GREMLIN Database
Q97VZ2 - Uncharacterized protein
UniProt: Q97VZ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (344)
Sequences: 249 (174)
Seq/√Len: 9.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_I343_W4.8841.00
202_D205_R4.0850.99
57_F91_V3.5490.97
16_V63_M3.3860.95
299_I345_V3.3500.95
58_N70_S3.2730.95
211_L288_L3.2120.94
106_V146_V3.1890.94
42_Q151_K3.0700.92
32_V44_V2.8840.90
180_E197_I2.8250.89
114_D117_K2.6960.86
127_K131_T2.5650.83
45_V147_T2.5470.83
101_K104_D2.4530.80
120_N124_I2.4400.80
253_R259_P2.3650.78
63_M187_G2.3620.77
63_M146_V2.3580.77
31_I179_V2.3410.77
59_N66_D2.3190.76
119_K144_M2.2970.75
11_L17_P2.2580.74
58_N66_D2.1030.68
9_L12_H2.0890.68
138_Q290_P2.0880.68
16_V146_V2.0630.67
97_K300_A2.0370.66
43_K46_E2.0330.66
340_K344_E1.9670.63
41_P147_T1.9580.63
178_V205_R1.9450.62
122_S142_H1.9440.62
145_L155_I1.8860.60
250_K253_R1.8500.58
31_I60_I1.8470.58
58_N321_F1.8390.58
19_W103_P1.8330.57
252_A255_I1.8160.57
142_H156_Q1.8130.56
110_I119_K1.7910.55
43_K60_I1.7520.54
63_M70_S1.7190.52
344_E347_Y1.7180.52
10_P20_L1.7060.52
12_H20_L1.6880.51
66_D321_F1.6810.51
338_N341_A1.6660.50
17_P20_L1.6620.50
128_V178_V1.6590.50
126_A156_Q1.6570.50
198_D201_K1.6280.48
201_K309_S1.5990.47
44_V48_F1.5970.47
92_L144_M1.5920.47
21_V77_I1.5910.47
176_N179_V1.5750.46
12_H17_P1.5440.45
16_V187_G1.5390.44
11_L20_L1.5380.44
274_E282_E1.5230.44
16_V70_S1.5220.44
10_P17_P1.5200.43
179_V202_D1.5200.43
92_L141_H1.5090.43
23_I342_A1.4920.42
92_L102_V1.4870.42
214_E306_E1.4840.42
155_I347_Y1.4720.41
82_T91_V1.4370.40
75_L141_H1.4350.40
133_V190_T1.4330.40
70_S321_F1.4280.40
352_F356_A1.4240.39
179_V197_I1.4180.39
25_K81_I1.4150.39
14_G17_P1.4100.39
35_M44_V1.4030.38
49_S180_E1.3980.38
49_S83_N1.3980.38
48_F128_V1.3940.38
219_I269_L1.3930.38
132_L284_L1.3790.37
164_K199_R1.3790.37
130_S183_S1.3660.37
49_S120_N1.3610.37
36_I200_D1.3440.36
355_R362_D1.3280.35
66_D70_S1.3280.35
50_N348_T1.3260.35
353_I358_L1.3250.35
203_R206_K1.3140.35
16_V21_V1.3120.35
146_V216_P1.3110.35
30_A356_A1.3010.34
291_S335_Y1.2990.34
28_A31_I1.2960.34
43_K47_R1.2870.34
280_F361_G1.2780.33
77_I81_I1.2750.33
39_L304_Y1.2720.33
13_T205_R1.2600.33
76_G366_A1.2590.33
11_L14_G1.2590.33
126_A142_H1.2540.32
212_L272_M1.2540.32
10_P67_S1.2430.32
64_D156_Q1.2420.32
327_I345_V1.2380.32
15_H155_I1.2380.32
45_V154_I1.2350.32
70_S73_V1.2300.32
64_D126_A1.2280.31
74_T310_Y1.2280.31
120_N281_E1.2230.31
56_G337_V1.2210.31
279_T286_N1.2180.31
58_N265_I1.2160.31
36_I87_H1.1990.30
212_L248_V1.1980.30
99_A144_M1.1980.30
4_E297_Y1.1960.30
10_P14_G1.1920.30
322_K333_I1.1820.30
112_D335_Y1.1730.29
14_G20_L1.1600.29
185_I214_E1.1580.29
12_H67_S1.1460.28
