Q97VZ5 - SULSO - GREMLIN Contacts

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Q97VZ5 - Isochorismatase, putative (EntB-like2)

UniProt:	Q97VZ5	Sequences: MRAVNLIMKIEVPSIPEHKEVILDPTNTALIIVDMQNDFVRKNGKLSVPTAEATIPFIKRLVDKARSSNALVIYTQDWHMKDDPEFKIWGEHALAGTWGAEIIDELTPEKSDFIVKKYRYDAFFESSLDYILRVKNIKNTIITGTVANICVLHTAGSAALRWYNVIMPKDSISAITEFDYYATLRQVDFLYKGIITTADGIKFER	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	205 (174)
Sequences:	10031 (7048)
Seq/√Len:	534.3

ECOLI - RUTB YECD PNCA YCAC
BACSU - YWOC YAAI YDDQ PNCA YRDC
HALSA - Q9HMH5 Q9HQL7
SULSO - Q97VZ5 Q97YW7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_D	133_R	3.079	1.00
139_N	164_N	2.743	1.00
129_D	163_Y	2.681	1.00
76_Q	116_K	2.636	1.00
121_D	157_S	2.613	1.00
65_A	70_A	2.432	1.00
58_I	143_T	2.305	1.00
142_I	155_A	2.277	1.00
28_T	139_N	2.270	1.00
35_M	58_I	2.183	1.00
129_D	161_R	2.175	1.00
139_N	166_I	2.144	1.00
177_E	181_Y	2.122	1.00
27_N	138_K	2.073	1.00
61_L	168_P	2.014	1.00
187_V	192_K	1.943	1.00
168_P	200_G	1.897	1.00
38_D	99_G	1.897	1.00
29_A	137_I	1.875	1.00
127_S	131_I	1.861	1.00
37_N	98_W	1.838	1.00
122_A	154_T	1.806	1.00
57_F	171_S	1.803	1.00
57_F	197_T	1.797	1.00
115_V	131_I	1.790	1.00
158_A	165_V	1.780	1.00
196_T	199_D	1.776	1.00
57_F	60_R	1.766	1.00
64_K	68_S	1.760	1.00
152_L	156_G	1.746	1.00
169_K	194_I	1.732	1.00
169_K	196_T	1.701	1.00
147_A	180_Y	1.672	1.00
37_N	104_D	1.601	1.00
73_I	131_I	1.592	1.00
28_T	141_I	1.589	1.00
40_V	103_I	1.559	1.00
66_R	112_D	1.500	1.00
113_F	131_I	1.476	1.00
140_T	158_A	1.468	1.00
32_I	62_V	1.468	1.00
75_T	122_A	1.452	1.00
60_R	198_A	1.441	1.00
59_K	63_D	1.419	1.00
32_I	143_T	1.414	1.00
141_I	168_P	1.411	1.00
174_A	180_Y	1.409	1.00
71_L	135_K	1.409	1.00
98_W	101_E	1.407	1.00
65_A	141_I	1.407	1.00
152_L	186_Q	1.363	1.00
147_A	184_L	1.352	1.00
147_A	172_I	1.349	1.00
170_D	197_T	1.337	1.00
50_T	53_A	1.331	1.00
148_N	174_A	1.329	1.00
178_F	181_Y	1.303	1.00
142_I	154_T	1.300	1.00
59_K	105_E	1.293	1.00
169_K	184_L	1.284	1.00
152_L	183_T	1.270	1.00
151_V	167_M	1.264	1.00
78_W	100_A	1.260	1.00
181_Y	185_R	1.251	1.00
131_I	135_K	1.235	1.00
76_Q	102_I	1.221	1.00
31_I	142_I	1.203	1.00
32_I	35_M	1.200	1.00
56_P	105_E	1.194	1.00
133_R	163_Y	1.190	1.00
32_I	58_I	1.186	1.00
95_A	116_K	1.182	1.00
130_Y	134_V	1.181	1.00
30_L	65_A	1.166	1.00
33_V	150_C	1.148	1.00
