GREMLIN Database
GUAAA - GMP synthase [glutamine-hydrolyzing] subunit A
UniProt: Q97VZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (178)
Sequences: 12955 (7506)
Seq/√Len: 562.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_R133_V3.1611.00
86_A132_V3.1071.00
85_I160_I2.6741.00
92_V133_V2.3901.00
142_L154_A2.3651.00
4_G30_I2.3071.00
119_S174_R2.2771.00
140_R154_A2.2551.00
86_A153_M2.2501.00
155_N158_N2.2421.00
141_V150_V2.2081.00
55_S87_Y2.2051.00
20_V46_I2.1571.00
22_Y176_I2.1151.00
140_R156_S2.1101.00
35_P38_E2.1041.00
23_L180_K2.0421.00
82_H162_G1.9391.00
174_R177_E1.9161.00
92_V134_E1.9151.00
143_A152_A1.8911.00
5_L17_L1.8901.00
19_N176_I1.8141.00
112_D154_A1.7931.00
141_V144_S1.7401.00
30_I34_K1.7071.00
61_M88_V1.7061.00
177_E180_K1.6911.00
8_Y47_F1.6291.00
123_N173_E1.6201.00
61_M87_Y1.6091.00
155_N159_S1.6001.00
153_M162_G1.5481.00
122_L174_R1.5381.00
138_G157_S1.5331.00
94_R131_E1.5181.00
180_K184_G1.4801.00
67_Y70_E1.4401.00
116_K184_G1.4051.00
28_E42_F1.3931.00
66_L84_L1.3861.00
5_L46_I1.3761.00
60_K84_L1.3751.00
132_V153_M1.3751.00
40_K72_K1.3681.00
86_A91_G1.3541.00
138_G156_S1.3491.00
154_A161_F1.3481.00
85_I162_G1.3471.00
118_F122_L1.3321.00
16_I78_I1.3221.00
105_R121_Q1.3051.00
3_V44_C1.2961.00
181_N184_G1.2951.00
139_F153_M1.2881.00
86_A136_P1.2811.00
89_L160_I1.2761.00
82_H132_V1.2761.00
101_Y129_N1.2641.00
44_C182_F1.2561.00
112_D142_L1.2411.00
104_T125_W1.2361.00
97_L149_R1.2361.00
25_A183_L1.2311.00
131_E149_R1.2171.00
34_K38_E1.2171.00
47_F60_K1.2121.00
115_L152_A1.1971.00
46_I76_L1.1891.00
66_L70_E1.1821.00
9_G33_H1.1811.00
106_I123_N1.1791.00
139_F155_N1.1731.00
40_K68_I1.1571.00
135_P141_V1.1521.00
144_S148_A1.1341.00
55_S92_V1.1281.00
106_I121_Q1.1221.00
82_H153_M1.1181.00
16_I179_F1.0931.00
89_L139_F1.0911.00
72_K158_N1.0791.00
125_W171_H1.0541.00
107_N121_Q1.0491.00
107_N124_V1.0401.00
110_D140_R1.0341.00
70_E158_N1.0281.00
122_L178_I1.0211.00
76_L163_V1.0171.00
67_Y71_L1.0091.00
19_N22_Y1.0071.00
96_A131_E1.0071.00
3_V25_A1.0031.00
161_F185_V1.0021.00
109_F144_S1.0011.00
45_V73_V0.9891.00
93_V132_V0.9771.00
8_Y60_K0.9751.00
36_V40_K0.9751.00
113_T154_A0.9751.00
79_C166_H0.9681.00
156_S159_S0.9671.00
37_E40_K0.9641.00
110_D144_S0.9601.00
52_Y56_E0.9531.00
45_V65_P0.9491.00
70_E160_I0.9471.00
138_G155_N0.9471.00
34_K39_L0.9391.00
4_G42_F0.9351.00
6_V30_I0.9321.00
78_I163_V0.9281.00
5_L12_Y0.9261.00
91_G136_P0.9111.00
135_P150_V0.9011.00
107_N144_S0.8981.00
165_F178_I0.8971.00
104_T123_N0.8921.00
108_I144_S0.8891.00
145_S149_R0.8881.00
23_L183_L0.8871.00
18_K21_K0.8851.00
113_T161_F0.8841.00
17_L21_K0.8801.00
119_S173_E0.8791.00
53_S56_E0.8771.00
15_L18_K0.8751.00
8_Y32_P0.8701.00
40_K73_V0.8641.00
44_C183_L0.8531.00
112_D140_R0.8511.00
20_V25_A0.8511.00
21_K27_I0.8511.00
47_F75_M0.8511.00
23_L176_I0.8491.00
50_G80_L0.8441.00
95_R99_P0.8391.00
23_L179_F0.8321.00
142_L152_A0.8321.00
68_I71_L0.8281.00
