GREMLIN Database
Q97W17 - Elongation factor 1-alpha, putative (TuF-2)
UniProt: Q97W17 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 523 (425)
Sequences: 4310 (2424)
Seq/√Len: 117.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_M329_L5.6721.00
239_K277_V4.7951.00
195_K334_P4.5011.00
505_F514_G4.0101.00
310_P328_F3.9001.00
130_A319_G3.6251.00
466_I472_F3.5901.00
372_N404_S3.4891.00
434_P441_K3.4841.00
434_P438_R3.4471.00
321_G324_L3.3191.00
130_A322_L3.2781.00
434_P437_V3.2551.00
282_G303_I3.2201.00
271_V313_K3.0111.00
405_V411_A2.9441.00
437_V441_K2.9181.00
79_N82_I2.8511.00
382_N421_E2.8031.00
332_L336_A2.7931.00
231_D261_K2.6881.00
319_G322_L2.6411.00
438_R441_K2.5711.00
271_V304_K2.4671.00
243_A494_Y2.3981.00
220_E348_Y2.3491.00
133_L319_G2.3471.00
343_G368_R2.3451.00
259_V320_K2.2531.00
434_P440_F2.2471.00
245_A252_I2.2151.00
364_G429_M2.1981.00
440_F444_V2.1751.00
226_L254_V2.1591.00
109_P195_K2.1411.00
313_K320_K2.1401.00
166_V196_I2.1371.00
264_E268_K2.1241.00
256_I311_I2.0991.00
253_F329_L2.0481.00
256_I313_K2.0441.00
280_I283_I2.0391.00
278_L282_G1.9751.00
257_T316_N1.9701.00
28_E32_Q1.9491.00
78_V83_V1.9281.00
275_K305_T1.9111.00
131_L322_L1.8741.00
161_S468_Q1.8681.00
53_E57_I1.8451.00
437_V440_F1.8391.00
239_K243_A1.8271.00
192_K195_K1.8271.00
166_V409_N1.7991.00
406_L409_N1.7991.00
434_P444_V1.7751.00
269_G273_D1.7611.00
67_S70_T1.7241.00
436_V440_F1.7071.00
24_D27_Q1.6891.00
28_E31_T1.6601.00
191_I196_I1.6591.00
106_E342_R1.6471.00
265_D268_K1.6221.00
227_V314_I1.6221.00
39_E42_G1.6211.00
436_V439_R1.6161.00
441_K444_V1.6131.00
106_E340_D1.5911.00
446_I450_P1.5741.00
453_I456_G1.5551.00
436_V443_R1.5401.00
87_D90_V1.5391.00
437_V444_V1.5341.00
69_A74_I1.5211.00
479_F483_G1.5191.00
30_A34_K1.5171.00
108_L341_D1.5161.00
459_A462_H1.5091.00
373_N403_D1.5071.00
279_K282_G1.4971.00
23_P27_Q1.4921.00
458_V462_H1.4701.00
65_E69_A1.4671.00
444_V447_L1.4491.00
25_R29_L1.4461.00
37_L40_G1.4391.00
51_S55_E1.4381.00
96_V102_R1.4371.00
394_S414_A1.4331.00
67_S90_V1.4311.00
340_D343_G1.4251.00
479_F482_T1.4251.00
273_D276_S1.3981.00
92_R95_Y1.3841.00
27_Q31_T1.3791.00
435_K441_K1.3721.00
440_F443_R1.3671.00
108_L342_R1.3631.00
346_L368_R1.3621.00
377_V416_Q1.3571.00
29_L33_M1.3511.00
476_Q495_R1.3381.00
36_R39_E1.3341.00
500_E516_G1.3341.00
75_T86_R1.3331.00
278_L281_P1.3321.00
166_V198_R1.3241.00
360_T422_S1.3151.00
281_P303_I1.3081.00
373_N401_F1.2921.00
94_K97_A1.2861.00
97_A102_R1.2841.00
395_I413_F1.2801.00
86_R90_V1.2720.99
31_T35_Y1.2640.99
318_S321_G1.2630.99
434_P443_R1.2620.99
81_K85_R1.2600.99
259_V266_R1.2600.99
33_M37_L1.2590.99
