GREMLIN Database
Q97W06 - Alcohol dehydrogenase (Zn containing) (Adh-7)
UniProt: Q97W06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (293)
Sequences: 52657 (36103)
Seq/√Len: 2109.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_L135_V3.0831.00
28_K67_V3.0141.00
306_D309_K2.9601.00
30_L65_E2.9381.00
7_K16_E2.7851.00
26_V67_V2.7841.00
159_S182_R2.7001.00
74_K77_D2.6091.00
25_I126_I2.5611.00
78_K129_R2.5491.00
77_D128_L2.5131.00
177_K202_D2.4511.00
28_K65_E2.3521.00
302_Y313_D2.3401.00
28_K118_Y2.2921.00
155_T158_D2.2671.00
7_K14_S2.2491.00
160_V176_L2.2051.00
62_I114_G2.1881.00
182_R203_E2.1861.00
300_N313_D2.1751.00
193_L197_K2.1361.00
72_T123_S2.1351.00
194_E198_E2.1291.00
152_K179_K2.1271.00
62_I81_V2.0911.00
5_I16_E2.0831.00
288_K292_E2.0631.00
26_V120_S2.0471.00
303_K306_D2.0251.00
23_N71_G2.0181.00
173_L201_A2.0091.00
132_G291_N2.0061.00
63_V135_V1.9691.00
67_V118_Y1.9671.00
312_R316_D1.9511.00
301_T326_V1.9381.00
43_N315_R1.9151.00
78_K135_V1.8981.00
194_E197_K1.8841.00
144_G171_L1.8841.00
161_L186_I1.8401.00
20_E118_Y1.8231.00
193_L204_V1.8221.00
152_K285_S1.8131.00
184_T222_F1.8041.00
178_L294_K1.7801.00
161_L222_F1.7781.00
247_E271_K1.7731.00
309_K312_R1.7651.00
129_R135_V1.7631.00
313_D318_R1.7621.00
223_D243_N1.7461.00
187_G193_L1.7241.00
190_K194_E1.6821.00
247_E273_R1.6651.00
309_K313_D1.6591.00
26_V118_Y1.6521.00
302_Y310_A1.6511.00
195_K198_E1.6431.00
158_D247_E1.6401.00
163_I238_S1.6311.00
182_R202_D1.6241.00
73_F77_D1.6151.00
4_A307_I1.6101.00
68_K75_E1.6041.00
190_K206_N1.5751.00
65_E78_K1.5751.00
242_L270_L1.5611.00
73_F128_L1.5591.00
115_F311_I1.5431.00
242_L248_L1.5351.00
190_K209_Y1.5221.00
242_L246_G1.5161.00
206_N209_Y1.5131.00
24_G122_P1.5131.00
23_N122_P1.5021.00
165_T185_V1.4941.00
29_V62_I1.4871.00
225_I242_L1.4751.00
24_G120_S1.4651.00
26_V68_K1.4601.00
225_I238_S1.4511.00
308_N312_R1.4461.00
173_L185_V1.4451.00
78_K131_D1.4251.00
66_V73_F1.3881.00
20_E68_K1.3841.00
25_I73_F1.3791.00
42_I311_I1.3681.00
159_S184_T1.3491.00
31_A326_V1.3331.00
288_K291_N1.3301.00
178_L289_L1.3291.00
148_Y152_K1.3231.00
163_I186_I1.3231.00
172_A226_I1.3171.00
65_E135_V1.3151.00
129_R137_L1.3111.00
188_H207_I1.3041.00
4_A15_L1.2831.00
154_I158_D1.2751.00
30_L78_K1.2501.00
190_K193_L1.2251.00
203_E216_E1.2101.00
193_L206_N1.2081.00
29_V119_V1.2061.00
73_F126_I1.2011.00
23_N123_S1.2011.00
159_S223_D1.1991.00
154_I181_A1.1761.00
197_K204_V1.1601.00
158_D223_D1.1421.00
121_V126_I1.1381.00
174_Q296_R1.1361.00
285_S288_K1.1291.00
22_S68_K1.1271.00
67_V75_E1.1271.00
20_E26_V1.1201.00
289_L294_K1.1171.00
27_L64_G1.1151.00
149_S282_D1.1061.00
8_N12_E1.1041.00
152_K282_D1.1011.00
195_K320_I1.0891.00
34_L310_A1.0831.00
42_I315_R1.0781.00
147_A172_A1.0721.00
240_W264_L1.0711.00
32_T115_F1.0601.00
27_L79_V1.0571.00
185_V201_A1.0561.00
31_A135_V1.0561.00
4_A304_L1.0521.00
229_V234_T1.0481.00
303_K326_V1.0421.00
188_H208_K1.0371.00
302_Y306_D1.0361.00
176_L181_A1.0271.00
147_A175_I1.0221.00
9_F54_L1.0161.00
312_R315_R1.0071.00
284_I288_K1.0001.00
184_T203_E0.9971.00
15_L305_R0.9911.00
307_I325_I0.9911.00
197_K203_E0.9911.00
150_S251_I0.9891.00
