Q97W01 - SULSO - GREMLIN Contacts

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Q97W01 - Ribokinase (RbsK-2)

UniProt:	Q97W01	Sequences: MIHLAVGRFNIDIIVKLDSIPPIDSSHMTDVLEIMPGGAATNYAVAVTKLGHSAKLLAKVGKSEVVRSLMEKVVELGVGLEYVEELNEKPSATLIFLRNDGTLSMVRRLGASILLTREDVKRRFGLFDVIHFASVSPNVVVRDPYAKLVSYDPGPQAKNIESVDVDILYVNEKEYEMIEDKNIRARFIVIKMGKKGAKIITETEECSVEPIQVEKIVDTTGAGDTFDAAFNVTYSEDKDIVKSLQVASVASGLKVSRIGGISSPTLEEVREYLRKKKPNVICK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	283 (259)
Sequences:	21983 (16140)
Seq/√Len:	1002.9

ECOLI - RBSK YDJH SQUV YEGV PFKB K1PF PSUK YEII KDGK FRLD INGK HLDE
BACSU - RBSK IOLC KDGK K1PF YDJE FRLD
HALSA - Q9HP13 Q9HSM7 Q9HMJ3
SULSO - Q97W01 Q981E2 KDGK Q980X6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_H	232_V	3.308	1.00
70_M	85_E	2.821	1.00
192_M	198_K	2.706	1.00
55_K	79_G	2.673	1.00
199_I	244_L	2.519	1.00
233_T	238_K	2.468	1.00
131_H	150_S	2.350	1.00
4_L	127_F	2.345	1.00
239_D	242_K	2.238	1.00
197_A	226_F	2.207	1.00
62_K	87_N	2.170	1.00
67_R	85_E	2.072	1.00
172_E	192_M	2.050	1.00
59_K	86_L	2.026	1.00
45_V	76_L	2.012	1.00
74_V	80_L	2.004	1.00
233_T	246_V	1.992	1.00
148_L	166_D	1.953	1.00
150_S	231_N	1.917	1.00
5_A	44_A	1.908	1.00
198_K	207_S	1.899	1.00
265_T	268_E	1.894	1.00
206_C	241_V	1.883	1.00
47_V	52_H	1.856	1.00
49_K	76_L	1.855	1.00
129_V	148_L	1.826	1.00
238_K	242_K	1.789	1.00
59_K	119_D	1.789	1.00
46_A	228_A	1.788	1.00
169_Y	227_D	1.780	1.00
225_T	250_A	1.771	1.00
142_R	147_K	1.742	1.00
166_D	186_R	1.723	1.00
167_I	187_F	1.719	1.00
72_K	75_E	1.715	1.00
199_I	206_C	1.710	1.00
197_A	248_S	1.691	1.00
236_E	266_L	1.674	1.00
70_M	74_V	1.670	1.00
192_M	195_K	1.647	1.00
229_A	250_A	1.632	1.00
129_V	150_S	1.623	1.00
251_S	255_V	1.619	1.00
230_F	243_S	1.617	1.00
187_F	201_T	1.614	1.00
241_V	245_Q	1.611	1.00
211_I	249_V	1.590	1.00
189_V	230_F	1.580	1.00
34_I	68_S	1.560	1.00
222_A	255_V	1.556	1.00
16_K	31_V	1.555	1.00
71_E	75_E	1.547	1.00
201_T	204_E	1.540	1.00
192_M	207_S	1.524	1.00
47_V	232_V	1.523	1.00
199_I	240_I	1.515	1.00
257_R	268_E	1.512	1.00
208_V	244_L	1.503	1.00
129_V	231_N	1.496	1.00
9_F	58_A	1.473	1.00
208_V	248_S	1.471	1.00
36_P	69_L	1.455	1.00
62_K	67_R	1.444	1.00
62_K	85_E	1.442	1.00
229_A	246_V	1.438	1.00
148_L	167_I	1.425	1.00
232_V	236_E	1.420	1.00
107_R	110_G	1.410	1.00
211_I	245_Q	1.397	1.00
125_G	145_Y	1.394	1.00
11_I	68_S	1.388	1.00
67_R	71_E	1.384	1.00
3_H	47_V	1.376	1.00
176_E	182_N	1.362	1.00
143_D	164_D	1.355	1.00
72_K	76_L	1.346	1.00
218_D	259_G	1.342	1.00
