GREMLIN Database
Q97W00 - TATA binding protein (TBP)-interacting protein (TIP49-like), putative
UniProt: Q97W00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 476 (434)
Sequences: 428 (203)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_L74_G7.2821.00
118_T143_S6.6551.00
204_L209_V5.3491.00
391_I418_G4.6901.00
73_A103_L4.6811.00
214_V247_L4.2080.99
407_D446_K4.1190.99
442_R449_D3.9780.99
436_I453_A3.8700.98
103_L221_T3.5360.97
76_V92_F3.4530.96
78_Q81_K3.3250.96
73_A107_I3.1050.94
156_E256_K3.0480.93
416_K420_E3.0300.93
50_L56_A2.8560.90
195_S221_T2.8170.90
122_A408_P2.5680.84
399_A430_L2.5070.83
387_N390_E2.4180.81
92_F382_P2.3870.80
66_Q69_A2.2990.77
50_L54_G2.2970.77
395_I427_V2.2830.76
79_L430_L2.2720.76
202_Q265_T2.1940.73
64_V397_I2.1780.73
98_T145_G2.1730.73
336_L370_I2.1180.71
392_K412_E2.1020.70
367_P376_D2.0900.70
433_S453_A2.0710.69
56_A74_G2.0640.69
356_L450_V2.0370.68
340_L348_L2.0270.67
301_D325_A2.0190.67
106_A349_I1.9870.66
45_I337_T1.9690.65
98_T418_G1.9530.64
165_K337_T1.9510.64
227_E337_T1.9340.63
448_E451_V1.9280.63
107_I349_I1.9230.63
330_L362_T1.8380.59
325_A350_L1.8330.59
399_A406_L1.7850.57
271_L292_I1.7180.54
437_A442_R1.7110.54
73_A381_I1.6820.52
395_I411_L1.6620.51
30_E35_I1.6540.51
37_E461_K1.6430.50
90_I395_I1.6190.49
29_R33_K1.5850.48
66_Q70_R1.5830.48
29_R32_K1.5770.47
45_I435_I1.5390.46
84_K108_A1.5310.45
114_D263_T1.5300.45
135_I352_T1.5270.45
120_I395_I1.5240.45
159_V209_V1.5200.45
159_V215_I1.5140.45
285_S460_V1.5110.45
459_D462_R1.5010.44
75_V122_A1.4970.44
68_E393_E1.4790.43
125_I296_V1.4760.43
202_Q364_I1.4710.43
358_K365_E1.4680.43
109_R352_T1.4670.43
155_Y254_V1.4670.43
167_A348_L1.4550.42
68_E384_R1.4520.42
76_V140_I1.4520.42
148_I337_T1.4470.42
108_A202_Q1.4450.42
45_I221_T1.4390.41
155_Y194_L1.4340.41
131_K258_K1.4300.41
396_K408_P1.4190.40
413_E460_V1.4140.40
359_I397_I1.4130.40
325_A333_F1.4100.40
285_S301_D1.3970.39
76_V203_Q1.3860.39
271_L407_D1.3830.39
239_Y367_P1.3790.39
348_L370_I1.3780.39
276_R279_A1.3770.39
391_I415_T1.3760.39
81_K107_I1.3640.38
76_V90_I1.3510.38
130_L261_T1.3510.38
75_V183_I1.3490.37
131_K194_L1.3470.37
47_G62_G1.3430.37
147_R445_I1.3420.37
227_E422_S1.3380.37
434_L438_Q1.3320.37
39_A43_S1.3270.36
278_L281_T1.3260.36
30_E36_R1.3230.36
107_I126_Y1.3180.36
396_K469_E1.3170.36
265_T359_I1.3160.36
43_S73_A1.3130.36
131_K251_T1.3120.36
97_G265_T1.3080.36
44_H49_G1.3000.35
393_E396_K1.2990.35
131_K155_Y1.2980.35
342_S428_Q1.2980.35
208_G301_D1.2970.35
286_F312_R1.2960.35
317_V327_T1.2930.35
32_K36_R1.2920.35
209_V405_E1.2900.35
344_L461_K1.2780.34
76_V352_T1.2780.34
54_G74_G1.2760.34
349_I434_L1.2750.34
106_A382_P1.2720.34
179_V309_N1.2630.34
236_A301_D1.2550.34
67_A450_V1.2520.33
