GREMLIN Database
Q97W19 - Small heat shock protein hsp20 family
UniProt: Q97W19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (149)
Sequences: 316 (280)
Seq/√Len: 22.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_A100_A3.1831.00
121_L158_I3.0951.00
100_A123_I2.9951.00
171_V175_V2.5840.99
107_K148_K2.5470.99
111_K172_D2.4410.98
83_R101_E2.4410.98
50_Y69_N2.4360.98
121_L147_A2.4070.98
164_A167_S2.2960.97
30_E34_G2.0870.95
143_D146_A2.0590.94
91_E162_K1.9520.93
33_R36_R1.9320.92
102_V132_Y1.8570.91
24_F32_M1.8480.90
113_K172_D1.8450.90
96_I140_A1.7560.88
27_I34_G1.7180.87
31_F34_G1.6830.86
110_I151_F1.6790.86
57_G60_G1.6630.85
138_L148_K1.6600.85
25_E29_R1.6420.84
89_V94_D1.6320.84
87_A134_K1.6120.83
57_G105_V1.5910.82
96_I173_I1.5800.82
84_E134_K1.5630.81
106_N153_N1.5560.81
108_E136_I1.5510.81
62_P66_E1.5420.80
144_E161_K1.5210.79
24_F31_F1.4950.78
25_E28_E1.4920.78
170_G175_V1.4860.78
95_E161_K1.4860.78
50_Y68_G1.4850.78
89_V98_V1.4330.75
146_A161_K1.4090.74
136_I142_V1.3790.72
147_A160_L1.3760.72
131_Q136_I1.3720.72
114_V132_Y1.3620.71
143_D158_I1.3410.70
145_K171_V1.3270.69
28_E31_F1.3240.69
30_E33_R1.3150.68
113_K122_V1.2980.67
109_D127_S1.2930.67
121_L155_V1.2850.66
89_V173_I1.2690.65
69_N84_E1.2630.65
34_G37_G1.2530.64
102_V109_D1.2250.63
59_D62_P1.1990.61
99_V157_E1.1970.61
98_V158_I1.1890.60
96_I157_E1.1840.60
49_V52_F1.1700.59
87_A138_L1.1630.59
67_F175_V1.1570.58
115_T120_K1.1370.57
142_V160_L1.1340.57
120_K135_E1.1340.57
110_I161_K1.1170.55
100_A157_E1.1150.55
24_F27_I1.1010.54
28_E33_R1.0930.54
111_K124_T1.0920.54
93_G97_K1.0870.53
122_V135_E1.0770.53
96_I147_A1.0680.52
121_L141_E1.0650.52
138_L162_K1.0640.52
111_K115_T1.0600.51
105_V110_I1.0540.51
49_V67_F1.0380.50
62_P68_G1.0220.49
101_E127_S1.0150.48
95_E98_V1.0130.48
26_R29_R0.9880.46
61_V83_R0.9820.46
65_E68_G0.9810.46
87_A125_A0.9770.46
52_F68_G0.9640.45
91_E155_V0.9630.45
86_L101_E0.9600.45
70_V132_Y0.9590.44
27_I35_F0.9570.44
164_A168_D0.9470.44
68_G71_R0.9420.43
49_V65_E0.9310.43
56_V60_G0.9290.42
92_K97_K0.9200.42
142_V149_A0.9170.42
28_E112_V0.9170.42
88_D155_V0.9150.41
27_I33_R0.9140.41
28_E35_F0.9040.41
73_I167_S0.9010.41
65_E93_G0.9000.40
98_V124_T0.9000.40
168_D171_V0.8810.39
96_I133_Y0.8640.38
91_E109_D0.8600.38
101_E155_V0.8540.37
44_Q114_V0.8500.37
48_Y59_D0.8490.37
24_F28_E0.8370.36
86_L132_Y0.8360.36
98_V136_I0.8350.36
61_V69_N0.8240.36
103_P156_L0.8230.35
87_A99_V0.8070.34
96_I162_K0.8040.34
96_I100_A0.8000.34
27_I31_F0.7990.34
28_E36_R0.7980.34
