GREMLIN Database
Q97VZ8 - Uncharacterized protein
UniProt: Q97VZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 262 (207)
Sequences: 10200 (5304)
Seq/√Len: 368.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_K127_L3.4891.00
53_P125_A3.4521.00
52_D125_A3.4461.00
6_S13_D3.1741.00
40_S164_T2.8861.00
44_I128_V2.8641.00
47_G126_R2.8291.00
7_T20_I2.7781.00
44_I54_C2.4981.00
26_I185_G2.3771.00
25_F151_K2.3051.00
22_Q158_N2.3021.00
76_D79_E2.2601.00
16_I185_G2.2521.00
22_Q125_A2.1911.00
8_G13_D2.1761.00
188_R205_E2.1241.00
40_S128_V2.1171.00
27_A183_A2.1131.00
20_I43_F2.1121.00
118_Q157_W2.0651.00
24_F65_S1.9301.00
147_S182_V1.9151.00
12_F187_I1.8591.00
187_I202_I1.8281.00
154_L161_I1.8131.00
207_M210_T1.7681.00
30_G189_F1.7501.00
55_I124_K1.7471.00
225_K228_V1.7071.00
46_K50_D1.6811.00
46_K49_R1.6741.00
127_L161_I1.6731.00
41_L70_A1.6601.00
222_V228_V1.6171.00
196_G216_V1.5941.00
114_I149_Y1.5831.00
127_L159_F1.5661.00
53_P123_G1.5531.00
45_A49_R1.5491.00
153_V157_W1.5371.00
44_I56_Y1.5311.00
11_D14_K1.5181.00
26_I160_T1.5001.00
33_G209_Q1.4871.00
20_I160_T1.4761.00
126_R162_Y1.4711.00
116_A119_K1.4661.00
169_I177_F1.4261.00
114_I153_V1.4261.00
110_V149_Y1.4181.00
185_G207_M1.3861.00
10_L229_L1.3761.00
128_V162_Y1.3681.00
12_F16_I1.3501.00
10_L14_K1.3491.00
20_I162_Y1.3451.00
15_L213_D1.3441.00
39_F43_F1.3311.00
103_N116_A1.3211.00
47_G54_C1.3161.00
126_R160_T1.3161.00
7_T13_D1.2911.00
189_F202_I1.2871.00
41_L66_I1.2631.00
201_Y216_V1.2611.00
226_G229_L1.2541.00
220_D228_V1.2251.00
23_G158_N1.2171.00
139_K142_M1.2081.00
3_S22_Q1.1991.00
65_S69_Q1.1901.00
60_E166_Q1.1861.00
67_I71_K1.1501.00
199_H218_E1.1401.00
47_G52_D1.1331.00
53_P122_Y1.1311.00
147_S163_A1.1281.00
30_G34_T1.1221.00
45_A73_F1.1201.00
33_G206_K1.1191.00
3_S21_P1.1181.00
153_V159_F1.1151.00
144_R178_G1.0981.00
25_F147_S1.0971.00
174_A177_F1.0871.00
117_K157_W1.0871.00
222_V225_K1.0861.00
115_E119_K1.0831.00
58_T66_I1.0671.00
48_L54_C1.0541.00
55_I117_K1.0541.00
44_I48_L1.0531.00
207_M211_D1.0461.00
28_L187_I1.0341.00
190_R203_L1.0341.00
109_L112_K1.0261.00
39_F189_F1.0151.00
133_S165_S1.0141.00
140_P144_R1.0131.00
177_F180_E0.9991.00
56_Y128_V0.9931.00
106_P109_L0.9911.00
201_Y214_K0.9861.00
192_M201_Y0.9861.00
39_F202_I0.9851.00
21_P24_F0.9811.00
193_I198_L0.9751.00
61_E208_R0.9691.00
54_C126_R0.9611.00
27_A186_I0.9591.00
132_V179_V0.9581.00
63_R67_I0.9561.00
52_D126_R0.9551.00
43_F126_R0.9481.00
5_L160_T0.9461.00
113_V135_L0.9441.00
183_A186_I0.9431.00
12_F204_I0.9431.00
27_A179_V0.9401.00
112_K115_E0.9291.00
37_T41_L0.9181.00
28_L39_F0.9171.00
112_K116_A0.9151.00
199_H216_V0.9151.00
148_Y152_R0.9151.00
57_V113_V0.9121.00
43_F47_G0.9111.00
149_Y152_R0.9031.00
203_L214_K0.8931.00
20_I26_I0.8921.00
41_L56_Y0.8911.00
9_I13_D0.8891.00
138_D141_A0.8871.00
102_V106_P0.8851.00
38_I69_Q0.8841.00
152_R156_K0.8821.00
25_F163_A0.8811.00
189_F200_R0.8811.00
15_L204_I0.8781.00
114_I156_K0.8741.00
42_H46_K0.8731.00
40_S162_Y0.8721.00
9_I229_L0.8681.00
114_I118_Q0.8641.00
24_F209_Q0.8631.00
38_I221_I0.8611.00
9_I42_H0.8541.00
108_E112_K0.8461.00
55_I127_L0.8461.00
59_T134_A0.8381.00
15_L217_W0.8321.00
105_T108_E0.8241.00
54_C128_V0.8211.00
25_F150_L0.8181.00
9_I217_W0.8131.00
168_A171_T0.8101.00
150_L161_I0.8101.00
57_V127_L0.8071.00
21_P207_M0.8051.00
43_F46_K0.8051.00
11_D217_W0.8041.00
6_S50_D0.8031.00
131_S164_T0.7971.00
