GREMLIN Database
Q97VZ0 - Phosphate permease, putative
UniProt: Q97VZ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (310)
Sequences: 2593 (1389)
Seq/√Len: 78.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_K50_Y5.3381.00
69_T268_G4.4781.00
26_Y230_T3.4851.00
163_L252_S3.3421.00
54_L189_A3.1791.00
317_A321_V2.7991.00
137_K140_V2.7941.00
121_A138_F2.7811.00
126_I316_L2.6571.00
31_N103_L2.6431.00
142_V146_V2.6101.00
95_S314_L2.5601.00
88_G123_L2.5341.00
22_L219_L2.5291.00
22_L223_S2.4951.00
158_L162_T2.4491.00
103_L110_S2.3641.00
46_I185_L2.3371.00
104_N234_I2.2941.00
52_Y229_L2.2791.00
60_L222_I2.2791.00
143_S147_I2.2591.00
20_V90_F2.2501.00
55_N192_S2.2391.00
37_L41_F2.2161.00
78_V124_T2.1681.00
153_I286_F2.1301.00
31_N104_N2.0981.00
40_L188_S2.0921.00
194_I261_N2.0911.00
257_S277_I2.0891.00
104_N110_S2.0451.00
147_I151_V1.9801.00
53_I57_V1.9611.00
98_I102_Y1.9581.00
164_N288_S1.9451.00
72_H75_Y1.9421.00
234_I237_R1.9251.00
197_A265_T1.8861.00
102_Y106_S1.8731.00
100_F112_L1.8681.00
59_I228_V1.8541.00
183_L251_S1.8531.00
31_N100_F1.8051.00
39_I254_L1.7991.00
61_V193_F1.7921.00
45_A254_L1.7921.00
64_V214_Y1.7831.00
114_Q275_Q1.7541.00
95_S311_A1.7531.00
91_T318_I1.7281.00
58_S189_A1.7251.00
125_L130_F1.7101.00
32_N35_T1.6941.00
161_L165_K1.6751.00
190_F258_N1.6651.00
265_T268_G1.6631.00
28_I112_L1.6561.00
17_L210_S1.6021.00
36_S191_T1.5921.00
139_W142_V1.5711.00
180_Y251_S1.5701.00
165_K168_S1.5470.99
261_N276_T1.5280.99
264_F271_L1.5120.99
56_M225_A1.5080.99
31_N110_S1.5080.99
31_N234_I1.5080.99
313_I317_A1.5020.99
108_I303_S1.4950.99
238_V281_I1.4940.99
110_S234_I1.4830.99
226_L230_T1.4770.99
200_I224_A1.4770.99
187_S255_I1.4740.99
15_Y19_I1.4620.99
310_F314_L1.4610.99
62_G221_G1.4600.99
162_T165_K1.4490.99
59_I195_V1.4460.99
159_L252_S1.4360.99
206_S210_S1.4320.99
289_F294_R1.4270.99
312_I316_L1.4180.99
55_N228_V1.3900.99
93_L193_F1.3850.99
31_N112_L1.3820.99
311_A315_S1.3790.99
182_N186_F1.3640.99
25_S223_S1.3610.99
117_Y141_I1.3600.99
238_V278_I1.3580.99
44_N240_F1.3580.99
36_S250_A1.3510.98
146_V305_A1.3390.98
316_L320_G1.3360.98
246_G288_S1.3250.98
315_S318_I1.3220.98
93_L258_N1.3200.98
199_A274_T1.3020.98
99_T307_S1.2950.98
293_V296_Q1.2900.98
52_Y56_M1.2790.98
183_L186_F1.2750.98
242_I297_V1.2670.98
92_S119_S1.2660.98
19_I150_I1.2640.98
246_G249_G1.2580.98
127_S319_F1.2520.98
142_V310_F1.2510.98
39_I277_I1.2510.98
157_L287_R1.2430.97
30_A104_N1.2390.97
257_S280_G1.2330.97
