GREMLIN Database
Q97W14 - Carbon monoxide dehydrogenase, small chain (CutC-1)
UniProt: Q97W14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (149)
Sequences: 6873 (4038)
Seq/√Len: 330.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_K158_L4.1111.00
132_E157_K3.8351.00
95_H121_Y2.7791.00
18_K81_E2.6741.00
131_T134_E2.5331.00
45_G85_I2.5161.00
26_V37_V2.5121.00
135_I157_K2.5011.00
63_D80_A2.4091.00
99_E103_E2.2701.00
104_K154_E2.2501.00
16_H25_E2.0611.00
120_A156_V2.0431.00
59_T66_S1.9721.00
35_V48_I1.9661.00
53_S71_T1.9661.00
18_K23_D1.9511.00
32_R37_V1.9291.00
62_M67_V1.9091.00
121_Y125_K1.8961.00
37_V74_A1.8881.00
103_E158_L1.8571.00
43_F46_V1.8351.00
16_H23_D1.8161.00
97_I117_I1.7981.00
62_M72_I1.7711.00
61_I118_M1.7531.00
127_N134_E1.7211.00
136_R153_I1.6841.00
14_K27_E1.6791.00
85_I117_I1.6541.00
48_I51_D1.5951.00
99_E162_K1.5581.00
45_G86_E1.4951.00
73_L76_E1.4591.00
20_N86_E1.4281.00
97_I121_Y1.4161.00
66_S122_W1.4011.00
61_I122_W1.3661.00
20_N43_F1.3621.00
158_L162_K1.3251.00
14_K25_E1.3171.00
59_T118_M1.2991.00
83_T87_G1.2971.00
34_L60_V1.2811.00
122_W126_E1.2651.00
123_L138_G1.2641.00
19_V41_L1.2521.00
139_I156_V1.2501.00
61_I121_Y1.2471.00
116_M139_I1.2381.00
17_L24_Y1.2361.00
28_T74_A1.2261.00
90_K93_K1.2211.00
72_I77_A1.2041.00
132_E154_E1.2041.00
127_N130_P1.2011.00
106_G155_A1.1971.00
67_V72_I1.1901.00
97_I120_A1.1821.00
62_M82_I1.1811.00
130_P160_S1.1491.00
94_L98_Q1.1431.00
62_M80_A1.1391.00
34_L82_I1.1271.00
101_F113_T1.1261.00
37_V41_L1.1131.00
150_Q154_E1.1111.00
19_V24_Y1.0701.00
151_N154_E1.0561.00
97_I159_A1.0551.00
88_L121_Y1.0481.00
15_V78_D1.0341.00
29_E32_R1.0321.00
89_A94_L1.0251.00
119_E141_G0.9931.00
34_L77_A0.9931.00
132_E136_R0.9921.00
62_M77_A0.9761.00
35_V46_V0.9751.00
115_G142_N0.9711.00
95_H98_Q0.9401.00
132_E153_I0.9261.00
33_L36_H0.9181.00
46_V85_I0.9171.00
26_V41_L0.9141.00
124_L160_S0.9011.00
65_R126_E0.8951.00
43_F86_E0.8951.00
63_D81_E0.8931.00
83_T125_K0.8871.00
66_S119_E0.8791.00
93_K99_E0.8651.00
60_V69_S0.8601.00
38_L60_V0.8571.00
19_V43_F0.8561.00
103_E162_K0.8501.00
91_D94_L0.8421.00
101_F117_I0.8411.00
153_I157_K0.8381.00
106_G113_T0.8331.00
97_I124_L0.8291.00
21_G24_Y0.8251.00
77_A80_A0.8241.00
61_I83_T0.8211.00
100_A158_L0.8201.00
21_G81_E0.8071.00
158_L161_E0.8041.00
96_P159_A0.7991.00
89_A92_G0.7981.00
88_L117_I0.7861.00
32_R40_E0.7851.00
89_A93_K0.7841.00
120_A139_I0.7831.00
16_H78_D0.7811.00
116_M152_I0.7801.00
72_I76_E0.7801.00
101_F120_A0.7781.00
133_E136_R0.7751.00
