Q97W12 - SULSO - GREMLIN Contacts

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Q97W12 - Uroporphyrinogen III methylase (CobA)

UniProt:	Q97W12	Sequences: MSGKVYLVGAGPGDPELITVKGLKILQRADVVVYDRLISKELLNFCKIEAEKIYVGKNIGDYVIQDEINELLVKKAMENKVVVRLKGGDPYVLGRGEEECLYVISKGIECEVIPGITSAIAVPAYAGIPVTSRIYSASGFTIISGTKAEDKLIDEDYIPRKGTLVILMGLRKIENMVNILIKLRNEREPVAVIENGTTENQRVFTGELKDLVNIVRSNNVTSPAVIVIGEVVKFREYLWKFK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	242 (218)
Sequences:	12949 (8209)
Seq/√Len:	556.0

ECOLI - CYSG RSMI
BACSU - NASF SUMT RSMI
HALSA - Q9HPM9 Q9HPN2 Q9HMY4 Q9HPN0 Q9HPM0 Q9HPN3
SULSO - Q97W12 Q97UT5 Q97WC9 Q97WC5 Q97WD1 Q97WC8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
16_E	24_K	3.838	1.00
23_L	27_Q	3.257	1.00
6_Y	25_I	2.615	1.00
4_K	111_E	2.532	1.00
125_Y	201_Q	2.525	1.00
186_E	209_K	2.499	1.00
29_A	83_V	2.497	1.00
75_K	80_K	2.478	1.00
206_G	210_D	2.471	1.00
194_E	202_R	2.349	1.00
4_K	109_E	2.297	1.00
8_V	83_V	2.135	1.00
24_K	28_R	2.131	1.00
51_E	75_K	2.127	1.00
20_V	23_L	2.085	1.00
122_V	196_G	2.041	1.00
193_I	196_G	2.040	1.00
118_S	167_L	2.033	1.00
6_Y	81_V	2.025	1.00
77_M	106_K	1.948	1.00
30_D	81_V	1.926	1.00
207_E	210_D	1.915	1.00
189_P	229_G	1.898	1.00
195_N	200_N	1.851	1.00
75_K	78_E	1.839	1.00
8_V	22_G	1.832	1.00
206_G	214_I	1.816	1.00
190_V	211_L	1.813	1.00
102_Y	106_K	1.754	1.00
30_D	80_K	1.724	1.00
9_G	113_I	1.693	1.00
73_V	106_K	1.675	1.00
24_K	27_Q	1.660	1.00
4_K	81_V	1.654	1.00
31_V	75_K	1.623	1.00
16_E	21_K	1.618	1.00
6_Y	111_E	1.604	1.00
102_Y	105_S	1.597	1.00
25_I	113_I	1.588	1.00
40_K	44_N	1.586	1.00
74_K	78_E	1.580	1.00
193_I	203_V	1.529	1.00
214_I	218_N	1.513	1.00
174_E	216_R	1.505	1.00
117_T	120_I	1.476	1.00
206_G	211_L	1.473	1.00
213_N	217_S	1.459	1.00
210_D	214_I	1.440	1.00
177_V	181_I	1.427	1.00
77_M	108_I	1.426	1.00
34_Y	52_K	1.421	1.00
14_D	21_K	1.413	1.00
150_D	179_I	1.405	1.00
119_A	167_L	1.401	1.00
187_R	209_K	1.386	1.00
71_L	75_K	1.385	1.00
195_N	198_T	1.374	1.00
179_I	182_K	1.368	1.00
126_A	191_A	1.361	1.00
125_Y	203_V	1.361	1.00
21_K	111_E	1.355	1.00
180_L	208_L	1.349	1.00
71_L	74_K	1.344	1.00
28_R	81_V	1.339	1.00
117_T	167_L	1.338	1.00
73_V	77_M	1.329	1.00
70_E	74_K	1.328	1.00
181_I	186_E	1.313	1.00
177_V	212_V	1.297	1.00
18_I	23_L	1.273	1.00
76_A	108_I	1.271	1.00
122_V	193_I	1.268	1.00
51_E	80_K	1.254	1.00
9_G	89_D	1.253	1.00
5_V	76_A	1.247	1.00
32_V	46_C	1.237	1.00
91_Y	96_G	1.234	1.00
166_I	228_I	1.221	1.00
141_T	161_K	1.197	1.00
19_T	116_I	1.195	1.00
25_I	83_V	1.193	1.00
112_V	124_A	1.191	1.00
67_E	70_E	1.187	1.00
214_I	217_S	1.182	1.00
204_F	214_I	1.177	1.00
23_L	45_F	1.176	1.00
174_E	178_N	1.174	1.00
69_N	102_Y	1.170	1.00
5_V	103_V	1.151	1.00
165_V	227_V	1.142	1.00
156_D	182_K	1.139	1.00
33_V	82_V	1.134	1.00
192_V	224_A	1.127	1.00
33_V	72_L	1.125	1.00
202_R	218_N	1.125	1.00
18_I	22_G	1.123	1.00
