GREMLIN Database
Q97W16 - Uncharacterized protein
UniProt: Q97W16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (137)
Sequences: 998 (693)
Seq/√Len: 59.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_K95_D4.7611.00
8_S96_G3.2501.00
14_D18_K3.2061.00
12_T15_Q3.0121.00
65_E75_I2.8871.00
94_L99_N2.7901.00
11_A16_I2.7701.00
6_S97_K2.7451.00
6_S99_N2.6281.00
9_I98_I2.6251.00
48_V55_K2.6231.00
21_D72_R2.4181.00
13_K70_N2.3851.00
28_Q136_R2.3061.00
10_N134_K2.2931.00
2_K103_D2.1201.00
84_N107_A2.0331.00
132_C136_R2.0311.00
77_K86_D2.0081.00
92_E99_N1.9481.00
66_K90_I1.9231.00
8_S97_K1.9191.00
34_K57_E1.8811.00
38_K41_E1.8331.00
73_K90_I1.8331.00
66_K73_K1.8020.99
7_I98_I1.7580.99
37_S44_K1.7480.99
94_L97_K1.7220.99
50_G55_K1.7210.99
71_K92_E1.7150.99
25_Q136_R1.7060.99
39_E42_E1.7050.99
2_K101_S1.6490.99
133_I137_V1.6250.99
66_K71_K1.5650.98
15_Q18_K1.5260.98
34_K46_V1.5250.98
68_D71_K1.5140.98
92_E101_S1.4360.97
51_I56_G1.4300.97
4_E101_S1.3770.97
33_I36_F1.3370.96
24_D27_A1.2990.95
21_D69_D1.2890.95
71_K90_I1.2850.95
115_A120_S1.2750.95
34_K48_V1.1760.92
61_N79_T1.1340.91
24_D28_Q1.1200.90
58_Y82_N1.0680.88
3_Y102_A1.0600.87
14_D69_D1.0350.86
3_Y23_P1.0310.86
5_G100_Y1.0200.85
42_E63_R0.9900.83
70_N95_D0.9890.83
60_A121_A0.9800.83
13_K93_A0.9720.82
49_T125_I0.9460.81
53_F129_L0.9380.80
32_G60_A0.9320.80
47_G51_I0.9280.79
56_G110_L0.9180.78
19_L25_Q0.9150.78
3_Y119_G0.9070.78
64_F106_V0.9040.77
20_L133_I0.9030.77
49_T121_A0.8980.77
53_F112_S0.8950.77
24_D38_K0.8940.77
81_M89_A0.8880.76
44_K61_N0.8880.76
26_V130_F0.8800.75
60_A85_V0.8780.75
48_V74_I0.8760.75
87_I117_L0.8760.75
49_T103_D0.8710.75
56_G109_V0.8650.74
40_G127_N0.8560.73
56_G112_S0.8550.73
43_Y49_T0.8540.73
29_C35_S0.8530.73
48_V57_E0.8460.73
42_E61_N0.8370.72
46_V59_R0.8300.71
18_K69_D0.8160.70
72_R91_A0.7900.67
50_G53_F0.7860.67
80_G113_V0.7860.67
122_V125_I0.7780.66
61_N77_K0.7780.66
119_G123_E0.7550.64
55_K76_A0.7530.64
21_D64_F0.7510.63
106_V118_M0.7510.63
87_I121_A0.7470.63
17_L72_R0.7470.63
93_A96_G0.7370.62
12_T16_I0.7360.62
115_A134_K0.7280.61
35_S41_E0.7250.61
5_G107_A0.7210.60
87_I102_A0.7200.60
116_R120_S0.7180.60
15_Q137_V0.7170.60
104_V126_I0.7150.60
20_L129_L0.7140.59
7_I132_C0.7110.59
58_Y83_S0.7070.59
63_R75_I0.6930.57
76_A85_V0.6910.57
4_E135_E0.6830.56
70_N93_A0.6780.56
27_A133_I0.6760.55
113_V118_M0.6740.55
33_I100_Y0.6730.55
56_G82_N0.6720.55
127_N131_N0.6710.55
7_I127_N0.6660.54
14_D70_N0.6620.54
47_G106_V0.6480.52
14_D41_E0.6420.52
46_V57_E0.6400.51
56_G80_G0.6330.51
119_G122_V0.6320.50
29_C112_S0.6310.50
40_G43_Y0.6300.50
65_E101_S0.6300.50
50_G110_L0.6280.50
19_L30_F0.6270.50
91_A98_I0.6260.50
81_M113_V0.6260.50
7_I49_T0.6230.49
56_G76_A0.6180.49
22_N25_Q0.6180.49
37_S133_I0.6160.49
76_A87_I0.6150.49
112_S115_A0.6130.48
97_K110_L0.6100.48
100_Y116_R0.6090.48
53_F117_L0.6080.48
73_K103_D0.6070.48
31_P128_D0.6050.47
25_Q28_Q0.6020.47
27_A33_I0.6000.47
114_G122_V0.5980.47
37_S63_R0.5940.46
90_I101_S0.5940.46
57_E97_K0.5930.46
21_D134_K0.5890.46
36_F46_V0.5890.46
58_Y110_L0.5870.45
70_N96_G0.5830.45
21_D67_I0.5810.45
6_S94_L0.5800.45
76_A112_S0.5730.44
23_P62_V0.5720.44
105_K133_I0.5660.43
26_V83_S0.5630.43
66_K72_R0.5590.42
69_D93_A0.5580.42
105_K135_E0.5570.42
36_F85_V0.5530.42
61_N135_E0.5530.42
122_V130_F0.5500.41
102_A112_S0.5500.41
127_N134_K0.5490.41
9_I131_N0.5490.41
128_D132_C0.5480.41
35_S45_V0.5460.41
24_D95_D0.5450.41
45_V76_A0.5450.41
83_S93_A0.5380.40
132_C135_E0.5370.40
72_R84_N0.5340.40
27_A59_R0.5330.40
58_Y84_N0.5300.39
128_D131_N0.5290.39
52_G111_A0.5280.39
76_A102_A0.5270.39
55_K115_A0.5250.39
23_P107_A0.5250.39
27_A35_S0.5230.38
47_G126_I0.5230.38
16_I19_L0.5230.38
23_P130_F0.5210.38
107_A120_S0.5200.38
37_S103_D0.5200.38
80_G130_F0.5180.38
20_L86_D0.5160.38
13_K17_L0.5160.38
9_I133_I0.5120.37
45_V104_V0.5120.37
8_S137_V0.5100.37
115_A119_G0.5100.37
23_P100_Y0.5100.37
5_G17_L0.5090.37
82_N85_V0.5090.37
87_I129_L0.5030.36
90_I103_D0.5030.36
38_K42_E0.5020.36
56_G89_A0.5020.36
67_I72_R0.5010.36
36_F117_L0.5010.36
10_N65_E0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pcsA 1 1 99.7 0.555 Contact Map
2ns9A 2 1 99.7 0.566 Contact Map
3p9vA 2 0.9784 99.3 0.672 Contact Map
3ggnA 2 0.8849 99.2 0.687 Contact Map
2d4rA 4 0.9712 99.1 0.696 Contact Map
1t17A 1 0.9712 99.1 0.701 Contact Map
3tl1A 1 0.9712 98.7 0.741 Contact Map
3tfzA 2 0.9712 98.7 0.744 Contact Map
3f08A 2 0.9209 98.6 0.747 Contact Map
3ijtA 2 0.9137 98.6 0.747 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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