GREMLIN Database
Q97W01 - Ribokinase (RbsK-2)
UniProt: Q97W01 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 283 (259)
Sequences: 21983 (16140)
Seq/√Len: 1002.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_H232_V3.3081.00
70_M85_E2.8211.00
192_M198_K2.7061.00
55_K79_G2.6731.00
199_I244_L2.5191.00
233_T238_K2.4681.00
131_H150_S2.3501.00
4_L127_F2.3451.00
239_D242_K2.2381.00
197_A226_F2.2071.00
62_K87_N2.1701.00
67_R85_E2.0721.00
172_E192_M2.0501.00
59_K86_L2.0261.00
45_V76_L2.0121.00
74_V80_L2.0041.00
233_T246_V1.9921.00
148_L166_D1.9531.00
150_S231_N1.9171.00
5_A44_A1.9081.00
198_K207_S1.8991.00
265_T268_E1.8941.00
206_C241_V1.8831.00
47_V52_H1.8561.00
49_K76_L1.8551.00
129_V148_L1.8261.00
238_K242_K1.7891.00
59_K119_D1.7891.00
46_A228_A1.7881.00
169_Y227_D1.7801.00
225_T250_A1.7711.00
142_R147_K1.7421.00
166_D186_R1.7231.00
167_I187_F1.7191.00
72_K75_E1.7151.00
199_I206_C1.7101.00
197_A248_S1.6911.00
236_E266_L1.6741.00
70_M74_V1.6701.00
192_M195_K1.6471.00
229_A250_A1.6321.00
129_V150_S1.6231.00
251_S255_V1.6191.00
230_F243_S1.6171.00
187_F201_T1.6141.00
241_V245_Q1.6111.00
211_I249_V1.5901.00
189_V230_F1.5801.00
34_I68_S1.5601.00
222_A255_V1.5561.00
16_K31_V1.5551.00
71_E75_E1.5471.00
201_T204_E1.5401.00
192_M207_S1.5241.00
47_V232_V1.5231.00
199_I240_I1.5151.00
257_R268_E1.5121.00
208_V244_L1.5031.00
129_V231_N1.4961.00
9_F58_A1.4731.00
208_V248_S1.4711.00
36_P69_L1.4551.00
62_K67_R1.4441.00
62_K85_E1.4421.00
229_A246_V1.4381.00
148_L167_I1.4251.00
232_V236_E1.4201.00
107_R110_G1.4101.00
211_I245_Q1.3971.00
125_G145_Y1.3941.00
11_I68_S1.3881.00
67_R71_E1.3841.00
3_H47_V1.3761.00
176_E182_N1.3621.00
143_D164_D1.3551.00
72_K76_L1.3461.00
218_D259_G1.3421.00
165_V168_L1.3371.00
53_S79_G1.3341.00
41_T73_V1.3231.00
36_P72_K1.2921.00
68_S71_E1.2781.00
233_T236_E1.2691.00
187_F240_I1.2611.00
89_K114_L1.2601.00
233_T243_S1.2531.00
70_M83_V1.2411.00
213_V256_S1.2401.00
13_I34_I1.2391.00
253_L256_S1.2311.00
197_A244_L1.2291.00
52_H235_S1.2261.00
152_D191_K1.2251.00
13_I32_L1.2241.00
116_T119_D1.2161.00
187_F234_Y1.2111.00
67_R70_M1.2011.00
153_P170_V1.1971.00
52_H236_E1.1821.00
55_K127_F1.1771.00
211_I248_S1.1741.00
132_F149_V1.1721.00
216_I255_V1.1701.00
229_A247_A1.1691.00
200_I205_E1.1651.00
211_I252_G1.1641.00
94_L97_L1.1551.00
216_I219_T1.1541.00
44_A54_A1.1511.00
253_L257_R1.1501.00
16_K33_E1.1471.00
124_F127_F1.1451.00
143_D166_D1.1401.00
167_I234_Y1.1331.00
169_Y191_K1.1271.00
131_H231_N1.1231.00
230_F247_A1.1221.00
160_I163_V1.1201.00
50_L229_A1.1191.00
141_V145_Y1.1171.00
175_Y190_I1.1171.00
148_L186_R1.1161.00
48_T78_V1.1161.00
48_T77_G1.1151.00
230_F234_Y1.1151.00
43_Y131_H1.1111.00
192_M196_G1.1101.00
47_V54_A1.1041.00
167_I230_F1.1031.00
55_K82_Y1.1021.00
