GREMLIN Database
Q97VZ3 - Uncharacterized protein
UniProt: Q97VZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (216)
Sequences: 254 (157)
Seq/√Len: 10.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_S35_L5.3821.00
34_L150_L3.9050.99
32_L102_L3.5900.98
26_G59_V3.3190.97
112_E115_T3.2560.96
102_L148_I3.2010.96
64_S85_I3.1600.95
9_I55_L3.0690.95
55_L85_I2.9270.93
116_L129_M2.8390.92
71_F120_S2.8180.92
78_Y81_N2.6570.89
3_I192_I2.4840.85
107_S131_R2.4450.84
19_F58_R2.3500.82
63_V95_I2.3440.82
40_V70_D2.3180.81
94_E144_A2.2730.79
149_L191_A2.1530.76
150_L215_A2.0240.71
98_E104_I1.9920.69
145_D191_A1.9610.68
214_V217_P1.9250.67
39_L70_D1.9240.67
25_L202_T1.8670.64
63_V221_R1.8620.64
25_L151_T1.7960.61
116_L126_D1.7840.61
87_W154_A1.7590.59
155_S172_G1.7520.59
45_Y78_Y1.7410.59
105_I110_V1.7250.58
117_W177_E1.7210.58
3_I180_S1.6890.56
49_T95_I1.6750.56
3_I32_L1.6700.55
63_V192_I1.6660.55
136_T182_K1.5990.52
16_T54_A1.5950.52
30_A155_S1.5820.51
18_F216_L1.5460.49
63_V76_K1.5350.49
90_D135_I1.5270.49
43_G159_T1.4580.45
13_R32_L1.4360.44
159_T172_G1.4350.44
64_S87_W1.4340.44
71_F79_R1.4290.44
48_F52_Y1.4150.43
30_A172_G1.4000.43
89_E146_I1.3980.43
84_D112_E1.3810.42
23_R95_I1.3550.41
79_R168_Y1.3430.40
105_I111_L1.3040.38
124_T128_Y1.2990.38
86_I93_V1.2950.38
36_A151_T1.2900.38
34_L191_A1.2770.37
135_I151_T1.2700.37
190_I212_Y1.2700.37
104_I125_E1.2580.36
63_V137_E1.2490.36
43_G172_G1.2410.35
102_L192_I1.2340.35
53_N71_F1.2090.34
12_P56_K1.1950.33
195_H213_N1.1630.32
197_H213_N1.1630.32
16_T53_N1.1570.32
177_E206_V1.1290.31
140_C192_I1.1180.30
157_F177_E1.1170.30
151_T191_A1.1100.30
80_E95_I1.1100.30
61_Q69_E1.1080.30
94_E101_K1.1010.30
108_E111_L1.0930.29
165_K168_Y1.0890.29
102_L130_K1.0850.29
42_R117_W1.0810.29
11_S51_V1.0760.29
12_P17_E1.0740.29
136_T183_G1.0730.29
205_V211_V1.0660.28
135_I149_L1.0660.28
183_G188_P1.0620.28
194_G215_A1.0580.28
150_L217_P1.0530.28
144_A183_G1.0490.28
21_A202_T1.0360.27
35_L51_V1.0330.27
40_V66_F1.0310.27
107_S135_I1.0280.27
48_F154_A1.0220.27
107_S110_V1.0200.27
26_G95_I1.0200.27
198_Y202_T1.0170.26
137_E217_P1.0140.26
32_L218_A1.0120.26
110_V113_K1.0040.26
100_R107_S1.0030.26
91_E94_E0.9980.26
85_I198_Y0.9970.26
80_E96_K0.9940.26
94_E143_K0.9800.25
149_L179_L0.9740.25
13_R63_V0.9690.25
201_R212_Y0.9630.24
71_F161_F0.9620.24
47_H119_T0.9580.24
22_L137_E0.9480.24
7_S215_A0.9440.24
161_F200_K0.9440.24
117_W218_A0.9400.24
117_W181_T0.9340.23
193_H197_H0.9340.23
193_H213_N0.9340.23
30_A103_I0.9300.23
19_F164_R0.9290.23
150_L218_A0.9280.23
135_I139_S0.9270.23
155_S159_T0.9270.23
95_I154_A0.9250.23
56_K76_K0.9230.23
124_T170_H0.9120.23
84_D210_R0.9110.23
44_E73_E0.9040.22
7_S19_F0.9030.22
35_L48_F0.8960.22
46_L58_R0.8950.22
206_V209_V0.8890.22
53_N134_K0.8880.22
85_I206_V0.8860.22
69_E118_Q0.8850.22
28_I96_K0.8840.22
107_S111_L0.8830.22
89_E209_V0.8800.22
160_V182_K0.8780.22
69_E199_A0.8730.21
9_I22_L0.8660.21
9_I17_E0.8620.21
45_Y75_R0.8580.21
28_I95_I0.8490.21
199_A208_S0.8470.21
91_E125_E0.8440.21
96_K187_L0.8380.20
181_T215_A0.8380.20
24_E153_Y0.8350.20
122_G149_L0.8320.20
31_D171_L0.8310.20
181_T206_V0.8300.20
140_C179_L0.8290.20
142_S219_N0.8270.20
161_F221_R0.8260.20
156_T177_E0.8230.20
49_T180_S0.8220.20
31_D35_L0.8190.20
122_G191_A0.8190.20
99_N105_I0.8160.20
71_F104_I0.8160.20
166_S215_A0.8150.20
9_I12_P0.8140.20
204_S210_R0.8130.20
169_P178_E0.8120.20
70_D139_S0.8100.20
50_P206_V0.8060.19
61_Q103_I0.8020.19
21_A209_V0.8000.19
40_V82_Y0.7990.19