127_S291_E1.2510.33
110_E471_E1.2490.33
115_T348_L1.2490.33
51_D57_K1.2470.33
327_T330_L1.2410.33
183_I381_I1.2340.33
95_P122_A1.2210.32
57_K60_A1.2030.31
326_H352_T1.1990.31
109_R163_K1.1950.31
405_E443_S1.1950.31
76_V126_Y1.1870.31
38_K46_K1.1870.31
97_G120_I1.1860.31
187_T367_P1.1800.31
237_K244_T1.1800.31
390_E442_R1.1790.31
417_I435_I1.1790.31
183_I300_V1.1740.30
84_K467_V1.1720.30
425_Y459_D1.1720.30
407_D444_I1.1710.30
32_K406_L1.1690.30
358_K420_E1.1660.30
381_I417_I1.1620.30
301_D460_V1.1570.30
31_L183_I1.1560.30
92_F125_I1.1540.30
66_Q72_A1.1540.30
113_E458_S1.1530.30
39_A135_I1.1480.29
158_V275_A1.1480.29
69_A72_A1.1470.29
153_L257_E1.1460.29
279_A286_F1.1450.29
413_E451_V1.1360.29
84_K148_I1.1360.29
81_K265_T1.1350.29
84_K349_I1.1340.29
397_I421_N1.1310.29
120_I352_T1.1290.29
408_P420_E1.1240.28
288_T292_I1.1220.28
308_I315_L1.1200.28
51_D63_L1.1200.28
84_K418_G1.1190.28
372_L435_I1.1170.28
194_L255_R1.1160.28
94_G99_G1.1100.28
172_N283_I1.1070.28
135_I165_K1.1060.28
421_N462_R1.1060.28
138_Q226_V1.1040.28
146_V315_L1.1020.28
44_H48_L1.1010.28
79_L359_I1.0940.27
352_T417_I1.0860.27
178_P296_V1.0820.27
216_M225_I1.0810.27
172_N301_D1.0800.27
162_R232_G1.0780.27
138_Q194_L1.0780.27
57_K130_L1.0770.27
464_V468_K1.0760.27
39_A106_A1.0750.27
122_A445_I1.0750.27
140_I348_L1.0720.27
92_F327_T1.0700.27
132_K329_D1.0680.26
115_T154_V1.0640.26
64_V108_A1.0640.26
140_I339_A1.0640.26
202_Q206_S1.0630.26
410_A450_V1.0610.26
80_I347_I1.0590.26
246_V279_A1.0570.26
109_R113_E1.0550.26
323_D326_H1.0520.26
227_E435_I1.0510.26
306_D401_E1.0440.26
198_E237_K1.0370.25
256_K428_Q1.0320.25
125_I418_G1.0270.25
367_P372_L1.0270.25
80_I393_E1.0220.25
279_A284_F1.0210.25
90_I381_I1.0190.25
94_G102_A1.0190.25
381_I385_P1.0140.25
169_S177_A1.0110.24
47_G124_E1.0100.24
109_R301_D1.0070.24
58_F113_E1.0050.24
406_L453_A1.0030.24
280_V283_I1.0030.24
181_A262_T1.0000.24
268_D433_S0.9970.24
326_H375_L0.9950.24
262_T299_E0.9920.24
288_T431_E0.9910.24
167_A268_D0.9890.24
97_G171_L0.9890.24
63_L372_L0.9870.24
139_L330_L0.9870.24
90_I314_E0.9850.24
162_R404_I0.9820.24
106_A425_Y0.9800.23
153_L206_S0.9790.23
209_V441_N0.9770.23
154_V316_V0.9770.23
164_I184_T0.9710.23
52_S74_G0.9690.23
83_G466_F0.9680.23
292_I349_I0.9630.23
79_L82_Q0.9600.23
125_I154_V0.9600.23
97_G428_Q0.9580.23
58_F109_R0.9570.23
108_A461_K0.9550.23
435_I453_A0.9530.23
145_G321_F0.9460.22
194_L242_E0.9460.22
305_K357_T0.9410.22
167_A391_I0.9390.22
122_A400_D0.9370.22
167_A171_L0.9350.22
203_Q431_E0.9340.22
126_Y404_I0.9310.22
76_V407_D0.9250.22
130_L269_L0.9250.22
154_V364_I0.9240.22
167_A170_R0.9170.21
160_K268_D0.9160.21
258_K316_V0.9120.21
147_R263_T0.9120.21
359_I431_E0.9060.21
59_I80_I0.9050.21
388_A416_K0.9050.21