165_V	168_L	1.337	1.00
53_S	79_G	1.334	1.00
41_T	73_V	1.323	1.00
36_P	72_K	1.292	1.00
68_S	71_E	1.278	1.00
233_T	236_E	1.269	1.00
187_F	240_I	1.261	1.00
89_K	114_L	1.260	1.00
233_T	243_S	1.253	1.00
70_M	83_V	1.241	1.00
213_V	256_S	1.240	1.00
13_I	34_I	1.239	1.00
253_L	256_S	1.231	1.00
197_A	244_L	1.229	1.00
52_H	235_S	1.226	1.00
152_D	191_K	1.225	1.00
13_I	32_L	1.224	1.00
116_T	119_D	1.216	1.00
187_F	234_Y	1.211	1.00
67_R	70_M	1.201	1.00
153_P	170_V	1.197	1.00
52_H	236_E	1.182	1.00
55_K	127_F	1.177	1.00
211_I	248_S	1.174	1.00
132_F	149_V	1.172	1.00
216_I	255_V	1.170	1.00
229_A	247_A	1.169	1.00
200_I	205_E	1.165	1.00
211_I	252_G	1.164	1.00
94_L	97_L	1.155	1.00
216_I	219_T	1.154	1.00
44_A	54_A	1.151	1.00
253_L	257_R	1.150	1.00
16_K	33_E	1.147	1.00
124_F	127_F	1.145	1.00
143_D	166_D	1.140	1.00
167_I	234_Y	1.133	1.00
169_Y	191_K	1.127	1.00
131_H	231_N	1.123	1.00
230_F	247_A	1.122	1.00
160_I	163_V	1.120	1.00
50_L	229_A	1.119	1.00
141_V	145_Y	1.117	1.00
175_Y	190_I	1.117	1.00
148_L	186_R	1.116	1.00
48_T	78_V	1.116	1.00
48_T	77_G	1.115	1.00
230_F	234_Y	1.115	1.00
43_Y	131_H	1.111	1.00
192_M	196_G	1.110	1.00
47_V	54_A	1.104	1.00
167_I	230_F	1.103	1.00
55_K	82_Y	1.102	1.00
187_F	230_F	1.101	1.00
191_K	226_F	1.100	1.00
187_F	199_I	1.095	1.00
64_E	67_R	1.093	1.00
242_K	245_Q	1.091	1.00
45_V	49_K	1.090	1.00
90_P	93_T	1.088	1.00
68_S	72_K	1.087	1.00
9_F	69_L	1.085	1.00
213_V	255_V	1.081	1.00
151_Y	165_V	1.065	1.00
36_P	68_S	1.061	1.00
71_E	74_V	1.059	1.00
70_M	80_L	1.051	1.00
245_Q	249_V	1.046	1.00
213_V	216_I	1.046	1.00
217_V	258_I	1.038	1.00
230_F	240_I	1.037	1.00
94_L	98_R	1.034	1.00
46_A	225_T	1.032	1.00
86_L	114_L	1.030	1.00
225_T	254_K	1.030	1.00
130_I	147_K	1.027	1.00
131_H	227_D	1.019	1.00
248_S	251_S	1.018	1.00
86_L	89_K	1.016	1.00
9_F	41_T	1.015	1.00
208_V	245_Q	1.012	1.00
130_I	142_R	1.001	1.00
169_Y	230_F	0.999	1.00
127_F	147_K	0.995	1.00
13_I	65_V	0.994	1.00
5_A	40_A	0.994	1.00
60_V	83_V	0.992	1.00
172_E	195_K	0.991	1.00
232_V	266_L	0.990	1.00
201_T	240_I	0.981	1.00
60_V	66_V	0.970	1.00
14_I	35_M	0.969	1.00
9_F	56_L	0.965	1.00
59_K	84_E	0.954	1.00
238_K	246_V	0.953	1.00
234_Y	243_S	0.953	1.00
216_I	256_S	0.952	1.00
89_K	92_A	0.949	1.00
243_S	247_A	0.946	1.00
186_R	202_E	0.944	1.00
232_V	246_V	0.943	1.00
60_V	70_M	0.934	1.00
48_T	53_S	0.931	1.00
80_L	83_V	0.928	1.00
50_L	250_A	0.927	1.00
47_V	228_A	0.927	1.00
34_I	65_V	0.921	1.00
172_E	176_E	0.911	1.00
239_D	243_S	0.900	1.00
6_V	130_I	0.899	1.00
84_E	119_D	0.894	1.00
210_P	248_S	0.892	1.00