24_E130_K0.7920.19
92_K144_A0.7890.19
24_E29_K0.7780.19
53_N104_I0.7770.19
81_N154_A0.7690.18
21_A85_I0.7680.18
104_I138_M0.7660.18
139_S147_K0.7570.18
127_L131_R0.7560.18
45_Y147_K0.7560.18
85_I168_Y0.7530.18
3_I134_K0.7520.18
47_H118_Q0.7510.18
147_K221_R0.7450.18
92_K96_K0.7440.18
19_F180_S0.7420.18
76_K79_R0.7410.18
189_N210_R0.7390.18
148_I190_I0.7360.17
45_Y73_E0.7350.17
49_T58_R0.7280.17
116_L153_Y0.7260.17
78_Y149_L0.7140.17
32_L125_E0.7140.17
6_T212_Y0.7140.17
44_E77_F0.7120.17
113_K148_I0.7110.17
35_L87_W0.7060.17
69_E203_L0.7050.17
75_R122_G0.7050.17
103_I203_L0.7030.17
31_D164_R0.7000.16
81_N189_N0.6990.16
51_V131_R0.6980.16
102_L105_I0.6970.16
79_R150_L0.6960.16
177_E181_T0.6960.16
127_L130_K0.6940.16
96_K102_L0.6940.16
3_I62_I0.6920.16
63_V202_T0.6900.16
46_L141_N0.6850.16
103_I172_G0.6840.16
193_H214_V0.6810.16
144_A157_F0.6780.16
13_R86_I0.6740.16
120_S148_I0.6700.16
75_R182_K0.6690.16
3_I95_I0.6680.16
49_T137_E0.6680.16
39_L171_L0.6650.16
5_S10_H0.6630.16
60_K150_L0.6630.16
164_R203_L0.6620.15
3_I126_D0.6600.15
49_T77_F0.6590.15
30_A159_T0.6590.15
64_S139_S0.6590.15
2_L5_S0.6580.15
117_W124_T0.6570.15
35_L215_A0.6560.15
129_M133_E0.6540.15
130_K143_K0.6510.15
15_L177_E0.6490.15
9_I204_S0.6440.15
56_K216_L0.6410.15
2_L6_T0.6400.15
26_G151_T0.6370.15
49_T52_Y0.6340.15
36_A192_I0.6300.15
32_L63_V0.6260.15
121_N190_I0.6240.15
123_I191_A0.6220.15
87_W150_L0.6190.14
19_F35_L0.6130.14
108_E112_E0.6060.14
21_A51_V0.6030.14
37_G109_G0.6000.14
37_G68_N0.6000.14
67_G152_H0.6000.14
38_D67_G0.6000.14
68_N152_H0.6000.14
37_G152_H0.6000.14
38_D68_N0.6000.14
38_D109_G0.6000.14
68_N109_G0.6000.14
37_G67_G0.6000.14
38_D152_H0.6000.14
67_G109_G0.6000.14
109_G152_H0.6000.14
59_V177_E0.5990.14
142_S153_Y0.5980.14
71_F75_R0.5960.14
151_T183_G0.5960.14
9_I51_V0.5940.14
31_D61_Q0.5920.14
96_K99_N0.5900.14
2_L147_K0.5880.14
34_L147_K0.5870.14
6_T33_A0.5860.14
34_L187_L0.5850.14
102_L107_S0.5840.14
111_L174_R0.5840.14
65_I135_I0.5820.14
99_N102_L0.5810.14
126_D148_I0.5800.14
130_K209_V0.5780.14
63_V104_I0.5760.13
168_Y175_V0.5750.13
94_E125_E0.5750.13
91_E141_N0.5670.13
158_E177_E0.5630.13
46_L49_T0.5610.13
102_L129_M0.5590.13
112_E165_K0.5560.13
3_I130_K0.5560.13
82_Y167_V0.5550.13
9_I217_P0.5550.13
133_E187_L0.5530.13
13_R153_Y0.5520.13
105_I113_K0.5480.13
52_Y72_I0.5470.13
90_D151_T0.5460.13
154_A171_L0.5450.13
113_K210_R0.5420.13
181_T205_V0.5410.13
111_L153_Y0.5390.13
80_E91_E0.5390.13
93_V218_A0.5380.13
25_L220_K0.5350.13
100_R104_I0.5330.13
3_I220_K0.5330.13
9_I173_Y0.5310.13
112_E173_Y0.5290.12
63_V187_L0.5270.12
22_L130_K0.5240.12
35_L55_L0.5220.12
81_N104_I0.5200.12
60_K82_Y0.5190.12
35_L99_N0.5160.12
24_E142_S0.5150.12
84_D181_T0.5120.12
132_L176_L0.5100.12
158_E190_I0.5100.12
87_W212_Y0.5090.12
30_A33_A0.5080.12
82_Y155_S0.5070.12
23_R94_E0.5060.12
105_I138_M0.5050.12
45_Y120_S0.5050.12
134_K177_E0.5050.12
16_T204_S0.5040.12
117_W215_A0.5030.12
154_A172_G0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4peiA 2 0.943 99.9 0.726 Contact Map
1uf3A 6 0.8947 99.9 0.728 Contact Map
2yvtA 1 0.9211 99.9 0.742 Contact Map
3d03A 5 0.9254 99.9 0.749 Contact Map
3rl5A 1 0.8684 99.9 0.75 Contact Map
3ib7A 2 0.9167 99.9 0.758 Contact Map
3iveA 1 0.943 99.9 0.762 Contact Map
4q7fA 1 0.9342 99.9 0.766 Contact Map
2nxfA 1 0.9518 99.9 0.766 Contact Map
2xmoA 1 0.9649 99.8 0.771 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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