GREMLIN Database
Q97W07 - Glutamine synthetase (Glutamate ammonia ligase) (GS). (GlnA-2)
UniProt: Q97W07 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 425 (406)
Sequences: 5822 (3017)
Seq/√Len: 149.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
380_E402_N5.1211.00
273_S357_L4.7931.00
242_L271_F3.8121.00
271_F349_G3.7871.00
165_L219_N3.7271.00
351_D355_R3.6301.00
119_K354_E3.4991.00
96_F114_N3.3491.00
270_N356_N3.2911.00
123_A354_E3.1561.00
99_Q103_L3.0621.00
277_E355_R2.9211.00
116_A347_Y2.8051.00
118_E122_E2.7001.00
386_K391_Q2.6811.00
281_S382_D2.6241.00
112_I393_L2.6051.00
136_Y185_G2.6021.00
162_F166_L2.6011.00
414_E418_D2.5591.00
252_I267_I2.5241.00
8_D12_S2.4751.00
129_V342_L2.4531.00
165_L218_M2.3461.00
212_I223_A2.3461.00
391_Q395_S2.3341.00
266_K356_N2.3291.00
278_H382_D2.3131.00
196_K200_E2.3011.00
242_L345_M2.2831.00
118_E121_K2.2631.00
285_I344_S2.2271.00
278_H351_D2.2251.00
377_S402_N2.2221.00
200_E204_S2.1421.00
373_K409_E2.1241.00
196_K204_S2.1181.00
269_Y358_M2.1141.00
126_T244_L2.1091.00
284_S379_L2.1081.00
270_N273_S2.1071.00
371_T374_E2.0801.00
117_I199_L2.0741.00
138_L230_F2.0461.00
280_P366_G2.0251.00
121_K126_T1.9741.00
9_A13_G1.9681.00
286_A341_L1.9621.00
281_S384_Y1.9441.00
37_A171_E1.9221.00
120_L127_L1.9151.00
197_P200_E1.9121.00
173_I211_V1.8961.00
137_L162_F1.8881.00
370_Q374_E1.8781.00
20_V95_S1.8651.00
166_L212_I1.8441.00
270_N357_L1.8171.00
379_L394_I1.8111.00
136_Y236_S1.8091.00
106_P392_D1.7581.00
176_K194_S1.7561.00
16_D168_K1.7431.00
264_L268_A1.7311.00
170_L211_V1.7291.00
202_A342_L1.7181.00
336_A341_L1.7181.00
407_E419_Y1.7171.00
117_I198_V1.7141.00
378_R381_N1.6971.00
266_K270_N1.6931.00
267_I353_I1.6841.00
208_S212_I1.6561.00
373_K377_S1.6521.00
278_H348_A1.6401.00
285_I379_L1.6371.00
43_I78_L1.6131.00
273_S359_A1.6071.00
277_E357_L1.6021.00
133_P205_L1.5901.00
10_L36_R1.5871.00
384_Y388_N1.5821.00
280_P378_R1.5721.00
376_L398_I1.5681.00
15_I83_A1.5371.00
125_Y252_I1.5331.00
75_I98_A1.5321.00
112_I343_A1.5231.00
80_T94_L1.5091.00
117_I197_P1.5031.00
127_L346_I1.4871.00
116_A343_A1.4691.00
120_L350_L1.4651.00
21_E92_R1.4591.00
114_N199_L1.4581.00
258_D269_Y1.4281.00
383_T387_Y1.4261.00
169_Y215_T1.4171.00
270_N358_M1.4091.00
242_L349_G1.3871.00
137_L216_A1.3741.00
128_Q245_Q1.3711.00
269_Y359_A1.3701.00
347_Y388_N1.3681.00
193_L201_A1.3671.00
92_R207_S1.3601.00
13_G89_R1.3561.00
170_L175_I1.3561.00
23_V206_I1.3441.00
406_E409_E1.3341.00
374_E377_S1.3311.00
380_E395_S1.3281.00
266_K358_M1.3261.00
114_N118_E1.3191.00
128_Q195_Q1.3121.00