298_I302_R1.2330.97
150_I154_G1.2160.97
125_L132_E1.1820.96
191_T245_L1.1790.96
60_L225_A1.1780.96
119_S123_L1.1690.96
157_L161_L1.1680.96
72_H76_G1.1570.96
237_R300_I1.1550.96
65_L193_F1.1530.96
23_I101_Y1.1530.96
204_V207_A1.1460.96
184_I247_Y1.1460.96
40_L54_L1.1350.96
27_V101_Y1.1330.96
70_M268_G1.1280.95
245_L253_A1.1250.95
46_I254_L1.1230.95
19_I23_I1.1190.95
61_V65_L1.1190.95
24_S96_S1.1040.95
198_N261_N1.1040.95
225_A228_V1.1030.95
100_F104_N1.0980.95
79_Y82_S1.0920.95
184_I250_A1.0900.94
118_P311_A1.0840.94
153_I279_G1.0700.94
173_I176_Q1.0610.94
54_L58_S1.0340.93
188_S192_S1.0290.93
204_V220_Y1.0260.92
193_F255_I1.0260.92
35_T273_I1.0250.92
69_T72_H1.0240.92
158_L317_A1.0150.92
311_A314_L1.0130.92
50_Y53_I1.0090.92
41_F235_A1.0050.92
74_V205_S1.0040.92
278_I282_V1.0020.92
248_L252_S1.0010.92
207_A220_Y0.9930.91
63_V221_G0.9910.91
90_F322_I0.9730.90
114_Q195_V0.9670.90
100_F103_L0.9670.90
20_V311_A0.9590.90
125_L128_H0.9510.89
163_L167_V0.9510.89
92_S120_I0.9490.89
104_N233_R0.9440.89
187_S254_L0.9410.89
277_I281_I0.9390.89
20_V193_F0.9360.89
100_F110_S0.9340.88
35_T307_S0.9300.88
95_S312_I0.9300.88
14_E210_S0.9300.88
27_V203_I0.9280.88
87_I322_I0.9240.88
242_I281_I0.9180.88
172_R225_A0.9170.87
102_Y314_L0.9140.87
57_V321_V0.9120.87
194_I276_T0.9100.87
134_D137_K0.9090.87
261_N265_T0.9090.87
121_A133_L0.9070.87
294_R297_V0.9060.87
41_F51_A0.9050.87
139_W143_S0.9050.87
48_R232_Q0.9020.87
43_T59_I0.8970.86
302_R306_T0.8930.86
171_T176_Q0.8900.86
249_G268_G0.8890.86
133_L138_F0.8860.86
66_G221_G0.8810.85
188_S191_T0.8810.85
33_N228_V0.8760.85
135_W139_W0.8730.85
160_Y248_L0.8710.85
98_I226_L0.8700.85
27_V100_F0.8690.85
57_V61_V0.8660.84
98_I318_I0.8640.84
115_T307_S0.8640.84
35_T59_I0.8630.84
179_I183_L0.8610.84
64_V218_P0.8610.84
35_T195_V0.8470.83
319_F322_I0.8440.83
175_K218_P0.8430.83
30_A112_L0.8410.83
236_I240_F0.8380.82
141_I198_N0.8310.82
123_L315_S0.8290.82
103_L112_L0.8270.81
18_F95_S0.8230.81
17_L90_F0.8230.81
141_I311_A0.8160.81
19_I212_P0.8160.81
244_K296_Q0.8150.81
203_I220_Y0.8140.80
301_F305_A0.8130.80
125_L158_L0.8110.80
30_A103_L0.8100.80
194_I265_T0.8080.80
13_I321_V0.8070.80
54_L62_G0.8030.80
144_S197_A0.8000.79
159_L255_I0.7990.79
133_L286_F0.7970.79
256_G260_I0.7960.79
254_L277_I0.7920.79
77_V80_G0.7900.78
55_N59_I0.7900.78
135_W218_P0.7880.78
96_S149_P0.7870.78
125_L312_I0.7860.78
60_L64_V0.7850.78
130_F218_P0.7840.78
274_T307_S0.7780.77
65_L224_A0.7770.77