131_Q134_K0.7870.33
126_K131_Q0.7840.33
61_V155_V0.7840.33
115_T121_L0.7830.33
125_A139_P0.7830.33
51_G68_G0.7820.33
84_E135_E0.7750.32
124_T145_K0.7740.32
86_L134_K0.7660.32
138_L160_L0.7620.32
68_G84_E0.7610.32
141_E162_K0.7580.31
101_E105_V0.7550.31
82_E158_I0.7540.31
149_A154_G0.7430.31
104_G162_K0.7380.30
93_G124_T0.7380.30
51_G69_N0.7280.30
87_A157_E0.7270.30
58_P66_E0.7240.29
59_D84_E0.7190.29
52_F67_F0.7100.29
164_A169_S0.7090.29
120_K163_K0.7050.28
125_A134_K0.7050.28
148_K160_L0.7020.28
109_D126_K0.7000.28
59_D68_G0.6990.28
125_A130_R0.6950.28
80_S93_G0.6940.28
85_P101_E0.6940.28
50_Y84_E0.6920.28
119_K128_E0.6900.28
57_G61_V0.6850.27
145_K169_S0.6790.27
124_T133_Y0.6740.27
63_K72_K0.6680.26
29_R98_V0.6610.26
30_E36_R0.6590.26
25_E30_E0.6570.26
55_T68_G0.6520.25
31_F112_V0.6510.25
120_K127_S0.6340.25
29_R33_R0.6300.24
66_E71_R0.6260.24
31_F35_F0.6230.24
50_Y57_G0.6190.24
51_G67_F0.6190.24
144_E158_I0.6130.23
54_I132_Y0.6100.23
66_E86_L0.6060.23
28_E32_M0.6040.23
90_I97_K0.6020.23
62_P65_E0.6000.23
41_G123_I0.5990.23
24_F35_F0.5950.23
107_K133_Y0.5930.22
158_I164_A0.5930.22
150_N160_L0.5910.22
55_T63_K0.5900.22
40_E46_G0.5750.22
72_K137_D0.5740.22
74_R155_V0.5730.22
47_P146_A0.5720.21
54_I64_I0.5680.21
64_I67_F0.5660.21
30_E145_K0.5660.21
91_E149_A0.5620.21
29_R32_M0.5610.21
105_V135_E0.5610.21
39_G42_I0.5580.21
82_E88_D0.5580.21
133_Y174_K0.5570.21
152_K175_V0.5550.21
99_V112_V0.5540.21
48_Y132_Y0.5470.20
71_R123_I0.5460.20
95_E111_K0.5440.20
58_P62_P0.5430.20
40_E140_A0.5370.20
77_P141_E0.5360.20
28_E34_G0.5350.20
52_F153_N0.5350.20
41_G112_V0.5310.20
85_P99_V0.5270.19
73_I78_M0.5260.19
107_K116_N0.5260.19
75_G89_V0.5230.19
127_S132_Y0.5230.19
42_I144_E0.5220.19
84_E87_A0.5200.19
44_Q110_I0.5170.19
26_R30_E0.5170.19
51_G58_P0.5150.19
149_A156_L0.5080.19
88_D136_I0.5080.19
45_F53_R0.5070.19
56_V59_D0.5070.19
125_A128_E0.5060.19
131_Q167_S0.5060.19
85_P151_F0.5050.19
88_D154_G0.5050.19
67_F78_M0.5050.19
69_N153_N0.5030.18
53_R61_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bolA 2 0.9205 99.9 0.447 Contact Map
4eldA 4 0.5682 99.9 0.455 Contact Map
1gmeA 6 0.7216 99.9 0.463 Contact Map
3aabA 2 0.5795 99.9 0.475 Contact Map
3w1zA 7 0.7102 99.9 0.479 Contact Map
4jutA 4 0.4545 99.9 0.499 Contact Map
4ydzA 4 0.608 99.9 0.501 Contact Map
3l1eA 2 0.517 99.9 0.503 Contact Map
4ye0A 2 0.5114 99.9 0.507 Contact Map
3glaA 2 0.4773 99.9 0.511 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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