GREMLIN Database
Q97W08 - Uncharacterized protein
UniProt: Q97W08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (247)
Sequences: 1109 (763)
Seq/√Len: 48.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_F159_V3.8661.00
152_Y155_Y3.8331.00
161_V169_V2.8061.00
122_I186_A2.7731.00
154_Y171_P2.7621.00
177_F202_E2.6631.00
80_S96_T2.4461.00
154_Y158_M2.4461.00
125_F200_A2.4371.00
25_V52_V2.3961.00
230_R234_N2.3771.00
123_N192_P2.3661.00
188_R215_H2.3651.00
132_S146_S2.3641.00
208_V212_G2.3291.00
124_M176_A2.3241.00
19_E102_E2.2891.00
82_T93_L2.2581.00
161_V171_P2.2581.00
73_H80_S2.1821.00
143_I170_L2.1591.00
93_L156_Y2.1461.00
37_D72_V2.0891.00
97_K152_Y2.0841.00
119_E188_R2.0811.00
109_L113_T2.0731.00
246_R254_H2.0541.00
231_I235_K2.0431.00
81_E156_Y2.0291.00
57_G72_V2.0171.00
53_K77_E2.0091.00
66_Y149_L1.9550.99
83_V90_K1.9100.99
90_K163_L1.9020.99
239_S260_K1.8670.99
83_V92_F1.8400.99
145_Y172_I1.7670.99
85_K90_K1.7500.99
91_Y134_L1.7390.99
215_H258_D1.7330.99
65_T149_L1.7320.98
129_G157_M1.7070.98
104_L192_P1.7000.98
119_E187_D1.6890.98
99_F104_L1.6740.98
234_N237_R1.6730.98
89_C133_I1.6390.98
247_S253_Y1.5990.97
135_S190_I1.5940.97
92_F163_L1.5780.97
46_L75_A1.5760.97
244_I253_Y1.5670.97
155_Y159_V1.5440.97
110_R256_V1.5420.97
25_V45_I1.5270.97
49_F52_V1.5240.97
99_F192_P1.4860.96
56_W71_Y1.4820.96
99_F103_K1.4650.96
159_V162_E1.4590.96
89_C137_V1.4320.95
93_L98_V1.4230.95
126_S148_D1.4200.95
58_R61_D1.4180.95
63_N70_T1.3900.94
188_R258_D1.3860.94
24_I82_T1.3820.94
103_K130_P1.3750.94
162_E167_Y1.3520.93
107_E110_R1.3490.93
192_P254_H1.3470.93
189_I208_V1.3320.93
130_P192_P1.3150.92
115_V121_I1.3050.92
104_L148_D1.2930.92
42_A74_L1.2770.91
233_M237_R1.2750.91
115_V190_I1.2700.91
213_I241_F1.2550.91
148_D192_P1.2480.90
94_D97_K1.2420.90
25_V49_F1.2420.90
19_E103_K1.2310.90
148_D154_Y1.2240.89
152_Y156_Y1.2240.89
231_I237_R1.2150.89
191_A200_A1.2150.89
123_N157_M1.2110.89
133_I166_A1.2090.89
123_N254_H1.2030.89
136_A169_V1.2020.88
213_I260_K1.1910.88
126_S157_M1.1870.88
42_A75_A1.1800.88
104_L246_R1.1790.88
136_A191_A1.1760.87
111_V190_I1.1560.86
123_N148_D1.1510.86
123_N246_R1.1500.86
172_I179_R1.1470.86
120_I186_A1.1420.86
99_F130_P1.1400.86
124_M204_A1.1400.86
103_K192_P1.1370.86
115_V135_S1.1350.85
104_L194_P1.1330.85
80_S94_D1.1310.85
104_L130_P1.1280.85
228_P231_I1.1230.85
91_Y133_I1.1140.84
53_K79_R1.0940.83
174_G182_E1.0910.83
54_S79_R1.0880.83
232_A237_R1.0840.83
111_V135_S1.0760.82
121_I190_I1.0740.82
111_V115_V1.0700.82
225_G228_P1.0610.81
193_L197_A1.0590.81
104_L254_H1.0560.81
232_A236_Y1.0490.81
54_S76_G1.0450.80
103_K194_P1.0360.80
151_P173_Y1.0340.80