28_T37_V0.7741.00
126_E138_G0.7721.00
123_L130_P0.7510.99
17_L26_V0.7490.99
133_E137_E0.7410.99
89_A98_Q0.7390.99
33_L48_I0.7270.99
130_P138_G0.7230.99
104_K155_A0.7170.99
119_E138_G0.7170.99
100_A159_A0.7090.99
20_N87_G0.7030.99
51_D54_N0.6980.99
32_R74_A0.6980.99
36_H48_I0.6940.99
31_R75_V0.6920.99
123_L135_I0.6910.99
66_S138_G0.6900.99
101_F106_G0.6900.99
116_M142_N0.6820.99
44_T114_P0.6800.99
159_A162_K0.6800.99
134_E138_G0.6780.99
124_L159_A0.6780.99
135_I153_I0.6770.99
47_H114_P0.6750.99
35_V49_G0.6740.99
101_F116_M0.6730.99
17_L37_V0.6700.99
105_H147_T0.6670.99
116_M148_G0.6660.99
105_H148_G0.6650.99
33_L73_L0.6590.99
154_E158_L0.6590.99
15_V28_T0.6590.99
55_C58_C0.6540.99
36_H40_E0.6510.99
61_I66_S0.6460.98
127_N138_G0.6440.98
83_T121_Y0.6400.98
107_L113_T0.6400.98
88_L118_M0.6350.98
24_Y41_L0.6350.98
68_K72_I0.6330.98
94_L102_W0.6260.98
50_C58_C0.6230.98
50_C55_C0.6210.98
119_E142_N0.6190.98
101_F107_L0.6180.98
38_L41_L0.6150.98
92_G96_P0.6110.98
123_L128_P0.6090.98
40_E44_T0.6050.98
105_H151_N0.6030.98
44_T47_H0.6020.98
135_I156_V0.5970.97
72_I80_A0.5960.97
38_L44_T0.5930.97
124_L130_P0.5920.97
64_G81_E0.5890.97
92_G98_Q0.5880.97
64_G80_A0.5810.97
59_T119_E0.5800.97
38_L46_V0.5780.97
123_L127_N0.5780.97
52_T68_K0.5750.97
129_N161_E0.5750.97
102_W107_L0.5730.97
28_T32_R0.5710.97
24_Y37_V0.5670.97
61_I125_K0.5640.96
141_G149_Y0.5640.96
33_L52_T0.5620.96
59_T142_N0.5620.96
92_G95_H0.5610.96
147_T150_Q0.5580.96
74_A77_A0.5570.96
50_C70_C0.5510.96
55_C70_C0.5460.96
30_P75_V0.5460.96
124_L127_N0.5430.96
54_N68_K0.5410.95
15_V74_A0.5410.95
48_I54_N0.5390.95
58_C70_C0.5380.95
32_R36_H0.5320.95
130_P134_E0.5310.95
90_K94_L0.5260.95
47_H68_K0.5240.95
99_E102_W0.5190.94
88_L95_H0.5180.94
87_G94_L0.5160.94
15_V75_V0.5150.94
34_L72_I0.5150.94
124_L128_P0.5110.94
17_L77_A0.5100.94
33_L51_D0.5090.94
17_L78_D0.5090.94
64_G125_K0.5090.94
19_V38_L0.5080.94
48_I111_Y0.5050.94
68_K119_E0.5030.93
107_L148_G0.5020.93
95_H99_E0.5010.93
19_V82_I0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uncA 2 0.8713 100 0.089 Contact Map
3zyvA 3 0.8772 100 0.097 Contact Map
2w3sA 1 0.9064 100 0.131 Contact Map
3nvwA 1 0.883 100 0.136 Contact Map
1dgjA 1 0.9357 100 0.157 Contact Map
4usaA 2 0.9357 100 0.169 Contact Map
1n62A 1 0.9298 100 0.217 Contact Map
3hrdD 1 0.9298 100 0.225 Contact Map
1t3qA 1 0.9415 100 0.269 Contact Map
1rm6C 1 0.9123 100 0.275 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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