327_I342_A1.1430.28
291_S338_N1.1420.28
63_M106_V1.1390.28
59_N63_M1.1370.28
132_L335_Y1.1340.28
52_L184_A1.1330.28
72_T142_H1.1310.28
58_N61_I1.1300.28
187_G344_E1.1300.28
89_F299_I1.1260.28
123_K182_H1.1170.27
359_E368_R1.1150.27
45_V177_F1.1140.27
155_I251_E1.1120.27
155_I303_I1.1070.27
102_V144_M1.1020.27
49_S221_S1.0990.27
279_T311_K1.0980.27
352_F366_A1.0980.27
58_N63_M1.0920.26
21_V106_V1.0890.26
63_M321_F1.0860.26
30_A366_A1.0810.26
41_P149_D1.0750.26
21_V63_M1.0730.26
16_V66_D1.0730.26
176_N281_E1.0720.26
73_V187_G1.0640.26
295_A308_P1.0640.26
16_V106_V1.0630.25
279_T282_E1.0610.25
83_N176_N1.0600.25
131_T290_P1.0570.25
186_S325_F1.0560.25
86_V352_F1.0520.25
7_A128_V1.0490.25
160_N170_H1.0450.25
56_G165_F1.0390.25
250_K259_P1.0390.25
61_I66_D1.0380.25
79_K346_I1.0360.25
128_V176_N1.0350.25
301_D322_K1.0340.25
204_T297_Y1.0250.24
147_T160_N1.0200.24
26_R178_V1.0100.24
36_I224_T1.0100.24
44_V121_I1.0100.24
114_D183_S1.0080.24
299_I335_Y1.0030.24
15_H61_I1.0030.24
36_I185_I0.9970.23
293_A323_Y0.9950.23
58_N327_I0.9920.23
196_V321_F0.9860.23
222_L225_Q0.9850.23
75_L308_P0.9820.23
53_W309_S0.9810.23
57_F219_I0.9790.23
109_L303_I0.9730.23
184_A194_V0.9690.22
261_D293_A0.9660.22
49_S357_K0.9660.22
77_I253_R0.9620.22
38_E49_S0.9610.22
192_V205_R0.9580.22
5_G205_R0.9530.22
34_I41_P0.9530.22
214_E357_K0.9520.22
124_I335_Y0.9500.22
9_L17_P0.9500.22
138_Q286_N0.9440.22
13_T192_V0.9420.22
265_I321_F0.9400.22
143_T353_I0.9390.22
143_T285_I0.9390.22
44_V95_K0.9370.21
108_M340_K0.9360.21
79_K105_E0.9330.21
8_D16_V0.9290.21
73_V291_S0.9270.21
59_N321_F0.9220.21
310_Y322_K0.9220.21
61_I321_F0.9180.21
250_K283_A0.9180.21
95_K141_H0.9130.21
95_K270_R0.9120.21
184_A354_T0.9110.21
103_P141_H0.9090.21
155_I286_N0.9070.21
82_T123_K0.9030.20
42_Q147_T0.8990.20
57_F174_T0.8980.20
42_Q86_V0.8930.20
185_I344_E0.8860.20
8_D307_P0.8840.20
266_K295_A0.8810.20
28_A74_T0.8760.20
153_S194_V0.8720.20
121_I125_V0.8690.20
106_V190_T0.8670.19
55_Q122_S0.8670.19
77_I333_I0.8660.19
133_V293_A0.8650.19
59_N70_S0.8630.19
207_L304_Y0.8630.19
31_I145_L0.8600.19
50_N311_K0.8590.19
291_S297_Y0.8570.19
55_Q142_H0.8570.19
201_K204_T0.8550.19
120_N151_K0.8540.19
342_A346_I0.8460.19
278_L282_E0.8450.19
209_L288_L0.8440.19
267_Q353_I0.8420.19
15_H270_R0.8400.19
356_A366_A0.8390.19
66_D327_I0.8370.19
171_W182_H0.8350.19
73_V95_K0.8330.19
42_Q205_R0.8320.18
16_V58_N0.8300.18
268_V272_M0.8280.18
105_E114_D0.8260.18
184_A353_I0.8230.18
210_D293_A0.8200.18
16_V59_N0.8180.18
214_E223_Y0.8170.18
73_V141_H0.8150.18
7_A16_V0.8150.18
39_L305_N0.8140.18
144_M259_P0.8130.18
193_V284_L0.8120.18
100_L299_I0.8110.18
60_I226_A0.8100.18
101_K163_I0.8100.18