153_A217_Y1.0310.79
122_I189_I1.0290.79
125_F216_L1.0240.79
99_F194_P1.0210.79
192_P246_R1.0190.79
57_G74_L1.0170.78
136_A166_A1.0160.78
28_G58_R1.0110.78
217_Y243_R0.9940.77
234_N238_G0.9920.77
213_I258_D0.9890.76
187_D209_K0.9810.76
27_I74_L0.9740.75
81_E92_F0.9610.74
191_A197_A0.9520.74
133_I160_N0.9440.73
111_V114_Q0.9430.73
21_V24_I0.9370.72
219_E252_K0.9320.72
103_K217_Y0.9260.72
194_P219_E0.9160.71
229_V232_A0.9150.71
230_R233_M0.9120.70
215_H256_V0.9080.70
219_E248_V0.9080.70
45_I49_F0.9040.70
177_F199_K0.9030.70
130_P194_P0.8960.69
131_F153_A0.8950.69
14_I18_I0.8940.69
146_S157_M0.8930.69
55_V75_A0.8900.69
122_I145_Y0.8890.68
154_Y173_Y0.8880.68
99_F254_H0.8870.68
104_L217_Y0.8860.68
198_D218_T0.8800.68
248_V252_K0.8700.67
43_N47_S0.8660.66
158_M162_E0.8640.66
254_H258_D0.8570.66
98_V156_Y0.8560.66
228_P232_A0.8540.65
122_I147_I0.8530.65
108_H153_A0.8510.65
64_G68_L0.8500.65
229_V238_G0.8500.65
165_K223_N0.8470.65
249_N252_K0.8460.65
154_Y161_V0.8430.64
69_S254_H0.8420.64
84_Y100_F0.8410.64
46_L52_V0.8380.64
42_A55_V0.8370.64
121_I142_K0.8320.63
131_F201_Y0.8210.62
225_G232_A0.8090.61
99_F217_Y0.8030.61
20_I50_P0.8000.60
69_S246_R0.7970.60
45_I52_V0.7900.59
34_K37_D0.7880.59
235_K238_G0.7860.59
119_E258_D0.7840.59
99_F246_R0.7830.59
159_V163_L0.7820.58
192_P217_Y0.7800.58
227_D231_I0.7790.58
62_V104_L0.7770.58
130_P254_H0.7760.58
195_E219_E0.7750.58
192_P219_E0.7750.58
194_P197_A0.7730.58
124_M180_I0.7720.57
158_M171_P0.7700.57
243_R258_D0.7680.57
46_L55_V0.7610.56
29_V41_I0.7590.56
43_N46_L0.7580.56
104_L123_N0.7580.56
87_H109_L0.7560.56
191_A201_Y0.7540.56
160_N175_D0.7490.55
121_I135_S0.7410.54
124_M128_F0.7410.54
33_K36_E0.7400.54
174_G179_R0.7330.54
91_Y99_F0.7300.53
191_A216_L0.7280.53
56_W95_F0.7230.53
73_H85_K0.7210.52
84_Y105_S0.7200.52
134_L166_A0.7190.52
177_F200_A0.7140.52
189_I255_V0.7090.51
156_Y159_V0.7070.51
86_E105_S0.7020.50
103_K246_R0.7000.50
248_V254_H0.6990.50
135_S144_V0.6990.50
254_H259_I0.6960.50
148_D252_K0.6960.50
102_E135_S0.6940.50
108_H131_F0.6920.49
137_V238_G0.6910.49
194_P217_Y0.6890.49
229_V233_M0.6890.49
54_S80_S0.6880.49
20_I52_V0.6880.49
220_V229_V0.6860.49
134_L157_M0.6830.49
121_I144_V0.6810.48
56_W160_N0.6730.48
39_V43_N0.6730.48
105_S109_L0.6690.47
121_I161_V0.6690.47
46_L87_H0.6690.47
201_Y214_I0.6680.47
60_R70_T0.6670.47
174_G178_K0.6580.46
41_I72_V0.6580.46
31_F190_I0.6570.46
74_L177_F0.6550.46
64_G86_E0.6540.46
26_I95_F0.6520.45
123_N129_G0.6520.45
118_D240_Y0.6490.45
29_V33_K0.6470.45
104_L219_E0.6470.45
228_P257_V0.6460.45
44_E47_S0.6440.45
101_S108_H0.6430.45
108_H195_E0.6390.44
195_E248_V0.6380.44
31_F34_K0.6380.44
24_I79_R0.6370.44