54_T	58_I	1.144	1.00
171_S	197_T	1.138	1.00
167_M	172_I	1.137	1.00
63_D	67_S	1.108	1.00
76_Q	114_I	1.095	1.00
61_L	171_S	1.071	1.00
62_V	66_R	1.070	1.00
155_A	167_M	1.070	1.00
157_S	161_R	1.052	1.00
78_W	116_K	1.051	1.00
57_F	170_D	1.037	1.00
37_N	101_E	1.034	1.00
141_I	166_I	1.030	1.00
127_S	130_Y	1.021	1.00
64_K	67_S	1.007	1.00
28_T	70_A	1.003	1.00
29_A	73_I	0.979	1.00
172_I	180_Y	0.974	1.00
102_I	114_I	0.970	1.00
140_T	165_V	0.960	1.00
123_F	158_A	0.956	1.00
101_E	107_T	0.952	1.00
155_A	187_V	0.950	1.00
166_I	193_G	0.949	1.00
62_V	74_Y	0.939	1.00
176_T	179_D	0.932	1.00
124_F	161_R	0.929	1.00
147_A	174_A	0.913	1.00
80_M	95_A	0.910	1.00
178_F	182_A	0.908	1.00
78_W	95_A	0.899	1.00
164_N	193_G	0.896	1.00
153_H	156_G	0.894	1.00
37_N	41_R	0.893	1.00
74_Y	102_I	0.890	1.00
184_L	194_I	0.888	1.00
59_K	108_P	0.883	1.00
119_R	162_W	0.883	1.00
178_F	185_R	0.882	1.00
131_I	134_V	0.876	1.00
109_E	112_D	0.872	1.00
168_P	171_S	0.864	1.00
89_W	92_H	0.857	1.00
80_M	83_D	0.855	1.00
54_T	173_S	0.854	1.00
143_T	171_S	0.853	1.00
34_D	117_K	0.847	1.00
138_K	164_N	0.841	1.00
61_L	143_T	0.840	1.00
195_I	199_D	0.837	1.00
71_L	137_I	0.827	1.00
33_V	142_I	0.826	1.00
60_R	64_K	0.824	1.00
132_L	163_Y	0.823	1.00
31_I	128_L	0.818	1.00
166_I	195_I	0.816	1.00
122_A	128_L	0.810	1.00
29_A	132_L	0.806	1.00
180_Y	184_L	0.802	1.00
35_M	145_T	0.799	1.00
195_I	200_G	0.795	1.00
27_N	139_N	0.793	1.00
157_S	160_L	0.785	1.00
119_R	125_E	0.785	1.00
73_I	135_K	0.785	1.00
168_P	195_I	0.779	1.00
62_V	72_V	0.779	1.00
185_R	188_D	0.770	1.00
148_N	186_Q	0.764	1.00
56_P	60_R	0.764	1.00
60_R	63_D	0.754	1.00
142_I	151_V	0.751	1.00
58_I	171_S	0.748	1.00
61_L	197_T	0.747	1.00
56_P	59_K	0.747	1.00
148_N	179_D	0.747	1.00
94_L	97_T	0.744	1.00
84_P	87_K	0.738	1.00
55_I	59_K	0.735	1.00
97_T	100_A	0.732	1.00
145_T	173_S	0.727	1.00
27_N	136_N	0.724	1.00
74_Y	108_P	0.720	1.00
108_P	112_D	0.717	1.00
37_N	103_I	0.713	1.00
39_F	150_C	0.712	1.00
183_T	187_V	0.711	1.00
148_N	175_I	0.710	1.00
32_I	74_Y	0.704	1.00
43_N	47_S	0.700	1.00
182_A	186_Q	0.700	1.00
172_I	184_L	0.699	1.00
98_W	104_D	0.694	1.00
141_I	200_G	0.694	1.00
60_R	197_T	0.694	1.00
159_A	192_K	0.693	1.00
130_Y	133_R	0.692	1.00
113_F	135_K	0.689	1.00
155_A	192_K	0.688	1.00
55_I	103_I	0.686	1.00
54_T	145_T	0.684	1.00
185_R	189_F	0.683	1.00
74_Y	114_I	0.681	1.00
179_D	182_A	0.681	1.00