438_R442_A1.2570.99
434_P442_A1.2450.99
340_D368_R1.2380.99
34_K38_E1.2360.99
34_K40_G1.2350.99
506_V509_E1.2210.99
377_V392_I1.2210.99
439_R443_R1.2170.99
36_R40_G1.2140.99
242_L277_V1.2070.99
265_D272_N1.2050.99
344_A433_I1.2040.99
367_V408_G1.1980.99
115_A224_V1.1860.99
85_R89_E1.1820.99
259_V321_G1.1820.99
80_A84_Y1.1800.99
75_T90_V1.1750.99
102_R105_K1.1720.99
443_R447_L1.1670.99
435_K438_R1.1660.99
377_V390_V1.1620.99
100_L103_R1.1610.99
126_T130_A1.1580.99
437_V443_R1.1490.99
353_Y412_T1.1490.99
310_P332_L1.1480.99
64_L86_R1.1470.99
24_D28_E1.1410.99
26_L29_L1.1400.99
312_F328_F1.1310.99
33_M38_E1.1270.99
135_R138_D1.1210.99
38_E41_D1.1210.99
464_Y472_F1.1170.99
29_L32_Q1.1140.99
354_N422_S1.1130.99
36_R41_D1.1120.99
25_R30_A1.1120.99
49_G52_D1.1110.99
402_V411_A1.1110.99
75_T79_N1.1110.99
476_Q481_R1.1050.99
37_L41_D1.1000.98
436_V442_A1.0980.98
271_V311_I1.0970.98
92_R103_R1.0970.98
27_Q35_Y1.0940.98
436_V441_K1.0930.98
447_L450_P1.0930.98
447_L451_T1.0930.98
322_L326_I1.0900.98
23_P28_E1.0890.98
233_G273_D1.0880.98
92_R96_V1.0860.98
101_V105_K1.0860.98
273_D278_L1.0830.98
23_P38_E1.0830.98
71_L85_R1.0770.98
67_S71_L1.0720.98
457_Y462_H1.0640.98
379_I416_Q1.0640.98
458_V461_L1.0570.98
80_A83_V1.0550.98
27_Q30_A1.0520.98
234_L311_I1.0490.98
243_A246_S1.0480.98
33_M36_R1.0460.98
59_L64_L1.0450.98
36_R42_G1.0430.98
35_Y38_E1.0380.98
38_E42_G1.0360.98
101_V104_Y1.0290.98
255_V314_I1.0280.98
226_L277_V1.0270.98
347_V429_M1.0270.98
438_R443_R1.0220.98
94_K103_R1.0190.98
83_V87_D1.0110.97
28_E33_M1.0110.97
114_V197_V1.0080.97
84_Y88_V1.0070.97
438_R444_V1.0050.97
96_V101_V1.0050.97
94_K98_E1.0040.97
27_Q39_E0.9990.97
85_R88_V0.9970.97
304_K313_K0.9930.97
30_A33_M0.9900.97
29_L35_Y0.9860.97
341_D370_K0.9840.97
478_G482_T0.9810.97
75_T87_D0.9810.97
35_Y39_E0.9800.97
63_Q66_E0.9790.97
61_K65_E0.9770.97
32_Q36_R0.9760.97
63_Q67_S0.9730.97
31_T39_E0.9720.97
396_Q401_F0.9690.97
224_V241_H0.9660.97
32_Q37_L0.9660.97
33_M39_E0.9650.97
81_K89_E0.9620.96
115_A250_F0.9580.96
66_E70_T0.9560.96
270_I273_D0.9540.96
354_N360_T0.9520.96
313_K316_N0.9510.96
94_K102_R0.9500.96
95_Y98_E0.9480.96
25_R33_M0.9460.96
274_I278_L0.9450.96
135_R323_D0.9450.96
395_I405_V0.9440.96
45_F48_I0.9420.96
115_A251_P0.9410.96
55_E58_G0.9400.96
117_M245_A0.9400.96
348_Y367_V0.9400.96
191_I194_T0.9390.96
130_A318_S0.9380.96
259_V313_K0.9330.96
26_L34_K0.9330.96
113_N365_S0.9320.96
97_A101_V0.9310.96
116_V322_L0.9300.96
94_K99_L0.9280.96
234_L238_G0.9280.96
350_D363_L0.9250.96
32_Q35_Y0.9210.95
24_D30_A0.9210.95
268_K272_N0.9200.95
434_P450_P0.9180.95
35_Y42_G0.9170.95
97_A103_R0.9150.95
