GREMLIN Database
Q97VZ4 - Uncharacterized protein
UniProt: Q97VZ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (274)
Sequences: 4016 (3486)
Seq/√Len: 210.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_S126_D3.5451.00
115_A136_D3.1401.00
154_R161_D2.8421.00
23_A122_K2.7271.00
21_A25_K2.7151.00
7_V13_G2.6461.00
154_R157_E2.4801.00
283_I286_R2.4181.00
108_H111_S2.4141.00
4_Y52_Y2.3931.00
153_R160_K2.2031.00
3_Y53_N2.1561.00
120_K151_K2.1381.00
142_W146_D2.0711.00
186_L189_V2.0441.00
148_M152_L2.0261.00
250_I277_A2.0181.00
149_G152_L1.9991.00
230_S234_M1.9901.00
112_T116_G1.9681.00
150_E161_D1.9651.00
31_V34_T1.9101.00
282_P286_R1.9021.00
154_R158_N1.8771.00
239_A243_V1.8741.00
282_P287_F1.8261.00
29_K34_T1.8261.00
215_V218_V1.8121.00
252_F263_A1.7901.00
153_R157_E1.7891.00
123_N158_N1.7791.00
214_V217_A1.7441.00
204_Y207_I1.7081.00
215_V219_R1.6971.00
227_S230_S1.6921.00
148_M153_R1.6661.00
261_Q264_V1.6331.00
18_A132_L1.6301.00
153_R156_V1.6281.00
155_I158_N1.6151.00
185_M188_E1.6111.00
186_L190_V1.6021.00
230_S236_R1.5801.00
152_L158_N1.5651.00
29_K32_F1.5531.00
210_N213_K1.5491.00
22_R129_S1.5451.00
187_E190_V1.5441.00
240_S243_V1.5401.00
258_D261_Q1.5391.00
150_E157_E1.5361.00
192_R196_G1.5321.00
152_L157_E1.5271.00
5_A21_A1.5201.00
212_H215_V1.5191.00
5_A20_Y1.5151.00
148_M151_K1.5091.00
185_M189_V1.4861.00
5_A17_A1.4811.00
283_I287_F1.4731.00
279_L287_F1.4711.00
5_A57_A1.4631.00
281_V286_R1.4471.00
186_L191_S1.4451.00
150_E153_R1.4441.00
188_E191_S1.4401.00
6_I54_V1.4391.00
157_E160_K1.4351.00
258_D272_P1.4301.00
199_K203_S1.4261.00
239_A242_F1.4151.00
16_S115_A1.4081.00
252_F259_V1.4031.00
54_V80_G1.3841.00
107_Y111_S1.3801.00
184_K187_E1.3641.00
22_R128_F1.3581.00
184_K188_E1.3521.00
238_D243_V1.3511.00
126_D129_S1.3401.00
11_F135_A1.3151.00
212_H216_V1.3061.00
119_Y158_N1.2971.00
149_G158_N1.2961.00
230_S233_L1.2941.00
151_K154_R1.2791.00
11_F139_V1.2701.00
69_I72_N1.2641.00
183_D186_L1.2621.00
199_K202_K1.2611.00
152_L159_N1.2541.00
192_R195_E1.2541.00
227_S237_T1.2501.00
206_L209_I1.2401.00
254_S259_V1.2401.00
202_K205_K1.2261.00
170_K174_N1.2191.00
212_H218_V1.2171.00
232_F236_R1.2161.00
151_K158_N1.2151.00
152_L160_K1.2121.00
201_M205_K1.2091.00
153_R158_N1.2061.00
230_S237_T1.2041.00
151_K155_I1.2031.00
231_Q235_T1.2031.00
165_K168_L1.2011.00
106_V109_D1.1951.00
149_G153_R1.1931.00
173_Y176_I1.1891.00
230_S235_T1.1891.00
194_L197_Y1.1871.00
178_W181_T1.1801.00
153_R159_N1.1791.00
112_T141_I1.1781.00
152_L155_I1.1741.00
190_V193_E1.1721.00
57_A114_G1.1651.00
56_I59_L1.1631.00
227_S234_M1.1611.00
170_K173_Y1.1591.00
200_V203_S1.1561.00
286_R290_R1.1391.00
284_I287_F1.1341.00
226_I230_S1.1301.00
202_K206_L1.1281.00
211_G214_V1.1271.00
127_E164_W1.1221.00
209_I213_K1.1181.00
210_N216_V1.1161.00
66_F69_I1.1151.00
231_Q234_M1.1031.00
53_N82_N1.1011.00
228_Y232_F1.1011.00
211_G215_V1.0981.00
179_D183_D1.0971.00
184_K189_V1.0851.00
156_V160_K1.0851.00
