GREMLIN Database
HELS - ATP-dependent DNA helicase Hel308
UniProt: Q97VY9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 708 (597)
Sequences: 5002 (3465)
Seq/√Len: 141.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_L173_A4.8831.00
234_I239_L4.4261.00
44_L55_I3.9951.00
472_W476_H3.8501.00
142_F166_A3.4101.00
69_G140_N3.3451.00
235_I242_L3.0721.00
234_I237_Y2.9651.00
492_G498_L2.8791.00
233_A237_Y2.8741.00
309_A332_I2.8571.00
473_L477_S2.8451.00
60_I71_A2.7781.00
235_I238_T2.6841.00
286_L289_I2.6621.00
494_R497_D2.5611.00
473_L479_I2.4741.00
489_T492_G2.4711.00
447_Q452_A2.4621.00
250_V334_V2.4471.00
284_K287_D2.4251.00
237_Y242_L2.3801.00
451_F456_L2.3001.00
84_K87_T2.2871.00
233_A238_T2.2801.00
447_Q451_F2.2591.00
203_M391_I2.2511.00
451_F455_S2.2261.00
498_L501_N2.2161.00
465_Y469_A2.2101.00
287_D290_E2.2071.00
144_L163_T2.2041.00
471_R474_S2.1801.00
177_T378_Q2.1781.00
405_D408_F2.1441.00
492_G496_A2.1351.00
311_H340_T2.1221.00
503_F507_I2.1221.00
492_G504_T2.1201.00
237_Y241_S2.0591.00
441_G444_S2.0481.00
495_V498_L2.0351.00
488_L494_R2.0281.00
204_E376_Y2.0191.00
496_A502_P2.0161.00
285_Q288_D2.0151.00
491_F495_V2.0041.00
496_A499_Y1.9801.00
97_K116_D1.9791.00
444_S447_Q1.9631.00
301_K305_S1.9521.00
499_Y502_P1.9441.00
325_E329_K1.9331.00
148_H378_Q1.9321.00
504_T507_I1.9191.00
311_H324_E1.9071.00
209_P212_K1.9041.00
39_G170_N1.8791.00
284_K288_D1.8791.00
440_E444_S1.8731.00
490_N494_R1.8601.00
449_E456_L1.8171.00
126_D130_R1.8011.00
239_L242_L1.7821.00
489_T494_R1.7701.00
498_L502_P1.7601.00
77_L343_A1.7321.00
462_V479_I1.7301.00
576_K579_L1.7301.00
235_I239_L1.7291.00
187_W191_E1.7211.00
492_G499_Y1.7161.00
419_I422_K1.7151.00
252_R336_V1.7121.00
437_L479_I1.6991.00
53_T88_F1.6931.00
417_E421_S1.6871.00
508_I511_G1.6851.00
237_Y240_D1.6801.00
451_F454_E1.6741.00
494_R498_L1.6731.00
505_A509_R1.6711.00
486_F494_R1.6671.00
452_A455_S1.6581.00
577_V580_I1.6551.00
123_E340_T1.6491.00
235_I241_S1.6481.00
472_W478_F1.6321.00
418_P421_S1.6171.00
504_T510_K1.6131.00
570_L573_N1.5961.00
448_L451_F1.5881.00
344_G382_R1.5801.00
234_I242_L1.5781.00
261_T336_V1.5661.00
486_F489_T1.5661.00
29_T33_K1.5621.00
473_L478_F1.5611.00
462_V469_A1.5591.00
490_N493_K1.5501.00
452_A457_L1.5501.00
560_E563_Y1.5441.00
584_W587_E1.5361.00
205_G393_E1.5351.00
494_R501_N1.5341.00
146_E382_R1.5341.00
404_V408_F1.5331.00
352_V355_G1.5321.00
602_G605_R1.5311.00
350_R355_G1.5301.00
405_D409_K1.5301.00
33_K38_D1.5301.00
575_L578_A1.5151.00
587_E590_E1.5141.00
601_S605_R1.5061.00
265_I336_V1.5041.00
496_A500_I1.4991.00
506_D510_K1.4941.00
323_I332_I1.4931.00
449_E455_S1.4901.00
163_T188_L1.4831.00
378_Q382_R1.4821.00
