GREMLIN Database
Q97W13 - Carbon monoxide dehydrogenase, medium chain. (CutB-1)
UniProt: Q97W13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (269)
Sequences: 5954 (4099)
Seq/√Len: 249.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_R223_E3.6721.00
129_K140_V3.6681.00
70_K163_E3.3531.00
131_R165_E3.3131.00
131_R163_E2.9701.00
132_I141_E2.9361.00
139_R159_E2.7671.00
61_Y75_V2.7021.00
111_S161_V2.5021.00
21_L29_P2.3851.00
204_D227_L2.3181.00
140_V165_E2.3141.00
68_V165_E2.2411.00
142_N145_S2.1501.00
131_R138_E2.1191.00
64_M168_L2.1091.00
241_T265_K2.1061.00
60_K79_D2.0891.00
196_K203_E2.0541.00
75_V80_I2.0051.00
10_I55_R1.9151.00
9_V49_Y1.9141.00
133_R138_E1.9091.00
13_N16_E1.8941.00
131_R140_V1.8821.00
196_K204_D1.8371.00
130_V161_V1.8301.00
132_I155_L1.8141.00
78_Y102_N1.8131.00
69_V81_I1.7961.00
133_R162_T1.7821.00
141_E154_D1.7751.00
127_N144_S1.7711.00
12_D16_E1.7671.00
70_K165_E1.7541.00
76_T79_D1.7431.00
53_I74_I1.7411.00
15_K133_R1.7311.00
19_E23_T1.7251.00
64_M84_N1.7021.00
198_N203_E1.7001.00
225_I242_K1.6771.00
237_E269_K1.6641.00
179_L263_M1.6521.00
202_I205_A1.6271.00
9_V20_F1.6131.00
71_I80_I1.5981.00
129_K165_E1.5981.00
63_K70_K1.5841.00
190_G210_T1.5661.00
118_D178_K1.5501.00
21_L51_V1.5461.00
107_G161_V1.5351.00
129_K142_N1.5291.00
113_L153_P1.5151.00
136_K158_G1.5081.00
29_P160_L1.4971.00
221_E246_Y1.4931.00
177_Q274_A1.4791.00
231_I236_I1.4731.00
24_H49_Y1.4721.00
68_V168_L1.4571.00
209_L219_A1.4551.00
224_K227_L1.4551.00
136_K156_N1.4401.00
130_V143_F1.4331.00
225_I235_L1.4261.00
172_Y194_A1.4021.00
144_S220_S1.3931.00
30_L50_L1.3911.00
148_K154_D1.3811.00
29_P53_I1.3781.00
233_E273_L1.3771.00
26_D48_S1.3751.00
193_V207_I1.3611.00
20_F51_V1.3561.00
17_A160_L1.3351.00
193_V271_A1.3321.00
14_V160_L1.3321.00
221_E224_K1.3271.00
262_K266_V1.3251.00
18_L134_S1.3151.00
177_Q270_R1.3101.00
195_L205_A1.3001.00
121_A210_T1.2961.00
209_L264_V1.2861.00
233_E237_E1.2711.00
7_S49_Y1.2621.00
14_V133_R1.2591.00
138_E162_T1.2571.00
28_K45_F1.2561.00
124_I143_F1.2561.00
31_A74_I1.2561.00
84_N168_L1.2521.00
77_H104_G1.2331.00
77_H119_Y1.2291.00
197_V200_D1.2171.00
54_R76_T1.2151.00
21_L158_G1.2061.00
110_I164_I1.2051.00
173_K275_A1.2041.00
229_G238_E1.2031.00
219_A222_A1.1981.00
70_K131_R1.1881.00
57_P60_K1.1791.00
27_A51_V1.1731.00
67_N168_L1.1731.00
244_M265_K1.1581.00
8_Y52_E1.1541.00
238_E241_T1.1521.00
60_K76_T1.1511.00
18_L133_R1.1491.00
117_A120_P1.1491.00
106_I164_I1.1481.00
251_S258_E1.1381.00
11_P53_I1.1371.00
10_I52_E1.1371.00
220_S224_K1.1331.00
232_S235_L1.1311.00
172_Y196_K1.1291.00
18_L135_T1.1241.00
269_K273_L1.1181.00
205_A227_L1.1051.00
16_E19_E1.1021.00
125_A208_G1.0991.00
195_L202_I1.0991.00
18_L160_L1.0961.00
225_I229_G1.0951.00
71_I166_V1.0931.00
221_E245_D1.0881.00
11_P16_E1.0831.00
180_E185_D1.0811.00
91_T122_A1.0721.00
148_K152_T1.0681.00
