GREMLIN Database
Q97W12 - Uroporphyrinogen III methylase (CobA)
UniProt: Q97W12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (218)
Sequences: 12949 (8209)
Seq/√Len: 556.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E24_K3.8381.00
23_L27_Q3.2571.00
6_Y25_I2.6151.00
4_K111_E2.5321.00
125_Y201_Q2.5251.00
186_E209_K2.4991.00
29_A83_V2.4971.00
75_K80_K2.4781.00
206_G210_D2.4711.00
194_E202_R2.3491.00
4_K109_E2.2971.00
8_V83_V2.1351.00
24_K28_R2.1311.00
51_E75_K2.1271.00
20_V23_L2.0851.00
122_V196_G2.0411.00
193_I196_G2.0401.00
118_S167_L2.0331.00
6_Y81_V2.0251.00
77_M106_K1.9481.00
30_D81_V1.9261.00
207_E210_D1.9151.00
189_P229_G1.8981.00
195_N200_N1.8511.00
75_K78_E1.8391.00
8_V22_G1.8321.00
206_G214_I1.8161.00
190_V211_L1.8131.00
102_Y106_K1.7541.00
30_D80_K1.7241.00
9_G113_I1.6931.00
73_V106_K1.6751.00
24_K27_Q1.6601.00
4_K81_V1.6541.00
31_V75_K1.6231.00
16_E21_K1.6181.00
6_Y111_E1.6041.00
102_Y105_S1.5971.00
25_I113_I1.5881.00
40_K44_N1.5861.00
74_K78_E1.5801.00
193_I203_V1.5291.00
214_I218_N1.5131.00
174_E216_R1.5051.00
117_T120_I1.4761.00
206_G211_L1.4731.00
213_N217_S1.4591.00
210_D214_I1.4401.00
177_V181_I1.4271.00
77_M108_I1.4261.00
34_Y52_K1.4211.00
14_D21_K1.4131.00
150_D179_I1.4051.00
119_A167_L1.4011.00
187_R209_K1.3861.00
71_L75_K1.3851.00
195_N198_T1.3741.00
179_I182_K1.3681.00
126_A191_A1.3611.00
125_Y203_V1.3611.00
21_K111_E1.3551.00
180_L208_L1.3491.00
71_L74_K1.3441.00
28_R81_V1.3391.00
117_T167_L1.3381.00
73_V77_M1.3291.00
70_E74_K1.3281.00
181_I186_E1.3131.00
177_V212_V1.2971.00
18_I23_L1.2731.00
76_A108_I1.2711.00
122_V193_I1.2681.00
51_E80_K1.2541.00
9_G89_D1.2531.00
5_V76_A1.2471.00
32_V46_C1.2371.00
91_Y96_G1.2341.00
166_I228_I1.2211.00
141_T161_K1.1971.00
19_T116_I1.1951.00
25_I83_V1.1931.00
112_V124_A1.1911.00
67_E70_E1.1871.00
214_I217_S1.1821.00
204_F214_I1.1771.00
23_L45_F1.1761.00
174_E178_N1.1741.00
69_N102_Y1.1701.00
5_V103_V1.1511.00
165_V227_V1.1421.00
156_D182_K1.1391.00
33_V82_V1.1341.00
192_V224_A1.1271.00
33_V72_L1.1251.00
202_R218_N1.1251.00
18_I22_G1.1231.00
156_D183_L1.1161.00
142_I167_L1.1021.00
190_V208_L1.0921.00
180_L228_I1.0891.00
7_L96_G1.0861.00
134_I162_G1.0731.00
141_T162_G1.0601.00
73_V102_Y1.0511.00
191_A205_T1.0501.00
41_E44_N1.0501.00
156_D160_R1.0471.00
31_V82_V1.0431.00
181_I209_K1.0321.00
178_N182_K1.0271.00
29_A81_V1.0271.00
157_Y160_R1.0261.00
191_A203_V1.0241.00
42_L45_F1.0181.00
89_D124_A1.0081.00
147_K151_K1.0071.00
17_L21_K1.0061.00
103_V108_I1.0051.00
33_V53_I1.0021.00
68_I71_L0.9981.00
84_R99_E0.9981.00
172_K175_N0.9971.00
6_Y113_I0.9971.00
175_N178_N0.9951.00
220_V224_A0.9861.00
179_I183_L0.9821.00
143_I155_E0.9781.00
173_I211_L0.9761.00
180_L184_R0.9611.00
65_Q98_E0.9561.00
156_D179_I0.9501.00
177_V208_L0.9441.00
9_G90_P0.9431.00
194_E221_T0.9431.00
175_N179_I0.9401.00
65_Q69_N0.9351.00
33_V75_K0.9291.00
174_E212_V0.9221.00
100_C110_C0.9181.00
104_I127_G0.9171.00
173_I226_I0.9111.00
16_E20_V0.9091.00
6_Y29_A0.9061.00
31_V80_K0.9051.00
20_V24_K0.9011.00
41_E45_F0.8991.00
121_A197_T0.8981.00
166_I169_G0.8951.00
112_V203_V0.8921.00
57_K63_V0.8901.00
104_I205_T0.8881.00
181_I212_V0.8861.00
156_D159_P0.8861.00
128_I191_A0.8791.00
22_G113_I0.8791.00
212_V216_R0.8781.00
136_S162_G0.8741.00
178_N212_V0.8651.00
33_V71_L0.8601.00
101_L105_S0.8591.00
8_V113_I0.8471.00
148_A152_L0.8431.00
31_V53_I0.8411.00
8_V25_I0.8391.00
91_Y112_V0.8361.00
69_N73_V0.8351.00
64_I67_E0.8341.00
56_G64_I0.8291.00
53_I71_L0.8271.00
42_L46_C0.8211.00
123_P130_V0.8161.00