16_D171_E1.3091.00
201_A204_S1.3061.00
284_S376_L1.3021.00
267_I270_N1.3001.00
108_C111_S1.2901.00
329_F345_M1.2811.00
116_A119_K1.2601.00
183_H190_E1.2461.00
386_K395_S1.2401.00
315_V327_V1.2351.00
283_L331_L1.2341.00
169_Y172_E1.2241.00
386_K394_I1.2231.00
77_D96_F1.2231.00
10_L39_F1.2141.00
139_N221_V1.2081.00
287_A292_S1.2061.00
255_D258_D1.2051.00
377_S381_N1.2041.00
281_S378_R1.2021.00
99_Q106_P1.2021.00
272_I327_V1.2021.00
380_E398_I1.2001.00
280_P374_E1.2001.00
273_S360_N1.1971.00
159_Q189_Y1.1931.00
377_S380_E1.1921.00
5_N8_D1.1891.00
56_A59_D1.1861.00
165_L169_Y1.1821.00
126_T247_V1.1801.00
119_K347_Y1.1781.00
266_K269_Y1.1771.00
272_I315_V1.1771.00
280_P283_L1.1721.00
278_H355_R1.1691.00
7_F40_E1.1661.00
282_I344_S1.1641.00
81_F91_A1.1581.00
142_L145_A1.1571.00
162_F215_T1.1511.00
282_I286_A1.1501.00
215_T219_N1.1491.00
74_A97_L1.1481.00
240_I345_M1.1441.00
406_E410_S1.1361.00
15_I91_A1.1351.00
281_S385_M1.1321.00
408_Y415_W1.1301.00
125_Y267_I1.1240.99
8_D11_K1.1230.99
401_K404_E1.1210.99
379_L385_M1.1200.99
196_K201_A1.1130.99
113_L198_V1.1110.99
185_G234_P1.1060.99
271_F345_M1.1030.99
282_I348_A1.1010.99
122_E354_E1.0860.99
276_L315_V1.0850.99
279_L314_I1.0780.99
24_D30_K1.0770.99
6_I81_F1.0740.99
18_V39_F1.0740.99
138_L224_T1.0680.99
186_P233_Y1.0630.99
120_L123_A1.0620.99
29_T94_L1.0560.99
382_D385_M1.0530.99
247_V250_K1.0470.99
226_M291_N1.0470.99
216_A223_A1.0410.99
379_L398_I1.0370.99
169_Y211_V1.0370.99
284_S397_Y1.0260.99
292_S333_D1.0230.99
382_D386_K1.0180.99
254_Y263_G1.0170.99
66_K69_Y1.0170.99
190_E239_D1.0160.99
191_V208_S1.0150.99
395_S399_N1.0110.99
179_T192_K1.0110.99
293_Y372_L1.0080.99
282_I385_M1.0070.99
137_L223_A1.0060.99
74_A95_S0.9960.99
183_H239_D0.9940.99
184_Y234_P0.9940.99
29_T206_I0.9880.99
6_I78_L0.9880.99
240_I341_L0.9870.99
403_I407_E0.9830.99
211_V215_T0.9790.99
285_I389_L0.9780.99
104_P111_S0.9770.99
18_V36_R0.9730.98
82_V92_R0.9690.98
314_I331_L0.9660.98
231_K412_I0.9650.98
294_K416_E0.9650.98
178_E194_S0.9630.98
376_L401_K0.9610.98
413_T416_E0.9590.98
275_I315_V0.9560.98
6_I93_V0.9450.98
376_L405_I0.9410.98
280_P305_P0.9400.98
5_N9_A0.9350.98
162_F221_V0.9340.98
227_P335_L0.9280.98
270_N353_I0.9280.98
373_K405_I0.9260.98
405_I409_E0.9230.98
273_S358_M0.9200.98
351_D387_Y0.9190.98
7_F11_K0.9160.98
412_I416_E0.9120.98
112_I116_A0.9080.98
402_N406_E0.9060.98
107_Y392_D0.9030.98
307_I317_L0.9030.98
389_L394_I0.9030.98
79_N200_E0.9000.97
408_Y413_T0.8940.97
193_L208_S0.8890.97
253_M268_A0.8890.97
306_G313_Y0.8880.97
120_L244_L0.8870.97
136_Y234_P0.8860.97