63_M66_D0.8090.18
265_I310_Y0.8080.18
10_P331_D0.8070.18
359_E364_R0.8060.18
28_A207_L0.8060.18
99_A123_K0.8060.18
148_E302_L0.8050.18
196_V293_A0.8020.18
186_S306_E0.8010.18
277_P282_E0.8000.18
163_I324_A0.8000.18
99_A127_K0.8000.18
10_P329_G0.7980.18
42_Q127_K0.7920.17
110_I115_K0.7920.17
120_N323_Y0.7910.17
62_G67_S0.7910.17
265_I270_R0.7900.17
32_V180_E0.7880.17
64_D142_H0.7880.17
176_N189_K0.7870.17
133_V185_I0.7870.17
99_A103_P0.7850.17
73_V333_I0.7840.17
253_R291_S0.7840.17
121_I346_I0.7830.17
130_S297_Y0.7830.17
196_V323_Y0.7820.17
25_K63_M0.7820.17
208_I280_F0.7820.17
19_W122_S0.7780.17
133_V357_K0.7770.17
116_N197_I0.7750.17
12_H331_D0.7720.17
347_Y367_L0.7720.17
130_S194_V0.7720.17
39_L146_V0.7690.17
278_L353_I0.7680.17
199_R303_I0.7680.17
126_A154_I0.7670.17
175_D202_D0.7660.17
101_K357_K0.7610.17
353_I367_L0.7610.17
12_H329_G0.7580.17
247_F250_K0.7570.17
58_N74_T0.7560.17
114_D220_V0.7550.17
46_E81_I0.7540.16
201_K308_P0.7540.16
303_I353_I0.7540.16
273_Y276_N0.7530.16
101_K346_I0.7520.16
277_P369_K0.7520.16
4_E311_K0.7510.16
213_R368_R0.7480.16
95_K267_Q0.7480.16
49_S161_L0.7440.16
25_K304_Y0.7380.16
253_R333_I0.7370.16
252_A259_P0.7370.16
24_M72_T0.7350.16
173_E283_A0.7350.16
77_I274_E0.7340.16
56_G287_G0.7330.16
103_P272_M0.7290.16
99_A255_I0.7280.16
215_N353_I0.7210.16
35_M175_D0.7170.16
149_D276_N0.7160.16
44_V123_K0.7150.16
18_P22_P0.7130.16
174_T220_V0.7110.15
43_K369_K0.7090.15
195_N299_I0.7090.15
288_L304_Y0.7080.15
204_T268_V0.7040.15
107_D119_K0.6980.15
215_N268_V0.6970.15
49_S151_K0.6960.15
66_D253_R0.6940.15
72_T122_S0.6940.15
196_V280_F0.6920.15
92_L301_D0.6920.15
128_V337_V0.6910.15
42_Q123_K0.6900.15
81_I285_I0.6870.15
43_K280_F0.6860.15
280_F310_Y0.6840.15
133_V340_K0.6800.15
165_F288_L0.6790.15
29_K297_Y0.6780.15
20_L23_I0.6780.15
321_F325_F0.6770.15
103_P152_W0.6730.15
266_K335_Y0.6720.15
8_D63_M0.6710.15
306_E337_V0.6690.15
102_V122_S0.6670.14
267_Q294_R0.6670.14
188_I324_A0.6630.14
163_I278_L0.6620.14
48_F155_I0.6620.14
209_L260_V0.6560.14
99_A119_K0.6560.14
97_K344_E0.6530.14
144_M253_R0.6520.14
213_R275_S0.6510.14
86_V175_D0.6510.14
7_A170_H0.6500.14
30_A268_V0.6490.14
117_K203_R0.6490.14
141_H207_L0.6480.14
201_K338_N0.6480.14
10_P35_M0.6470.14
29_K349_L0.6470.14
112_D321_F0.6460.14
38_E142_H0.6450.14
80_D291_S0.6440.14
41_P148_E0.6430.14
34_I264_R0.6410.14
52_L154_I0.6380.14
76_G141_H0.6360.14
59_N327_I0.6350.14
147_T325_F0.6340.14
49_S52_L0.6340.14
9_L156_Q0.6330.14
137_H255_I0.6330.14
85_K175_D0.6320.14
3_V9_L0.6320.14
324_A337_V0.6310.14
225_Q340_K0.6300.14
223_Y303_I0.6290.14
130_S325_F0.6260.14
7_A209_L0.6250.14
45_V99_A0.6220.14
31_I146_V0.6220.14
55_Q298_L0.6210.13