204_E	241_V	0.888	1.00
202_E	205_E	0.885	1.00
195_K	207_S	0.874	1.00
55_K	81_E	0.872	1.00
95_I	98_R	0.867	1.00
60_V	85_E	0.864	1.00
43_Y	227_D	0.860	1.00
124_F	147_K	0.860	1.00
208_V	241_V	0.855	1.00
41_T	261_I	0.855	1.00
15_V	94_L	0.852	1.00
225_T	263_S	0.852	1.00
4_L	57_L	0.848	1.00
134_S	151_Y	0.847	1.00
226_F	248_S	0.845	1.00
96_F	104_S	0.838	1.00
170_V	175_Y	0.838	1.00
141_V	144_P	0.837	1.00
48_T	54_A	0.837	1.00
45_V	261_I	0.837	1.00
112_S	115_L	0.835	1.00
142_R	145_Y	0.833	1.00
4_L	55_K	0.828	1.00
158_K	161_E	0.819	1.00
229_A	233_T	0.818	1.00
44_A	56_L	0.817	1.00
213_V	252_G	0.806	1.00
196_G	210_P	0.800	1.00
11_I	65_V	0.796	1.00
72_K	261_I	0.784	1.00
249_V	253_L	0.781	1.00
50_L	246_V	0.781	1.00
171_N	174_E	0.779	1.00
152_D	169_Y	0.777	1.00
33_E	258_I	0.777	1.00
16_K	258_I	0.776	1.00
129_V	235_S	0.771	1.00
161_E	183_I	0.769	1.00
102_T	105_M	0.766	1.00
201_T	206_C	0.765	1.00
226_F	251_S	0.764	1.00
248_S	252_G	0.759	1.00
29_T	106_V	0.758	1.00
11_I	34_I	0.748	1.00
98_R	102_T	0.746	1.00
189_V	199_I	0.744	1.00
225_T	251_S	0.740	1.00
64_E	68_S	0.739	1.00
214_E	217_V	0.735	1.00
225_T	229_A	0.735	1.00
196_G	207_S	0.734	1.00
66_V	91_S	0.729	1.00
246_V	266_L	0.728	1.00
107_R	111_A	0.722	1.00
150_S	167_I	0.719	1.00
44_A	78_V	0.718	1.00
50_L	269_V	0.712	1.00
58_A	83_V	0.712	1.00
152_D	170_V	0.711	1.00
159_N	162_S	0.709	1.00
119_D	122_R	0.701	1.00
159_N	163_V	0.700	1.00
142_R	146_A	0.698	1.00
150_S	227_D	0.697	1.00
103_L	106_V	0.697	1.00
3_H	235_S	0.696	1.00
107_R	112_S	0.695	1.00
96_F	106_V	0.693	1.00
118_E	121_K	0.691	1.00
15_V	29_T	0.687	1.00
23_I	102_T	0.684	1.00
246_V	269_V	0.684	1.00
50_L	232_V	0.683	1.00
226_F	244_L	0.677	1.00
250_A	269_V	0.676	1.00
251_S	254_K	0.675	1.00
238_K	243_S	0.674	1.00
226_F	247_A	0.674	1.00
62_K	88_E	0.672	1.00
128_D	147_K	0.672	1.00
150_S	169_Y	0.671	1.00
173_K	177_M	0.669	1.00
12_D	37_G	0.668	1.00
197_A	208_V	0.664	1.00
194_K	212_Q	0.658	1.00
112_S	116_T	0.654	1.00
15_V	32_L	0.650	1.00
95_I	105_M	0.650	1.00
3_H	129_V	0.648	1.00
76_L	265_T	0.648	1.00
41_T	56_L	0.645	1.00
53_S	235_S	0.645	1.00
96_F	99_N	0.645	1.00
149_V	165_V	0.642	1.00
244_L	248_S	0.641	1.00
253_L	268_E	0.640	1.00
253_L	269_V	0.636	1.00
185_A	188_I	0.636	1.00
115_L	120_V	0.635	1.00
53_S	128_D	0.633	1.00
143_D	146_A	0.633	1.00
98_R	104_S	0.631	1.00
189_V	244_L	0.628	1.00
48_T	76_L	0.628	1.00
169_Y	189_V	0.626	1.00
101_G	105_M	0.625	1.00
206_C	244_L	0.623	1.00
214_E	256_S	0.621	1.00
189_V	226_F	0.620	1.00
73_V	80_L	0.618	1.00