62_S65_S0.7971.00
111_N149_Y0.7931.00
173_Q186_I0.7911.00
22_Q52_D0.7871.00
13_D46_K0.7871.00
34_T200_R0.7861.00
117_K124_K0.7811.00
194_R197_E0.7781.00
53_P124_K0.7761.00
152_R155_N0.7731.00
187_I204_I0.7711.00
139_K175_F0.7671.00
166_Q181_H0.7621.00
16_I19_G0.7601.00
48_L100_S0.7581.00
123_G157_W0.7561.00
40_S56_Y0.7561.00
140_P178_G0.7541.00
194_R199_H0.7541.00
100_S104_L0.7491.00
43_F162_Y0.7491.00
226_G230_K0.7481.00
29_T188_R0.7441.00
195_N198_L0.7421.00
26_I187_I0.7371.00
20_I126_R0.7281.00
18_G21_P0.7261.00
174_A181_H0.7241.00
129_I150_L0.7211.00
104_L108_E0.7201.00
74_N77_F0.7191.00
37_T66_I0.7161.00
221_I226_G0.7161.00
33_G212_H0.7141.00
194_R198_L0.7130.99
101_L104_L0.7120.99
145_K149_Y0.7110.99
110_V146_I0.7060.99
23_G62_S0.7050.99
147_S179_V0.7000.99
60_E208_R0.6990.99
28_L162_Y0.6950.99
190_R201_Y0.6940.99
105_T116_A0.6920.99
169_I180_E0.6910.99
175_F179_V0.6880.99
224_G227_I0.6870.99
16_I187_I0.6850.99
15_L207_M0.6820.99
227_I230_K0.6820.99
71_K78_E0.6820.99
225_K229_L0.6810.99
205_E212_H0.6760.99
66_I69_Q0.6740.99
69_Q209_Q0.6700.99
115_E118_Q0.6590.99
107_E112_K0.6550.99
103_N106_P0.6530.99
173_Q177_F0.6520.99
21_P185_G0.6510.99
113_V129_I0.6500.99
218_E221_I0.6490.99
24_F184_D0.6470.99
200_R214_K0.6450.99
4_R210_T0.6370.99
154_L160_T0.6360.99
22_Q160_T0.6340.99
11_D229_L0.6340.99
228_V231_G0.6310.99
153_V161_I0.6310.99
151_K184_D0.6310.99
173_Q176_G0.6290.99
75_W79_E0.6280.99
12_F202_I0.6280.99
42_H45_A0.6280.99
117_K153_V0.6260.99
5_L47_G0.6210.99
69_Q73_F0.6200.99
29_T173_Q0.6170.99
34_T190_R0.6160.99
59_T135_L0.6130.98
9_I232_R0.6110.98
151_K154_L0.6110.98
74_N78_E0.6090.98
184_D208_R0.6060.98
72_Q80_Y0.6050.98
144_R148_Y0.6050.98
129_I135_L0.5990.98
191_R198_L0.5990.98
34_T171_T0.5990.98
143_A176_G0.5930.98
15_L212_H0.5910.98
68_R71_K0.5900.98
56_Y100_S0.5900.98
109_L113_V0.5870.98
202_I219_I0.5820.98
8_G46_K0.5810.98
195_N199_H0.5810.98
24_F185_G0.5790.98
31_E177_F0.5780.98
220_D224_G0.5770.98
20_I47_G0.5770.98
31_E34_T0.5740.98
138_D142_M0.5740.98
202_I217_W0.5720.98
132_V146_I0.5670.97
3_S18_G0.5650.97
213_D217_W0.5550.97
103_N122_Y0.5530.97
45_A76_D0.5470.97
196_G201_Y0.5460.97
40_S43_F0.5460.97
167_Y177_F0.5430.97
191_R200_R0.5410.97
100_S103_N0.5400.97
48_L80_Y0.5390.97
153_V156_K0.5390.97
69_Q72_Q0.5380.97
110_V135_L0.5380.97
196_G199_H0.5360.96
133_S175_F0.5360.96
177_F181_H0.5350.96
31_E188_R0.5330.96
102_V105_T0.5320.96
118_Q156_K0.5320.96
183_A206_K0.5310.96
125_A160_T0.5310.96
65_S209_Q0.5310.96
136_F152_R0.5300.96
75_W80_Y0.5300.96
27_A163_A0.5290.96
176_G179_V0.5230.96
131_S134_A0.5210.96
45_A70_A0.5170.96
135_L146_I0.5160.96
25_F161_I0.5140.96
151_K163_A0.5120.95
218_E230_K0.5100.95
165_S176_G0.5090.95
200_R221_I0.5080.95
131_S165_S0.5080.95
32_P180_E0.5080.95
58_T61_E0.5050.95
16_I204_I0.5040.95
131_S166_Q0.5030.95
179_V183_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bgwA 3 0.874 100 0.352 Contact Map
2dr3A 3 0.9084 100 0.362 Contact Map
2q6tA 1 0.8511 100 0.372 Contact Map
4nmnA 3 0.8702 100 0.374 Contact Map
3bs4A 1 0.8397 100 0.375 Contact Map
1n0wA 1 0.7481 100 0.412 Contact Map
2w0mA 1 0.8282 100 0.414 Contact Map
2cvhA 1 0.7901 100 0.419 Contact Map
2r6aA 5 0.8588 100 0.422 Contact Map
3ldaA 1 0.7634 100 0.423 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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