165_T187_G0.9881.00
227_D230_G0.9841.00
30_L63_V0.9811.00
115_F307_I0.9711.00
148_Y285_S0.9701.00
35_C61_E0.9651.00
237_D240_W0.9641.00
185_V196_A0.9631.00
236_S240_W0.9571.00
189_N192_K0.9551.00
186_I207_I0.9551.00
313_D323_A0.9531.00
32_T114_G0.9521.00
150_S226_I0.9501.00
39_L314_L0.9481.00
23_N69_G0.9421.00
173_L183_V0.9411.00
56_K112_N0.9401.00
144_G286_V0.9371.00
134_P137_L0.9341.00
170_L195_K0.9301.00
188_H193_L0.9291.00
5_I57_I0.9251.00
136_K296_R0.9221.00
184_T205_I0.9201.00
35_C60_H0.9191.00
162_I172_A0.9181.00
80_L287_Y0.9181.00
187_G204_V0.9161.00
285_S289_L0.9101.00
214_A219_E0.9091.00
161_L241_L0.9001.00
162_I176_L0.9001.00
158_D224_Y0.8991.00
163_I225_I0.8971.00
245_E269_G0.8891.00
191_N194_E0.8881.00
7_K12_E0.8831.00
74_K128_L0.8811.00
192_K320_I0.8801.00
62_I119_V0.8771.00
214_A217_V0.8761.00
175_I286_V0.8761.00
140_L290_Y0.8741.00
28_K117_E0.8671.00
4_A13_L0.8561.00
33_G61_E0.8471.00
145_I282_D0.8461.00
159_S222_F0.8461.00
5_I18_V0.8441.00
261_P264_L0.8421.00
281_D285_S0.8421.00
131_D291_N0.8411.00
115_F325_I0.8391.00
265_L272_V0.8381.00
165_T196_A0.8361.00
25_I123_S0.8341.00
34_L314_L0.8261.00
136_K301_T0.8221.00
133_E137_L0.8221.00
264_L268_K0.8181.00
196_A201_A0.8181.00
151_A176_L0.8161.00
31_A324_V0.8161.00
35_C38_D0.8131.00
179_K285_S0.8121.00
238_S248_L0.8041.00
81_V121_V0.8031.00
225_I248_L0.8031.00
160_V181_A0.8031.00
281_D284_I0.8011.00
176_L183_V0.8001.00
4_A308_N0.7951.00
163_I234_T0.7951.00
147_A171_L0.7951.00
189_N206_N0.7931.00
236_S257_T0.7911.00
213_I217_V0.7901.00
150_S172_A0.7851.00
23_N70_N0.7851.00
154_I224_Y0.7841.00
314_L323_A0.7821.00
175_I289_L0.7821.00
319_V323_A0.7781.00
183_V202_D0.7771.00
37_G60_H0.7721.00
224_Y249_R0.7691.00
127_L284_I0.7681.00
114_G119_V0.7681.00
79_V126_I0.7661.00
228_Y251_I0.7631.00
289_L292_E0.7561.00
181_A224_Y0.7531.00
313_D316_D0.7481.00
152_K175_I0.7441.00
133_E290_Y0.7441.00
80_L129_R0.7431.00
212_T237_D0.7391.00
257_T261_P0.7391.00
153_G271_K0.7371.00
250_I272_V0.7371.00
159_S220_S0.7341.00
147_A168_V0.7321.00
162_I185_V0.7321.00
149_S269_G0.7291.00
187_G196_A0.7281.00
165_T173_L0.7231.00
217_V220_S0.7211.00
211_S237_D0.7141.00
214_A218_K0.7141.00
287_Y291_N0.7101.00
19_R22_S0.7101.00
127_L283_L0.7101.00
148_Y286_V0.7091.00
23_N124_D0.7091.00
265_L274_G0.7061.00
61_E142_D0.7051.00
130_V291_N0.7031.00
147_A151_A0.7021.00
6_L12_E0.7011.00
35_C142_D0.7001.00
235_L248_L0.6991.00
213_I222_F0.6971.00
302_Y325_I0.6961.00
244_R268_K0.6961.00
77_D131_D0.6961.00
289_L293_G0.6951.00
215_S218_K0.6941.00
31_A301_T0.6941.00
60_H142_D0.6931.00
265_L270_L0.6911.00
10_G42_I0.6861.00
198_E296_R0.6861.00
222_F225_I0.6861.00
153_G273_R0.6851.00
31_A63_V0.6851.00
302_Y323_A0.6841.00
160_V224_Y0.6811.00
22_S26_V0.6801.00
193_L196_A0.6791.00
146_T168_V0.6761.00
148_Y289_L0.6751.00
227_D248_L0.6741.00
224_Y247_E0.6691.00
63_V78_K0.6691.00
153_G247_E0.6691.00
29_V32_T0.6681.00
142_D146_T0.6681.00
34_L115_F0.6681.00
80_L141_A0.6661.00
25_I66_V0.6641.00
215_S219_E0.6641.00
63_V129_R0.6621.00
173_L199_L0.6611.00
195_K199_L0.6611.00
22_S120_S0.6561.00
20_E67_V0.6491.00
35_C143_A0.6471.00