92_V120_I0.8111.00
12_P17_L0.8101.00
25_I28_R0.8101.00
165_V225_V0.8081.00
43_L46_C0.8051.00
149_E152_L0.8031.00
181_I208_L0.8021.00
185_N188_E0.8011.00
18_I42_L0.7981.00
53_I68_I0.7951.00
25_I111_E0.7911.00
174_E213_N0.7911.00
74_K77_M0.7841.00
187_R207_E0.7811.00
148_A151_K0.7791.00
189_P207_E0.7781.00
188_E230_E0.7781.00
192_V211_L0.7771.00
150_D175_N0.7761.00
97_E101_L0.7761.00
168_M172_K0.7731.00
140_F144_S0.7611.00
36_R54_Y0.7601.00
204_F211_L0.7591.00
96_G100_C0.7571.00
25_I81_V0.7531.00
122_V227_V0.7511.00
167_L225_V0.7511.00
66_D102_Y0.7461.00
70_E102_Y0.7441.00
104_I110_C0.7401.00
90_P94_G0.7371.00
46_C50_A0.7331.00
21_K24_K0.7311.00
112_V125_Y0.7291.00
56_G63_V0.7231.00
32_V50_A0.7221.00
140_F143_I0.7191.00
15_P41_E0.7161.00
121_A196_G0.7131.00
204_F220_V0.7101.00
125_Y197_T0.7091.00
97_E129_P0.7041.00
176_M226_I0.7021.00
89_D112_V0.7001.00
76_A82_V0.6991.00
6_Y83_V0.6981.00
178_N216_R0.6981.00
21_K113_I0.6971.00
14_D17_L0.6971.00
191_A227_V0.6961.00
63_V67_E0.6921.00
157_Y161_K0.6881.00
27_Q45_F0.6871.00
204_F218_N0.6861.00
164_L180_L0.6781.00
213_N216_R0.6771.00
70_E106_K0.6771.00
97_E132_S0.6731.00
86_K94_G0.6721.00
9_G121_A0.6701.00
194_E224_A0.6691.00
25_I29_A0.6691.00
119_A165_V0.6681.00
170_L220_V0.6651.00
170_L224_A0.6611.00
73_V103_V0.6601.00
91_Y124_A0.6531.00
18_I46_C0.6521.00
14_D197_T0.6521.00
53_I75_K0.6521.00
47_K50_A0.6461.00
100_C104_I0.6451.00
23_L46_C0.6421.00
26_L32_V0.6411.00
145_G149_E0.6381.00
97_E131_T0.6371.00
159_P183_L0.6341.00
29_A32_V0.6331.00
9_G116_I0.6291.00
151_K179_I0.6271.00
7_L100_C0.6271.00
210_D213_N0.6211.00
66_D70_E0.6191.00
21_K25_I0.6171.00
26_L83_V0.6141.00
92_V130_V0.6141.00
164_L228_I0.6141.00
166_I176_M0.6121.00
63_V71_L0.6111.00
65_Q68_I0.6101.00
123_P227_V0.6101.00
147_K179_I0.6081.00
205_T232_V0.6051.00
22_G83_V0.6031.00
40_K43_L0.6021.00
33_V55_V0.6011.00
132_S135_Y0.5981.00
92_V140_F0.5971.00
147_K150_D0.5971.00
41_E46_C0.5961.00
20_V45_F0.5951.00
143_I166_I0.5911.00
30_D47_K0.5911.00
67_E71_L0.5891.00
46_C52_K0.5871.00
146_T149_E0.5841.00
173_I224_A0.5831.00
140_F158_I0.5831.00
132_S136_S0.5811.00
47_K52_K0.5791.00
177_V211_L0.5791.00
15_P44_N0.5770.99
55_V65_Q0.5760.99
209_K212_V0.5710.99
130_V165_V0.5700.99
26_L46_C0.5680.99
57_K65_Q0.5670.99
66_D69_N0.5660.99
155_E176_M0.5650.99
69_N72_L0.5630.99
160_R183_L0.5630.99
176_M180_L0.5620.99
69_N98_E0.5570.99
155_E159_P0.5570.99
38_I42_L0.5530.99
101_L132_S0.5510.99
122_V225_V0.5500.99
15_P45_F0.5500.99
72_L76_A0.5480.99
121_A125_Y0.5480.99
155_E158_I0.5480.99
103_V110_C0.5370.99
73_V108_I0.5340.99
10_A38_I0.5340.99
164_L184_R0.5330.99
93_L135_Y0.5320.99
173_I177_V0.5270.99
4_K76_A0.5250.99
193_I227_V0.5240.99
22_G42_L0.5220.99
211_L214_I0.5210.99
141_T157_Y0.5210.99
101_L104_I0.5200.99
66_D98_E0.5170.99
135_Y230_E0.5160.99
12_P197_T0.5120.99
195_N223_P0.5110.99
20_V27_Q0.5110.99
184_R188_E0.5090.99
40_K52_K0.5090.99
7_L110_C0.5060.99
214_I220_V0.5030.99
9_G117_T0.5010.99
190_V212_V0.5000.99
9_G125_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s4dA 4 0.9959 100 0.187 Contact Map
1pjqA 2 0.9793 100 0.187 Contact Map
2yboA 2 0.9669 100 0.193 Contact Map
1ve2A 2 0.9298 100 0.212 Contact Map
3kwpA 2 0.9298 100 0.214 Contact Map
1cbfA 2 0.9421 100 0.238 Contact Map
4e16A 2 0.9256 100 0.257 Contact Map
3ndcA 2 0.9545 100 0.263 Contact Map
1va0A 2 0.9215 100 0.264 Contact Map
1wyzA 2 0.876 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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