Q97W13 - SULSO - GREMLIN Contacts

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Q97W13 - Carbon monoxide dehydrogenase, medium chain. (CutB-1)

UniProt:	Q97W13	Sequences: MYPPKFSYVIPDNVKEALEFLETHDDAKPLAGGHSLIPMLKLRIFRPSYLVEIRRLPELKYIKMEGNVVKIGPIVTHYDIIKANIPLLSETASKIADPQVRNMGTIGGSISHLDPSADYPAALIAMNAKVRIRSTKGERVENFSSFAKDMFTPDLNPGELVTEIEVPLLKDYKFSYQKLERRAGDFAIVGVAVALKVNGDVIEDARIGLTAVNKTAVRASEAEKILLSGKISEKLIEEAATKAMDYANPTSDIRGSAEYKKKMVKVMTKRAILAALNR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	278 (269)
Sequences:	5954 (4099)
Seq/√Len:	249.9

ECOLI - XDHB YAGS YGFM
BACSU - XDHC
SULSO - Q97W13 Q97VI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
218_R	223_E	3.672	1.00
129_K	140_V	3.668	1.00
70_K	163_E	3.353	1.00
131_R	165_E	3.313	1.00
131_R	163_E	2.970	1.00
132_I	141_E	2.936	1.00
139_R	159_E	2.767	1.00
61_Y	75_V	2.702	1.00
111_S	161_V	2.502	1.00
21_L	29_P	2.385	1.00
204_D	227_L	2.318	1.00
140_V	165_E	2.314	1.00
68_V	165_E	2.241	1.00
142_N	145_S	2.150	1.00
131_R	138_E	2.119	1.00
64_M	168_L	2.109	1.00
241_T	265_K	2.106	1.00
60_K	79_D	2.089	1.00
196_K	203_E	2.054	1.00
75_V	80_I	2.005	1.00
10_I	55_R	1.915	1.00
9_V	49_Y	1.914	1.00
133_R	138_E	1.909	1.00
13_N	16_E	1.894	1.00
131_R	140_V	1.882	1.00
196_K	204_D	1.837	1.00
130_V	161_V	1.830	1.00
132_I	155_L	1.814	1.00
78_Y	102_N	1.813	1.00
69_V	81_I	1.796	1.00
133_R	162_T	1.782	1.00
141_E	154_D	1.775	1.00
127_N	144_S	1.771	1.00
12_D	16_E	1.767	1.00
70_K	165_E	1.754	1.00
76_T	79_D	1.743	1.00
53_I	74_I	1.741	1.00
15_K	133_R	1.731	1.00
19_E	23_T	1.725	1.00
64_M	84_N	1.702	1.00
198_N	203_E	1.700	1.00
225_I	242_K	1.677	1.00
237_E	269_K	1.664	1.00
179_L	263_M	1.652	1.00
202_I	205_A	1.627	1.00
9_V	20_F	1.613	1.00
71_I	80_I	1.598	1.00
129_K	165_E	1.598	1.00
63_K	70_K	1.584	1.00
190_G	210_T	1.566	1.00
118_D	178_K	1.550	1.00
21_L	51_V	1.546	1.00
107_G	161_V	1.535	1.00
129_K	142_N	1.529	1.00
113_L	153_P	1.515	1.00
136_K	158_G	1.508	1.00
29_P	160_L	1.497	1.00
221_E	246_Y	1.493	1.00
177_Q	274_A	1.479	1.00
231_I	236_I	1.473	1.00
24_H	49_Y	1.472	1.00
68_V	168_L	1.457	1.00
209_L	219_A	1.455	1.00
224_K	227_L	1.455	1.00
136_K	156_N	1.440	1.00
130_V	143_F	1.433	1.00
225_I	235_L	1.426	1.00
172_Y	194_A	1.402	1.00
144_S	220_S	1.393	1.00
30_L	50_L	1.391	1.00
148_K	154_D	1.381	1.00
29_P	53_I	1.378	1.00
233_E	273_L	1.377	1.00
26_D	48_S	1.375	1.00
193_V	207_I	1.361	1.00
20_F	51_V	1.356	1.00
17_A	160_L	1.335	1.00
193_V	271_A	1.332	1.00
14_V	160_L	1.332	1.00
221_E	224_K	1.327	1.00
262_K	266_V	1.325	1.00
18_L	134_S	1.315	1.00
177_Q	270_R	1.310	1.00
195_L	205_A	1.300	1.00