22_R25_K1.0841.00
228_Y234_M1.0791.00
40_H45_S1.0741.00
226_I229_A1.0741.00
282_P285_Y1.0721.00
150_E154_R1.0631.00
118_I122_K1.0601.00
31_V35_E1.0601.00
228_Y231_Q1.0571.00
65_T69_I1.0561.00
21_A31_V1.0551.00
213_K217_A1.0531.00
158_N161_D1.0521.00
20_Y57_A1.0501.00
150_E160_K1.0471.00
131_R164_W1.0341.00
266_L290_R1.0331.00
19_V118_I1.0321.00
281_V284_I1.0321.00
29_K33_F1.0251.00
228_Y236_R1.0181.00
96_K99_L1.0141.00
182_F185_M1.0031.00
20_Y55_M1.0011.00
198_K201_M0.9981.00
127_E131_R0.9951.00
203_S206_L0.9901.00
252_F277_A0.9761.00
19_V133_S0.9751.00
7_V17_A0.9751.00
213_K218_V0.9671.00
90_V272_P0.9521.00
227_S233_L0.9511.00
244_S247_G0.9420.99
148_M159_N0.9420.99
119_Y155_I0.9410.99
51_V81_A0.9400.99
214_V219_R0.9390.99
119_Y123_N0.9380.99
287_F290_R0.9350.99
233_L236_R0.9320.99
227_S232_F0.9310.99
282_P290_R0.9310.99
179_D182_F0.9250.99
186_L192_R0.9140.99
41_S44_A0.9080.99
134_S164_W0.9050.99
225_D230_S0.9040.99
284_I288_L0.9020.99
29_K35_E0.8980.99
228_Y233_L0.8960.99
259_V275_A0.8940.99
203_S207_I0.8930.99
254_S273_L0.8910.99
149_G160_K0.8890.99
195_E198_K0.8880.99
22_R26_S0.8870.99
17_A33_F0.8830.99
4_Y51_V0.8830.99
66_F70_I0.8820.99
115_A137_C0.8760.99
152_L156_V0.8720.99
183_D187_E0.8700.99
85_W92_K0.8610.99
67_N70_I0.8590.99
256_E273_L0.8590.99
21_A33_F0.8570.99
239_A244_S0.8480.99
207_I211_G0.8460.99
198_K202_K0.8450.99
30_N34_T0.8400.99
68_E71_R0.8390.99
214_V218_V0.8370.99
16_S57_A0.8340.99
209_I214_V0.8330.99
26_S129_S0.8310.99
216_V219_R0.8290.99
148_M157_E0.8280.99
285_Y289_N0.8280.99
22_R126_D0.8270.99
134_S138_S0.8270.99
188_E192_R0.8260.99
86_F121_Y0.8260.99
120_K124_P0.8230.99
265_K290_R0.8200.99
227_S236_R0.8190.99
205_K209_I0.8170.98
197_Y200_V0.8150.98
252_F262_F0.8100.98
205_K208_Q0.8100.98
201_M204_Y0.8090.98
210_N215_V0.8080.98
231_Q236_R0.8050.98
209_I212_H0.8040.98
151_K157_E0.8020.98
23_A129_S0.8010.98
49_R52_Y0.7980.98
187_E191_S0.7920.98
19_V129_S0.7920.98
286_R289_N0.7840.98
31_V37_N0.7840.98
205_K210_N0.7780.98
193_E196_G0.7760.98
155_I160_K0.7760.98
185_M190_V0.7690.98
191_S194_L0.7670.98
137_C156_V0.7650.98
149_G155_I0.7620.98
182_F186_L0.7600.98
196_G199_K0.7500.97
29_K36_P0.7480.97
213_K216_V0.7480.97
208_Q211_G0.7450.97
203_S208_Q0.7430.97
150_E156_V0.7430.97
243_V246_N0.7380.97
230_S240_S0.7380.97
198_K203_S0.7370.97
20_Y118_I0.7350.97
210_N214_V0.7290.97
200_V205_K0.7290.97
232_F237_T0.7270.97
32_F35_E0.7270.97
238_D241_V0.7240.97
211_G216_V0.7190.97
131_R168_L0.7180.97
178_W182_F0.7160.97
30_N33_F0.7120.96
47_E50_G0.7120.96
83_V97_E0.7110.96
210_N218_V0.7100.96
106_V111_S0.7080.96
189_V193_E0.7070.96
97_E100_K0.7070.96
40_H43_L0.7040.96
200_V204_Y0.7030.96
187_E192_R0.7020.96
213_K219_R0.7000.96
164_W169_I0.6990.96
267_G280_K0.6980.96
24_I33_F0.6970.96
226_I234_M0.6960.96
107_Y110_T0.6960.96
148_M156_V0.6940.96
266_L279_L0.6920.96
240_S244_S0.6910.96
260_R264_V0.6890.96
92_K264_V0.6890.96
118_I133_S0.6860.96
32_F51_V0.6860.96