37_G41_V0.6461.00
15_L304_L0.6451.00
311_I315_R0.6451.00
143_A171_L0.6451.00
187_G207_I0.6441.00
127_L287_Y0.6431.00
39_L315_R0.6421.00
177_K183_V0.6411.00
313_D319_V0.6391.00
236_S259_T0.6371.00
53_E56_K0.6371.00
8_N14_S0.6361.00
222_F241_L0.6351.00
236_S264_L0.6341.00
78_K132_G0.6341.00
174_Q199_L0.6331.00
139_P324_V0.6321.00
36_H40_H0.6311.00
27_L81_V0.6301.00
148_Y282_D0.6281.00
143_A167_A0.6281.00
72_T128_L0.6271.00
172_A251_I0.6231.00
269_G279_S0.6221.00
220_S243_N0.6221.00
40_H45_D0.6201.00
205_I210_D0.6191.00
52_V56_K0.6181.00
81_V126_I0.6171.00
173_L196_A0.6171.00
232_D236_S0.6161.00
231_S234_T0.6151.00
72_T75_E0.6141.00
73_F123_S0.6121.00
175_I179_K0.6111.00
217_V221_K0.6101.00
129_R138_A0.6071.00
18_V112_N0.6061.00
18_V57_I0.6051.00
216_E219_E0.6051.00
82_Y127_L0.6011.00
150_S275_I0.6001.00
59_G115_F0.5981.00
156_N180_G0.5971.00
123_S126_I0.5971.00
41_V46_W0.5961.00
225_I241_L0.5951.00
187_G192_K0.5951.00
206_N211_S0.5951.00
196_A204_V0.5921.00
39_L43_N0.5911.00
290_Y297_P0.5901.00
36_H166_G0.5891.00
234_T238_S0.5881.00
9_F44_G0.5851.00
161_L225_I0.5841.00
150_S249_R0.5821.00
227_D252_G0.5811.00
20_E120_S0.5801.00
146_T251_I0.5801.00
186_I205_I0.5801.00
213_I216_E0.5771.00
63_V138_A0.5761.00
37_G40_H0.5751.00
208_K211_S0.5711.00
57_I113_G0.5701.00
156_N179_K0.5681.00
151_A175_I0.5641.00
300_N320_I0.5621.00
122_P125_N0.5611.00
148_Y179_K0.5601.00
188_H206_N0.5591.00
275_I280_F0.5581.00
209_Y212_T0.5581.00
24_G111_I0.5571.00
159_S203_E0.5561.00
139_P297_P0.5551.00
70_N123_S0.5551.00
24_G123_S0.5541.00
27_L126_I0.5521.00
153_G158_D0.5521.00
283_L287_Y0.5511.00
29_V81_V0.5471.00
282_D285_S0.5461.00
187_G206_N0.5451.00
174_Q295_I0.5451.00
30_L326_V0.5421.00
24_G69_G0.5411.00
162_I173_L0.5401.00
32_T325_I0.5391.00
170_L199_L0.5371.00
302_Y309_K0.5371.00
193_L207_I0.5371.00
267_L276_L0.5361.00
293_G296_R0.5341.00
6_L9_F0.5331.00
171_L175_I0.5301.00
81_V114_G0.5291.00
177_K201_A0.5281.00
12_E308_N0.5271.00
171_L295_I0.5261.00
184_T216_E0.5251.00
290_Y295_I0.5241.00
191_N318_R0.5241.00
249_R275_I0.5221.00
6_L56_K0.5201.00
18_V21_P0.5191.00
192_K318_R0.5191.00
284_I287_Y0.5191.00
128_L131_D0.5181.00
258_I261_P0.5181.00
151_A172_A0.5181.00
238_S242_L0.5171.00
81_V119_V0.5151.00
178_L295_I0.5131.00
275_I278_G0.5121.00
249_R273_R0.5101.00
72_T77_D0.5091.00
170_L298_I0.5081.00
171_L174_Q0.5081.00
172_A228_Y0.5071.00
234_T237_D0.5061.00
197_K201_A0.5061.00
133_E291_N0.5061.00
144_G175_I0.5051.00
235_L250_I0.5041.00
13_L311_I0.5041.00
266_V274_G0.5031.00
221_K243_N0.5021.00
57_I116_A0.5021.00
159_S221_K0.5021.00
153_G179_K0.5021.00
35_C322_R0.5011.00
65_E75_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h2bA 4 0.9939 100 0.17 Contact Map
3jv7A 4 0.9878 100 0.193 Contact Map
4c4oA 4 0.9695 100 0.196 Contact Map
2h6eA 4 0.9238 100 0.198 Contact Map
3ip1A 4 0.9848 100 0.199 Contact Map
4ej6A 1 0.9756 100 0.203 Contact Map
1rjwA 4 0.9878 100 0.204 Contact Map
2dq4A 4 0.9878 100 0.207 Contact Map
2d8aA 3 0.9573 100 0.208 Contact Map
4uejA 2 0.9817 100 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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