61_L	200_G	0.680	1.00
30_L	143_T	0.676	1.00
66_R	111_S	0.670	1.00
63_D	107_T	0.669	1.00
74_Y	112_D	0.668	1.00
53_A	56_P	0.667	1.00
71_L	131_I	0.665	1.00
30_L	61_L	0.663	1.00
104_D	107_T	0.661	1.00
74_Y	111_S	0.659	1.00
108_P	114_I	0.658	1.00
146_V	149_I	0.655	1.00
146_V	174_A	0.653	1.00
38_D	93_A	0.652	1.00
179_D	185_R	0.652	1.00
96_G	101_E	0.652	1.00
142_I	165_V	0.648	1.00
35_M	103_I	0.645	1.00
59_K	107_T	0.644	1.00
73_I	115_V	0.643	1.00
40_V	55_I	0.641	1.00
65_A	69_N	0.639	1.00
167_M	184_L	0.636	1.00
73_I	113_F	0.632	1.00
103_I	106_L	0.631	1.00
74_Y	106_L	0.626	1.00
30_L	72_V	0.623	1.00
49_P	53_A	0.623	1.00
61_L	65_A	0.621	1.00
49_P	52_E	0.616	1.00
62_V	65_A	0.614	1.00
66_R	109_E	0.613	1.00
124_F	160_L	0.611	1.00
182_A	185_R	0.611	1.00
51_A	145_T	0.610	1.00
81_K	91_E	0.609	1.00
63_D	109_E	0.607	1.00
35_M	106_L	0.607	1.00
87_K	90_G	0.607	1.00
35_M	54_T	0.603	1.00
184_L	188_D	0.602	1.00
38_D	44_G	0.599	1.00
48_V	51_A	0.597	1.00
33_V	151_V	0.595	1.00
156_G	190_L	0.595	1.00
66_R	72_V	0.591	1.00
155_A	165_V	0.588	0.99
169_K	180_Y	0.582	0.99
165_V	168_P	0.580	0.99
76_Q	101_E	0.574	0.99
71_L	113_F	0.567	0.99
179_D	189_F	0.567	0.99
49_P	173_S	0.566	0.99
149_I	175_I	0.562	0.99
30_L	62_V	0.557	0.99
44_G	47_S	0.554	0.99
91_E	94_L	0.550	0.99
40_V	51_A	0.547	0.99
52_E	105_E	0.547	0.99
102_I	108_P	0.546	0.99
167_M	187_V	0.545	0.99
143_T	168_P	0.544	0.99
62_V	112_D	0.542	0.99
66_R	74_Y	0.538	0.99
55_I	105_E	0.537	0.99
80_M	118_Y	0.534	0.99
79_H	82_D	0.532	0.99
55_I	106_L	0.530	0.99
124_F	157_S	0.530	0.99
76_Q	100_A	0.527	0.99
169_K	188_D	0.526	0.99
47_S	52_E	0.522	0.99
159_A	190_L	0.516	0.99
120_Y	154_T	0.515	0.99
115_V	127_S	0.515	0.99
96_G	99_G	0.511	0.99
153_H	191_Y	0.510	0.99
146_V	175_I	0.509	0.99
71_L	112_D	0.504	0.98
36_Q	75_T	0.502	0.98
159_A	165_V	0.502	0.98
121_D	160_L	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3hb7A	3	0.8976	100	0.193	Contact Map
3irvA	2	0.9366	100	0.199	Contact Map
3kl2A	4	0.9122	100	0.205	Contact Map
3hu5A	3	0.8829	100	0.215	Contact Map
4l07A	4	0.9659	100	0.217	Contact Map
1nbaA	4	0.9854	100	0.22	Contact Map
2fq1A	2	0.9854	100	0.222	Contact Map
1nf9A	2	0.9707	100	0.228	Contact Map
3ot4A	4	0.9512	100	0.23	Contact Map
3eefA	4	0.839	100	0.233	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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