395_I414_L0.9010.21
363_D437_A0.8980.21
264_L340_L0.8960.21
133_T327_T0.8950.21
81_K149_R0.8950.21
92_F348_L0.8940.21
92_F167_A0.8940.21
97_G403_E0.8940.21
191_E244_T0.8920.21
79_L106_A0.8920.21
118_T223_Q0.8920.21
76_V469_E0.8910.21
45_I210_K0.8880.21
389_D465_K0.8860.21
359_I453_A0.8860.21
381_I451_V0.8830.20
409_Q467_V0.8830.20
255_R300_V0.8790.20
454_S462_R0.8760.20
144_I186_T0.8730.20
79_L379_L0.8710.20
80_I352_T0.8710.20
422_S456_L0.8710.20
148_I172_N0.8680.20
149_R430_L0.8680.20
387_N472_N0.8650.20
348_L460_V0.8630.20
162_R268_D0.8630.20
315_L343_E0.8620.20
278_L285_S0.8620.20
327_T355_G0.8600.20
406_L445_I0.8570.20
79_L137_T0.8560.20
189_D216_M0.8560.20
108_A384_R0.8540.20
80_I107_I0.8530.20
107_I268_D0.8510.20
29_R345_A0.8470.19
30_E33_K0.8450.19
417_I453_A0.8440.19
109_R172_N0.8430.19
347_I365_E0.8430.19
264_L311_G0.8400.19
413_E416_K0.8390.19
52_S75_V0.8290.19
65_G70_R0.8280.19
330_L356_L0.8260.19
389_D470_Y0.8230.19
67_A209_V0.8220.19
209_V394_I0.8200.19
46_K60_A0.8190.19
106_A366_S0.8160.19
387_N405_E0.8150.19
47_G96_P0.8120.18
76_V382_P0.8110.18
224_V411_L0.8100.18
143_S249_M0.8050.18
378_L422_S0.8050.18
81_K412_E0.8040.18
138_Q439_R0.8020.18
40_S164_I0.8020.18
396_K411_L0.7970.18
79_L171_L0.7960.18
277_N308_I0.7930.18
208_G347_I0.7930.18
113_E171_L0.7920.18
130_L350_L0.7920.18
327_T380_I0.7910.18
171_L202_Q0.7900.18
219_A269_L0.7890.18
450_V466_F0.7890.18
142_K363_D0.7880.18
106_A227_E0.7870.18
225_I276_R0.7860.18
69_A104_A0.7840.18
373_D377_R0.7790.18
299_E308_I0.7790.18
107_I449_D0.7780.18
262_T290_R0.7770.18
126_Y205_V0.7770.18
200_I265_T0.7770.18
64_V387_N0.7770.18
106_A220_Q0.7760.17
433_S465_K0.7760.17
31_L36_R0.7750.17
283_I338_R0.7740.17
323_D341_E0.7720.17
388_A400_D0.7690.17
356_L422_S0.7680.17
31_L412_E0.7680.17
92_F350_L0.7670.17
80_I439_R0.7650.17
120_I135_I0.7630.17
236_A239_Y0.7620.17
288_T381_I0.7610.17
162_R405_E0.7580.17
192_R195_S0.7580.17
370_I379_L0.7570.17
162_R334_S0.7570.17
65_G377_R0.7550.17
273_L324_D0.7550.17
363_D432_P0.7550.17
43_S62_G0.7550.17
37_E115_T0.7550.17
373_D376_D0.7540.17
267_N271_L0.7530.17
305_K392_K0.7530.17
126_Y397_I0.7500.17
372_L470_Y0.7490.17
138_Q242_E0.7470.17
144_I374_L0.7450.17
383_T386_Y0.7450.17
102_A228_G0.7440.17
37_E40_S0.7430.17
417_I461_K0.7420.17
96_P366_S0.7420.17
92_F349_I0.7410.17
87_G228_G0.7410.17
158_V186_T0.7410.17
120_I411_L0.7400.17
358_K448_E0.7390.17
121_N466_F0.7390.17
54_G71_E0.7370.16
278_L352_T0.7370.16
337_T422_S0.7370.16
365_E450_V0.7360.16
119_A382_P0.7360.16
143_S400_D0.7360.16
120_I247_L0.7350.16
394_I397_I0.7320.16
415_T418_G0.7320.16
125_I332_A0.7310.16
195_S254_V0.7310.16
115_T296_V0.7300.16
167_A428_Q0.7270.16
125_I461_K0.7260.16
55_K71_E0.7250.16
