GREMLIN Database
Q97W10 - Uncharacterized protein
UniProt: Q97W10 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (227)
Sequences: 4808 (2696)
Seq/√Len: 178.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_V106_A4.5731.00
83_T105_L4.3221.00
122_G125_S3.5111.00
27_I37_A3.5011.00
86_K107_D3.0981.00
69_V133_V3.0661.00
37_A69_V2.9491.00
68_I82_A2.9261.00
24_N49_K2.8171.00
126_F168_I2.7901.00
84_K87_G2.6881.00
23_D64_R2.6301.00
22_L65_P2.5891.00
189_F218_L2.5601.00
65_P92_Y2.3461.00
82_A102_L2.3351.00
40_I133_V2.3231.00
207_L222_I2.3101.00
173_M184_T2.2591.00
70_S102_L2.2421.00
34_Y38_L2.1331.00
80_L83_T2.0351.00
112_I128_M2.0031.00
177_A185_N1.9971.00
95_T103_A1.9611.00
98_E111_L1.9361.00
84_K88_K1.9131.00
24_N47_R1.9031.00
66_L89_T1.9031.00
74_R101_Q1.8611.00
41_E49_K1.8541.00
52_D188_R1.8521.00
103_A109_L1.8041.00
23_D63_D1.7701.00
155_N201_A1.7651.00
32_D122_G1.7581.00
90_R108_Y1.7511.00
170_Y186_S1.7421.00
28_A66_L1.7031.00
147_S233_S1.6721.00
155_N203_R1.6691.00
25_A65_P1.6641.00
166_Y170_Y1.6411.00
51_L59_Y1.6371.00
26_Y56_G1.6261.00
68_I91_L1.6181.00
27_I48_F1.5841.00
150_L231_D1.5561.00
66_L85_F1.5551.00
76_K80_L1.5421.00
172_A208_F1.5251.00
25_A67_V1.4661.00
45_N60_E1.4541.00
209_R215_E1.4501.00
222_I232_C1.4141.00
91_L106_A1.3991.00
171_Y175_K1.3731.00
143_E146_E1.3691.00
138_G141_A1.3501.00
28_A56_G1.3301.00
38_L170_Y1.3251.00
139_E142_D1.3161.00
90_R107_D1.3111.00
156_N183_A1.3081.00
115_K124_L1.2941.00
85_F89_T1.2841.00
16_V20_L1.2811.00
225_T230_T1.2741.00
86_K105_L1.2731.00
45_N62_L1.2721.00
18_L90_R1.2531.00
145_K149_R1.2481.00
94_I133_V1.2471.00
146_E149_R1.2441.00
147_S151_L1.2191.00
98_E109_L1.2131.00
205_I230_T1.2111.00
30_A53_P1.2081.00
86_K91_L1.1991.00
30_A75_P1.1871.00
223_D226_D1.1611.00
160_V192_F1.1501.00
157_P176_F1.1501.00
27_I67_V1.1441.00
99_D103_A1.1381.00
93_V102_L1.1241.00
209_R222_I1.1231.00
110_I132_A1.1201.00
22_L90_R1.1181.00
40_I137_A1.1081.00
57_L80_L1.1021.00
38_L50_A1.1021.00
93_V109_L1.0841.00
215_E219_I1.0831.00
159_F176_F1.0801.00
68_I78_N1.0771.00
117_I123_T1.0711.00
44_T48_F1.0691.00
112_I115_K1.0691.00
82_A106_A1.0671.00
157_P182_Y1.0581.00
43_K134_Y1.0541.00
137_A141_A1.0431.00
169_A208_F1.0431.00
68_I85_F1.0310.99
112_I129_S1.0220.99
193_C224_Y1.0080.99
32_D171_Y1.0070.99
200_T230_T1.0040.99
205_I225_T1.0000.99
126_F167_G0.9960.99
34_Y52_D0.9920.99
113_P116_P0.9900.99
24_N63_D0.9800.99
200_T205_I0.9750.99