104_L176_A0.6370.44
209_K214_I0.6350.44
154_Y157_M0.6330.44
17_R99_F0.6330.44
74_L165_K0.6280.43
53_K85_K0.6270.43
148_D193_L0.6260.43
69_S131_F0.6250.43
132_S147_I0.6250.43
27_I87_H0.6240.43
19_E156_Y0.6220.42
132_S148_D0.6200.42
191_A214_I0.6200.42
64_G70_T0.6180.42
19_E145_Y0.6170.42
180_I189_I0.6150.42
147_I176_A0.6150.42
116_K239_S0.6150.42
98_V153_A0.6140.42
87_H122_I0.6130.42
130_P246_R0.6120.41
24_I237_R0.6100.41
69_S192_P0.6080.41
103_K193_L0.6070.41
69_S103_K0.6060.41
110_R243_R0.6060.41
64_G82_T0.6040.41
247_S254_H0.6020.40
52_V257_V0.6020.40
124_M147_I0.6010.40
108_H148_D0.5960.40
224_K227_D0.5920.40
93_L153_A0.5910.39
176_A217_Y0.5890.39
21_V102_E0.5860.39
31_F35_P0.5830.39
33_K41_I0.5820.39
85_K133_I0.5810.38
118_D142_K0.5790.38
195_E246_R0.5780.38
95_F149_L0.5780.38
18_I25_V0.5770.38
58_R219_E0.5770.38
217_Y246_R0.5750.38
62_V68_L0.5740.38
202_E214_I0.5740.38
45_I210_K0.5720.38
148_D176_A0.5720.38
93_L134_L0.5690.37
56_W148_D0.5690.37
86_E94_D0.5690.37
99_F123_N0.5670.37
202_E206_Q0.5640.37
104_L108_H0.5630.37
69_S130_P0.5620.37
37_D74_L0.5610.37
189_I204_A0.5610.37
214_I259_I0.5590.36
56_W73_H0.5580.36
148_D246_R0.5560.36
168_E185_D0.5560.36
103_K254_H0.5560.36
124_M191_A0.5540.36
99_F105_S0.5540.36
252_K258_D0.5540.36
119_E215_H0.5470.35
84_Y94_D0.5470.35
219_E249_N0.5450.35
88_K165_K0.5430.35
220_V228_P0.5420.35
216_L221_E0.5400.35
106_Y245_V0.5400.35
81_E93_L0.5400.35
79_R133_I0.5400.35
112_A188_R0.5390.35
130_P219_E0.5390.35
103_K176_A0.5390.35
122_I143_I0.5380.34
56_W80_S0.5380.34
81_E94_D0.5370.34
29_V36_E0.5370.34
42_A46_L0.5360.34
108_H246_R0.5360.34
68_L86_E0.5340.34
163_L261_A0.5330.34
101_S255_V0.5310.34
37_D40_E0.5310.34
124_M214_I0.5290.34
29_V72_V0.5290.34
219_E254_H0.5280.34
31_F73_H0.5260.33
94_D126_S0.5240.33
147_I179_R0.5230.33
22_G42_A0.5230.33
26_I98_V0.5220.33
59_H80_S0.5210.33
92_F167_Y0.5190.33
66_Y151_P0.5170.33
26_I71_Y0.5140.32
130_P217_Y0.5110.32
57_G111_V0.5100.32
37_D41_I0.5100.32
74_L171_P0.5090.32
226_E230_R0.5050.31
60_R63_N0.5050.31
130_P134_L0.5030.31
31_F55_V0.5030.31
131_F254_H0.5010.31
180_I203_V0.5000.31
224_K249_N0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yx1A 2 0.9313 100 0.533 Contact Map
3k6rA 1 0.9351 100 0.543 Contact Map
3a27A 1 0.8015 100 0.565 Contact Map
2b78A 1 0.9542 100 0.692 Contact Map
3vseA 1 0.958 99.9 0.703 Contact Map
2as0A 2 0.9809 99.9 0.712 Contact Map
1wxxA 2 0.9618 99.9 0.714 Contact Map
3v97A 1 0.8931 99.9 0.722 Contact Map
3c0kA 2 0.9695 99.9 0.728 Contact Map
4dmgA 2 0.9656 99.9 0.73 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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