95_I	103_L	0.618	1.00
240_I	243_S	0.617	1.00
198_K	205_E	0.616	1.00
134_S	138_N	0.614	1.00
221_G	263_S	0.611	1.00
63_S	66_V	0.608	1.00
99_N	103_L	0.607	1.00
242_K	246_V	0.607	1.00
100_D	103_L	0.607	1.00
184_R	188_I	0.606	1.00
166_D	187_F	0.606	1.00
145_Y	148_L	0.604	1.00
70_M	84_E	0.603	1.00
175_Y	200_I	0.598	1.00
228_A	232_V	0.597	1.00
73_V	78_V	0.597	1.00
176_E	179_E	0.594	1.00
156_Q	177_M	0.592	1.00
88_E	114_L	0.592	1.00
84_E	122_R	0.591	1.00
165_V	185_A	0.591	1.00
128_D	148_L	0.587	1.00
10_N	92_A	0.587	1.00
35_M	261_I	0.585	1.00
36_P	261_I	0.584	1.00
201_T	205_E	0.583	1.00
50_L	228_A	0.582	1.00
237_D	243_S	0.579	1.00
13_I	93_T	0.579	1.00
43_Y	231_N	0.578	1.00
137_P	140_V	0.574	1.00
233_T	266_L	0.566	1.00
69_L	91_S	0.565	1.00
109_L	113_I	0.565	1.00
176_E	181_K	0.565	1.00
37_G	42_N	0.565	1.00
194_K	216_I	0.565	1.00
208_V	211_I	0.564	1.00
174_E	179_E	0.559	1.00
179_E	182_N	0.557	1.00
220_T	260_G	0.556	1.00
168_L	188_I	0.556	1.00
23_I	98_R	0.555	1.00
118_E	122_R	0.554	1.00
158_K	162_S	0.552	1.00
172_E	193_G	0.551	1.00
236_E	246_V	0.550	1.00
108_R	111_A	0.548	1.00
82_Y	85_E	0.548	1.00
129_V	234_Y	0.548	1.00
142_R	149_V	0.546	1.00
9_F	73_V	0.541	1.00
63_S	91_S	0.541	1.00
56_L	73_V	0.539	1.00
102_T	106_V	0.538	1.00
8_R	135_V	0.537	1.00
11_I	69_L	0.537	1.00
186_R	201_T	0.535	1.00
188_I	200_I	0.535	1.00
65_V	68_S	0.535	1.00
54_A	78_V	0.535	1.00
234_Y	237_D	0.534	1.00
47_V	231_N	0.534	1.00
5_A	54_A	0.532	1.00
39_A	154_G	0.532	1.00
34_I	64_E	0.527	1.00
67_R	74_V	0.527	1.00
28_M	109_L	0.525	1.00
168_L	185_A	0.524	1.00
240_I	244_L	0.523	1.00
123_R	126_L	0.523	1.00
129_V	167_I	0.523	1.00
64_E	71_E	0.523	1.00
45_V	78_V	0.521	1.00
117_R	140_V	0.520	1.00
59_K	114_L	0.518	1.00
42_N	224_D	0.517	1.00
41_T	45_V	0.514	1.00
24_D	28_M	0.512	1.00
249_V	269_V	0.512	1.00
45_V	48_T	0.510	1.00
61_G	91_S	0.509	1.00
41_T	72_K	0.509	1.00
35_M	258_I	0.507	1.00
46_A	250_A	0.505	1.00
128_D	235_S	0.504	1.00
133_A	136_S	0.501	1.00
115_L	119_D	0.500	1.00
233_T	242_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ikhA	2	0.9576	100	0.238	Contact Map
2rbcA	2	0.9859	100	0.239	Contact Map
3go6A	4	0.9541	100	0.245	Contact Map
4xdaA	2	0.9753	100	0.246	Contact Map
1rkdA	2	0.9753	100	0.246	Contact Map
1vm7A	2	0.9647	100	0.247	Contact Map
2fv7A	2	0.9647	100	0.251	Contact Map
3vasA	1	0.9505	100	0.256	Contact Map
2c4eA	2	0.9647	100	0.258	Contact Map
3ry7A	2	0.9576	100	0.26	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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