209_R219_I0.9690.99
221_S224_Y0.9580.99
211_D215_E0.9570.99
158_F204_Q0.9560.99
121_P179_I0.9510.99
60_E84_K0.9410.99
236_F240_I0.9400.99
18_L21_K0.9400.99
29_G33_S0.9390.99
112_I116_P0.9370.99
44_T140_Q0.9360.99
165_N208_F0.9260.99
79_I83_T0.9250.99
236_F239_S0.9230.99
20_L90_R0.9180.99
175_K198_F0.9020.99
159_F206_V0.8990.99
192_F225_T0.8930.99
26_Y66_L0.8910.99
99_D104_R0.8860.98
215_E240_I0.8840.98
27_I50_A0.8780.98
193_C197_I0.8770.98
98_E113_P0.8750.98
67_V92_Y0.8720.98
94_I132_A0.8640.98
187_E196_P0.8640.98
224_Y228_Q0.8600.98
163_K214_R0.8560.98
83_T87_G0.8520.98
21_K64_R0.8510.98
21_K90_R0.8510.98
32_D174_L0.8500.98
192_F197_I0.8490.98
181_G198_F0.8470.98
44_T137_A0.8430.98
211_D237_C0.8330.98
30_A191_Q0.8310.98
35_A170_Y0.8310.98
60_E88_K0.8310.98
138_G142_D0.8300.98
71_V117_I0.8230.98
71_V96_A0.8170.97
79_I101_Q0.8110.97
212_N215_E0.8090.97
28_A68_I0.8040.97
25_A46_G0.8020.97
91_L107_D0.7970.97
39_T168_I0.7930.97
33_S95_T0.7910.97
77_S190_E0.7860.97
165_N210_S0.7860.97
82_A91_L0.7810.97
41_E50_A0.7810.97
29_G50_A0.7790.97
117_I124_L0.7760.96
136_L140_Q0.7760.96
60_E213_E0.7740.96
209_R218_L0.7720.96
160_V207_L0.7700.96
101_Q105_L0.7630.96
103_A111_L0.7620.96
226_D229_A0.7620.96
95_T131_S0.7610.96
38_L167_G0.7560.96
168_I208_F0.7500.96
122_G198_F0.7490.96
156_N204_Q0.7480.96
151_L157_P0.7470.96
160_V225_T0.7460.96
34_Y50_A0.7410.95
171_Y198_F0.7390.95
41_E48_F0.7380.95
114_Y128_M0.7370.95
18_L22_L0.7370.95
36_V133_V0.7350.95
146_E150_L0.7350.95
26_Y49_K0.7270.95
35_A38_L0.7240.95
38_L41_E0.7220.95
68_I102_L0.7190.95
143_E147_S0.7180.95
216_K220_N0.7170.95
19_D22_L0.7170.95
110_I136_L0.7150.94
45_N48_F0.7110.94
223_D227_T0.7090.94
17_N21_K0.7080.94
75_P181_G0.7050.94
99_D109_L0.7010.94
207_L218_L0.7000.94
32_D126_F0.7000.94
135_S139_E0.6950.94
71_V122_G0.6940.94
80_L220_N0.6930.93
52_D191_Q0.6920.93
98_E103_A0.6890.93
149_R152_N0.6840.93
52_D190_E0.6830.93
225_T232_C0.6780.93
217_E220_N0.6760.93
39_T167_G0.6750.93
17_N20_L0.6740.93
61_N84_K0.6700.92
123_T171_Y0.6690.92
157_P206_V0.6630.92
32_D175_K0.6630.92
77_S193_C0.6620.92
174_L195_S0.6620.92
218_L221_S0.6600.92
17_N149_R0.6600.92
45_N61_N0.6570.92
130_L134_Y0.6560.92
173_M186_S0.6560.92
219_I223_D0.6550.91
99_D111_L0.6540.91
103_A106_A0.6500.91
96_A124_L0.6450.91
54_F190_E0.6450.91
54_F162_H0.6420.91
171_Y174_L0.6420.91
220_N224_Y0.6420.91
56_G66_L0.6330.90
43_K137_A0.6320.90
135_S138_G0.6310.90