584_W590_E1.4791.00
252_R258_A1.4781.00
523_Y526_L1.4701.00
180_N183_Q1.4701.00
449_E453_Y1.4691.00
449_E452_A1.4671.00
404_V407_V1.4621.00
78_R104_D1.4581.00
466_F478_F1.4421.00
419_I423_L1.4401.00
445_E467_D1.4391.00
85_Y89_K1.4381.00
183_Q187_W1.4311.00
255_R314_G1.4271.00
285_Q289_I1.4271.00
88_F117_I1.4261.00
175_S178_I1.4191.00
513_E516_K1.4181.00
462_V466_F1.4171.00
583_D597_Y1.4161.00
494_R499_Y1.4151.00
350_R389_D1.4101.00
488_L495_V1.4101.00
543_E546_L1.4081.00
103_G121_T1.4081.00
242_L246_G1.4001.00
452_A456_L1.3881.00
631_S634_L1.3881.00
75_T81_T1.3831.00
636_I639_L1.3821.00
600_G603_D1.3811.00
589_D592_T1.3811.00
79_A123_E1.3801.00
540_R543_E1.3741.00
659_G662_R1.3731.00
199_P202_L1.3691.00
466_F470_I1.3601.00
491_F496_A1.3541.00
429_F433_L1.3531.00
77_L123_E1.3471.00
238_T242_L1.3431.00
549_L553_L1.3431.00
416_V421_S1.3371.00
286_L290_E1.3361.00
418_P423_L1.3361.00
189_G192_P1.3351.00
601_S606_N1.3341.00
295_D304_I1.3341.00
46_S50_S1.3331.00
48_T381_G1.3321.00
97_K114_N1.3281.00
239_L243_S1.3191.00
380_S394_S1.3191.00
493_K497_D1.3151.00
324_E340_T1.3091.00
436_I439_A1.3061.00
294_S297_K1.3001.00
503_F506_D1.2971.00
492_G500_I1.2951.00
285_Q290_E1.2911.00
182_K186_K1.2891.00
471_R475_E1.2811.00
603_D606_N1.2811.00
74_V120_T1.2761.00
234_I238_T1.2751.00
85_Y100_M1.2721.00
489_T496_A1.2701.00
198_R202_L1.2691.00
504_T508_I1.2681.00
493_K498_L1.2651.00
349_A352_V1.2631.00
573_N577_V1.2571.00
461_V464_V1.2551.00
420_E423_L1.2541.00
414_S417_E1.2541.00
466_F472_W1.2481.00
459_K462_V1.2461.00
446_K450_A1.2441.00
433_L436_I1.2421.00
488_L493_K1.2411.00
491_F498_L1.2401.00
406_R409_K1.2381.00
490_N495_V1.2381.00
376_Y394_S1.2361.00
338_T384_G1.2331.00
453_Y457_L1.2321.00
592_T595_G1.2311.00
469_A473_L1.2281.00
455_S458_A1.2241.00
48_T80_L1.2221.00
539_G542_E1.2191.00
453_Y456_L1.2191.00
488_L497_D1.2191.00
491_F494_R1.2151.00
62_S66_K1.2121.00
418_P422_K1.2111.00
491_F509_R1.2081.00
460_S463_D1.2071.00
633_K636_I1.2041.00
320_R324_E1.2041.00
587_E592_T1.2031.00
480_R487_T1.2021.00
474_S477_S1.1991.00
450_A453_Y1.1971.00
447_Q456_L1.1971.00
88_F119_I1.1961.00
505_A511_G1.1941.00
559_V562_P1.1921.00
486_F496_A1.1891.00
449_E454_E1.1871.00
74_V125_L1.1861.00
492_G495_V1.1811.00
56_A174_L1.1811.00
433_L448_L1.1791.00
156_G160_E1.1771.00
495_V499_Y1.1731.00
44_L174_L1.1721.00
264_K268_Y1.1701.00
604_L607_I1.1691.00
602_G606_N1.1691.00
146_E344_G1.1691.00
522_A525_H1.1671.00
445_E452_A1.1641.00
208_Y212_K1.1641.00
144_L159_V1.1641.00
488_L491_F1.1560.99
492_G497_D1.1520.99
445_E456_L1.1500.99
447_Q454_E1.1480.99
48_T146_E1.1470.99
322_I326_S1.1470.99
433_L439_A1.1390.99
581_M611_M1.1370.99