320_Y324_T0.8850.97
306_G365_Y0.8830.97
116_A120_L0.8770.97
351_D384_Y0.8770.97
132_E190_E0.8760.97
132_E183_H0.8670.97
173_I207_S0.8660.97
380_E383_T0.8660.97
380_E391_Q0.8660.97
376_L402_N0.8650.97
290_V372_L0.8650.97
98_A104_P0.8650.97
143_N146_D0.8600.97
373_K402_N0.8590.97
108_C112_I0.8560.97
397_Y401_K0.8560.97
58_M61_K0.8540.97
205_L238_M0.8510.96
123_A350_L0.8480.96
227_P333_D0.8460.96
318_P326_Q0.8450.96
111_S115_K0.8430.96
127_L242_L0.8430.96
258_D262_I0.8410.96
129_V201_A0.8410.96
275_I327_V0.8400.96
57_L61_K0.8370.96
46_N49_V0.8350.96
131_F205_L0.8330.96
385_M394_I0.8330.96
383_T391_Q0.8310.96
42_V47_K0.8270.96
162_F219_N0.8270.96
87_L90_T0.8240.96
411_Q415_W0.8230.96
13_G83_A0.8220.96
244_L252_I0.8210.96
289_T335_L0.8200.96
394_I398_I0.8180.96
129_V271_F0.8140.95
271_F350_L0.8120.95
48_G320_Y0.8120.95
125_Y244_L0.8100.95
398_I402_N0.8090.95
132_E241_T0.8090.95
77_D114_N0.8070.95
116_A388_N0.8050.95
140_S217_K0.8030.95
40_E44_N0.8030.95
275_I345_M0.7980.95
169_Y218_M0.7960.95
242_L329_F0.7960.95
321_Y324_T0.7950.95
161_N219_N0.7950.95
13_G81_F0.7940.95
302_P330_R0.7920.95
226_M294_K0.7910.95
20_V42_V0.7910.95
158_E217_K0.7840.94
34_L42_V0.7830.94
245_Q252_I0.7800.94
240_I342_L0.7770.94
184_Y300_V0.7750.94
285_I394_I0.7690.94
258_D263_G0.7690.94
286_A382_D0.7690.94
344_S389_L0.7680.94
120_L125_Y0.7640.94
37_A176_K0.7630.94
222_I421_L0.7610.94
135_F166_L0.7600.94
38_E41_N0.7600.94
168_K171_E0.7560.93
278_H281_S0.7560.93
408_Y411_Q0.7550.93
106_P390_G0.7530.93
298_E303_N0.7520.93
269_Y273_S0.7520.93
142_L146_D0.7500.93
243_S326_Q0.7470.93
275_I329_F0.7470.93
279_L315_V0.7430.93
407_E410_S0.7430.93
227_P292_S0.7410.93
412_I415_W0.7390.93
129_V198_V0.7370.92
115_K119_K0.7340.92
231_K411_Q0.7330.92
387_Y391_Q0.7300.92
396_I399_N0.7300.92
290_V408_Y0.7290.92
134_T183_H0.7290.92
278_H357_L0.7280.92
96_F108_C0.7270.92
294_K408_Y0.7270.92
119_K122_E0.7230.92
255_D263_G0.7200.92
131_F238_M0.7180.91
126_T245_Q0.7170.91
17_Y167_I0.7140.91
84_I92_R0.7110.91
378_R382_D0.7110.91
288_P292_S0.7090.91
111_S114_N0.7080.91
139_N143_N0.7070.91
104_P114_N0.7060.91
391_Q394_I0.7060.91
32_R151_F0.7040.91
83_A89_R0.7020.91
48_G73_I0.7020.91
279_L305_P0.7020.91
183_H241_T0.7000.90
403_I406_E0.7000.90
283_L369_P0.6980.90
90_T164_K0.6970.90
82_V207_S0.6970.90
244_L346_I0.6970.90
77_D80_T0.6970.90
160_Q164_K0.6970.90
134_T239_D0.6960.90
343_A389_L0.6960.90
57_L60_Y0.6940.90
195_Q198_V0.6940.90
175_I193_L0.6930.90
417_R421_L0.6880.90
113_L343_A0.6870.90
408_Y419_Y0.6850.89
311_R330_R0.6830.89
351_D357_L0.6820.89