187_F230_F1.1011.00
191_K226_F1.1001.00
187_F199_I1.0951.00
64_E67_R1.0931.00
242_K245_Q1.0911.00
45_V49_K1.0901.00
90_P93_T1.0881.00
68_S72_K1.0871.00
9_F69_L1.0851.00
213_V255_V1.0811.00
151_Y165_V1.0651.00
36_P68_S1.0611.00
71_E74_V1.0591.00
70_M80_L1.0511.00
245_Q249_V1.0461.00
213_V216_I1.0461.00
217_V258_I1.0381.00
230_F240_I1.0371.00
94_L98_R1.0341.00
46_A225_T1.0321.00
86_L114_L1.0301.00
225_T254_K1.0301.00
130_I147_K1.0271.00
131_H227_D1.0191.00
248_S251_S1.0181.00
86_L89_K1.0161.00
9_F41_T1.0151.00
208_V245_Q1.0121.00
130_I142_R1.0011.00
169_Y230_F0.9991.00
127_F147_K0.9951.00
13_I65_V0.9941.00
5_A40_A0.9941.00
60_V83_V0.9921.00
172_E195_K0.9911.00
232_V266_L0.9901.00
201_T240_I0.9811.00
60_V66_V0.9701.00
14_I35_M0.9691.00
9_F56_L0.9651.00
59_K84_E0.9541.00
238_K246_V0.9531.00
234_Y243_S0.9531.00
216_I256_S0.9521.00
89_K92_A0.9491.00
243_S247_A0.9461.00
186_R202_E0.9441.00
232_V246_V0.9431.00
60_V70_M0.9341.00
48_T53_S0.9311.00
80_L83_V0.9281.00
50_L250_A0.9271.00
47_V228_A0.9271.00
34_I65_V0.9211.00
172_E176_E0.9111.00
239_D243_S0.9001.00
6_V130_I0.8991.00
84_E119_D0.8941.00
210_P248_S0.8921.00
204_E241_V0.8881.00
202_E205_E0.8851.00
195_K207_S0.8741.00
55_K81_E0.8721.00
95_I98_R0.8671.00
60_V85_E0.8641.00
43_Y227_D0.8601.00
124_F147_K0.8601.00
208_V241_V0.8551.00
41_T261_I0.8551.00
15_V94_L0.8521.00
225_T263_S0.8521.00
4_L57_L0.8481.00
134_S151_Y0.8471.00
226_F248_S0.8451.00
96_F104_S0.8381.00
170_V175_Y0.8381.00
141_V144_P0.8371.00
48_T54_A0.8371.00
45_V261_I0.8371.00
112_S115_L0.8351.00
142_R145_Y0.8331.00
4_L55_K0.8281.00
158_K161_E0.8191.00
229_A233_T0.8181.00
44_A56_L0.8171.00
213_V252_G0.8061.00
196_G210_P0.8001.00
11_I65_V0.7961.00
72_K261_I0.7841.00
249_V253_L0.7811.00
50_L246_V0.7811.00
171_N174_E0.7791.00
152_D169_Y0.7771.00
33_E258_I0.7771.00
16_K258_I0.7761.00
129_V235_S0.7711.00
161_E183_I0.7691.00
102_T105_M0.7661.00
201_T206_C0.7651.00
226_F251_S0.7641.00
248_S252_G0.7591.00
29_T106_V0.7581.00
11_I34_I0.7481.00
98_R102_T0.7461.00
189_V199_I0.7441.00
225_T251_S0.7401.00
64_E68_S0.7391.00
214_E217_V0.7351.00
225_T229_A0.7351.00
196_G207_S0.7341.00
66_V91_S0.7291.00
246_V266_L0.7281.00
107_R111_A0.7221.00
150_S167_I0.7191.00
44_A78_V0.7181.00
50_L269_V0.7121.00
58_A83_V0.7121.00
152_D170_V0.7111.00
159_N162_S0.7091.00
119_D122_R0.7011.00
159_N163_V0.7001.00
142_R146_A0.6981.00
150_S227_D0.6971.00
103_L106_V0.6971.00
3_H235_S0.6961.00
107_R112_S0.6951.00
96_F106_V0.6931.00
118_E121_K0.6911.00
15_V29_T0.6871.00
23_I102_T0.6841.00
246_V269_V0.6841.00
50_L232_V0.6831.00
226_F244_L0.6771.00
250_A269_V0.6761.00
251_S254_K0.6751.00
238_K243_S0.6741.00
226_F247_A0.6741.00
62_K88_E0.6721.00
128_D147_K0.6721.00
150_S169_Y0.6711.00
173_K177_M0.6691.00
12_D37_G0.6681.00