156_D	183_L	1.116	1.00
142_I	167_L	1.102	1.00
190_V	208_L	1.092	1.00
180_L	228_I	1.089	1.00
7_L	96_G	1.086	1.00
134_I	162_G	1.073	1.00
141_T	162_G	1.060	1.00
73_V	102_Y	1.051	1.00
191_A	205_T	1.050	1.00
41_E	44_N	1.050	1.00
156_D	160_R	1.047	1.00
31_V	82_V	1.043	1.00
181_I	209_K	1.032	1.00
178_N	182_K	1.027	1.00
29_A	81_V	1.027	1.00
157_Y	160_R	1.026	1.00
191_A	203_V	1.024	1.00
42_L	45_F	1.018	1.00
89_D	124_A	1.008	1.00
147_K	151_K	1.007	1.00
17_L	21_K	1.006	1.00
103_V	108_I	1.005	1.00
33_V	53_I	1.002	1.00
68_I	71_L	0.998	1.00
84_R	99_E	0.998	1.00
172_K	175_N	0.997	1.00
6_Y	113_I	0.997	1.00
175_N	178_N	0.995	1.00
220_V	224_A	0.986	1.00
179_I	183_L	0.982	1.00
143_I	155_E	0.978	1.00
173_I	211_L	0.976	1.00
180_L	184_R	0.961	1.00
65_Q	98_E	0.956	1.00
156_D	179_I	0.950	1.00
177_V	208_L	0.944	1.00
9_G	90_P	0.943	1.00
194_E	221_T	0.943	1.00
175_N	179_I	0.940	1.00
65_Q	69_N	0.935	1.00
33_V	75_K	0.929	1.00
174_E	212_V	0.922	1.00
100_C	110_C	0.918	1.00
104_I	127_G	0.917	1.00
173_I	226_I	0.911	1.00
16_E	20_V	0.909	1.00
6_Y	29_A	0.906	1.00
31_V	80_K	0.905	1.00
20_V	24_K	0.901	1.00
41_E	45_F	0.899	1.00
121_A	197_T	0.898	1.00
166_I	169_G	0.895	1.00
112_V	203_V	0.892	1.00
57_K	63_V	0.890	1.00
104_I	205_T	0.888	1.00
181_I	212_V	0.886	1.00
156_D	159_P	0.886	1.00
128_I	191_A	0.879	1.00
22_G	113_I	0.879	1.00
212_V	216_R	0.878	1.00
136_S	162_G	0.874	1.00
178_N	212_V	0.865	1.00
33_V	71_L	0.860	1.00
101_L	105_S	0.859	1.00
8_V	113_I	0.847	1.00
148_A	152_L	0.843	1.00
31_V	53_I	0.841	1.00
8_V	25_I	0.839	1.00
91_Y	112_V	0.836	1.00
69_N	73_V	0.835	1.00
64_I	67_E	0.834	1.00
56_G	64_I	0.829	1.00
53_I	71_L	0.827	1.00
42_L	46_C	0.821	1.00
123_P	130_V	0.816	1.00
92_V	120_I	0.811	1.00
12_P	17_L	0.810	1.00
25_I	28_R	0.810	1.00
165_V	225_V	0.808	1.00
43_L	46_C	0.805	1.00
149_E	152_L	0.803	1.00
181_I	208_L	0.802	1.00
185_N	188_E	0.801	1.00
18_I	42_L	0.798	1.00
53_I	68_I	0.795	1.00
25_I	111_E	0.791	1.00
174_E	213_N	0.791	1.00
74_K	77_M	0.784	1.00
187_R	207_E	0.781	1.00
148_A	151_K	0.779	1.00
189_P	207_E	0.778	1.00
188_E	230_E	0.778	1.00
192_V	211_L	0.777	1.00
150_D	175_N	0.776	1.00
97_E	101_L	0.776	1.00
168_M	172_K	0.773	1.00
140_F	144_S	0.761	1.00
36_R	54_Y	0.760	1.00
204_F	211_L	0.759	1.00
96_G	100_C	0.757	1.00
25_I	81_V	0.753	1.00
122_V	227_V	0.751	1.00
167_L	225_V	0.751	1.00
66_D	102_Y	0.746	1.00
70_E	102_Y	0.744	1.00
104_I	110_C	0.740	1.00
90_P	94_G	0.737	1.00
46_C	50_A	0.733	1.00
21_K	24_K	0.731	1.00
112_V	125_Y	0.729	1.00
56_G	63_V	0.723	1.00
32_V	50_A	0.722	1.00
140_F	143_I	0.719	1.00
15_P	41_E	0.716	1.00
121_A	196_G	0.713	1.00
204_F	220_V	0.710	1.00
125_Y	197_T	0.709	1.00
97_E	129_P	0.704	1.00
176_M	226_I	0.702	1.00
89_D	112_V	0.700	1.00
76_A	82_V	0.699	1.00
6_Y	83_V	0.698	1.00
178_N	216_R	0.698	1.00
21_K	113_I	0.697	1.00
14_D	17_L	0.697	1.00
191_A	227_V	0.696	1.00
63_V	67_E	0.692	1.00
