GREMLIN Database
Q97VZ7 - Uncharacterized protein
UniProt: Q97VZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (148)
Sequences: 3268 (2171)
Seq/√Len: 178.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_V93_L4.7971.00
11_G103_T3.2161.00
108_A123_I2.9011.00
9_I110_Y2.5361.00
44_S47_D2.4981.00
11_G107_L2.4961.00
109_S146_V2.4471.00
108_A143_L2.4381.00
24_W93_L2.4261.00
100_I132_G2.2571.00
50_Y53_S2.1901.00
17_T47_D2.1741.00
111_L122_A2.1071.00
112_I122_A2.0741.00
113_L150_R2.0681.00
21_I24_W2.0451.00
23_E93_L1.9121.00
118_E121_S1.8571.00
25_R57_K1.8441.00
68_P71_G1.8131.00
13_G16_Y1.7301.00
108_A126_V1.7281.00
28_G57_K1.7011.00
11_G133_A1.6851.00
12_S93_L1.6841.00
98_G101_G1.6461.00
64_H81_I1.6421.00
112_I147_E1.6321.00
126_V133_A1.6151.00
119_V144_L1.6111.00
76_S149_M1.5711.00
96_C103_T1.5641.00
123_I134_V1.5501.00
40_E45_W1.5411.00
69_D98_G1.5381.00
22_L26_K1.5351.00
34_V61_Q1.4991.00
109_S143_L1.4351.00
14_L46_G1.4211.00
67_I73_P1.3981.00
62_P85_L1.3961.00
112_I119_V1.3551.00
48_K56_K1.2951.00
73_P142_F1.2941.00
64_H67_I1.2731.00
29_V90_E1.2691.00
98_G135_Q1.2571.00
36_P46_G1.2511.00
127_R134_V1.2381.00
120_E124_D1.2281.00
85_L106_I1.2131.00
101_G135_Q1.2081.00
12_S20_E1.2011.00
61_Q95_H1.1811.00
33_L106_I1.1741.00
119_V143_L1.1551.00
61_Q67_I1.1521.00
48_K55_L1.1271.00
48_K52_L1.1231.00
97_V102_R1.1171.00
125_E128_L1.1101.00
111_L126_V1.1091.00
123_I127_R1.0981.00
105_T109_S1.0951.00
78_F81_I1.0911.00
64_H73_P1.0671.00
50_Y54_I1.0611.00
121_S124_D1.0591.00
134_V143_L1.0561.00
123_I133_A1.0541.00
37_E65_I1.0431.00
42_E46_G1.0411.00
68_P73_P1.0280.99
98_G102_R1.0280.99
68_P72_V1.0180.99
48_K51_Y1.0130.99
39_W42_E1.0000.99
17_T44_S0.9930.99
120_E140_E0.9800.99
14_L98_G0.9720.99
140_E144_L0.9690.99
141_M145_R0.9650.99
141_M144_L0.9430.99
107_L133_A0.9360.99
33_L85_L0.9280.99
127_R130_R0.9270.99
31_R62_P0.9180.99
79_L150_R0.9130.99
13_G19_N0.9120.99
99_G102_R0.8920.99
19_N22_L0.8890.98
19_N23_E0.8820.98
97_V101_G0.8820.98
36_P45_W0.8810.98
149_M153_W0.8730.98
78_F109_S0.8660.98
141_M148_G0.8630.98
94_V107_L0.8600.98
34_V38_D0.8560.98
23_E34_V0.8480.98
33_L81_I0.8440.98
42_E45_W0.8380.98
49_D56_K0.8320.98
99_G103_T0.8300.98
101_G104_G0.8290.98
99_G130_R0.8280.98
24_W29_V0.8250.98
28_G55_L0.8190.97
59_G67_I0.8080.97
97_V135_Q0.8060.97
48_K53_S0.7910.97
119_V122_A0.7800.97
94_V106_I0.7790.97
14_L21_I0.7770.96
111_L125_E0.7750.96
66_P76_S0.7740.96
14_L36_P0.7730.96
57_K67_I0.7690.96