121_A	210_T	1.296	1.00
209_L	264_V	1.286	1.00
233_E	237_E	1.271	1.00
7_S	49_Y	1.262	1.00
14_V	133_R	1.259	1.00
138_E	162_T	1.257	1.00
28_K	45_F	1.256	1.00
124_I	143_F	1.256	1.00
31_A	74_I	1.256	1.00
84_N	168_L	1.252	1.00
77_H	104_G	1.233	1.00
77_H	119_Y	1.229	1.00
197_V	200_D	1.217	1.00
54_R	76_T	1.215	1.00
21_L	158_G	1.206	1.00
110_I	164_I	1.205	1.00
173_K	275_A	1.204	1.00
229_G	238_E	1.203	1.00
219_A	222_A	1.198	1.00
70_K	131_R	1.188	1.00
57_P	60_K	1.179	1.00
27_A	51_V	1.173	1.00
67_N	168_L	1.173	1.00
244_M	265_K	1.158	1.00
8_Y	52_E	1.154	1.00
238_E	241_T	1.152	1.00
60_K	76_T	1.151	1.00
18_L	133_R	1.149	1.00
117_A	120_P	1.149	1.00
106_I	164_I	1.148	1.00
251_S	258_E	1.138	1.00
11_P	53_I	1.137	1.00
10_I	52_E	1.137	1.00
220_S	224_K	1.133	1.00
232_S	235_L	1.131	1.00
172_Y	196_K	1.129	1.00
18_L	135_T	1.124	1.00
269_K	273_L	1.118	1.00
205_A	227_L	1.105	1.00
16_E	19_E	1.102	1.00
125_A	208_G	1.099	1.00
195_L	202_I	1.099	1.00
18_L	160_L	1.096	1.00
225_I	229_G	1.095	1.00
71_I	166_V	1.093	1.00
221_E	245_D	1.088	1.00
11_P	16_E	1.083	1.00
180_E	185_D	1.081	1.00
91_T	122_A	1.072	1.00
148_K	152_T	1.068	1.00
111_S	146_F	1.068	1.00
229_G	235_L	1.067	1.00
62_I	75_V	1.061	1.00
88_L	119_Y	1.052	1.00
80_I	106_I	1.043	1.00
201_V	230_K	1.040	1.00
243_A	268_T	1.038	1.00
236_I	240_A	1.038	1.00
65_E	70_K	1.036	1.00
132_I	159_E	1.035	1.00
249_P	261_K	1.034	1.00
90_E	274_A	1.029	1.00
179_L	267_M	1.027	1.00
14_V	18_L	1.024	1.00
134_S	137_G	1.014	1.00
16_E	20_F	1.014	1.00
226_L	239_A	1.014	1.00
30_L	33_G	1.013	1.00
31_A	105_T	1.010	1.00
222_A	242_K	1.008	1.00
77_H	95_I	1.006	1.00
73_P	107_G	1.006	1.00
29_P	51_V	1.004	1.00
110_I	123_L	1.003	1.00
61_Y	163_E	0.998	1.00
202_I	231_I	0.997	1.00
242_K	245_D	0.992	1.00
209_L	212_V	0.989	1.00
120_P	147_A	0.977	1.00
225_I	238_E	0.968	1.00
207_I	222_A	0.966	1.00
95_I	104_G	0.963	1.00
251_S	257_A	0.960	1.00
222_A	246_Y	0.956	1.00
123_L	130_V	0.954	1.00
88_L	122_A	0.951	1.00
238_E	242_K	0.950	1.00
175_S	274_A	0.942	1.00
257_A	261_K	0.937	1.00
234_K	238_E	0.937	1.00
68_V	167_P	0.934	1.00
156_N	159_E	0.930	1.00
15_K	58_E	0.929	1.00
249_P	258_E	0.926	1.00
171_D	196_K	0.925	1.00
205_A	226_L	0.919	1.00
266_V	270_R	0.917	1.00
77_H	92_A	0.915	1.00
60_K	74_I	0.897	1.00
78_Y	98_P	0.895	1.00
240_A	269_K	0.890	1.00
194_A	206_R	0.889	1.00
177_Q	271_A	0.886	1.00
76_T	105_T	0.884	1.00
14_V	58_E	0.872	1.00
230_K	235_L	0.867	0.99
262_K	265_K	0.866	0.99
255_G	260_K	0.864	0.99
22_E	158_G	0.855	0.99
87_L	174_F	0.852	0.99
12_D	55_R	0.849	0.99
212_V	264_V	0.848	0.99
144_S	218_R	0.846	0.99
65_E	68_V	0.845	0.99