239_Y280_V0.7240.16
74_G120_I0.7240.16
216_M248_E0.7220.16
31_L35_I0.7200.16
335_F352_T0.7200.16
185_L428_Q0.7180.16
171_L391_I0.7170.16
325_A348_L0.7170.16
161_D390_E0.7150.16
162_R408_P0.7150.16
387_N397_I0.7130.16
77_V107_I0.7120.16
97_G167_A0.7120.16
62_G65_G0.7100.16
336_L342_S0.7100.16
90_I467_V0.7070.16
37_E151_K0.7060.16
404_I430_L0.7050.16
408_P425_Y0.7000.16
32_K359_I0.6980.16
50_L120_I0.6970.16
236_A285_S0.6970.16
126_Y436_I0.6970.16
197_G273_L0.6960.15
94_G157_G0.6950.15
98_T339_A0.6940.15
320_L340_L0.6930.15
130_L135_I0.6910.15
95_P344_L0.6910.15
197_G201_A0.6910.15
94_G100_K0.6890.15
44_H47_G0.6890.15
162_R245_K0.6870.15
83_G349_I0.6860.15
447_V451_V0.6850.15
152_R451_V0.6840.15
53_N68_E0.6830.15
294_E438_Q0.6820.15
82_Q458_S0.6800.15
292_I427_V0.6770.15
92_F435_I0.6750.15
133_T240_D0.6750.15
32_K467_V0.6740.15
138_Q251_T0.6730.15
468_K471_E0.6710.15
108_A472_N0.6710.15
120_I462_R0.6690.15
325_A330_L0.6660.15
166_V176_Q0.6660.15
134_E371_P0.6650.15
103_L246_V0.6640.15
138_Q190_D0.6620.15
171_L177_A0.6620.15
129_E304_V0.6610.15
105_V110_E0.6610.15
361_G377_R0.6610.15
271_L288_T0.6590.15
64_V338_R0.6590.15
39_A120_I0.6590.15
445_I453_A0.6560.15
220_Q399_A0.6550.15
188_K332_A0.6540.15
146_V308_I0.6540.15
241_I288_T0.6530.14
408_P412_E0.6520.14
388_A415_T0.6510.14
29_R381_I0.6510.14
63_L105_V0.6500.14
201_A254_V0.6490.14
224_V376_D0.6490.14
43_S309_N0.6490.14
167_A462_R0.6490.14
76_V412_E0.6470.14
196_V332_A0.6470.14
46_K126_Y0.6450.14
341_E346_P0.6440.14
412_E450_V0.6430.14
400_D435_I0.6420.14
301_D395_I0.6420.14
187_T445_I0.6410.14
95_P352_T0.6390.14
97_G185_L0.6350.14
336_L379_L0.6340.14
359_I466_F0.6340.14
49_G70_R0.6320.14
131_K269_L0.6300.14
307_W312_R0.6290.14
320_L328_L0.6290.14
184_T366_S0.6280.14
39_A462_R0.6270.14
163_K209_V0.6240.14
358_K409_Q0.6220.14
154_V393_E0.6210.14
123_S351_A0.6190.14
92_F205_V0.6170.14
257_E445_I0.6150.14
395_I415_T0.6150.14
209_V444_I0.6150.14
84_K232_G0.6150.14
253_P337_T0.6140.14
93_V260_I0.6130.14
120_I345_A0.6100.14
43_S350_L0.6100.14
158_V232_G0.6080.14
95_P397_I0.6060.13
137_T260_I0.6060.13
245_K258_K0.6060.13
81_K169_S0.6050.13
167_A243_T0.6050.13
204_L472_N0.6050.13
90_I372_L0.6040.13
421_N450_V0.6020.13
106_A389_D0.6020.13
51_D55_K0.6020.13
356_L359_I0.6020.13
189_D244_T0.6000.13
218_D290_R0.6000.13
59_I90_I0.6000.13
109_R465_K0.5990.13
326_H354_R0.5950.13
45_I207_L0.5940.13
208_G469_E0.5940.13
98_T105_V0.5930.13
184_T344_L0.5920.13
397_I407_D0.5920.13
106_A406_L0.5910.13
76_V385_P0.5900.13
155_Y288_T0.5870.13
191_E295_D0.5870.13
101_T104_A0.5860.13
119_A315_L0.5860.13
67_A122_A0.5860.13
280_V450_V0.5820.13
146_V248_E0.5820.13
465_K472_N0.5810.13
396_K451_V0.5810.13
262_T276_R0.5800.13
340_L347_I0.5790.13