134_V139_Q0.7670.96
140_E143_L0.7670.96
15_P35_L0.7610.96
62_P67_I0.7480.96
20_E24_W0.7450.96
78_F82_M0.7440.95
62_P81_I0.7390.95
9_I21_I0.7380.95
64_H79_L0.7340.95
40_E46_G0.7320.95
40_E43_E0.7320.95
82_M106_I0.7300.95
114_T117_L0.7280.95
30_K90_E0.7270.95
35_L100_I0.7170.95
98_G103_T0.7150.94
123_I143_L0.7140.94
142_F146_V0.7110.94
122_A126_V0.7060.94
14_L97_V0.7060.94
135_Q139_Q0.7010.94
48_K54_I0.6990.94
24_W32_V0.6980.94
98_G139_Q0.6930.93
50_Y55_L0.6930.93
95_H103_T0.6920.93
126_V129_V0.6850.93
101_G134_V0.6840.93
34_V63_L0.6760.93
34_V95_H0.6700.92
104_G133_A0.6690.92
99_G104_G0.6690.92
43_E47_D0.6660.92
28_G88_E0.6600.92
69_D96_C0.6590.92
31_R85_L0.6580.92
85_L92_N0.6540.91
96_C139_Q0.6530.91
124_D128_L0.6460.91
28_G89_K0.6430.91
86_L89_K0.6430.91
16_Y19_N0.6370.90
77_Q149_M0.6340.90
10_G29_V0.6320.90
108_A112_I0.6290.90
110_Y113_L0.6290.90
98_G104_G0.6270.90
147_E151_K0.6260.89
69_D135_Q0.6240.89
69_D97_V0.6160.89
108_A122_A0.6140.89
25_R59_G0.6110.88
102_R130_R0.6100.88
49_D53_S0.6090.88
101_G105_T0.6010.88
9_I111_L0.5990.87
31_R60_L0.5970.87
18_E51_Y0.5900.87
34_V46_G0.5860.86
9_I107_L0.5830.86
14_L45_W0.5820.86
45_W69_D0.5800.86
52_L55_L0.5790.86
138_E146_V0.5720.85
78_F142_F0.5690.85
10_G27_E0.5660.84
49_D52_L0.5640.84
64_H142_F0.5630.84
76_S79_L0.5630.84
83_K153_W0.5630.84
18_E22_L0.5630.84
114_T118_E0.5620.84
105_T134_V0.5600.84
107_L143_L0.5600.84
76_S142_F0.5590.83
45_W135_Q0.5580.83
21_I34_V0.5510.83
104_G134_V0.5490.82
121_S125_E0.5490.82
51_Y88_E0.5490.82
97_V103_T0.5460.82
76_S146_V0.5440.82
70_G98_G0.5430.82
31_R129_V0.5430.82
25_R43_E0.5430.82
14_L34_V0.5420.82
107_L110_Y0.5370.81
23_E26_K0.5350.81
21_I59_G0.5330.81
45_W98_G0.5310.80
30_K89_K0.5310.80
79_L82_M0.5270.80
119_V123_I0.5190.79
120_E131_P0.5180.79
52_L56_K0.5170.79
107_L112_I0.5170.79
53_S58_N0.5150.78
28_G90_E0.5140.78
39_W44_S0.5130.78
51_Y56_K0.5110.78
36_P40_E0.5100.78
123_I140_E0.5030.77
98_G105_T0.5000.76
145_R151_K0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ygrA 1 0.9627 100 0.126 Contact Map
1larA 1 0.9565 100 0.129 Contact Map
2jjdA 1 0.9379 100 0.131 Contact Map
2nlkA 1 1 100 0.134 Contact Map
3ps5A 2 1 100 0.135 Contact Map
2h4vA 1 0.9379 100 0.136 Contact Map
1yfoA 1 0.9317 100 0.142 Contact Map
3i36A 1 0.9627 100 0.143 Contact Map
2b3oA 1 1 100 0.147 Contact Map
2ooqA 1 0.9503 100 0.151 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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