GREMLIN Database
NFI - Endonuclease V
UniProt: Q97VZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (186)
Sequences: 1034 (705)
Seq/√Len: 51.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_D57_S3.9391.00
110_K151_E3.5941.00
23_I164_P3.0801.00
189_D193_K3.0251.00
37_V86_M2.8321.00
111_S115_A2.7931.00
169_D172_D2.7651.00
155_V174_I2.5701.00
33_K60_Y2.4451.00
122_D167_K2.4191.00
137_L161_F2.3681.00
62_Y191_L2.3521.00
90_I121_L2.2981.00
103_H106_A2.1921.00
105_I115_A2.1331.00
99_L185_L2.1221.00
164_P170_L2.1081.00
97_L176_L2.0731.00
105_I164_P2.0731.00
46_G69_V2.0251.00
21_V119_V2.0191.00
17_I111_S2.0141.00
26_Y169_D1.9971.00
126_I177_G1.9120.99
15_F18_S1.9110.99
11_E77_F1.8770.99
99_L177_G1.8720.99
141_S145_Y1.8640.99
67_G85_L1.8520.99
41_Y69_V1.8280.99
46_G85_L1.7800.99
40_A192_T1.7350.99
98_L125_T1.7090.99
61_N94_D1.7020.99
90_I98_L1.6890.99
35_C52_S1.6810.99
189_D192_T1.6520.98
83_A117_I1.6400.98
152_K155_V1.6220.98
132_R156_K1.5760.98
141_S146_V1.5600.98
53_M58_G1.5370.97
35_C50_G1.5080.97
40_A47_F1.4930.97
141_S144_T1.4770.97
26_Y167_K1.4460.96
157_F178_K1.4380.96
49_V192_T1.4030.95
50_G90_I1.3820.95
156_K161_F1.3750.95
159_R180_G1.3640.95
67_G88_K1.3550.94
100_V117_I1.3450.94
39_I86_M1.3370.94
99_L128_V1.3160.94
11_E15_F1.3130.93
148_L153_V1.3080.93
146_V156_K1.2960.93
155_V170_L1.2940.93
40_A193_K1.2890.93
88_K91_E1.2700.92
117_I121_L1.2660.92
100_V184_V1.2340.91
159_R186_K1.2170.91
52_S94_D1.2040.90
183_K186_K1.1950.90
16_L20_N1.1780.89
31_V176_L1.1760.89
129_A187_I1.1720.89
184_V187_I1.1570.88
103_H129_A1.1560.88
139_N142_E1.1440.88
71_F189_D1.1420.88
37_V117_I1.1410.88
110_K148_L1.1400.87
141_S147_Y1.1330.87
21_V115_A1.1320.87
137_L144_T1.1110.86
54_D59_D1.1070.86
103_H133_L1.0990.85
55_I179_R1.0830.85
174_I178_K1.0810.84
164_P173_C1.0680.84
89_A93_L1.0520.83
31_V96_H1.0410.82
10_L71_F1.0340.82
51_V187_I1.0340.82
126_I176_L1.0310.82
180_G186_K1.0280.81
47_F193_K1.0240.81
45_L66_V1.0100.80
33_K52_S1.0000.80
53_M185_L0.9960.79
106_A154_G0.9920.79
13_L77_F0.9900.79
176_L184_V0.9890.79
143_I155_V0.9800.78
103_H131_S0.9770.78
28_I31_V0.9750.78
35_C96_H0.9740.78
134_T153_V0.9670.77
79_F116_V0.9550.76
39_I46_G0.9530.76
42_K47_F0.9520.76
18_S21_V0.9510.76
22_K27_G0.9480.76
52_S93_L0.9380.75
176_L179_R0.9340.75
39_I85_L0.9190.73
34_I37_V0.9140.73
90_I117_I0.9070.73
36_G185_L0.8870.71
119_V166_N0.8860.71
21_V105_I0.8830.70
132_R146_V0.8780.70
157_F174_I0.8750.70
98_L123_F0.8680.69
141_S148_L0.8680.69
143_I174_I0.8650.69
65_Y92_G0.8650.69
145_Y152_K0.8610.69
41_Y78_L0.8600.68
13_L16_L0.8480.67
48_S89_A0.8480.67
26_Y122_D0.8350.66
98_L117_I0.8350.66
27_G169_D0.8340.66
143_I157_F0.8280.65
22_K167_K0.8280.65
49_V64_S0.8240.65
113_I133_L0.8230.65
175_E179_R0.8230.65
115_A125_T0.8040.63
10_L77_F0.7980.63
80_M116_V0.7970.63
64_S191_L0.7970.63
50_G89_A0.7920.62
40_A189_D0.7870.62
46_G113_I0.7860.61
180_G183_K0.7820.61
106_A153_V0.7810.61
63_K92_G0.7810.61
26_Y172_D0.7800.61
86_M100_V0.7780.61
39_I78_L0.7650.59
17_I20_N0.7610.59
