GREMLIN Database
Q97VY7 - Biotin carboxyl carrier protein of propionyl-CoA carboxylase beta subunit
UniProt: Q97VY7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (154)
Sequences: 2103 (1839)
Seq/√Len: 148.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_N162_G6.7341.00
134_K137_D5.8531.00
137_D143_Q4.1031.00
144_P156_V3.9061.00
135_E167_K3.3521.00
140_N143_Q3.2971.00
167_K184_V3.2551.00
130_K172_E2.8221.00
131_I168_I2.7361.00
171_K174_Q2.6881.00
133_V165_V2.6661.00
138_A164_I2.6011.00
166_Q184_V2.4291.00
122_S148_I2.4201.00
146_L182_L2.3941.00
176_V182_L2.3781.00
150_A155_T2.2731.00
141_K162_G2.2191.00
67_L74_K2.0141.00
145_L183_I1.9061.00
135_E168_I1.7651.00
169_L181_I1.7451.00
128_V182_L1.7011.00
177_K180_D1.6931.00
42_L53_E1.6131.00
46_K49_D1.5141.00
132_R144_P1.4911.00
90_Q93_L1.4721.00
46_K51_N1.4321.00
129_V149_E1.4111.00
174_Q180_D1.4011.00
166_Q185_I1.3881.00
55_K69_E1.3811.00
170_I180_D1.3781.00
123_P157_I1.3781.00
99_T102_P1.3501.00
128_V148_I1.3141.00
128_V131_I1.2961.00
133_V137_D1.2881.00
65_E76_Y1.2841.00
44_K53_E1.2611.00
68_F77_V1.2221.00
92_F95_L1.2211.00
67_L76_Y1.2061.00
52_Y71_N1.1901.00
161_I185_I1.1671.00
168_I183_I1.1661.00
155_T175_G1.1561.00
54_V70_I1.1491.00
88_N92_F1.1411.00
44_K51_N1.1350.99
69_E74_K1.1320.99
85_L96_D1.1290.99
144_P158_S1.1100.99
90_Q95_L1.0950.99
148_I179_G1.0780.99
33_V36_E1.0690.99
132_R146_L1.0640.99
118_G185_I1.0470.99
128_V146_L1.0320.99
163_G185_I1.0200.99
33_V45_I1.0200.99
33_V47_I1.0150.99
118_G155_T1.0150.99
32_L36_E1.0120.99
120_I129_V1.0110.99
34_S46_K0.9920.99
118_G161_I0.9770.98
126_G150_A0.9630.98
128_V165_V0.9600.98
127_R175_G0.9580.98
125_F178_K0.9490.98
126_G155_T0.9440.98
119_E181_I0.9420.98
101_I104_K0.9330.98
118_G175_G0.9280.98
149_E173_G0.8970.97
150_A176_V0.8890.97
170_I178_K0.8820.97
148_I170_I0.8780.97
132_R147_S0.8750.97
125_F175_G0.8680.97
35_Y45_I0.8570.97
150_A153_A0.8550.96
119_E184_V0.8500.96
90_Q97_K0.8470.96
131_I146_L0.8450.96
39_N42_L0.8180.95
42_L55_K0.8160.95
124_L155_T0.8140.95
124_L150_A0.8120.95
104_K107_E0.8070.95
44_K47_I0.8060.95
30_M36_E0.8020.95
157_I169_L0.7990.95
175_G178_K0.7980.95
36_E44_K0.7890.95
127_R155_T0.7880.94
135_E171_K0.7850.94
146_L176_V0.7820.94
130_K154_E0.7760.94
125_F179_G0.7700.94
41_S45_I0.7700.94
165_V183_I0.7680.94
31_Y34_S0.7680.94
128_V170_I0.7670.94
128_V183_I0.7640.94
97_K105_G0.7570.93
132_R135_E0.7550.93
120_I183_I0.7520.93
146_L183_I0.7520.93
85_L88_N0.7430.93
120_I170_I0.7380.92
146_L157_I0.7340.92
40_N44_K0.7270.92
148_I178_K0.7250.92
116_K119_E0.7220.91
129_V147_S0.7210.91
33_V39_N0.7180.91
105_G108_R0.7170.91