111_S146_F1.0681.00
229_G235_L1.0671.00
62_I75_V1.0611.00
88_L119_Y1.0521.00
80_I106_I1.0431.00
201_V230_K1.0401.00
243_A268_T1.0381.00
236_I240_A1.0381.00
65_E70_K1.0361.00
132_I159_E1.0351.00
249_P261_K1.0341.00
90_E274_A1.0291.00
179_L267_M1.0271.00
14_V18_L1.0241.00
134_S137_G1.0141.00
16_E20_F1.0141.00
226_L239_A1.0141.00
30_L33_G1.0131.00
31_A105_T1.0101.00
222_A242_K1.0081.00
77_H95_I1.0061.00
73_P107_G1.0061.00
29_P51_V1.0041.00
110_I123_L1.0031.00
61_Y163_E0.9981.00
202_I231_I0.9971.00
242_K245_D0.9921.00
209_L212_V0.9891.00
120_P147_A0.9771.00
225_I238_E0.9681.00
207_I222_A0.9661.00
95_I104_G0.9631.00
251_S257_A0.9601.00
222_A246_Y0.9561.00
123_L130_V0.9541.00
88_L122_A0.9511.00
238_E242_K0.9501.00
175_S274_A0.9421.00
257_A261_K0.9371.00
234_K238_E0.9371.00
68_V167_P0.9341.00
156_N159_E0.9301.00
15_K58_E0.9291.00
249_P258_E0.9261.00
171_D196_K0.9251.00
205_A226_L0.9191.00
266_V270_R0.9171.00
77_H92_A0.9151.00
60_K74_I0.8971.00
78_Y98_P0.8951.00
240_A269_K0.8901.00
194_A206_R0.8891.00
177_Q271_A0.8861.00
76_T105_T0.8841.00
14_V58_E0.8721.00
230_K235_L0.8670.99
262_K265_K0.8660.99
255_G260_K0.8640.99
22_E158_G0.8550.99
87_L174_F0.8520.99
12_D55_R0.8490.99
212_V264_V0.8480.99
144_S218_R0.8460.99
65_E68_V0.8450.99
64_M69_V0.8360.99
271_A275_A0.8360.99
106_I119_Y0.8320.99
176_Y190_G0.8320.99
124_I144_S0.8260.99
124_I147_A0.8260.99
191_V267_M0.8260.99
130_V146_F0.8250.99
53_I160_L0.8210.99
187_A190_G0.8210.99
236_I272_I0.8200.99
123_L128_A0.8190.99
22_E135_T0.8140.99
209_L268_T0.8130.99
143_F147_A0.8100.99
71_I106_I0.8100.99
35_S112_H0.8100.99
82_K89_S0.8070.99
92_A95_I0.8010.99
220_S223_E0.7920.99
127_N218_R0.7890.99
33_G37_I0.7890.99
203_E227_L0.7850.99
83_A86_P0.7790.99
75_V106_I0.7770.99
123_L166_V0.7750.99
15_K19_E0.7750.99
109_S119_Y0.7740.99
131_R162_T0.7740.99
237_E241_T0.7710.99
241_T245_D0.7640.99
69_V168_L0.7640.99
24_H27_A0.7630.99
240_A268_T0.7620.99
54_R74_I0.7580.99
222_A239_A0.7570.99
146_F154_D0.7500.99
127_N206_R0.7470.98
14_V59_L0.7430.98
20_F24_H0.7400.98
17_A56_L0.7390.98
134_S159_E0.7350.98
252_D260_K0.7350.98
90_E175_S0.7290.98
177_Q267_M0.7290.98
174_F194_A0.7270.98
229_G232_S0.7270.98
90_E174_F0.7270.98
75_V79_D0.7250.98
139_R156_N0.7200.98
181_R185_D0.7190.98
121_A190_G0.7170.98
59_L74_I0.7160.98
261_K265_K0.7120.98
208_G218_R0.7110.98
35_S114_D0.7080.98
170_K196_K0.7060.98
132_I139_R0.7050.98
64_M68_V0.7050.98
155_L158_G0.7040.98
9_V24_H0.7030.98
213_N217_V0.6960.98
80_I119_Y0.6950.98
30_L37_I0.6920.97
125_A192_A0.6880.97
231_I235_L0.6860.97
243_A246_Y0.6860.97
134_S138_E0.6830.97
146_F155_L0.6820.97
207_I219_A0.6810.97
169_L172_Y0.6780.97
144_S206_R0.6780.97
41_K97_D0.6750.97
235_L238_E0.6720.97
34_H109_S0.6710.97
127_N142_N0.6690.97
30_L36_L0.6680.97
257_A260_K0.6670.97
112_H117_A0.6670.97
200_D230_K0.6640.97
209_L247_A0.6620.97
219_A243_A0.6590.97
