GREMLIN Database
Q97W15 - Uncharacterized protein
UniProt: Q97W15 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (178)
Sequences: 8296 (6312)
Seq/√Len: 473.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_T36_R4.8161.00
4_G87_Y3.0741.00
21_L95_G2.7051.00
16_F23_A2.6571.00
29_P32_M2.6551.00
5_V38_Y2.5531.00
6_I80_G2.5501.00
43_K62_I2.4241.00
5_V41_L2.4151.00
89_A112_F2.2641.00
101_T171_V2.2281.00
104_D171_V2.2131.00
177_K180_D2.1431.00
4_G43_K2.0841.00
112_F119_V2.0811.00
38_Y93_A2.0791.00
23_A181_L1.9221.00
175_I184_L1.8701.00
28_T33_R1.8521.00
140_E156_K1.8041.00
6_I90_V1.7671.00
94_L97_M1.7391.00
99_F184_L1.7171.00
32_M36_R1.7131.00
118_A157_I1.6941.00
71_E75_T1.6921.00
50_Y53_E1.6811.00
40_D102_K1.6781.00
4_G84_F1.6711.00
28_T32_M1.6491.00
93_A105_V1.6271.00
91_L105_V1.6231.00
82_R142_E1.5691.00
84_F90_V1.5441.00
66_N75_T1.5231.00
12_E70_N1.5141.00
101_T104_D1.5141.00
140_E157_I1.4911.00
149_G152_V1.4781.00
32_M57_L1.4521.00
120_I127_R1.4471.00
51_V55_L1.4401.00
122_T164_F1.4301.00
37_I102_K1.3831.00
102_K106_N1.3781.00
77_L92_V1.3711.00
81_L142_E1.3651.00
173_I183_R1.3451.00
93_A100_V1.3401.00
173_I184_L1.3331.00
90_V134_S1.3171.00
7_I35_I1.3101.00
13_G18_G1.2961.00
180_D183_R1.2631.00
45_I83_F1.2431.00
140_E143_K1.2351.00
116_C163_C1.2301.00
153_I157_I1.2161.00
81_L90_V1.2121.00
25_I30_I1.2061.00
19_D50_Y1.1931.00
30_I175_I1.1911.00
75_T78_K1.1881.00
4_G45_I1.1801.00
140_E153_I1.1781.00
55_L65_Y1.1741.00
29_P57_L1.1551.00
81_L138_F1.1441.00
47_V80_G1.1211.00
25_I184_L1.1181.00
89_A134_S1.1141.00
135_K138_F1.1121.00
68_F71_E1.1101.00
39_G60_D1.1061.00
71_E148_V1.0991.00
45_I64_I1.0991.00
151_R155_N1.0841.00
126_E130_P1.0771.00
137_L140_E1.0711.00
26_D33_R1.0641.00
127_R164_F1.0621.00
24_K29_P1.0421.00
16_F178_K1.0321.00
53_E56_P1.0311.00
24_K27_N1.0241.00
139_N142_E1.0151.00
133_I136_S1.0121.00
163_C166_E1.0111.00
111_T114_P1.0111.00
117_K134_S1.0071.00
134_S138_F1.0061.00
7_I38_Y1.0031.00
7_I34_T1.0031.00
6_I47_V0.9961.00
48_G51_V0.9961.00
122_T166_E0.9921.00
62_I83_F0.9881.00
106_N110_N0.9851.00
108_I119_V0.9811.00
78_K82_R0.9801.00
175_I181_L0.9791.00
182_M185_R0.9771.00
6_I92_V0.9771.00
110_N114_P0.9761.00
77_L150_A0.9751.00
75_T79_L0.9741.00
107_K110_N0.9711.00
29_P33_R0.9581.00
62_I65_Y0.9551.00
18_G178_K0.9521.00
116_C119_V0.9481.00
123_H128_G0.9361.00
181_L185_R0.9311.00
139_N143_K0.9311.00
89_A113_K0.9301.00
78_K142_E0.9291.00
9_A46_I0.8991.00
34_T37_I0.8931.00
39_G44_I0.8911.00
30_I95_G0.8841.00
122_T125_G0.8831.00
117_K136_S0.8811.00
33_R37_I0.8791.00
13_G21_L0.8761.00
107_K111_T0.8711.00
22_L57_L0.8691.00
89_A132_L0.8591.00
144_L147_D0.8511.00
111_T163_C0.8491.00
118_A154_L0.8481.00
64_I79_L0.8431.00
37_I40_D0.8431.00
77_L94_L0.8421.00
144_L153_I0.8401.00
91_L109_I0.8351.00
51_V65_Y0.8331.00
35_I44_I0.8251.00
152_V155_N0.8251.00
143_K156_K0.8141.00
48_G70_N0.8131.00
133_I141_I0.8131.00
32_M59_M0.8081.00