122_S156_Q0.6200.13
28_A81_I0.6190.13
130_S184_A0.6190.13
64_D67_S0.6180.13
86_V197_I0.6170.13
151_K164_K0.6160.13
62_G370_L0.6150.13
77_I342_A0.6120.13
12_H16_V0.6120.13
47_R91_V0.6120.13
147_T154_I0.6110.13
29_K369_K0.6100.13
67_S331_D0.6080.13
337_V342_A0.6070.13
32_V202_D0.6070.13
85_K272_M0.6070.13
199_R204_T0.6050.13
50_N138_Q0.6010.13
59_N73_V0.6010.13
7_A91_V0.6000.13
199_R339_R0.5990.13
31_I261_D0.5960.13
26_R130_S0.5960.13
40_G47_R0.5900.13
219_I224_T0.5880.13
73_V259_P0.5860.13
16_V321_F0.5860.13
113_V323_Y0.5860.13
80_D214_E0.5860.13
64_D72_T0.5850.13
110_I205_R0.5830.13
332_G370_L0.5830.13
182_H335_Y0.5820.13
9_L16_V0.5800.13
190_T345_V0.5790.13
75_L295_A0.5780.13
78_L269_L0.5760.13
191_N310_Y0.5750.13
298_L335_Y0.5750.13
142_H298_L0.5730.13
9_L62_G0.5720.13
219_I355_R0.5720.13
57_F248_V0.5700.12
117_K339_R0.5690.12
151_K204_T0.5670.12
26_R213_R0.5660.12
56_G349_L0.5640.12
42_Q149_D0.5640.12
25_K77_I0.5620.12
220_V225_Q0.5620.12
85_K163_I0.5590.12
91_V288_L0.5570.12
288_L293_A0.5540.12
41_P44_V0.5530.12
183_S205_R0.5530.12
292_T301_D0.5520.12
213_R297_Y0.5520.12
102_V301_D0.5510.12
304_Y308_P0.5500.12
70_S77_I0.5480.12
54_F158_G0.5480.12
184_A371_K0.5470.12
366_A369_K0.5470.12
9_L14_G0.5470.12
61_I70_S0.5440.12
10_P62_G0.5440.12
41_P145_L0.5430.12
13_T56_G0.5430.12
133_V202_D0.5420.12
259_P342_A0.5410.12
24_M55_Q0.5400.12
143_T341_A0.5390.12
76_G252_A0.5380.12
297_Y308_P0.5380.12
101_K155_I0.5370.12
21_V70_S0.5350.12
302_L322_K0.5350.12
109_L355_R0.5340.12
29_K80_D0.5330.12
146_V187_G0.5330.12
64_D331_D0.5320.12
6_I56_G0.5310.12
250_K370_L0.5310.12
60_I263_N0.5310.12
35_M303_I0.5310.12
164_K188_I0.5300.12
44_V362_D0.5300.12
324_A369_K0.5290.12
73_V193_V0.5290.12
194_V308_P0.5290.12
123_K252_A0.5280.12
132_L272_M0.5260.12
74_T132_L0.5250.12
149_D299_I0.5240.12
165_F283_A0.5220.12
28_A91_V0.5220.12
132_L256_Y0.5200.12
125_V186_S0.5200.12
125_V263_N0.5190.12
97_K101_K0.5190.12
135_D196_V0.5190.12
104_D107_D0.5190.12
77_I321_F0.5180.11
311_K356_A0.5160.11
198_D260_V0.5160.11
47_R299_I0.5150.11
164_K213_R0.5120.11
341_A353_I0.5100.11
171_W177_F0.5060.11
266_K298_L0.5060.11
4_E209_L0.5050.11
89_F354_T0.5040.11
58_N322_K0.5020.11
7_A17_P0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h6eA 1 0.3061 37.6 0.981 Contact Map
3ll3A 2 0.3087 35 0.981 Contact Map
2bcqA 1 0.3588 32.6 0.981 Contact Map
2w40A 3 0.3377 32.6 0.981 Contact Map
3mtuE 2 0.0897 31.9 0.981 Contact Map
1pu6A 1 0.4749 27.2 0.982 Contact Map
3b0xA 1 0.4354 25.1 0.982 Contact Map
3fhgA 2 0.5356 24.6 0.982 Contact Map
2abkA 1 0.4274 23.8 0.983 Contact Map
3wxlA 2 0.3377 22.8 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0104 seconds.