_K1.6491.00
95_R99_E1.6451.00
31_L47_L1.6021.00
94_N98_E1.5931.00
64_D69_S1.5611.00
32_V56_S1.5571.00
100_L136_L1.5481.00
41_G64_D1.4481.00
127_K133_L1.4151.00
115_G120_L1.4131.00
70_N73_A1.3841.00
6_L86_L1.3611.00
24_Q31_L1.3491.00
96_A100_L1.3301.00
101_T107_L1.3221.00
18_E21_K1.3201.00
21_K24_Q1.2891.00
31_L34_Y1.2881.00
12_V72_V1.2701.00
99_E102_A1.2491.00
62_P76_L1.2221.00
49_S88_I1.2151.00
87_A137_V1.2151.00
94_N120_L1.1961.00
34_Y43_K1.1941.00
83_L86_L1.1891.00
46_F58_E1.1811.00
8_H87_A1.1731.00
20_I24_Q1.1451.00
62_P73_A1.1431.00
108_V127_K1.1171.00
90_V96_A1.1121.00
109_D112_P1.1081.00
10_G60_L1.1071.00
13_V59_L1.1051.00
62_P70_N1.1051.00
96_A99_E1.1001.00
32_V48_V1.0961.00
65_H69_S1.0931.00
17_D34_Y1.0901.00
94_N111_S1.0821.00
100_L124_L1.0771.00
111_S114_K1.0691.00
22_F26_T1.0681.00
88_I134_L1.0551.00
17_D21_K1.0541.00
46_F60_L1.0511.00
25_N103_K1.0451.00
95_R98_E1.0381.00
93_I138_Q1.0371.00
14_G76_L1.0191.00
12_V82_G1.0101.00
31_L45_A1.0021.00
6_L55_T0.9931.00
19_A23_Y0.9901.00
108_V133_L0.9811.00
37_I40_R0.9641.00
7_D89_K0.9531.00
86_L134_L0.9521.00
32_V51_E0.9271.00
13_V16_L0.9271.00
20_I47_L0.9201.00
94_N122_A0.8970.99
123_F135_E0.8960.99
93_I136_L0.8940.99
80_G87_A0.8890.99
35_E41_G0.8890.99
16_L20_I0.8810.99
20_I31_L0.8780.99
19_A22_F0.8750.99
127_K131_G0.8700.99
41_G63_I0.8700.99
37_I42_I0.8650.99
97_L122_A0.8620.99
12_V84_H0.8510.99
5_N54_E0.8480.99
116_A119_H0.8440.99
93_I97_L0.8400.99
109_D113_R0.8290.99
44_V60_L0.8290.99
24_Q30_K0.8180.99
124_L129_V0.8090.99
53_N56_S0.8030.99
73_A76_L0.8010.99
119_H128_S0.7970.99
15_N21_K0.7890.99
98_E101_T0.7870.99
9_I86_L0.7850.99
15_N19_A0.7850.99
19_A59_L0.7820.99
7_D87_A0.7660.98
122_A138_Q0.7650.98
29_M49_S0.7650.98
11_I83_L0.7650.98
43_K61_E0.7440.98
15_N61_E0.7320.98
106_Q128_S0.7160.97
11_I86_L0.7110.97
115_G123_F0.7080.97
48_V54_E0.7000.97
75_F82_G0.6990.97
100_L107_L0.6980.97
87_A134_L0.6930.97
35_E44_V0.6920.97
75_F80_G0.6830.97
12_V60_L0.6830.97
42_I46_F0.6810.97
42_I60_L0.6800.97
93_I96_A0.6780.96
93_I111_S0.6780.96
69_S72_V0.6720.96
17_D47_L0.6690.96
128_S132_V0.6640.96
119_H123_F0.6630.96
129_V132_V0.6570.96
11_I57_I0.6540.96
128_S131_G0.6500.95
120_L123_F0.6470.95
119_H122_A0.6450.95
16_L45_A0.6450.95
13_V57_I0.6430.95
41_G45_A0.6400.95
46_F49_S0.6370.95
19_A130_M0.6370.95
38_P63_I0.6360.95
14_G77_K0.6340.95
26_T103_K0.6270.95
36_L63_I0.6270.95
75_F132_V0.6270.95
74_K78_N0.6210.94
12_V76_L0.6150.94
113_R120_L0.6150.94
71_T84_H0.6130.94
17_D45_A0.6090.94
43_K63_I0.6050.93
60_L72_V0.6030.93
112_P123_F0.6000.93
48_V56_S0.5980.93
70_N75_F0.5930.93
22_F27_F0.5860.92
29_M52_K0.5820.92
120_L124_L0.5790.92
70_N77_K0.5760.92
21_K26_T0.5720.91
115_G121_V0.5710.91
44_V58_E0.5710.91
16_L61_E0.5640.91
51_E54_E0.5600.91
35_E60_L0.5570.90
52_K55_T0.5570.90
14_G18_E0.5510.90
23_Y59_L0.5480.90
121_V137_V0.5410.89
10_G84_H0.5390.89
41_G65_H0.5390.89
85_H134_L0.5370.89
120_L138_Q0.5310.88
76_L84_H0.5290.88
101_T112_P0.5270.88
13_V76_L0.5270.88
94_N112_P0.5240.87
71_T75_F0.5240.87
7_D137_V0.5230.87
114_K120_L0.5210.87
12_V62_P0.5190.87
56_S119_H0.5160.87
29_M55_T0.5130.86
94_N113_R0.5120.86
72_V76_L0.5100.86
127_K136_L0.5070.86
122_A128_S0.5060.86
21_K78_N0.5050.85
84_H123_F0.5040.85
41_G44_V0.5000.85
93_I107_L0.5000.85
118_G121_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3isqA 2 0.9718 99.9 0.356 Contact Map
1sqdA 2 0.9718 99.9 0.369 Contact Map
1sp8A 2 0.9718 99.9 0.374 Contact Map
2r5vA 1 0.9155 99.8 0.404 Contact Map
1t47A 2 0.9718 99.8 0.424 Contact Map
1cjxA 2 0.8803 99.8 0.428 Contact Map
1jc4A 2 0.9718 99.7 0.454 Contact Map
3gm5A 2 0.9085 99.7 0.454 Contact Map
3zgjA 1 0.9366 99.7 0.455 Contact Map
3hdpA 2 0.9155 99.7 0.456 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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