228_K235_S0.6820.89
297_K303_N0.6820.89
103_L106_P0.6800.89
19_R31_G0.6790.89
88_E168_K0.6790.89
242_L275_I0.6780.89
33_S87_L0.6770.89
98_A111_S0.6760.89
17_Y168_K0.6710.88
21_E207_S0.6700.88
129_V202_A0.6690.88
283_L368_L0.6680.88
133_P208_S0.6650.88
132_E239_D0.6650.88
137_L166_L0.6620.88
134_T190_E0.6600.88
262_I362_N0.6590.88
106_P111_S0.6590.88
123_A252_I0.6580.87
123_A356_N0.6580.87
138_L229_P0.6570.87
230_F233_Y0.6550.87
361_V364_Y0.6530.87
209_R213_R0.6530.87
15_I89_R0.6530.87
39_F93_V0.6530.87
168_K172_E0.6520.87
286_A329_F0.6480.87
286_A348_A0.6470.87
26_L400_I0.6470.87
117_I127_L0.6460.87
112_I115_K0.6450.86
290_V413_T0.6440.86
78_L93_V0.6430.86
227_P289_T0.6420.86
99_Q105_Y0.6420.86
113_L117_I0.6410.86
271_F275_I0.6370.86
354_E357_L0.6370.86
346_I350_L0.6350.86
30_K152_S0.6350.86
86_Y211_V0.6340.86
326_Q330_R0.6340.86
167_I180_I0.6340.86
38_E176_K0.6330.85
308_G313_Y0.6330.85
205_L342_L0.6330.85
202_A338_P0.6330.85
117_I121_K0.6320.85
270_N359_A0.6260.85
379_L389_L0.6260.85
130_S192_K0.6260.85
332_A341_L0.6260.85
17_Y33_S0.6250.85
133_P193_L0.6250.85
162_F216_A0.6230.85
22_F74_A0.6230.85
379_L382_D0.6210.84
285_I397_Y0.6200.84
290_V405_I0.6200.84
277_E366_G0.6190.84
115_K118_E0.6190.84
16_D89_R0.6190.84
278_H282_I0.6180.84
288_P336_A0.6180.84
25_I393_L0.6180.84
56_A60_Y0.6170.84
347_Y385_M0.6160.84
165_L215_T0.6160.84
21_E29_T0.6140.84
358_M361_V0.6140.84
277_E351_D0.6140.84
17_Y87_L0.6130.84
387_Y390_G0.6120.83
157_L214_D0.6100.83
178_E195_Q0.6100.83
415_W419_Y0.6090.83
126_T197_P0.6070.83
305_P314_I0.6060.83
170_L208_S0.6060.83
129_V242_L0.6060.83
5_N10_L0.6040.83
235_S295_R0.6040.83
310_E363_E0.6040.83
119_K123_A0.6030.83
135_F191_V0.6030.83
163_L180_I0.6020.82
188_Q236_S0.6020.82
268_A272_I0.6010.82
92_R173_I0.6010.82
241_T326_Q0.6000.82
167_I177_V0.6000.82
10_L18_V0.5990.82
19_R210_E0.5980.82
41_N45_D0.5960.82
9_A83_A0.5930.82
72_I76_P0.5930.82
150_A181_N0.5920.81
176_K204_S0.5910.81
285_I340_I0.5880.81
291_N416_E0.5860.81
175_I207_S0.5850.81
344_S385_M0.5850.81
177_V180_I0.5840.81
269_Y307_I0.5840.81
34_L39_F0.5840.81
341_L344_S0.5830.80
113_L199_L0.5820.80
149_K152_S0.5820.80
42_V45_D0.5820.80
130_S243_S0.5810.80
41_N323_D0.5810.80
46_N52_P0.5780.80
132_E311_R0.5770.80
385_M389_L0.5770.80
371_T375_S0.5770.80
9_A81_F0.5770.80
120_L346_I0.5760.80
83_A91_A0.5750.80
67_S70_E0.5750.80
139_N142_L0.5740.79
290_V416_E0.5730.79
279_L331_L0.5730.79
332_A336_A0.5730.79
262_I269_Y0.5710.79
175_I208_S0.5700.79
153_L210_E0.5700.79
170_L177_V0.5690.79
87_L161_N0.5690.79
137_L221_V0.5670.79