195_V199_A0.7760.77
43_T113_S0.7710.77
107_G233_R0.7710.77
70_M73_S0.7700.77
236_I241_R0.7660.76
199_A273_I0.7660.76
158_L163_L0.7630.76
159_L282_V0.7630.76
194_I198_N0.7600.76
172_R175_K0.7590.76
184_I254_L0.7570.75
162_T166_V0.7510.75
104_N112_L0.7480.75
185_L261_N0.7460.74
315_S319_F0.7450.74
98_I314_L0.7450.74
158_L173_I0.7450.74
151_V260_I0.7450.74
92_S148_S0.7440.74
199_A202_I0.7430.74
44_N49_R0.7430.74
237_R297_V0.7410.74
208_L216_V0.7410.74
18_F22_L0.7390.74
115_T310_F0.7380.74
156_S280_G0.7370.73
235_A242_I0.7350.73
118_P122_I0.7340.73
98_I106_S0.7310.73
275_Q308_P0.7300.73
178_T182_N0.7290.73
218_P222_I0.7270.72
65_L69_T0.7250.72
19_I266_I0.7250.72
198_N265_T0.7170.71
100_F202_I0.7170.71
40_L185_L0.7150.71
207_A210_S0.7150.71
96_S280_G0.7150.71
66_G197_A0.7140.71
97_I219_L0.7130.71
103_L234_I0.7110.71
256_G279_G0.7110.71
68_L217_I0.7100.71
219_L226_L0.7040.70
145_W149_P0.6960.69
222_I226_L0.6880.68
191_T254_L0.6860.68
95_S119_S0.6860.68
76_G133_L0.6860.68
141_I144_S0.6840.68
273_I307_S0.6830.68
275_Q303_S0.6820.68
250_A254_L0.6780.67
67_S217_I0.6770.67
64_V217_I0.6760.67
34_A149_P0.6750.67
91_T322_I0.6730.67
136_V313_I0.6710.66
167_V171_T0.6710.66
23_I27_V0.6710.66
167_V180_Y0.6690.66
32_N274_T0.6690.66
24_S112_L0.6680.66
194_I262_E0.6680.66
250_A273_I0.6600.65
252_S255_I0.6570.65
14_E82_S0.6550.64
68_L204_V0.6470.64
191_T257_S0.6460.63
235_A254_L0.6440.63
243_T288_S0.6400.63
67_S208_L0.6370.62
248_L308_P0.6350.62
192_S279_G0.6350.62
156_S167_V0.6330.62
20_V310_F0.6330.62
144_S148_S0.6300.61
271_L276_T0.6280.61
173_I177_I0.6270.61
114_Q307_S0.6270.61
54_L221_G0.6270.61
78_V84_Y0.6250.61
254_L260_I0.6240.61
43_T250_A0.6210.60
174_I300_I0.6170.60
63_V200_I0.6170.60
318_I322_I0.6160.60
302_R313_I0.6160.60
51_A281_I0.6150.60
59_I114_Q0.6150.60
115_T203_I0.6130.59
31_N149_P0.6120.59
25_S97_I0.6110.59
155_F256_G0.6110.59
26_Y101_Y0.6100.59
87_I150_I0.6070.59
30_A100_F0.6050.58
45_A181_K0.6030.58
110_S115_T0.5990.58
14_E85_V0.5980.57
129_G137_K0.5970.57
275_Q319_F0.5960.57
253_A277_I0.5950.57
44_N181_K0.5940.57
194_I268_G0.5940.57
70_M201_G0.5910.57
124_T130_F0.5900.56
144_S162_T0.5890.56
12_I317_A0.5890.56
62_G191_T0.5890.56
66_G191_T0.5870.56
317_A320_G0.5860.56
104_N202_I0.5840.56
69_T141_I0.5830.56
77_V92_S0.5830.56
308_P311_A0.5820.55
108_I113_S0.5820.55
19_I53_I0.5810.55
184_I195_V0.5800.55
125_L222_I0.5790.55
14_E18_F0.5780.55
146_V255_I0.5780.55
68_L226_L0.5780.55
34_A113_S0.5770.55