543_E547_I1.1320.99
497_D502_P1.1270.99
574_A577_V1.1270.99
327_F335_I1.1240.99
470_I486_F1.1240.99
488_L492_G1.1230.99
599_I603_D1.1230.99
486_F491_F1.1150.99
23_K29_T1.1140.99
576_K580_I1.1130.99
417_E423_L1.1130.99
491_F497_D1.1100.99
496_A501_N1.1100.99
430_Y435_G1.1080.99
462_V465_Y1.1060.99
252_R261_T1.1060.99
495_V501_N1.1010.99
120_T125_L1.0970.99
382_R385_R1.0950.99
573_N576_K1.0940.99
465_Y468_R1.0880.99
445_E455_S1.0850.99
470_I474_S1.0840.99
284_K301_K1.0830.99
239_L246_G1.0820.99
542_E546_L1.0820.99
79_A341_L1.0800.99
259_E310_Y1.0770.99
601_S604_L1.0750.99
99_A115_Y1.0720.99
467_D476_H1.0720.99
487_T493_K1.0690.99
461_V465_Y1.0680.99
459_K466_F1.0640.99
560_E564_E1.0630.99
657_G661_K1.0610.99
600_G604_L1.0610.99
448_L455_S1.0590.99
495_V500_I1.0570.99
489_T500_I1.0570.99
590_E593_I1.0540.99
485_T488_L1.0530.99
384_G392_G1.0530.99
48_T348_P1.0490.99
587_E593_I1.0480.99
525_H528_A1.0460.99
566_D570_L1.0460.99
432_F435_G1.0460.99
488_L498_L1.0440.99
63_F66_K1.0430.99
48_T384_G1.0420.99
296_E299_L1.0410.99
493_K496_A1.0410.99
431_T434_L1.0380.99
430_Y436_I1.0370.99
575_L580_I1.0320.99
238_T241_S1.0320.99
72_I118_I1.0320.99
469_A472_W1.0310.99
43_L173_A1.0310.99
562_P566_D1.0290.99
492_G501_N1.0260.99
571_Y577_V1.0250.99
491_F500_I1.0230.99
526_L530_T1.0230.99
581_M585_I1.0210.99
26_P30_E1.0160.99
284_K290_E1.0150.99
79_A340_T1.0110.99
207_M210_E1.0060.99
155_R340_T1.0030.99
430_Y433_L1.0010.98
155_R311_H0.9980.98
583_D588_V0.9980.98
342_A379_M0.9970.98
488_L496_A0.9970.98
232_D235_I0.9970.98
35_G38_D0.9970.98
570_L578_A0.9960.98
583_D587_E0.9960.98
358_Y370_E0.9950.98
472_W475_E0.9950.98
251_F379_M0.9930.98
27_P46_S0.9910.98
627_L630_H0.9890.98
238_T246_G0.9880.98
545_E548_E0.9880.98
232_D237_Y0.9880.98
429_F437_L0.9870.98
558_L561_E0.9860.98
429_F432_F0.9820.98
525_H529_F0.9790.98
321_D325_E0.9780.98
574_A578_A0.9780.98
581_M584_W0.9760.98
358_Y368_Y0.9740.98
582_K585_I0.9730.98
572_L575_L0.9700.98
417_E420_E0.9660.98
491_F501_N0.9660.98
430_Y438_S0.9650.98
497_D501_N0.9610.98
123_E155_R0.9560.98
466_F469_A0.9560.98
505_A510_K0.9560.98
550_L554_E0.9550.98
36_L42_L0.9520.98
414_S421_S0.9520.98
539_G546_L0.9520.98
460_S466_F0.9500.98
414_S423_L0.9500.98
599_I602_G0.9490.98
344_G385_R0.9490.98
468_R472_W0.9480.98
432_F437_L0.9470.98
495_V502_P0.9470.98
504_T509_R0.9460.98
463_D467_D0.9450.98
233_A240_D0.9440.98
444_S449_E0.9440.98
570_L575_L0.9430.98
233_A241_S0.9420.98
207_M212_K0.9410.98
57_E379_M0.9400.98
506_D509_R0.9390.98
72_I139_A0.9380.98
309_A326_S0.9380.98
115_Y118_I0.9350.98
552_D556_E0.9340.98
563_Y566_D0.9330.98
467_D470_I0.9330.98
445_E449_E0.9320.98
460_S469_A0.9320.98