64_M	69_V	0.836	0.99
271_A	275_A	0.836	0.99
106_I	119_Y	0.832	0.99
176_Y	190_G	0.832	0.99
124_I	144_S	0.826	0.99
124_I	147_A	0.826	0.99
191_V	267_M	0.826	0.99
130_V	146_F	0.825	0.99
53_I	160_L	0.821	0.99
187_A	190_G	0.821	0.99
236_I	272_I	0.820	0.99
123_L	128_A	0.819	0.99
22_E	135_T	0.814	0.99
209_L	268_T	0.813	0.99
143_F	147_A	0.810	0.99
71_I	106_I	0.810	0.99
35_S	112_H	0.810	0.99
82_K	89_S	0.807	0.99
92_A	95_I	0.801	0.99
220_S	223_E	0.792	0.99
127_N	218_R	0.789	0.99
33_G	37_I	0.789	0.99
203_E	227_L	0.785	0.99
83_A	86_P	0.779	0.99
75_V	106_I	0.777	0.99
123_L	166_V	0.775	0.99
15_K	19_E	0.775	0.99
109_S	119_Y	0.774	0.99
131_R	162_T	0.774	0.99
237_E	241_T	0.771	0.99
241_T	245_D	0.764	0.99
69_V	168_L	0.764	0.99
24_H	27_A	0.763	0.99
240_A	268_T	0.762	0.99
54_R	74_I	0.758	0.99
222_A	239_A	0.757	0.99
146_F	154_D	0.750	0.99
127_N	206_R	0.747	0.98
14_V	59_L	0.743	0.98
20_F	24_H	0.740	0.98
17_A	56_L	0.739	0.98
134_S	159_E	0.735	0.98
252_D	260_K	0.735	0.98
90_E	175_S	0.729	0.98
177_Q	267_M	0.729	0.98
174_F	194_A	0.727	0.98
229_G	232_S	0.727	0.98
90_E	174_F	0.727	0.98
75_V	79_D	0.725	0.98
139_R	156_N	0.720	0.98
181_R	185_D	0.719	0.98
121_A	190_G	0.717	0.98
59_L	74_I	0.716	0.98
261_K	265_K	0.712	0.98
208_G	218_R	0.711	0.98
35_S	114_D	0.708	0.98
170_K	196_K	0.706	0.98
132_I	139_R	0.705	0.98
64_M	68_V	0.705	0.98
155_L	158_G	0.704	0.98
9_V	24_H	0.703	0.98
213_N	217_V	0.696	0.98
80_I	119_Y	0.695	0.98
30_L	37_I	0.692	0.97
125_A	192_A	0.688	0.97
231_I	235_L	0.686	0.97
243_A	246_Y	0.686	0.97
134_S	138_E	0.683	0.97
146_F	155_L	0.682	0.97
207_I	219_A	0.681	0.97
169_L	172_Y	0.678	0.97
144_S	206_R	0.678	0.97
41_K	97_D	0.675	0.97
235_L	238_E	0.672	0.97
34_H	109_S	0.671	0.97
127_N	142_N	0.669	0.97
30_L	36_L	0.668	0.97
257_A	260_K	0.667	0.97
112_H	117_A	0.667	0.97
200_D	230_K	0.664	0.97
209_L	247_A	0.662	0.97
219_A	243_A	0.659	0.97
77_H	96_A	0.655	0.97
87_L	194_A	0.650	0.96
81_I	84_N	0.650	0.96
85_I	166_V	0.650	0.96
110_I	143_F	0.650	0.96
63_K	163_E	0.649	0.96
240_A	243_A	0.648	0.96
66_G	168_L	0.648	0.96
65_E	168_L	0.648	0.96
202_I	236_I	0.648	0.96
60_K	75_V	0.646	0.96
17_A	29_P	0.645	0.96
85_I	168_L	0.644	0.96
106_I	123_L	0.642	0.96
35_S	38_P	0.640	0.96
11_P	14_V	0.637	0.96
217_V	247_A	0.637	0.96
176_Y	180_E	0.635	0.96
126_M	166_V	0.629	0.96
62_I	71_I	0.629	0.96
87_L	126_M	0.629	0.96
96_A	100_V	0.628	0.96
149_D	152_T	0.626	0.96
244_M	264_V	0.625	0.95
61_Y	79_D	0.624	0.95
147_A	216_A	0.623	0.95
118_D	176_Y	0.621	0.95
189_V	212_V	0.620	0.95
110_I	120_P	0.616	0.95
31_A	53_I	0.613	0.95
90_E	94_K	0.609	0.95
114_D	186_F	0.608	0.95