54_L185_L0.5760.55
94_S222_I0.5750.55
94_S318_I0.5730.54
62_G145_W0.5730.54
187_S191_T0.5710.54
200_I220_Y0.5710.54
121_A126_I0.5700.54
31_N195_V0.5700.54
144_S274_T0.5700.54
21_G93_L0.5670.54
78_V141_I0.5660.53
126_I320_G0.5660.53
143_S313_I0.5640.53
120_I274_T0.5640.53
124_T128_H0.5640.53
37_L54_L0.5640.53
24_S48_R0.5620.53
21_G34_A0.5610.53
84_Y88_G0.5590.53
217_I221_G0.5580.52
40_L63_V0.5580.52
94_S97_I0.5570.52
187_S258_N0.5570.52
82_S147_I0.5560.52
27_V97_I0.5550.52
243_T285_S0.5540.52
190_F259_V0.5540.52
94_S98_I0.5540.52
130_F321_V0.5530.52
123_L246_G0.5530.52
32_N307_S0.5530.52
88_G189_A0.5520.52
12_I172_R0.5500.51
91_T199_A0.5500.51
23_I97_I0.5490.51
63_V197_A0.5490.51
151_V154_G0.5480.51
19_I106_S0.5480.51
292_D295_K0.5470.51
187_S251_S0.5470.51
154_G291_S0.5450.51
280_G293_V0.5440.51
58_S229_L0.5440.51
13_I322_I0.5420.50
152_A269_I0.5420.50
36_S195_V0.5410.50
63_V210_S0.5400.50
19_I171_T0.5390.50
15_Y18_F0.5380.50
96_S121_A0.5370.50
49_R53_I0.5340.49
99_T231_S0.5340.49
217_I300_I0.5340.49
21_G24_S0.5340.49
249_G288_S0.5330.49
40_L46_I0.5330.49
197_A210_S0.5320.49
177_I252_S0.5310.49
30_A101_Y0.5310.49
51_A285_S0.5300.49
171_T175_K0.5290.49
77_V83_L0.5290.49
77_V85_V0.5290.49
99_T195_V0.5280.49
313_I320_G0.5270.48
195_V231_S0.5270.48
202_I309_I0.5270.48
276_T280_G0.5250.48
76_G204_V0.5240.48
200_I206_S0.5230.48
145_W202_I0.5220.48
123_L189_A0.5210.48
253_A283_G0.5200.48
64_V222_I0.5200.48
201_G204_V0.5190.47
31_N37_L0.5190.47
107_G283_G0.5180.47
103_L118_P0.5180.47
131_I154_G0.5180.47
276_T282_V0.5150.47
104_N113_S0.5120.46
57_V226_L0.5120.46
39_I43_T0.5110.46
214_Y218_P0.5100.46
139_W171_T0.5100.46
155_F259_V0.5100.46
73_S76_G0.5080.46
79_Y136_V0.5080.46
84_Y280_G0.5070.46
19_I158_L0.5050.46
117_Y270_P0.5050.46
186_F259_V0.5050.46
131_I175_K0.5040.45
202_I206_S0.5040.45
263_I267_L0.5040.45
252_S256_G0.5030.45
13_I90_F0.5030.45
56_M192_S0.5030.45
54_L192_S0.5020.45
41_F284_L0.5010.45
151_V158_L0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.5 15.2 0.967 Contact Map
4n7wA 2 0.8415 4.7 0.974 Contact Map
3rlbA 1 0.4787 4.5 0.974 Contact Map
1jb0I 1 0.1159 3.4 0.976 Contact Map
4xk8I 1 0.0884 3.2 0.976 Contact Map
4l6vi 1 0.1159 3.1 0.976 Contact Map
4cz8A 2 0.6768 3 0.976 Contact Map
2b2hA 3 0.5091 2.7 0.977 Contact Map
4i7zE 1 0.0854 2.7 0.977 Contact Map
4tkrA 2 0.4756 2.5 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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