GREMLIN Database
Q97VZ5 - Isochorismatase, putative (EntB-like2)
UniProt: Q97VZ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (174)
Sequences: 10031 (7048)
Seq/√Len: 534.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_D133_R3.0791.00
139_N164_N2.7431.00
129_D163_Y2.6811.00
76_Q116_K2.6361.00
121_D157_S2.6131.00
65_A70_A2.4321.00
58_I143_T2.3051.00
142_I155_A2.2771.00
28_T139_N2.2701.00
35_M58_I2.1831.00
129_D161_R2.1751.00
139_N166_I2.1441.00
177_E181_Y2.1221.00
27_N138_K2.0731.00
61_L168_P2.0141.00
187_V192_K1.9431.00
168_P200_G1.8971.00
38_D99_G1.8971.00
29_A137_I1.8751.00
127_S131_I1.8611.00
37_N98_W1.8381.00
122_A154_T1.8061.00
57_F171_S1.8031.00
57_F197_T1.7971.00
115_V131_I1.7901.00
158_A165_V1.7801.00
196_T199_D1.7761.00
57_F60_R1.7661.00
64_K68_S1.7601.00
152_L156_G1.7461.00
169_K194_I1.7321.00
169_K196_T1.7011.00
147_A180_Y1.6721.00
37_N104_D1.6011.00
73_I131_I1.5921.00
28_T141_I1.5891.00
40_V103_I1.5591.00
66_R112_D1.5001.00
113_F131_I1.4761.00
140_T158_A1.4681.00
32_I62_V1.4681.00
75_T122_A1.4521.00
60_R198_A1.4411.00
59_K63_D1.4191.00
32_I143_T1.4141.00
141_I168_P1.4111.00
174_A180_Y1.4091.00
71_L135_K1.4091.00
98_W101_E1.4071.00
65_A141_I1.4071.00
152_L186_Q1.3631.00
147_A184_L1.3521.00
147_A172_I1.3491.00
170_D197_T1.3371.00
50_T53_A1.3311.00
148_N174_A1.3291.00
178_F181_Y1.3031.00
142_I154_T1.3001.00
59_K105_E1.2931.00
169_K184_L1.2841.00
152_L183_T1.2701.00
151_V167_M1.2641.00
78_W100_A1.2601.00
181_Y185_R1.2511.00
131_I135_K1.2351.00
76_Q102_I1.2211.00
31_I142_I1.2031.00
32_I35_M1.2001.00
56_P105_E1.1941.00
133_R163_Y1.1901.00
32_I58_I1.1861.00
95_A116_K1.1821.00
130_Y134_V1.1811.00
30_L65_A1.1661.00
33_V150_C1.1481.00
54_T58_I1.1441.00
171_S197_T1.1381.00
167_M172_I1.1371.00
63_D67_S1.1081.00
76_Q114_I1.0951.00
61_L171_S1.0711.00
62_V66_R1.0701.00
155_A167_M1.0701.00
157_S161_R1.0521.00
78_W116_K1.0511.00
57_F170_D1.0371.00
37_N101_E1.0341.00
141_I166_I1.0301.00
127_S130_Y1.0211.00
64_K67_S1.0071.00
28_T70_A1.0031.00
29_A73_I0.9791.00
172_I180_Y0.9741.00
102_I114_I0.9701.00
140_T165_V0.9601.00
123_F158_A0.9561.00
101_E107_T0.9521.00
155_A187_V0.9501.00
166_I193_G0.9491.00
62_V74_Y0.9391.00
176_T179_D0.9321.00
124_F161_R0.9291.00
147_A174_A0.9131.00
80_M95_A0.9101.00
178_F182_A0.9081.00
78_W95_A0.8991.00
164_N193_G0.8961.00
153_H156_G0.8941.00
37_N41_R0.8931.00
74_Y102_I0.8901.00
184_L194_I0.8881.00
59_K108_P0.8831.00
119_R162_W0.8831.00
178_F185_R0.8821.00
131_I134_V0.8761.00
109_E112_D0.8721.00
168_P171_S0.8641.00
89_W92_H0.8571.00
80_M83_D0.8551.00
54_T173_S0.8541.00
143_T171_S0.8531.00
34_D117_K0.8471.00
138_K164_N0.8411.00
61_L143_T0.8401.00
195_I199_D0.8371.00
71_L137_I0.8271.00
33_V142_I0.8261.00
60_R64_K0.8241.00
132_L163_Y0.8231.00
31_I128_L0.8181.00
166_I195_I0.8161.00
122_A128_L0.8101.00
29_A132_L0.8061.00
180_Y184_L0.8021.00
35_M145_T0.7991.00
195_I200_G0.7951.00
27_N139_N0.7931.00
