GREMLIN Database
Q97W18 - Uncharacterized protein
UniProt: Q97W18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 174 (158)
Sequences: 839 (522)
Seq/√Len: 41.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_S142_K4.8921.00
160_S164_S3.5581.00
94_E146_T3.5181.00
117_E139_M3.1831.00
129_K132_E3.1171.00
24_T45_W2.9621.00
87_F153_S2.9261.00
137_S143_I2.8731.00
128_D131_C2.8201.00
136_R140_E2.5801.00
93_P148_I2.5391.00
160_S163_A2.5271.00
138_A145_F2.5091.00
97_I119_L2.4571.00
12_E25_L2.4371.00
112_I147_L2.3171.00
14_T23_K2.2171.00
73_E144_K2.1901.00
91_V98_E2.1771.00
91_V96_G2.1470.99
88_A149_I2.1310.99
110_S115_I2.1260.99
134_R143_I2.0670.99
67_L150_E2.0160.99
133_D137_S1.9790.99
138_A141_G1.9560.99
43_S56_D1.8700.98
68_V158_I1.8610.98
72_I145_F1.8490.98
42_L55_R1.7930.98
43_S55_R1.7840.98
70_M112_I1.7420.98
41_V60_Y1.7310.97
120_L136_R1.6710.97
108_Y118_I1.5750.96
121_D133_D1.5750.96
22_S49_N1.5570.95
30_Y45_W1.5450.95
33_N39_K1.5430.95
129_K133_D1.4870.94
12_E27_A1.4730.94
9_V93_P1.4150.92
17_C20_C1.3950.92
48_E51_G1.3710.91
91_V150_E1.3180.89
78_L93_P1.3050.89
120_L139_M1.2740.87
90_I115_I1.2690.87
71_K144_K1.2460.86
83_Y109_I1.2270.85
81_L109_I1.2170.85
88_A156_S1.2040.84
67_L148_I1.1820.83
31_L41_V1.1760.83
37_T152_E1.1690.82
34_T107_G1.1680.82
31_L39_K1.1670.82
13_E28_V1.1650.82
46_Y53_K1.1250.80
70_M158_I1.1140.79
40_L154_G1.1040.79
136_R139_M1.0730.76
124_G129_K1.0710.76
162_K165_T1.0610.76
127_C130_E1.0600.76
88_A147_L1.0560.75
161_E164_S1.0520.75
141_G156_S1.0490.75
23_K88_A1.0410.74
16_I23_K0.9680.69
58_K106_Q0.9560.68
39_K155_L0.9550.68
116_L120_L0.9540.68
70_M80_A0.9420.67
16_I26_K0.9370.66
21_K52_Y0.9290.66
73_E77_D0.9270.65
56_D96_G0.9230.65
116_L141_G0.9200.65
75_E78_L0.9140.64
82_V147_L0.9130.64
34_T40_L0.9110.64
22_S121_D0.9040.63
27_A44_N0.8930.62
64_E95_L0.8900.62
13_E26_K0.8900.62
71_K146_T0.8840.62
89_K152_E0.8790.61
26_K45_W0.8740.61
68_V111_T0.8710.60
92_I115_I0.8600.59
34_T37_T0.8540.59
70_M131_C0.8530.59
141_G147_L0.8510.59
28_V41_V0.8470.58
116_L152_E0.8390.58
15_L27_A0.8360.57
125_N128_D0.8320.57
112_I162_K0.8290.57
87_F102_A0.8180.56
83_Y159_K0.8110.55
94_E128_D0.8070.55
8_K11_F0.7950.54
24_T30_Y0.7900.53
27_A83_Y0.7900.53
73_E162_K0.7860.53
117_E147_L0.7850.53
18_P52_Y0.7850.53
13_E52_Y0.7830.52
88_A152_E0.7720.51
16_I21_K0.7640.51
57_V109_I0.7600.50
89_K110_S0.7580.50
109_I159_K0.7540.50
72_I138_A0.7410.48
71_K94_E0.7340.48
69_E149_I0.7190.46
139_M158_I0.7150.46
112_I136_R0.7040.45
53_K74_N0.6970.44
163_A166_R0.6960.44
24_T27_A0.6950.44
93_P138_A0.6890.44
158_I162_K0.6880.44
75_E142_K0.6840.43
76_D140_E0.6810.43