65_T70_I0.6840.96
71_R78_D0.6830.95
238_D242_F0.6810.95
148_M154_R0.6790.95
239_A247_G0.6770.95
181_T185_M0.6760.95
207_I210_N0.6640.95
229_A234_M0.6640.95
117_V120_K0.6630.95
29_K37_N0.6620.95
202_K207_I0.6580.94
227_S235_T0.6580.94
46_L132_L0.6550.94
209_I216_V0.6550.94
205_K213_K0.6550.94
182_F189_V0.6530.94
53_N84_E0.6520.94
138_S143_L0.6500.94
156_V159_N0.6480.94
209_I215_V0.6470.94
208_Q212_H0.6450.94
225_D228_Y0.6410.94
209_I217_A0.6410.94
56_I97_E0.6400.94
191_S195_E0.6390.94
225_D235_T0.6330.93
91_W260_R0.6310.93
150_E159_N0.6310.93
204_Y209_I0.6280.93
183_D188_E0.6250.93
208_Q213_K0.6240.93
228_Y235_T0.6240.93
26_S125_N0.6220.93
85_W97_E0.6220.93
229_A233_L0.6220.93
160_K163_S0.6180.92
207_I216_V0.6180.92
193_E197_Y0.6180.92
55_M84_E0.6160.92
113_C116_G0.6140.92
284_I290_R0.6140.92
129_S133_S0.6130.92
151_K160_K0.6130.92
127_E163_S0.6130.92
150_E158_N0.6120.92
42_L45_S0.6100.92
239_A246_N0.6060.92
227_S231_Q0.6060.92
228_Y237_T0.6040.92
225_D234_M0.6030.92
209_I219_R0.6020.91
250_I263_A0.6000.91
201_M207_I0.5970.91
13_G17_A0.5970.91
229_A232_F0.5960.91
211_G218_V0.5950.91
179_D188_E0.5910.91
190_V195_E0.5900.91
190_V196_G0.5890.91
192_R197_Y0.5880.90
234_M240_S0.5850.90
35_E38_K0.5830.90
238_D244_S0.5820.90
231_Q237_T0.5800.90
17_A57_A0.5800.90
207_I212_H0.5780.90
128_F131_R0.5760.90
283_I290_R0.5750.89
233_L240_S0.5750.89
149_G156_V0.5750.89
149_G157_E0.5680.89
185_M192_R0.5670.89
9_N13_G0.5650.89
224_P227_S0.5650.89
206_L210_N0.5640.89
23_A27_L0.5620.88
178_W186_L0.5600.88
41_S45_S0.5600.88
204_Y212_H0.5590.88
190_V194_L0.5570.88
57_A115_A0.5550.88
154_R160_K0.5530.88
232_F235_T0.5500.87
179_D186_L0.5480.87
186_L193_E0.5470.87
225_D229_A0.5440.87
226_I235_T0.5420.87
13_G57_A0.5400.86
158_N162_Y0.5390.86
61_I92_K0.5390.86
208_Q214_V0.5370.86
149_G154_R0.5360.86
204_Y210_N0.5340.86
114_G118_I0.5340.86
189_V192_R0.5330.86
194_L198_K0.5330.86
67_N72_N0.5330.86
90_V260_R0.5320.86
202_K209_I0.5320.86
54_V83_V0.5300.85
46_L135_A0.5290.85
65_T68_E0.5280.85
157_E161_D0.5270.85
226_I232_F0.5250.85
17_A115_A0.5240.85
239_A259_V0.5220.85
13_G16_S0.5180.84
203_S209_I0.5170.84
114_G117_V0.5160.84
281_V285_Y0.5150.84
82_N98_E0.5110.83
35_E43_L0.5110.83
224_P228_Y0.5090.83
188_E195_E0.5080.83
179_D191_S0.5070.83
239_A257_I0.5070.83
188_E193_E0.5070.83
120_K123_N0.5060.83
39_L44_A0.5030.82
243_V248_K0.5020.82
229_A237_T0.5010.82
234_M237_T0.5010.82
80_G83_V0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4py9A 2 0.8693 100 0.418 Contact Map
4ls9A 2 0.8237 100 0.423 Contact Map
3devA 2 0.8511 100 0.427 Contact Map
2hawA 2 0.8267 100 0.563 Contact Map
2zxrA 1 0.8298 100 0.581 Contact Map
4rpaA 3 0.8267 100 0.586 Contact Map
2eb0A 2 0.7933 99.9 0.653 Contact Map
1wpnA 2 0.5015 99.9 0.661 Contact Map
1k20A 2 0.8176 99.9 0.666 Contact Map
2qb7A 1 0.8602 99.8 0.714 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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