157_S160_L0.7851.00
119_R125_E0.7851.00
73_I135_K0.7851.00
168_P195_I0.7791.00
62_V72_V0.7791.00
185_R188_D0.7701.00
148_N186_Q0.7641.00
56_P60_R0.7641.00
60_R63_D0.7541.00
142_I151_V0.7511.00
58_I171_S0.7481.00
61_L197_T0.7471.00
56_P59_K0.7471.00
148_N179_D0.7471.00
94_L97_T0.7441.00
84_P87_K0.7381.00
55_I59_K0.7351.00
97_T100_A0.7321.00
145_T173_S0.7271.00
27_N136_N0.7241.00
74_Y108_P0.7201.00
108_P112_D0.7171.00
37_N103_I0.7131.00
39_F150_C0.7121.00
183_T187_V0.7111.00
148_N175_I0.7101.00
32_I74_Y0.7041.00
43_N47_S0.7001.00
182_A186_Q0.7001.00
172_I184_L0.6991.00
98_W104_D0.6941.00
141_I200_G0.6941.00
60_R197_T0.6941.00
159_A192_K0.6931.00
130_Y133_R0.6921.00
113_F135_K0.6891.00
155_A192_K0.6881.00
55_I103_I0.6861.00
54_T145_T0.6841.00
185_R189_F0.6831.00
74_Y114_I0.6811.00
179_D182_A0.6811.00
61_L200_G0.6801.00
30_L143_T0.6761.00
66_R111_S0.6701.00
63_D107_T0.6691.00
74_Y112_D0.6681.00
53_A56_P0.6671.00
71_L131_I0.6651.00
30_L61_L0.6631.00
104_D107_T0.6611.00
74_Y111_S0.6591.00
108_P114_I0.6581.00
146_V149_I0.6551.00
146_V174_A0.6531.00
38_D93_A0.6521.00
179_D185_R0.6521.00
96_G101_E0.6521.00
142_I165_V0.6481.00
35_M103_I0.6451.00
59_K107_T0.6441.00
73_I115_V0.6431.00
40_V55_I0.6411.00
65_A69_N0.6391.00
167_M184_L0.6361.00
73_I113_F0.6321.00
103_I106_L0.6311.00
74_Y106_L0.6261.00
30_L72_V0.6231.00
49_P53_A0.6231.00
61_L65_A0.6211.00
49_P52_E0.6161.00
62_V65_A0.6141.00
66_R109_E0.6131.00
124_F160_L0.6111.00
182_A185_R0.6111.00
51_A145_T0.6101.00
81_K91_E0.6091.00
63_D109_E0.6071.00
35_M106_L0.6071.00
87_K90_G0.6071.00
35_M54_T0.6031.00
184_L188_D0.6021.00
38_D44_G0.5991.00
48_V51_A0.5971.00
33_V151_V0.5951.00
156_G190_L0.5951.00
66_R72_V0.5911.00
155_A165_V0.5880.99
169_K180_Y0.5820.99
165_V168_P0.5800.99
76_Q101_E0.5740.99
71_L113_F0.5670.99
179_D189_F0.5670.99
49_P173_S0.5660.99
149_I175_I0.5620.99
30_L62_V0.5570.99
44_G47_S0.5540.99
91_E94_L0.5500.99
40_V51_A0.5470.99
52_E105_E0.5470.99
102_I108_P0.5460.99
167_M187_V0.5450.99
143_T168_P0.5440.99
62_V112_D0.5420.99
66_R74_Y0.5380.99
55_I105_E0.5370.99
80_M118_Y0.5340.99
79_H82_D0.5320.99
55_I106_L0.5300.99
124_F157_S0.5300.99
76_Q100_A0.5270.99
169_K188_D0.5260.99
47_S52_E0.5220.99
159_A190_L0.5160.99
120_Y154_T0.5150.99
115_V127_S0.5150.99
96_G99_G0.5110.99
153_H191_Y0.5100.99
146_V175_I0.5090.99
71_L112_D0.5040.98
36_Q75_T0.5020.98
159_A165_V0.5020.98
121_D160_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hb7A 3 0.8976 100 0.193 Contact Map
3irvA 2 0.9366 100 0.199 Contact Map
3kl2A 4 0.9122 100 0.205 Contact Map
3hu5A 3 0.8829 100 0.215 Contact Map
4l07A 4 0.9659 100 0.217 Contact Map
1nbaA 4 0.9854 100 0.22 Contact Map
2fq1A 2 0.9854 100 0.222 Contact Map
1nf9A 2 0.9707 100 0.228 Contact Map
3ot4A 4 0.9512 100 0.23 Contact Map
3eefA 4 0.839 100 0.233 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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