157_Y	161_K	0.688	1.00
27_Q	45_F	0.687	1.00
204_F	218_N	0.686	1.00
164_L	180_L	0.678	1.00
213_N	216_R	0.677	1.00
70_E	106_K	0.677	1.00
97_E	132_S	0.673	1.00
86_K	94_G	0.672	1.00
9_G	121_A	0.670	1.00
194_E	224_A	0.669	1.00
25_I	29_A	0.669	1.00
119_A	165_V	0.668	1.00
170_L	220_V	0.665	1.00
170_L	224_A	0.661	1.00
73_V	103_V	0.660	1.00
91_Y	124_A	0.653	1.00
18_I	46_C	0.652	1.00
14_D	197_T	0.652	1.00
53_I	75_K	0.652	1.00
47_K	50_A	0.646	1.00
100_C	104_I	0.645	1.00
23_L	46_C	0.642	1.00
26_L	32_V	0.641	1.00
145_G	149_E	0.638	1.00
97_E	131_T	0.637	1.00
159_P	183_L	0.634	1.00
29_A	32_V	0.633	1.00
9_G	116_I	0.629	1.00
151_K	179_I	0.627	1.00
7_L	100_C	0.627	1.00
210_D	213_N	0.621	1.00
66_D	70_E	0.619	1.00
21_K	25_I	0.617	1.00
26_L	83_V	0.614	1.00
92_V	130_V	0.614	1.00
164_L	228_I	0.614	1.00
166_I	176_M	0.612	1.00
63_V	71_L	0.611	1.00
65_Q	68_I	0.610	1.00
123_P	227_V	0.610	1.00
147_K	179_I	0.608	1.00
205_T	232_V	0.605	1.00
22_G	83_V	0.603	1.00
40_K	43_L	0.602	1.00
33_V	55_V	0.601	1.00
132_S	135_Y	0.598	1.00
92_V	140_F	0.597	1.00
147_K	150_D	0.597	1.00
41_E	46_C	0.596	1.00
20_V	45_F	0.595	1.00
143_I	166_I	0.591	1.00
30_D	47_K	0.591	1.00
67_E	71_L	0.589	1.00
46_C	52_K	0.587	1.00
146_T	149_E	0.584	1.00
173_I	224_A	0.583	1.00
140_F	158_I	0.583	1.00
132_S	136_S	0.581	1.00
47_K	52_K	0.579	1.00
177_V	211_L	0.579	1.00
15_P	44_N	0.577	0.99
55_V	65_Q	0.576	0.99
209_K	212_V	0.571	0.99
130_V	165_V	0.570	0.99
26_L	46_C	0.568	0.99
57_K	65_Q	0.567	0.99
66_D	69_N	0.566	0.99
155_E	176_M	0.565	0.99
69_N	72_L	0.563	0.99
160_R	183_L	0.563	0.99
176_M	180_L	0.562	0.99
69_N	98_E	0.557	0.99
155_E	159_P	0.557	0.99
38_I	42_L	0.553	0.99
101_L	132_S	0.551	0.99
122_V	225_V	0.550	0.99
15_P	45_F	0.550	0.99
72_L	76_A	0.548	0.99
121_A	125_Y	0.548	0.99
155_E	158_I	0.548	0.99
103_V	110_C	0.537	0.99
73_V	108_I	0.534	0.99
10_A	38_I	0.534	0.99
164_L	184_R	0.533	0.99
93_L	135_Y	0.532	0.99
173_I	177_V	0.527	0.99
4_K	76_A	0.525	0.99
193_I	227_V	0.524	0.99
22_G	42_L	0.522	0.99
211_L	214_I	0.521	0.99
141_T	157_Y	0.521	0.99
101_L	104_I	0.520	0.99
66_D	98_E	0.517	0.99
135_Y	230_E	0.516	0.99
12_P	197_T	0.512	0.99
195_N	223_P	0.511	0.99
20_V	27_Q	0.511	0.99
184_R	188_E	0.509	0.99
40_K	52_K	0.509	0.99
7_L	110_C	0.506	0.99
214_I	220_V	0.503	0.99
9_G	117_T	0.501	0.99
190_V	212_V	0.500	0.99
9_G	125_Y	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1s4dA	4	0.9959	100	0.187	Contact Map
1pjqA	2	0.9793	100	0.187	Contact Map
2yboA	2	0.9669	100	0.193	Contact Map
1ve2A	2	0.9298	100	0.212	Contact Map
3kwpA	2	0.9298	100	0.214	Contact Map
1cbfA	2	0.9421	100	0.238	Contact Map
4e16A	2	0.9256	100	0.257	Contact Map
3ndcA	2	0.9545	100	0.263	Contact Map
1va0A	2	0.9215	100	0.264	Contact Map
1wyzA	2	0.876	100	0.27	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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