92_R97_A0.9120.95
94_K101_V0.9120.95
97_A100_L0.9080.95
280_I303_I0.9040.95
275_K282_G0.9040.95
28_E35_Y0.9030.95
436_V447_L0.9010.95
87_D94_K0.9000.95
83_V90_V0.8960.95
345_P371_L0.8920.95
224_V245_A0.8920.95
29_L34_K0.8900.95
98_E101_V0.8810.94
131_L326_I0.8810.94
25_R32_Q0.8800.94
59_L63_Q0.8780.94
200_I210_R0.8750.94
25_R28_E0.8700.94
441_K447_L0.8660.94
26_L30_A0.8660.94
159_T162_I0.8660.94
440_F447_L0.8630.94
84_Y96_V0.8620.94
274_I277_V0.8580.93
457_Y461_L0.8580.93
79_N90_V0.8560.93
57_I60_S0.8540.93
97_A105_K0.8530.93
75_T78_V0.8530.93
31_T34_K0.8520.93
317_V320_K0.8500.93
319_G323_D0.8500.93
381_P445_F0.8450.93
98_E102_R0.8390.93
442_A445_F0.8390.93
313_K324_L0.8380.93
472_F495_R0.8370.93
241_H244_L0.8360.93
266_R313_K0.8360.93
44_A48_I0.8330.92
268_K313_K0.8290.92
481_R492_F0.8290.92
402_V405_V0.8270.92
29_L40_G0.8230.92
94_K105_K0.8230.92
44_A47_V0.8220.92
24_D36_R0.8210.92
275_K278_L0.8190.92
310_P313_K0.8190.92
96_V100_L0.8150.92
270_I274_I0.8120.91
282_G304_K0.8110.91
312_F324_L0.8100.91
62_G65_E0.8100.91
31_T42_G0.8070.91
34_K42_G0.8060.91
107_N340_D0.8050.91
439_R442_A0.8040.91
478_G481_R0.8030.91
377_V429_M0.8030.91
95_Y102_R0.8020.91
83_V86_R0.8010.91
26_L35_Y0.8000.91
92_R104_Y0.8000.91
135_R398_N0.8000.91
29_L36_R0.7990.91
99_L102_R0.7960.91
76_R90_V0.7950.91
209_L510_G0.7940.90
228_V234_L0.7940.90
382_N417_G0.7940.90
26_L31_T0.7920.90
100_L104_Y0.7920.90
49_G78_V0.7900.90
57_I68_I0.7870.90
49_G53_E0.7850.90
315_S318_S0.7830.90
99_L104_Y0.7820.90
29_L42_G0.7820.90
48_I56_I0.7810.90
67_S89_E0.7800.90
98_E103_R0.7790.90
274_I279_K0.7770.89
47_V80_A0.7760.89
29_L41_D0.7750.89
378_L432_G0.7740.89
53_E83_V0.7730.89
30_A42_G0.7720.89
274_I281_P0.7690.89
126_T137_D0.7690.89
31_T40_G0.7680.89
27_Q34_K0.7680.89
314_I317_V0.7670.89
99_L105_K0.7640.89
62_G69_A0.7640.89
441_K449_H0.7630.89
109_P337_K0.7620.89
34_K37_L0.7620.89
44_A50_V0.7550.88
283_I303_I0.7550.88
476_Q492_F0.7530.88
32_Q42_G0.7490.88
82_I90_V0.7470.88
435_K440_F0.7460.88
115_A221_V0.7460.88
62_G66_E0.7440.87
32_Q38_E0.7400.87
371_L413_F0.7380.87
402_V413_F0.7350.87
210_R478_G0.7330.87
457_Y460_T0.7330.87
79_N83_V0.7310.86
98_E104_Y0.7250.86
33_M40_G0.7250.86
45_F78_V0.7250.86
30_A37_L0.7230.86
281_P304_K0.7210.86
437_V442_A0.7200.86
25_R39_E0.7200.86
312_F321_G0.7160.85
27_Q32_Q0.7160.85
130_A134_G0.7150.85
357_G464_Y0.7150.85
23_P32_Q0.7110.85
461_L470_V0.7110.85
437_V450_P0.7090.85
25_R35_Y0.7080.85
48_I52_D0.7060.84
29_L39_E0.7050.84
383_K417_G0.7040.84
60_S332_L0.7040.84
73_M86_R0.7040.84
441_K445_F0.7030.84
65_E75_T0.7030.84
30_A40_G0.6990.84
45_F56_I0.6990.84