77_H96_A0.6550.97
87_L194_A0.6500.96
81_I84_N0.6500.96
85_I166_V0.6500.96
110_I143_F0.6500.96
63_K163_E0.6490.96
240_A243_A0.6480.96
66_G168_L0.6480.96
65_E168_L0.6480.96
202_I236_I0.6480.96
60_K75_V0.6460.96
17_A29_P0.6450.96
85_I168_L0.6440.96
106_I123_L0.6420.96
35_S38_P0.6400.96
11_P14_V0.6370.96
217_V247_A0.6370.96
176_Y180_E0.6350.96
126_M166_V0.6290.96
62_I71_I0.6290.96
87_L126_M0.6290.96
96_A100_V0.6280.96
149_D152_T0.6260.96
244_M264_V0.6250.95
61_Y79_D0.6240.95
147_A216_A0.6230.95
118_D176_Y0.6210.95
189_V212_V0.6200.95
110_I120_P0.6160.95
31_A53_I0.6130.95
90_E94_K0.6090.95
114_D186_F0.6080.95
181_R186_F0.6080.95
143_F146_F0.6040.95
35_S185_D0.6040.95
132_I154_D0.6020.94
149_D214_K0.6000.94
128_A166_V0.5990.94
35_S186_F0.5930.94
75_V107_G0.5890.94
105_T108_G0.5870.94
134_S156_N0.5850.94
69_V85_I0.5850.94
247_A264_V0.5840.94
27_A49_Y0.5810.93
34_H97_D0.5810.93
68_V166_V0.5790.93
240_A265_K0.5780.93
97_D178_K0.5760.93
266_V269_K0.5750.93
124_I216_A0.5740.93
59_L73_P0.5730.93
81_I85_I0.5710.93
58_E61_Y0.5710.93
205_A223_E0.5710.93
128_A164_I0.5700.93
206_R218_R0.5700.93
130_V141_E0.5700.93
77_H106_I0.5690.93
165_E168_L0.5690.93
113_L147_A0.5690.93
22_E136_K0.5680.93
21_L157_P0.5670.93
249_P252_D0.5660.92
251_S260_K0.5630.92
77_H80_I0.5630.92
219_A246_Y0.5620.92
64_M67_N0.5600.92
96_A184_G0.5580.92
15_K138_E0.5580.92
244_M261_K0.5560.92
41_K176_Y0.5540.92
116_S211_A0.5540.92
112_H186_F0.5530.92
213_N216_A0.5500.91
141_E146_F0.5500.91
236_I273_L0.5490.91
22_E134_S0.5490.91
258_E262_K0.5490.91
236_I239_A0.5490.91
263_M266_V0.5480.91
132_I156_N0.5460.91
145_S154_D0.5450.91
124_I208_G0.5450.91
180_E186_F0.5410.91
241_T269_K0.5410.91
71_I75_V0.5380.90
186_F211_A0.5380.90
112_H151_F0.5330.90
35_S39_M0.5310.90
212_V247_A0.5300.90
117_A186_F0.5280.90
252_D256_S0.5280.90
263_M267_M0.5270.90
21_L27_A0.5260.89
207_I239_A0.5260.89
202_I227_L0.5240.89
97_D184_G0.5210.89
109_S186_F0.5210.89
178_K187_A0.5210.89
100_V184_G0.5210.89
21_L28_K0.5200.89
39_M112_H0.5200.89
242_K246_Y0.5160.89
80_I123_L0.5150.88
89_S93_S0.5130.88
182_R185_D0.5130.88
81_I89_S0.5120.88
19_E135_T0.5110.88
39_M151_F0.5110.88
114_D151_F0.5100.88
235_L239_A0.5100.88
85_I126_M0.5090.88
233_E269_K0.5080.88
29_P158_G0.5080.88
81_I86_P0.5080.88
9_V16_E0.5080.88
137_G156_N0.5070.88
231_I275_A0.5070.88
39_M45_F0.5060.88
171_D199_G0.5020.87
82_K93_S0.5010.87
68_V129_K0.5000.87
97_D180_E0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t3qC 1 0.9964 100 0.094 Contact Map
1rm6B 1 0.9892 100 0.102 Contact Map
1n62C 1 1 100 0.109 Contact Map
3zyvA 3 0.9892 100 0.13 Contact Map
1ffvC 1 1 100 0.135 Contact Map
2w3sA 1 0.9748 100 0.151 Contact Map
3hrdC 1 0.9928 100 0.154 Contact Map
3uncA 2 1 100 0.16 Contact Map
3nvzB 1 1 100 0.171 Contact Map
4pytA 1 0.8849 98.3 0.869 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.