12_K15_F0.7560.58
37_V78_L0.7530.58
61_N92_G0.7470.58
187_I190_M0.7400.57
33_K96_H0.7330.56
21_V111_S0.7330.56
103_H135_G0.7310.56
71_F77_F0.7280.56
69_V85_L0.7270.55
177_G180_G0.7220.55
77_F119_V0.7190.55
87_I121_L0.7180.55
9_F12_K0.7150.54
8_E12_K0.7120.54
166_N172_D0.7050.53
37_V100_V0.7030.53
9_F13_L0.6980.52
99_L126_I0.6970.52
132_R161_F0.6970.52
159_R183_K0.6960.52
65_Y89_A0.6820.51
99_L121_L0.6810.51
128_V192_T0.6810.51
132_R148_L0.6810.51
47_F66_V0.6790.50
152_K170_L0.6770.50
34_I59_D0.6760.50
53_M187_I0.6750.50
38_D130_K0.6730.50
23_I105_I0.6720.50
79_F103_H0.6710.50
87_I91_E0.6710.50
155_V164_P0.6700.50
106_A163_S0.6670.49
34_I43_G0.6610.49
118_G166_N0.6610.49
106_A132_R0.6610.49
128_V177_G0.6580.48
46_G51_V0.6580.48
78_L103_H0.6570.48
148_L151_E0.6540.48
101_D130_K0.6540.48
73_Y81_R0.6530.48
34_I126_I0.6470.47
18_S111_S0.6470.47
26_Y29_E0.6460.47
48_S180_G0.6440.47
115_A164_P0.6360.46
16_L19_K0.6310.45
168_V172_D0.6310.45
129_A153_V0.6310.45
132_R135_G0.6290.45
83_A100_V0.6250.45
73_Y78_L0.6240.45
105_I111_S0.6230.45
40_A190_M0.6180.44
117_I123_F0.6130.44
77_F174_I0.6110.43
32_K54_D0.6090.43
123_F167_K0.6050.43
190_M194_K0.6050.43
47_F192_T0.6040.43
145_Y155_V0.6010.42
39_I113_I0.5950.42
80_M101_D0.5940.42
36_G53_M0.5940.42
118_G167_K0.5930.42
31_V98_L0.5930.42
136_D150_G0.5920.41
37_V90_I0.5910.41
128_V180_G0.5910.41
84_P87_I0.5890.41
63_K94_D0.5890.41
20_N24_S0.5870.41
71_F113_I0.5860.41
77_F106_A0.5860.41
73_Y82_E0.5840.41
44_N158_G0.5820.40
65_Y88_K0.5820.40
13_L194_K0.5820.40
95_C116_V0.5800.40
164_P167_K0.5790.40
103_H132_R0.5770.40
171_Q175_E0.5770.40
13_L20_N0.5760.40
45_L49_V0.5740.40
47_F189_D0.5730.40
39_I90_I0.5730.40
181_Y184_V0.5700.39
43_G175_E0.5690.39
124_P173_C0.5680.39
114_A127_G0.5680.39
79_F193_K0.5650.39
90_I123_F0.5640.39
27_G30_N0.5620.38
138_V142_E0.5600.38
39_I181_Y0.5600.38
145_Y148_L0.5590.38
187_I191_L0.5550.38
31_V131_S0.5540.38
132_R155_V0.5520.38
36_G52_S0.5500.37
147_Y153_V0.5490.37
70_N143_I0.5490.37
56_N179_R0.5490.37
45_L68_E0.5480.37
140_E178_K0.5470.37
11_E39_I0.5430.37
152_K162_Y0.5420.37
124_P189_D0.5400.36
97_L126_I0.5380.36
147_Y152_K0.5340.36
34_I125_T0.5340.36
78_L131_S0.5320.36
160_Y177_G0.5320.36
39_I83_A0.5300.35
41_Y64_S0.5280.35
157_F162_Y0.5270.35
143_I170_L0.5230.35
41_Y47_F0.5190.34
34_I99_L0.5190.34
54_D58_G0.5180.34
68_E78_L0.5170.34
62_Y187_I0.5160.34
35_C131_S0.5120.34
12_K152_K0.5110.34
119_V124_P0.5100.33
136_D147_Y0.5100.33
130_K163_S0.5060.33
31_V168_V0.5040.33
138_V147_Y0.5040.33
78_L81_R0.5030.33
37_V41_Y0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ga2A 1 1 100 0.214 Contact Map
4nspA 1 0.9697 100 0.239 Contact Map
2w36A 1 0.9949 100 0.334 Contact Map
3gocA 2 0.9949 100 0.365 Contact Map
2qh9A 2 0.803 100 0.516 Contact Map
2ygkA 2 0.9444 96.7 0.906 Contact Map
2nrrA 1 0.6717 96.1 0.911 Contact Map
3c65A 1 0.7121 94.5 0.92 Contact Map
2nrtA 1 0.7475 94 0.922 Contact Map
2w42A 1 0.8485 54.3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0076 seconds.