605_R609_E0.9280.98
445_E454_E0.9270.98
473_L492_G0.9270.98
538_V546_L0.9240.97
411_Y421_S0.9230.97
428_A432_F0.9210.97
71_A141_Y0.9170.97
360_F368_Y0.9170.97
265_I270_N0.9160.97
416_V419_I0.9150.97
340_T384_G0.9150.97
298_E302_S0.9120.97
454_E457_L0.9110.97
437_L440_E0.9110.97
414_S418_P0.9100.97
160_E187_W0.9090.97
448_L452_A0.9070.97
340_T346_N0.9050.97
123_E324_E0.9030.97
370_E402_E0.9030.97
411_Y417_E0.9020.97
77_L83_E0.9010.97
504_T512_L0.9010.97
489_T493_K0.9000.97
522_A530_T0.8980.97
432_F438_S0.8950.97
600_G605_R0.8940.97
507_I511_G0.8910.97
300_L303_L0.8900.97
32_V58_M0.8890.97
462_V467_D0.8880.97
381_G392_G0.8860.97
207_M232_D0.8830.97
553_L557_L0.8820.97
475_E479_I0.8820.97
517_A521_I0.8810.97
434_L437_L0.8800.97
485_T495_V0.8800.97
148_H314_G0.8780.97
502_P506_D0.8780.97
632_D635_R0.8760.97
519_C522_A0.8750.96
640_R646_K0.8750.96
148_H343_A0.8700.96
430_Y437_L0.8690.96
499_Y503_F0.8680.96
485_T494_R0.8680.96
302_S306_K0.8630.96
303_L310_Y0.8600.96
488_L501_N0.8570.96
431_T435_G0.8560.96
641_V652_L0.8560.96
84_K88_F0.8550.96
338_T382_R0.8550.96
286_L295_D0.8540.96
487_T501_N0.8540.96
300_L323_I0.8530.96
572_L576_K0.8530.96
160_E164_I0.8530.96
521_I525_H0.8520.96
299_L303_L0.8500.96
578_A586_D0.8500.96
152_D372_P0.8500.96
493_K499_Y0.8500.96
485_T492_G0.8470.96
502_P505_A0.8460.96
123_E311_H0.8450.96
489_T498_L0.8440.96
251_F342_A0.8420.96
432_F436_I0.8420.96
311_H384_G0.8410.96
463_D469_A0.8400.96
543_E550_L0.8400.96
588_V592_T0.8390.96
479_I489_T0.8370.95
262_A266_A0.8340.95
499_Y505_A0.8320.95
501_N505_A0.8320.95
523_Y528_A0.8320.95
270_N334_V0.8260.95
590_E594_L0.8250.95
467_D474_S0.8240.95
83_E346_N0.8230.95
658_V661_K0.8220.95
442_S448_L0.8220.95
467_D471_R0.8220.95
158_V161_S0.8210.95
447_Q455_S0.8200.95
146_E378_Q0.8180.95
123_E341_L0.8170.95
141_Y170_N0.8150.95
476_H479_I0.8150.95
415_D421_S0.8150.95
434_L438_S0.8140.95
25_N46_S0.8130.95
243_S246_G0.8090.95
453_Y458_A0.8080.95
449_E457_L0.8080.95
431_T437_L0.8040.94
352_V356_D0.8010.94
568_Y575_L0.8000.94
248_V353_I0.7980.94
506_D512_L0.7970.94
570_L580_I0.7970.94
316_S319_L0.7960.94
258_A262_A0.7940.94
345_V396_I0.7920.94
80_L344_G0.7910.94
295_D298_E0.7900.94
155_R324_E0.7840.94
255_R337_A0.7840.94
470_I476_H0.7820.94
294_S299_L0.7820.94
376_Y380_S0.7800.93
630_H633_K0.7800.93
233_A239_L0.7790.93
433_L437_L0.7790.93
572_L579_L0.7780.93
571_Y575_L0.7780.93
469_A479_I0.7780.93
569_S572_L0.7770.93
495_V505_A0.7770.93
547_I550_L0.7770.93
295_D299_L0.7760.93
250_V353_I0.7750.93
39_G62_S0.7740.93
537_S547_I0.7710.93
553_L558_L0.7700.93
82_N85_Y0.7700.93
521_I528_A0.7690.93
489_T495_V0.7670.93
448_L456_L0.7670.93
398_V402_E0.7650.93