86_R89_E0.6980.84
29_L37_L0.6970.84
331_L334_P0.6970.84
69_A72_N0.6950.84
60_S63_Q0.6930.83
24_D32_Q0.6930.83
328_F332_L0.6900.83
25_R42_G0.6890.83
443_R446_I0.6890.83
92_R98_E0.6870.83
377_V413_F0.6850.83
51_S54_G0.6850.83
96_V104_Y0.6820.82
30_A39_E0.6820.82
390_V416_Q0.6810.82
206_E482_T0.6800.82
246_S278_L0.6800.82
283_I304_K0.6790.82
225_M253_F0.6790.82
35_Y40_G0.6790.82
75_T83_V0.6780.82
30_A35_Y0.6770.82
464_Y476_Q0.6770.82
93_D493_L0.6760.82
439_R491_Y0.6750.82
27_Q36_R0.6740.82
446_I449_H0.6740.82
93_D103_R0.6720.81
24_D31_T0.6720.81
82_I87_D0.6710.81
379_I382_N0.6700.81
82_I85_R0.6680.81
139_G155_L0.6680.81
92_R105_K0.6660.81
446_I451_T0.6660.81
33_M42_G0.6650.81
92_R99_L0.6650.81
442_A449_H0.6640.81
448_H451_T0.6630.81
438_R449_H0.6620.81
84_Y87_D0.6600.80
116_V329_L0.6600.80
25_R36_R0.6590.80
394_S401_F0.6580.80
346_L430_V0.6580.80
311_I316_N0.6570.80
264_E270_I0.6570.80
303_I310_P0.6560.80
243_A496_P0.6560.80
434_P446_I0.6550.80
86_R91_R0.6540.80
481_R484_D0.6540.80
67_S86_R0.6520.80
52_D55_E0.6500.79
458_V489_V0.6470.79
312_F315_S0.6470.79
100_L105_K0.6460.79
358_V361_V0.6450.79
228_V270_I0.6450.79
246_S277_V0.6440.79
271_V275_K0.6430.79
76_R83_V0.6420.78
119_H122_A0.6390.78
33_M41_D0.6390.78
96_V99_L0.6390.78
35_Y41_D0.6370.78
435_K446_I0.6340.78
24_D33_M0.6320.77
381_P448_H0.6310.77
504_I508_R0.6290.77
66_E69_A0.6280.77
247_V462_H0.6280.77
436_V444_V0.6270.77
366_V411_A0.6270.77
483_G487_E0.6270.77
237_M240_E0.6260.77
94_K104_Y0.6260.77
440_F450_P0.6250.77
345_P431_K0.6250.77
405_V409_N0.6250.77
32_Q39_E0.6250.77
34_K39_E0.6230.76
63_Q71_L0.6230.76
34_K41_D0.6230.76
437_V446_I0.6220.76
26_L33_M0.6220.76
75_T82_I0.6200.76
270_I278_L0.6200.76
121_N205_H0.6180.76
108_L339_L0.6180.76
77_L86_R0.6180.76
28_E38_E0.6180.76
268_K271_V0.6170.76
391_K416_Q0.6160.76
268_K305_T0.6130.75
80_A85_R0.6130.75
103_R106_E0.6130.75
480_L486_S0.6110.75
93_D98_E0.6100.75
26_L40_G0.6090.75
357_G361_V0.6070.75
27_Q42_G0.6070.75
82_I86_R0.6070.75
47_V77_L0.6050.74
23_P39_E0.6040.74
28_E34_K0.6030.74
49_G55_E0.6030.74
50_V71_L0.6010.74
393_K399_K0.6010.74
95_Y104_Y0.6010.74
23_P26_L0.6000.74
349_I379_I0.6000.74
223_Y333_P0.6000.74
371_L392_I0.5990.74
28_E42_G0.5990.74
230_A233_G0.5980.73
50_V64_L0.5970.73
445_F449_H0.5970.73
346_L428_V0.5960.73
309_V315_S0.5950.73
358_V414_A0.5940.73
326_I329_L0.5930.73
305_T309_V0.5920.73
399_K412_T0.5920.73
440_F445_F0.5910.73
23_P30_A0.5910.73
67_S76_R0.5910.73
92_R101_V0.5900.72
370_K404_S0.5890.72
462_H491_Y0.5890.72
80_A86_R0.5890.72
76_R86_R0.5870.72
333_P336_A0.5870.72
97_A104_Y0.5850.72
79_N86_R0.5850.72
117_M351_E0.5850.72