130_S181_N0.5670.79
152_S155_G0.5660.78
85_P173_I0.5650.78
350_L354_E0.5650.78
390_G393_L0.5650.78
98_A103_L0.5640.78
181_N184_Y0.5640.78
149_K155_G0.5630.78
75_I102_G0.5610.78
407_E415_W0.5610.78
383_T386_K0.5600.78
11_K14_K0.5600.78
23_V109_S0.5600.78
281_S379_L0.5590.78
159_Q221_V0.5580.77
250_K323_D0.5580.77
8_D13_G0.5570.77
130_S195_Q0.5570.77
19_R33_S0.5560.77
303_N367_T0.5560.77
371_T377_S0.5550.77
132_E328_E0.5550.77
163_L189_Y0.5550.77
22_F97_L0.5540.77
175_I205_L0.5530.77
94_L207_S0.5520.77
14_K89_R0.5520.77
282_I285_I0.5520.77
178_E192_K0.5510.77
311_R328_E0.5500.76
286_A332_A0.5490.76
243_S310_E0.5480.76
56_A61_K0.5480.76
150_A157_L0.5460.76
214_D217_K0.5440.76
273_S277_E0.5440.76
16_D172_E0.5420.75
46_N50_D0.5410.75
255_D269_Y0.5410.75
17_Y164_K0.5410.75
50_D300_V0.5400.75
210_E214_D0.5400.75
232_D410_S0.5400.75
127_L244_L0.5390.75
190_E328_E0.5390.75
286_A331_L0.5380.75
136_Y233_Y0.5380.75
199_L275_I0.5380.75
367_T370_Q0.5370.75
178_E243_S0.5360.75
371_T409_E0.5360.75
265_S268_A0.5350.74
25_I340_I0.5340.74
241_T311_R0.5340.74
281_S284_S0.5330.74
45_D48_G0.5330.74
239_D328_E0.5330.74
39_F78_L0.5330.74
254_Y325_H0.5330.74
124_G174_D0.5290.74
302_P312_H0.5290.74
264_L325_H0.5280.74
137_L159_Q0.5270.73
376_L380_E0.5250.73
26_L397_Y0.5240.73
138_L142_L0.5230.73
311_R316_R0.5230.73
192_K326_Q0.5230.73
50_D56_A0.5220.73
144_P147_Y0.5220.73
355_R358_M0.5220.73
38_E178_E0.5210.73
164_K168_K0.5210.73
43_I93_V0.5210.73
305_P366_G0.5210.73
371_T405_I0.5190.72
287_A293_Y0.5180.72
128_Q243_S0.5160.72
140_S222_I0.5160.72
9_A14_K0.5150.72
245_Q248_D0.5150.72
293_Y375_S0.5140.72
52_P71_D0.5140.72
286_A344_S0.5140.72
169_Y173_I0.5130.71
24_D311_R0.5130.71
278_H384_Y0.5130.71
128_Q197_P0.5120.71
400_I403_I0.5120.71
50_D71_D0.5100.71
51_Y74_A0.5100.71
294_K413_T0.5080.71
119_K350_L0.5060.70
125_Y350_L0.5060.70
281_S383_T0.5050.70
7_F43_I0.5050.70
150_A153_L0.5050.70
343_A347_Y0.5030.70
52_P70_E0.5030.70
369_P375_S0.5030.70
69_Y72_I0.5020.70
34_L47_K0.5020.70
253_M264_L0.5020.70
50_D181_N0.5010.70
299_V410_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lniA 5 0.9741 100 0.112 Contact Map
4s17A 5 0.9506 100 0.12 Contact Map
1f52A 5 0.9671 100 0.129 Contact Map
3ng0A 5 0.9694 100 0.131 Contact Map
4acfA 5 0.9718 100 0.132 Contact Map
4hppA 3 0.9553 100 0.141 Contact Map
2j9iA 5 0.9506 100 0.178 Contact Map
3o6xA 3 0.84 100 0.338 Contact Map
2ojwA 5 0.7741 100 0.355 Contact Map
3fkyA 8 0.7412 100 0.359 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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