136_S139_N0.8061.00
45_I62_I0.8011.00
109_I112_F0.7961.00
26_D185_R0.7921.00
18_G21_L0.7911.00
84_F87_Y0.7861.00
74_S144_L0.7841.00
61_Q64_I0.7751.00
31_I58_L0.7641.00
112_F134_S0.7631.00
35_I61_Q0.7621.00
167_C171_V0.7601.00
30_I34_T0.7581.00
18_G23_A0.7571.00
23_A178_K0.7531.00
111_T165_I0.7501.00
68_F75_T0.7481.00
48_G69_W0.7471.00
69_W75_T0.7471.00
7_I31_I0.7401.00
112_F132_L0.7391.00
72_G75_T0.7371.00
49_K69_W0.7331.00
137_L157_I0.7301.00
103_E106_N0.7211.00
90_V138_F0.7181.00
35_I39_G0.7131.00
170_G173_I0.7101.00
66_N79_L0.7091.00
108_I121_P0.7041.00
109_I113_K0.7041.00
108_I132_L0.7041.00
179_E182_M0.6981.00
117_K158_K0.6911.00
13_G19_D0.6831.00
179_E183_R0.6811.00
4_G88_D0.6811.00
31_I35_I0.6771.00
167_C172_L0.6731.00
132_L153_I0.6721.00
88_D135_K0.6711.00
55_L63_V0.6701.00
6_I45_I0.6681.00
111_T119_V0.6661.00
48_G54_M0.6651.00
24_K28_T0.6621.00
52_N55_L0.6591.00
147_D152_V0.6571.00
140_E144_L0.6571.00
138_F142_E0.6571.00
13_G181_L0.6531.00
127_R130_P0.6531.00
74_S78_K0.6521.00
34_T38_Y0.6511.00
106_N109_I0.6511.00
34_T93_A0.6501.00
99_F173_I0.6481.00
85_K88_D0.6481.00
178_K182_M0.6451.00
138_F144_L0.6411.00
148_V152_V0.6391.00
70_N75_T0.6391.00
66_N76_S0.6351.00
133_I137_L0.6331.00
6_I84_F0.6291.00
19_D22_L0.6270.99
11_G15_R0.6260.99
117_K120_I0.6210.99
107_K165_I0.6210.99
25_I185_R0.6180.99
24_K185_R0.6140.99
162_L165_I0.6130.99
120_I154_L0.6130.99
91_L132_L0.6100.99
73_I76_S0.6100.99
87_Y135_K0.6090.99
12_E69_W0.6070.99
41_L44_I0.6060.99
4_G90_V0.6050.99
41_L91_L0.6020.99
74_S141_I0.5950.99
43_K87_Y0.5910.99
45_I84_F0.5890.99
60_D63_V0.5860.99
36_R59_M0.5860.99
51_V66_N0.5860.99
141_I153_I0.5860.99
103_E107_K0.5850.99
116_C134_S0.5850.99
16_F181_L0.5840.99
38_Y41_L0.5820.99
162_L167_C0.5770.99
151_R154_L0.5770.99
134_S137_L0.5740.99
97_M172_L0.5690.99
43_K85_K0.5670.99
54_M57_L0.5640.99
21_L31_I0.5610.99
117_K121_P0.5590.99
141_I144_L0.5570.99
5_V34_T0.5570.99
144_L156_K0.5570.99
122_T127_R0.5550.99
123_H169_E0.5530.99
169_E172_L0.5480.99
94_L129_N0.5470.99
150_A153_I0.5450.99
163_C167_C0.5430.99
36_R39_G0.5410.99
97_M129_N0.5300.98
66_N69_W0.5280.98
10_A73_I0.5280.98
104_D121_P0.5240.98
144_L152_V0.5220.98
155_N158_K0.5210.98
94_L130_P0.5180.98
78_K81_L0.5170.98
136_S140_E0.5130.98
135_K139_N0.5120.98
117_K137_L0.5090.98
53_E57_L0.5050.98
50_Y54_M0.5010.98
47_V64_I0.5010.98
39_G59_M0.5000.98
51_V54_M0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d5nA 2 0.9524 100 0.24 Contact Map
2weeA 1 0.9788 100 0.267 Contact Map
2wawA 1 0.9894 100 0.27 Contact Map
1e5kA 1 0.9365 100 0.318 Contact Map
2e8bA 1 0.8942 100 0.325 Contact Map
3ngwA 2 0.9471 100 0.327 Contact Map
2px7A 2 0.9153 100 0.417 Contact Map
2xwlA 2 0.9735 99.9 0.448 Contact Map
1vpaA 2 0.9683 99.9 0.458 Contact Map
1w55A 4 0.9683 99.9 0.459 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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