138_D317_V0.5840.72
92_R102_R0.5840.72
114_V199_L0.5840.72
120_V205_H0.5840.72
24_D38_E0.5830.72
23_P31_T0.5830.72
226_L274_I0.5790.71
48_I83_V0.5790.71
113_N220_E0.5780.71
128_T199_L0.5770.71
460_T491_Y0.5760.71
122_A232_D0.5750.71
230_A256_I0.5730.70
396_Q414_A0.5720.70
230_A264_E0.5710.70
347_V365_S0.5700.70
49_G54_G0.5700.70
27_Q37_L0.5690.70
79_N91_R0.5680.70
56_I80_A0.5680.70
345_P366_V0.5670.69
397_V402_V0.5660.69
70_T73_M0.5660.69
95_Y99_L0.5650.69
84_Y89_E0.5630.69
269_G278_L0.5630.69
275_K279_K0.5630.69
438_R446_I0.5620.69
46_Y49_G0.5610.69
313_K321_G0.5610.69
309_V313_K0.5600.69
88_V93_D0.5580.68
93_D97_A0.5580.68
37_L42_G0.5580.68
54_G58_G0.5560.68
67_S85_R0.5560.68
94_K100_L0.5560.68
445_F448_H0.5560.68
95_Y101_V0.5550.68
116_V134_G0.5540.68
320_K324_L0.5510.67
271_V281_P0.5510.67
452_T511_R0.5500.67
484_D489_V0.5500.67
27_Q38_E0.5500.67
310_P335_E0.5490.67
75_T80_A0.5480.67
435_K442_A0.5480.67
30_A36_R0.5470.67
279_K283_I0.5470.67
362_V415_I0.5440.66
24_D39_E0.5440.66
196_I409_N0.5430.66
512_T515_V0.5400.66
117_M163_T0.5400.66
225_M255_V0.5390.66
32_Q41_D0.5380.65
444_V448_H0.5380.65
436_V446_I0.5360.65
95_Y103_R0.5340.65
230_A266_R0.5330.65
324_L327_K0.5330.65
102_R340_D0.5320.65
116_V398_N0.5320.65
93_D102_R0.5320.65
377_V417_G0.5310.64
127_V325_L0.5310.64
311_I315_S0.5290.64
279_K309_V0.5290.64
157_G232_D0.5280.64
96_V103_R0.5280.64
31_T36_R0.5270.64
93_D96_V0.5270.64
30_A38_E0.5250.64
50_V73_M0.5240.63
30_A41_D0.5240.63
193_S513_R0.5230.63
51_S67_S0.5230.63
159_T163_T0.5220.63
60_S70_T0.5220.63
439_R445_F0.5210.63
46_Y80_A0.5190.63
306_R309_V0.5180.63
77_L81_K0.5170.62
53_E60_S0.5170.62
309_V328_F0.5170.62
131_L135_R0.5160.62
62_G73_M0.5160.62
85_R91_R0.5150.62
165_R198_R0.5140.62
480_L488_I0.5130.62
119_H238_G0.5130.62
43_E47_V0.5120.62
46_Y52_D0.5110.62
46_Y50_V0.5110.62
45_F80_A0.5080.61
413_F416_Q0.5080.61
464_Y514_G0.5060.61
77_L80_A0.5060.61
68_I73_M0.5050.61
29_L38_E0.5040.60
352_I469_A0.5040.60
435_K443_R0.5030.60
23_P34_K0.5020.60
273_D277_V0.5020.60
52_D56_I0.5010.60
255_V325_L0.5010.60
440_F446_I0.5000.60
440_F449_H0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcaA 1 0.6424 100 0.466 Contact Map
4crnP 1 0.7247 100 0.467 Contact Map
1f60A 1 0.7285 100 0.468 Contact Map
4d61i 1 0.7208 100 0.473 Contact Map
1jnyA 1 0.7017 100 0.475 Contact Map
3wy9A 1 0.7094 100 0.476 Contact Map
1r5bA 1 0.6845 100 0.482 Contact Map
1d2eA 3 0.6979 100 0.486 Contact Map
3avxA 1 0.8317 100 0.489 Contact Map
3p26A 1 0.7304 100 0.491 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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