71_V114_Y0.6290.90
144_I148_G0.6270.90
71_V115_K0.6270.90
117_I120_L0.6240.89
72_S96_A0.6240.89
123_T175_K0.6230.89
77_S96_A0.6230.89
18_L152_N0.6220.89
216_K219_I0.6220.89
238_N241_I0.6220.89
137_A140_Q0.6200.89
176_F180_F0.6180.89
159_F189_F0.6180.89
96_A114_Y0.6170.89
71_V124_L0.6160.89
43_K164_E0.6100.88
183_A199_M0.6100.88
27_I133_V0.6080.88
71_V171_Y0.6060.88
80_L84_K0.6060.88
32_D195_S0.6010.88
119_P125_S0.5980.87
129_S133_V0.5940.87
193_C198_F0.5830.86
28_A85_F0.5820.86
154_A231_D0.5800.86
120_L123_T0.5780.85
117_I121_P0.5770.85
16_V139_E0.5770.85
16_V108_Y0.5730.85
94_I112_I0.5710.85
131_S135_S0.5700.85
96_A122_G0.5690.85
95_T100_S0.5690.85
218_L222_I0.5680.85
30_A52_D0.5670.84
83_T104_R0.5610.84
162_H189_F0.5600.84
160_V189_F0.5600.84
22_L25_A0.5600.84
83_T101_Q0.5550.83
192_F200_T0.5550.83
77_S122_G0.5540.83
29_G37_A0.5540.83
34_Y53_P0.5540.83
36_V40_I0.5530.83
143_E150_L0.5510.83
171_Y195_S0.5500.83
75_P179_I0.5480.82
82_A86_K0.5480.82
40_I43_K0.5470.82
59_Y62_L0.5460.82
117_I195_S0.5460.82
222_I234_G0.5450.82
149_R242_L0.5390.81
28_A81_L0.5370.81
167_G170_Y0.5370.81
94_I110_I0.5340.81
131_S134_Y0.5330.81
36_V175_K0.5330.81
78_N82_A0.5310.80
126_F130_L0.5290.80
234_G237_C0.5270.80
57_L84_K0.5260.80
150_L153_L0.5260.80
68_I106_A0.5240.79
25_A48_F0.5220.79
96_A129_S0.5220.79
157_P204_Q0.5220.79
32_D196_P0.5210.79
56_G85_F0.5190.79
200_T204_Q0.5190.79
75_P120_L0.5180.79
159_F172_A0.5150.78
181_G193_C0.5150.78
71_V190_E0.5150.78
102_L111_L0.5130.78
23_D26_Y0.5130.78
19_D140_Q0.5120.78
102_L106_A0.5110.78
177_A183_A0.5110.78
131_S138_G0.5110.78
53_P75_P0.5100.78
101_Q104_R0.5100.78
120_L124_L0.5100.78
24_N64_R0.5090.78
32_D198_F0.5070.77
71_V77_S0.5060.77
79_I105_L0.5050.77
165_N168_I0.5040.77
30_A55_E0.5040.77
117_I171_Y0.5030.77
187_E191_Q0.5030.77
75_P129_S0.5030.77
202_N229_A0.5030.77
167_G196_P0.5030.77
22_L46_G0.5010.76
77_S181_G0.5010.76
217_E221_S0.5000.76
92_Y110_I0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2amlA 2 1 100 0.341 Contact Map
2zj3A 2 0.9927 100 0.348 Contact Map
3tbfA 2 1 100 0.359 Contact Map
1moqA 2 1 100 0.36 Contact Map
3knzA 2 0.9455 100 0.361 Contact Map
4amvA 2 1 100 0.363 Contact Map
2pocA 4 0.9927 100 0.363 Contact Map
4s1wA 2 1 100 0.364 Contact Map
3fj1A 2 1 100 0.364 Contact Map
3g68A 3 0.9964 100 0.366 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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