247_Q351_T0.7640.93
472_W477_S0.7630.93
79_A155_R0.7610.93
123_E343_A0.7600.93
45_T173_A0.7600.93
180_N187_W0.7590.93
464_V468_R0.7580.92
489_T504_T0.7570.92
487_T494_R0.7570.92
445_E453_Y0.7530.92
188_L191_E0.7530.92
645_V649_L0.7530.92
462_V473_L0.7510.92
637_L641_V0.7490.92
143_V174_L0.7480.92
490_N496_A0.7480.92
236_A241_S0.7480.92
490_N501_N0.7470.92
36_L172_L0.7470.92
235_I240_D0.7460.92
470_I473_L0.7420.92
285_Q325_E0.7410.92
389_D392_G0.7390.91
561_E565_E0.7370.91
489_T499_Y0.7370.91
503_F511_G0.7360.91
492_G511_G0.7340.91
487_T490_N0.7320.91
508_I530_T0.7320.91
566_D571_Y0.7320.91
531_P534_P0.7310.91
57_E88_F0.7300.91
442_S447_Q0.7280.91
492_G505_A0.7270.91
497_D503_F0.7260.91
311_H341_L0.7250.91
361_N369_D0.7230.91
241_S246_G0.7230.91
522_A526_L0.7220.91
87_T90_D0.7220.91
32_V37_L0.7220.91
376_Y396_I0.7210.90
466_F476_H0.7200.90
653_V660_R0.7190.90
582_K590_E0.7170.90
533_G539_G0.7170.90
632_D636_I0.7170.90
232_D238_T0.7160.90
459_K463_D0.7160.90
583_D592_T0.7160.90
155_R160_E0.7150.90
539_G543_E0.7150.90
266_A306_K0.7140.90
462_V475_E0.7140.90
547_I551_E0.7130.90
564_E567_E0.7130.90
582_K588_V0.7120.90
166_A175_S0.7110.90
440_E443_L0.7110.90
64_L96_F0.7090.90
125_L166_A0.7080.90
416_V420_E0.7060.90
542_E545_E0.7050.89
417_E422_K0.7040.89
498_L503_F0.7030.89
636_I648_E0.7020.89
487_T495_V0.7010.89
77_L340_T0.7000.89
300_L310_Y0.7000.89
578_A582_K0.6990.89
469_A477_S0.6990.89
435_G438_S0.6980.89
150_L173_A0.6980.89
494_R505_A0.6960.89
240_D244_K0.6960.89
546_L550_L0.6950.89
635_R639_L0.6940.89
486_F501_N0.6940.89
124_K346_N0.6930.89
469_A474_S0.6930.89
460_S472_W0.6920.89
83_E392_G0.6920.89
445_E451_F0.6910.89
44_L172_L0.6910.89
503_F509_R0.6900.88
381_G384_G0.6900.88
184_I188_L0.6890.88
288_D294_S0.6890.88
544_E547_I0.6870.88
522_A529_F0.6870.88
465_Y470_I0.6860.88
494_R500_I0.6860.88
582_K586_D0.6860.88
290_E294_S0.6850.88
265_I334_V0.6840.88
233_A242_L0.6840.88
467_D472_W0.6840.88
257_M260_S0.6820.88
183_Q191_E0.6810.88
234_I241_S0.6800.88
574_A580_I0.6790.88
84_K392_G0.6790.88
415_D418_P0.6780.88
563_Y567_E0.6770.88
298_E301_K0.6770.88
176_A179_S0.6750.87
265_I268_Y0.6740.87
342_A348_P0.6740.87
48_T176_A0.6740.87
638_N641_V0.6720.87
599_I604_L0.6720.87
580_I593_I0.6700.87
284_K289_I0.6700.87
505_A512_L0.6700.87
491_F499_Y0.6690.87
469_A478_F0.6680.87
142_F163_T0.6680.87
560_E568_Y0.6660.87
610_T614_L0.6650.87
49_G378_Q0.6630.86
427_R431_T0.6620.86
78_R378_Q0.6600.86
303_L306_K0.6580.86
532_D539_G0.6580.86
542_E576_K0.6580.86
474_S479_I0.6560.86
566_D569_S0.6550.86
36_L55_I0.6550.86
183_Q188_L0.6540.86
581_M589_D0.6540.86
287_D294_S0.6520.85
247_Q253_N0.6520.85
565_E569_S0.6510.85