274_A279_A0.5790.13
215_I420_E0.5780.13
138_Q197_G0.5780.13
285_S436_I0.5770.13
90_I419_V0.5770.13
161_D237_K0.5750.13
333_F368_H0.5740.13
190_D262_T0.5720.13
145_G368_H0.5710.13
217_I224_V0.5700.13
85_M103_L0.5700.13
63_L85_M0.5690.13
154_V419_V0.5690.13
224_V258_K0.5670.13
90_I278_L0.5660.13
324_D337_T0.5660.13
52_S57_K0.5650.13
229_K304_V0.5650.13
31_L359_I0.5640.13
164_I193_T0.5640.13
148_I344_L0.5620.13
32_K35_I0.5610.13
33_K263_T0.5610.13
80_I399_A0.5610.13
197_G287_F0.5600.13
165_K245_K0.5580.12
56_A126_Y0.5580.12
58_F206_S0.5580.12
56_A221_T0.5580.12
177_A180_E0.5580.12
88_K150_E0.5570.12
148_I292_I0.5570.12
72_A102_A0.5560.12
67_A108_A0.5550.12
396_K425_Y0.5550.12
146_V232_G0.5550.12
68_E113_E0.5540.12
148_I421_N0.5530.12
93_V418_G0.5530.12
75_V359_I0.5510.12
31_L195_S0.5510.12
200_I219_A0.5500.12
254_V366_S0.5500.12
128_T350_L0.5500.12
187_T376_D0.5490.12
190_D290_R0.5480.12
393_E412_E0.5470.12
91_L369_G0.5460.12
379_L395_I0.5450.12
126_Y461_K0.5450.12
387_N412_E0.5440.12
439_R467_V0.5430.12
84_K256_K0.5420.12
204_L360_R0.5420.12
359_I380_I0.5420.12
149_R386_Y0.5410.12
96_P140_I0.5400.12
43_S260_I0.5400.12
63_L418_G0.5380.12
104_A424_R0.5380.12
77_V374_L0.5380.12
153_L255_R0.5380.12
390_E471_E0.5380.12
273_L279_A0.5360.12
79_L310_Q0.5340.12
210_K396_K0.5340.12
150_E204_L0.5330.12
185_L254_V0.5330.12
422_S428_Q0.5320.12
96_P112_G0.5320.12
400_D451_V0.5310.12
314_E329_D0.5310.12
68_E89_G0.5280.12
171_L204_L0.5280.12
45_I167_A0.5260.12
51_D345_A0.5260.12
209_V421_N0.5260.12
146_V307_W0.5240.12
258_K315_L0.5240.12
84_K406_L0.5230.12
395_I465_K0.5230.12
57_K345_A0.5200.12
378_L394_I0.5200.12
160_K287_F0.5200.12
248_E262_T0.5200.12
122_A444_I0.5190.12
32_K453_A0.5190.12
366_S392_K0.5180.12
77_V110_E0.5170.12
396_K444_I0.5170.12
63_L360_R0.5170.12
30_E451_V0.5170.12
166_V198_E0.5170.12
181_A275_A0.5150.12
292_I417_I0.5150.12
150_E351_A0.5150.12
215_I394_I0.5140.12
227_E350_L0.5110.12
233_F316_V0.5090.12
364_I400_D0.5090.12
182_Q249_M0.5070.12
236_A413_E0.5060.11
29_R36_R0.5060.11
200_I224_V0.5050.11
107_I363_D0.5030.11
200_I255_R0.5030.11
120_I268_D0.5020.11
192_R198_E0.5010.11
40_S121_N0.5010.11
389_D404_I0.5010.11
29_R55_K0.5010.11
154_V162_R0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ww4B 2 0.8992 100 0.561 Contact Map
4ww4A 2 0.8529 100 0.667 Contact Map
2c9oA 3 0.8403 100 0.706 Contact Map
3uk6A 3 0.6954 100 0.751 Contact Map
2cqaA 1 0.1996 100 0.844 Contact Map
1g41A 3 0.5336 100 0.868 Contact Map
3k1jA 4 0.6408 99.9 0.881 Contact Map
3nbxX 1 0.5168 99.9 0.884 Contact Map
1in4A 1 0.4832 99.9 0.888 Contact Map
1hqcA 1 0.4832 99.9 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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