39_K157_F0.6800.43
8_K53_K0.6790.43
40_L64_E0.6750.42
38_G155_L0.6680.42
13_E61_E0.6660.42
57_V107_G0.6650.41
25_L112_I0.6630.41
80_A123_V0.6630.41
28_V61_E0.6600.41
88_A159_K0.6580.41
15_L54_F0.6580.41
84_R88_A0.6510.40
45_W54_F0.6490.40
63_R80_A0.6460.40
16_I31_L0.6410.39
39_K52_Y0.6400.39
30_Y42_L0.6360.39
109_I150_E0.6340.39
78_L143_I0.6290.38
48_E53_K0.6280.38
74_N137_S0.6270.38
26_K80_A0.6270.38
70_M160_S0.6240.38
102_A111_T0.6200.37
42_L46_Y0.6200.37
83_Y165_T0.6190.37
59_P155_L0.6190.37
100_E154_G0.6170.37
64_E154_G0.6160.37
118_I121_D0.6130.37
116_L135_I0.6090.36
18_P21_K0.6090.36
14_T25_L0.6050.36
73_E82_V0.6030.36
69_E144_K0.6010.36
128_D133_D0.6000.36
41_V51_G0.6000.36
116_L139_M0.5990.36
91_V116_L0.5940.35
37_T156_S0.5930.35
14_T22_S0.5890.35
121_D142_K0.5870.35
115_I118_I0.5860.35
74_N116_L0.5820.34
97_I104_M0.5800.34
7_P10_I0.5780.34
34_T58_K0.5780.34
149_I156_S0.5780.34
7_P101_P0.5750.34
26_K30_Y0.5720.33
80_A84_R0.5710.33
124_G127_C0.5700.33
82_V166_R0.5680.33
65_P102_A0.5660.33
96_G100_E0.5650.33
8_K65_P0.5650.33
64_E153_S0.5630.33
57_V93_P0.5580.32
56_D101_P0.5550.32
77_D80_A0.5540.32
108_Y122_Q0.5540.32
7_P96_G0.5540.32
67_L120_L0.5540.32
91_V134_R0.5530.32
73_E146_T0.5530.32
153_S159_K0.5500.32
40_L48_E0.5490.31
15_L155_L0.5490.31
21_K112_I0.5480.31
117_E132_E0.5450.31
157_F161_E0.5430.31
83_Y107_G0.5420.31
16_I54_F0.5420.31
37_T109_I0.5400.31
79_S159_K0.5380.31
93_P96_G0.5380.31
42_L163_A0.5370.30
12_E154_G0.5360.30
90_I93_P0.5360.30
7_P11_F0.5350.30
9_V92_I0.5340.30
106_Q122_Q0.5330.30
84_R107_G0.5330.30
68_V107_G0.5320.30
56_D99_I0.5260.30
90_I124_G0.5250.30
95_L144_K0.5230.29
17_C85_S0.5230.29
39_K55_R0.5230.29
43_S115_I0.5230.29
131_C136_R0.5200.29
110_S126_F0.5180.29
56_D88_A0.5170.29
32_Y56_D0.5170.29
131_C135_I0.5160.29
14_T107_G0.5160.29
73_E139_M0.5160.29
58_K81_L0.5140.29
19_V52_Y0.5140.29
150_E157_F0.5110.28
95_L134_R0.5090.28
24_T44_N0.5080.28
19_V122_Q0.5070.28
31_L40_L0.5050.28
130_E137_S0.5040.28
37_T89_K0.5030.28
54_F155_L0.5020.28
32_Y99_I0.5020.28
56_D147_L0.5020.28
74_N162_K0.5010.28
15_L26_K0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qkdA 2 0.977 100 0.097 Contact Map
3ga8A 1 0.3506 87.6 0.92 Contact Map
3h0gI 1 0.3161 85.7 0.922 Contact Map
5aunA 1 0.4138 85.2 0.922 Contact Map
2k5cA 1 0.3333 84.3 0.923 Contact Map
1qypA 1 0.3218 79.9 0.927 Contact Map
4cgyA 1 0 75 0.93 Contact Map
2kdxA 1 0.3391 71.8 0.932 Contact Map
4c2mI 1 0.3161 70.2 0.932 Contact Map
2k4xA 1 0.2816 69.7 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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