197_A208_V0.6641.00
194_K212_Q0.6581.00
112_S116_T0.6541.00
15_V32_L0.6501.00
95_I105_M0.6501.00
3_H129_V0.6481.00
76_L265_T0.6481.00
41_T56_L0.6451.00
53_S235_S0.6451.00
96_F99_N0.6451.00
149_V165_V0.6421.00
244_L248_S0.6411.00
253_L268_E0.6401.00
253_L269_V0.6361.00
185_A188_I0.6361.00
115_L120_V0.6351.00
53_S128_D0.6331.00
143_D146_A0.6331.00
98_R104_S0.6311.00
189_V244_L0.6281.00
48_T76_L0.6281.00
169_Y189_V0.6261.00
101_G105_M0.6251.00
206_C244_L0.6231.00
214_E256_S0.6211.00
189_V226_F0.6201.00
73_V80_L0.6181.00
95_I103_L0.6181.00
240_I243_S0.6171.00
198_K205_E0.6161.00
134_S138_N0.6141.00
221_G263_S0.6111.00
63_S66_V0.6081.00
99_N103_L0.6071.00
242_K246_V0.6071.00
100_D103_L0.6071.00
184_R188_I0.6061.00
166_D187_F0.6061.00
145_Y148_L0.6041.00
70_M84_E0.6031.00
175_Y200_I0.5981.00
228_A232_V0.5971.00
73_V78_V0.5971.00
176_E179_E0.5941.00
156_Q177_M0.5921.00
88_E114_L0.5921.00
84_E122_R0.5911.00
165_V185_A0.5911.00
128_D148_L0.5871.00
10_N92_A0.5871.00
35_M261_I0.5851.00
36_P261_I0.5841.00
201_T205_E0.5831.00
50_L228_A0.5821.00
237_D243_S0.5791.00
13_I93_T0.5791.00
43_Y231_N0.5781.00
137_P140_V0.5741.00
233_T266_L0.5661.00
69_L91_S0.5651.00
109_L113_I0.5651.00
176_E181_K0.5651.00
37_G42_N0.5651.00
194_K216_I0.5651.00
208_V211_I0.5641.00
174_E179_E0.5591.00
179_E182_N0.5571.00
220_T260_G0.5561.00
168_L188_I0.5561.00
23_I98_R0.5551.00
118_E122_R0.5541.00
158_K162_S0.5521.00
172_E193_G0.5511.00
236_E246_V0.5501.00
108_R111_A0.5481.00
82_Y85_E0.5481.00
129_V234_Y0.5481.00
142_R149_V0.5461.00
9_F73_V0.5411.00
63_S91_S0.5411.00
56_L73_V0.5391.00
102_T106_V0.5381.00
8_R135_V0.5371.00
11_I69_L0.5371.00
186_R201_T0.5351.00
188_I200_I0.5351.00
65_V68_S0.5351.00
54_A78_V0.5351.00
234_Y237_D0.5341.00
47_V231_N0.5341.00
5_A54_A0.5321.00
39_A154_G0.5321.00
34_I64_E0.5271.00
67_R74_V0.5271.00
28_M109_L0.5251.00
168_L185_A0.5241.00
240_I244_L0.5231.00
123_R126_L0.5231.00
129_V167_I0.5231.00
64_E71_E0.5231.00
45_V78_V0.5211.00
117_R140_V0.5201.00
59_K114_L0.5181.00
42_N224_D0.5171.00
41_T45_V0.5141.00
24_D28_M0.5121.00
249_V269_V0.5121.00
45_V48_T0.5101.00
61_G91_S0.5091.00
41_T72_K0.5091.00
35_M258_I0.5071.00
46_A250_A0.5051.00
128_D235_S0.5041.00
133_A136_S0.5011.00
115_L119_D0.5001.00
233_T242_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ikhA 2 0.9576 100 0.238 Contact Map
2rbcA 2 0.9859 100 0.239 Contact Map
3go6A 4 0.9541 100 0.245 Contact Map
4xdaA 2 0.9753 100 0.246 Contact Map
1rkdA 2 0.9753 100 0.246 Contact Map
1vm7A 2 0.9647 100 0.247 Contact Map
2fv7A 2 0.9647 100 0.251 Contact Map
3vasA 1 0.9505 100 0.256 Contact Map
2c4eA 2 0.9647 100 0.258 Contact Map
3ry7A 2 0.9576 100 0.26 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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