181_R	186_F	0.608	0.95
143_F	146_F	0.604	0.95
35_S	185_D	0.604	0.95
132_I	154_D	0.602	0.94
149_D	214_K	0.600	0.94
128_A	166_V	0.599	0.94
35_S	186_F	0.593	0.94
75_V	107_G	0.589	0.94
105_T	108_G	0.587	0.94
134_S	156_N	0.585	0.94
69_V	85_I	0.585	0.94
247_A	264_V	0.584	0.94
27_A	49_Y	0.581	0.93
34_H	97_D	0.581	0.93
68_V	166_V	0.579	0.93
240_A	265_K	0.578	0.93
97_D	178_K	0.576	0.93
266_V	269_K	0.575	0.93
124_I	216_A	0.574	0.93
59_L	73_P	0.573	0.93
81_I	85_I	0.571	0.93
58_E	61_Y	0.571	0.93
205_A	223_E	0.571	0.93
128_A	164_I	0.570	0.93
206_R	218_R	0.570	0.93
130_V	141_E	0.570	0.93
77_H	106_I	0.569	0.93
165_E	168_L	0.569	0.93
113_L	147_A	0.569	0.93
22_E	136_K	0.568	0.93
21_L	157_P	0.567	0.93
249_P	252_D	0.566	0.92
251_S	260_K	0.563	0.92
77_H	80_I	0.563	0.92
219_A	246_Y	0.562	0.92
64_M	67_N	0.560	0.92
96_A	184_G	0.558	0.92
15_K	138_E	0.558	0.92
244_M	261_K	0.556	0.92
41_K	176_Y	0.554	0.92
116_S	211_A	0.554	0.92
112_H	186_F	0.553	0.92
213_N	216_A	0.550	0.91
141_E	146_F	0.550	0.91
236_I	273_L	0.549	0.91
22_E	134_S	0.549	0.91
258_E	262_K	0.549	0.91
236_I	239_A	0.549	0.91
263_M	266_V	0.548	0.91
132_I	156_N	0.546	0.91
145_S	154_D	0.545	0.91
124_I	208_G	0.545	0.91
180_E	186_F	0.541	0.91
241_T	269_K	0.541	0.91
71_I	75_V	0.538	0.90
186_F	211_A	0.538	0.90
112_H	151_F	0.533	0.90
35_S	39_M	0.531	0.90
212_V	247_A	0.530	0.90
117_A	186_F	0.528	0.90
252_D	256_S	0.528	0.90
263_M	267_M	0.527	0.90
21_L	27_A	0.526	0.89
207_I	239_A	0.526	0.89
202_I	227_L	0.524	0.89
97_D	184_G	0.521	0.89
109_S	186_F	0.521	0.89
178_K	187_A	0.521	0.89
100_V	184_G	0.521	0.89
21_L	28_K	0.520	0.89
39_M	112_H	0.520	0.89
242_K	246_Y	0.516	0.89
80_I	123_L	0.515	0.88
89_S	93_S	0.513	0.88
182_R	185_D	0.513	0.88
81_I	89_S	0.512	0.88
19_E	135_T	0.511	0.88
39_M	151_F	0.511	0.88
114_D	151_F	0.510	0.88
235_L	239_A	0.510	0.88
85_I	126_M	0.509	0.88
233_E	269_K	0.508	0.88
29_P	158_G	0.508	0.88
81_I	86_P	0.508	0.88
9_V	16_E	0.508	0.88
137_G	156_N	0.507	0.88
231_I	275_A	0.507	0.88
39_M	45_F	0.506	0.88
171_D	199_G	0.502	0.87
82_K	93_S	0.501	0.87
68_V	129_K	0.500	0.87
97_D	180_E	0.500	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1t3qC	1	0.9964	100	0.094	Contact Map
1rm6B	1	0.9892	100	0.102	Contact Map
1n62C	1	1	100	0.109	Contact Map
3zyvA	3	0.9892	100	0.13	Contact Map
1ffvC	1	1	100	0.135	Contact Map
2w3sA	1	0.9748	100	0.151	Contact Map
3hrdC	1	0.9928	100	0.154	Contact Map
3uncA	2	1	100	0.16	Contact Map
3nvzB	1	1	100	0.171	Contact Map
4pytA	1	0.8849	98.3	0.869	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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