4_G39_L0.8221.00
115_L165_F0.8181.00
119_S122_L0.8141.00
118_F174_R0.8141.00
108_I120_Q0.8121.00
105_R123_N0.8091.00
61_M84_L0.8061.00
66_L71_L0.8041.00
42_F73_V0.8021.00
40_K71_L0.8001.00
108_I121_Q0.7961.00
9_G31_P0.7951.00
143_A165_F0.7891.00
71_L158_N0.7701.00
3_V20_V0.7671.00
57_E60_K0.7661.00
24_G27_I0.7651.00
30_I38_E0.7641.00
5_L20_V0.7631.00
142_L161_F0.7611.00
14_H17_L0.7591.00
59_Q65_P0.7581.00
91_G134_E0.7561.00
105_R146_A0.7541.00
163_V167_P0.7531.00
55_S93_V0.7471.00
79_C83_Q0.7451.00
39_L42_F0.7431.00
112_D161_F0.7431.00
65_P69_K0.7401.00
124_V172_T0.7391.00
176_I180_K0.7351.00
111_E120_Q0.7311.00
61_M66_L0.7311.00
126_E151_Q0.7301.00
66_L88_V0.7291.00
91_G132_V0.7261.00
53_S130_D0.7231.00
12_Y17_L0.7211.00
89_L155_N0.7191.00
99_P129_N0.7111.00
34_K37_E0.7061.00
20_V183_L0.7051.00
55_S61_M0.7031.00
7_Y13_N0.7021.00
114_I161_F0.7011.00
98_N147_N0.7001.00
57_E61_M0.6961.00
136_P139_F0.6931.00
37_E68_I0.6911.00
53_S95_R0.6841.00
110_D142_L0.6831.00
118_F177_E0.6801.00
161_F182_F0.6791.00
101_Y127_S0.6761.00
68_I72_K0.6751.00
25_A44_C0.6731.00
20_V179_F0.6731.00
45_V75_M0.6681.00
46_I182_F0.6581.00
6_V39_L0.6551.00
154_A181_N0.6541.00
75_M85_I0.6531.00
4_G28_E0.6511.00
87_Y92_V0.6501.00
134_E137_S0.6401.00
69_K75_M0.6371.00
117_G181_N0.6341.00
103_L125_W0.6321.00
108_I146_A0.6311.00
65_P68_I0.6281.00
54_V87_Y0.6261.00
89_L158_N0.6211.00
5_L13_N0.6211.00
109_F121_Q0.6201.00
13_N29_V0.6151.00
18_K22_Y0.6101.00
69_K73_V0.6081.00
93_V130_D0.6081.00
58_I61_M0.6051.00
52_Y55_S0.6001.00
15_L19_N0.5991.00
155_N160_I0.5971.00
61_M65_P0.5971.00
165_F175_G0.5941.00
53_S87_Y0.5941.00
55_S130_D0.5891.00
100_E145_S0.5841.00
6_V34_K0.5831.00
19_N179_F0.5700.99
109_F113_T0.5690.99
5_L27_I0.5680.99
118_F178_I0.5640.99
163_V178_I0.5580.99
69_K85_I0.5580.99
4_G34_K0.5560.99
65_P84_L0.5540.99
44_C74_P0.5530.99
66_L72_K0.5470.99
41_K73_V0.5470.99
76_L178_I0.5470.99
13_N48_S0.5470.99
36_V39_L0.5460.99
17_L29_V0.5430.99
87_Y93_V0.5420.99
44_C76_L0.5420.99
35_P39_L0.5370.99
177_E181_N0.5320.99
131_E148_A0.5290.99
49_G79_C0.5240.99
75_M160_I0.5240.99
36_V68_I0.5210.99
106_I143_A0.5200.99
125_W173_E0.5200.99
84_L88_V0.5200.99
8_Y84_L0.5170.99
79_C128_H0.5160.99
125_W169_V0.5150.99
83_Q164_Q0.5140.99
96_A149_R0.5100.99
180_K183_L0.5070.99
45_V68_I0.5050.99
109_F122_L0.5040.99
100_E103_L0.5040.99
94_R149_R0.5030.99
137_S156_S0.5030.99
27_I30_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqiA 3 0.9149 100 0.18 Contact Map
2ywbA 4 0.9628 100 0.184 Contact Map
1gpmA 3 0.9894 100 0.192 Contact Map
2vxoA 2 0.9681 100 0.205 Contact Map
3uowA 2 0.9947 100 0.224 Contact Map
3r75A 2 0.9787 100 0.253 Contact Map
1a9xB 1 0.9521 100 0.258 Contact Map
2vpiA 1 0.9362 100 0.264 Contact Map
1qdlB 2 0.9894 100 0.266 Contact Map
1i1qB 1 0.9521 100 0.268 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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