154_E369_D0.6480.85
326_S331_K0.6470.85
448_L458_A0.6470.85
621_L625_L0.6460.85
92_E96_F0.6460.85
24_L54_L0.6420.85
78_R103_G0.6420.85
573_N580_I0.6420.85
81_T119_I0.6400.84
61_I64_L0.6400.84
503_F512_L0.6380.84
451_F457_L0.6370.84
560_E566_D0.6370.84
57_E87_T0.6350.84
466_F474_S0.6320.84
497_D500_I0.6320.84
264_K267_N0.6300.84
561_E564_E0.6300.84
540_R547_I0.6280.83
445_E457_L0.6280.83
176_A381_G0.6270.83
72_I125_L0.6270.83
415_D420_E0.6260.83
527_L530_T0.6250.83
290_E296_E0.6250.83
497_D508_I0.6250.83
350_R356_D0.6250.83
249_L337_A0.6240.83
40_N191_E0.6240.83
236_A239_L0.6230.83
489_T501_N0.6220.83
46_S342_A0.6210.83
589_D595_G0.6210.83
486_F499_Y0.6200.83
203_M393_E0.6190.82
27_P44_L0.6180.82
485_T489_T0.6180.82
550_L553_L0.6180.82
428_A438_S0.6160.82
604_L608_V0.6150.82
539_G547_I0.6150.82
466_F473_L0.6140.82
549_L555_C0.6130.82
463_D466_F0.6120.82
485_T501_N0.6120.82
585_I590_E0.6100.82
123_E346_N0.6090.81
91_W117_I0.6080.81
84_K122_Y0.6080.81
644_G649_L0.6070.81
311_H346_N0.6070.81
462_V470_I0.6070.81
497_D511_G0.6070.81
20_G23_K0.6070.81
47_P384_G0.6070.81
430_Y434_L0.6060.81
340_T383_A0.6060.81
568_Y572_L0.6060.81
49_G177_T0.6060.81
314_G378_Q0.6050.81
604_L611_M0.6030.81
262_A272_V0.6020.81
70_K138_E0.6010.81
615_T641_V0.6010.81
593_I596_K0.6010.81
469_A488_L0.6000.80
470_I478_F0.6000.80
562_P565_E0.5980.80
651_E654_Q0.5980.80
114_N135_W0.5970.80
524_L528_A0.5970.80
71_A143_V0.5960.80
176_A378_Q0.5950.80
81_T100_M0.5940.80
614_L617_S0.5920.80
611_M615_T0.5920.80
92_E95_G0.5910.79
53_T251_F0.5900.79
547_I556_E0.5900.79
79_A378_Q0.5900.79
181_Y184_I0.5900.79
558_L562_P0.5890.79
514_G518_S0.5860.79
409_K417_E0.5860.79
628_D632_D0.5860.79
603_D607_I0.5850.79
485_T502_P0.5850.79
288_D296_E0.5840.79
537_S546_L0.5840.79
577_V581_M0.5840.79
76_P384_G0.5830.79
579_L597_Y0.5820.78
487_T491_F0.5800.78
324_E341_L0.5800.78
118_I122_Y0.5800.78
320_R341_L0.5790.78
80_L83_E0.5790.78
465_Y473_L0.5780.78
462_V477_S0.5780.78
494_R503_F0.5780.78
55_I59_G0.5770.78
655_I658_V0.5760.78
569_S576_K0.5760.78
324_E384_G0.5760.78
258_A312_H0.5750.78
548_E551_E0.5750.78
252_R356_D0.5740.77
494_R502_P0.5740.77
252_R255_R0.5730.77
608_V617_S0.5730.77
470_I479_I0.5730.77
184_I187_W0.5730.77
640_R647_E0.5730.77
554_E557_L0.5720.77
522_A528_A0.5700.77
415_D423_L0.5700.77
413_L417_E0.5700.77
551_E555_C0.5690.77
429_F434_L0.5690.77
348_P381_G0.5670.77
79_A346_N0.5660.76
483_N486_F0.5660.76
47_P173_A0.5660.76
47_P341_L0.5660.76
569_S590_E0.5650.76
540_R544_E0.5650.76
465_Y472_W0.5650.76
459_K477_S0.5630.76
560_E571_Y0.5630.76
412_I417_E0.5620.76
81_T102_S0.5620.76
470_I477_S0.5610.76
83_E344_G0.5610.76
83_E340_T0.5610.76