43_D46_K0.7160.91
84_T93_L0.7140.91
125_F177_K0.7110.91
144_P147_S0.7080.91
31_Y35_Y0.7050.90
36_E46_K0.7030.90
113_I116_K0.6980.90
157_I170_I0.6960.90
175_G179_G0.6960.90
145_L157_I0.6880.89
109_V165_V0.6870.89
50_K65_E0.6850.89
49_D52_Y0.6840.89
71_N74_K0.6840.89
176_V179_G0.6830.89
38_S53_E0.6820.89
55_K67_L0.6800.89
120_I149_E0.6760.89
169_L184_V0.6750.88
109_V116_K0.6670.88
170_I175_G0.6640.88
87_F94_R0.6610.87
125_F128_V0.6590.87
87_F92_F0.6570.87
146_L168_I0.6540.87
40_N51_N0.6520.87
30_M34_S0.6490.86
51_N81_S0.6490.86
61_N64_N0.6490.86
91_D95_L0.6450.86
174_Q177_K0.6420.86
58_G62_R0.6400.86
41_S53_E0.6330.85
89_H178_K0.6320.85
33_V41_S0.6310.85
122_S125_F0.6260.84
32_L37_Q0.6260.84
38_S42_L0.6230.84
168_I185_I0.6230.84
127_R178_K0.6220.84
155_T170_I0.6200.84
68_F75_Y0.6160.84
65_E81_S0.6150.83
117_E160_P0.6140.83
124_L177_K0.6120.83
111_E179_G0.6110.83
170_I181_I0.6060.83
32_L48_G0.6050.82
165_V172_E0.6050.82
148_I155_T0.6030.82
133_V168_I0.6030.82
68_F147_S0.6000.82
139_V163_G0.5990.82
138_A162_G0.5960.81
90_Q99_T0.5950.81
31_Y36_E0.5910.81
156_V178_K0.5900.81
58_G61_N0.5900.81
73_K110_E0.5860.80
53_E65_E0.5860.80
75_Y78_F0.5850.80
35_Y38_S0.5850.80
97_K108_R0.5840.80
69_E78_F0.5810.80
86_I96_D0.5790.80
169_L180_D0.5790.80
65_E78_F0.5780.80
149_E178_K0.5760.79
33_V40_N0.5760.79
69_E72_G0.5750.79
121_V150_A0.5740.79
32_L35_Y0.5730.79
95_L99_T0.5730.79
37_Q40_N0.5720.79
135_E166_Q0.5670.78
99_T104_K0.5650.78
92_F99_T0.5620.78
57_L141_K0.5560.77
35_Y49_D0.5530.76
75_Y79_I0.5520.76
89_H93_L0.5500.76
34_S38_S0.5440.75
95_L98_V0.5430.75
35_Y39_N0.5420.75
51_N114_R0.5400.75
86_I90_Q0.5380.75
40_N53_E0.5380.75
46_K55_K0.5370.74
88_N104_K0.5360.74
150_A178_K0.5300.73
127_R177_K0.5290.73
84_T97_K0.5260.73
30_M33_V0.5260.73
58_G66_Y0.5250.73
90_Q94_R0.5200.72
118_G182_L0.5170.72
40_N72_G0.5150.71
127_R174_Q0.5140.71
177_K185_I0.5140.71
66_Y77_V0.5130.71
135_E138_A0.5130.71
123_P180_D0.5120.71
127_R157_I0.5110.71
130_K179_G0.5110.71
94_R99_T0.5090.70
91_D97_K0.5080.70
132_R168_I0.5080.70
125_F153_A0.5070.70
89_H94_R0.5030.70
122_S147_S0.5010.69
43_D56_Y0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6rA 1 0.9731 100 0.371 Contact Map
3u9tA 3 0.4839 100 0.399 Contact Map
4qshA 4 0.8817 99.9 0.491 Contact Map
3bg3A 4 0.8763 99.9 0.492 Contact Map
2qf7A 4 0.871 99.9 0.497 Contact Map
3va7A 1 0.9462 99.9 0.511 Contact Map
3hblA 4 0.9032 99.9 0.519 Contact Map
4rcnA 6 0.9677 99.9 0.555 Contact Map
4hr7B 1 0.3925 99.7 0.611 Contact Map
2kccA 1 0.3925 99.7 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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