369_D375_E0.5600.76
486_F492_G0.5570.75
285_Q294_S0.5570.75
83_E343_A0.5570.75
96_F116_D0.5560.75
415_D419_I0.5560.75
574_A584_W0.5550.75
198_R201_P0.5550.75
79_A311_H0.5550.75
485_T491_F0.5550.75
613_W617_S0.5540.75
580_I597_Y0.5540.75
490_N500_I0.5530.75
47_P50_S0.5530.75
564_E571_Y0.5530.75
499_Y506_D0.5520.75
447_Q450_A0.5520.75
287_D295_D0.5520.75
289_I297_K0.5520.75
25_N386_P0.5510.75
476_H502_P0.5510.75
476_H492_G0.5490.74
290_E305_S0.5480.74
656_G660_R0.5480.74
233_A236_A0.5470.74
77_L374_M0.5460.74
424_G427_R0.5440.74
48_T52_K0.5440.74
649_L653_V0.5440.74
348_P384_G0.5430.74
650_L658_V0.5420.73
507_I510_K0.5410.73
175_S179_S0.5410.73
466_F479_I0.5400.73
501_N511_G0.5400.73
156_G198_R0.5390.73
474_S478_F0.5390.73
606_N614_L0.5380.73
443_L447_Q0.5370.73
78_R311_H0.5350.72
72_I142_F0.5350.72
545_E549_L0.5350.72
607_I611_M0.5340.72
160_E163_T0.5330.72
48_T392_G0.5330.72
76_P123_E0.5330.72
204_E377_K0.5330.72
294_S298_E0.5320.72
562_P569_S0.5320.72
77_L148_H0.5320.72
109_D114_N0.5300.72
544_E548_E0.5290.72
193_V197_W0.5280.71
286_L305_S0.5280.71
102_S317_K0.5280.71
433_L438_S0.5280.71
573_N579_L0.5280.71
484_N490_N0.5260.71
580_I588_V0.5260.71
343_A378_Q0.5250.71
263_L299_L0.5230.71
428_A433_L0.5230.71
459_K467_D0.5230.71
644_G654_Q0.5220.71
295_D301_K0.5220.71
286_L299_L0.5210.70
489_T497_D0.5210.70
339_P345_V0.5210.70
410_K415_D0.5200.70
508_I512_L0.5190.70
444_S485_T0.5190.70
490_N498_L0.5190.70
578_A597_Y0.5180.70
649_L652_L0.5170.70
123_E383_A0.5160.70
350_R353_I0.5150.70
490_N502_P0.5150.70
309_A323_I0.5140.69
311_H320_R0.5140.69
83_E311_H0.5140.69
521_I529_F0.5140.69
573_N581_M0.5130.69
634_L637_L0.5130.69
656_G659_G0.5110.69
464_V469_A0.5100.69
150_L184_I0.5100.69
584_W602_G0.5080.69
490_N497_D0.5080.69
578_A584_W0.5080.69
78_R102_S0.5080.69
492_G502_P0.5070.68
429_F439_A0.5070.68
148_H312_H0.5060.68
657_G662_R0.5050.68
340_T347_L0.5050.68
56_A143_V0.5040.68
607_I614_L0.5040.68
598_N601_S0.5040.68
83_E339_P0.5040.68
613_W616_Y0.5030.68
560_E573_N0.5030.68
484_N488_L0.5020.68
487_T492_G0.5020.68
373_V377_K0.5010.68
470_I475_E0.5010.68
351_T395_I0.5000.67
566_D579_L0.5000.67
328_R388_F0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2va8A 1 0.976 100 0.255 Contact Map
2zj8A 2 0.9633 100 0.285 Contact Map
2p6rA 1 0.9449 100 0.29 Contact Map
5agaA 4 0.9732 100 0.326 Contact Map
4f92B 1 0.9463 100 0.351 Contact Map
4bgdA 1 0.9449 100 0.371 Contact Map
4bujA 1 0.8785 100 0.435 Contact Map
4qu4A 1 0.8503 100 0.453 Contact Map
4u4cA 1 0.8884 100 0.454 Contact Map
4a4zA 1 0.863 100 0.466 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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