GREMLIN Database
Q97VY6 - Biotin carboxylase a subunit of propionyl-CoA carboxylase (AccC)
UniProt: Q97VY6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 510 (418)
Sequences: 13399 (7104)
Seq/√Len: 347.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_G176_P3.7401.00
70_D74_K3.6521.00
6_K29_K3.0891.00
142_N145_E3.0731.00
95_E113_N3.0631.00
147_L180_A3.0081.00
175_N178_E2.9521.00
255_K259_E2.8241.00
95_E99_K2.8171.00
259_E263_R2.8171.00
73_E100_A2.7361.00
64_N67_R2.6521.00
398_S401_Y2.6191.00
90_N116_K2.6101.00
36_D52_W2.5931.00
174_D206_I2.5551.00
244_A306_I2.5181.00
281_S286_E2.5081.00
9_V20_M2.4951.00
174_D178_E2.4631.00
125_A264_F2.3661.00
5_N78_D2.3411.00
219_K271_F2.2741.00
357_Y381_V2.2721.00
7_V105_I2.2551.00
256_E260_A2.2001.00
96_A100_A2.1911.00
317_R322_E2.1901.00
340_F406_G2.1661.00
155_Y176_P2.1521.00
251_E255_K2.1111.00
191_Y197_A2.0811.00
314_L325_P2.0791.00
353_P356_G2.0631.00
149_I152_E2.0591.00
397_Q401_Y2.0261.00
65_I96_A2.0201.00
308_G332_K1.9911.00
396_G401_Y1.9901.00
66_E96_A1.9881.00
187_K197_A1.9681.00
260_A287_F1.9481.00
36_D39_K1.9231.00
265_G268_I1.9221.00
120_E123_M1.9221.00
127_K267_E1.9051.00
260_A263_R1.8971.00
22_A25_E1.8771.00
265_G269_N1.8651.00
372_D375_I1.8651.00
407_L430_Q1.8321.00
80_V102_M1.8131.00
4_F78_D1.8121.00
123_M127_K1.7871.00
346_D419_K1.7621.00
69_I100_A1.7611.00
72_A102_M1.7531.00
51_Y71_A1.7451.00
172_K204_A1.7411.00
250_K253_E1.7401.00
72_A80_V1.7031.00
264_F269_N1.6941.00
80_V97_V1.6871.00
17_I46_Y1.6751.00
217_G223_Y1.6691.00
264_F268_I1.6681.00
108_S111_V1.6561.00
216_I314_L1.6191.00
34_Y39_K1.6181.00
143_V183_F1.6131.00
313_K317_R1.6131.00
71_A75_A1.6011.00
96_A99_K1.6001.00
97_V102_M1.5961.00
6_K31_V1.5901.00
25_E313_K1.5831.00
4_F320_A1.5801.00
343_N418_V1.5761.00
296_V311_L1.5601.00
176_P180_A1.5531.00
368_G371_V1.5531.00
134_P203_K1.5531.00
206_I282_P1.5531.00
162_A198_E1.5471.00
205_A290_L1.5331.00
23_V30_A1.5301.00
253_E280_F1.5281.00
305_F393_I1.5201.00
213_T257_I1.5141.00
358_I375_I1.5131.00
305_F395_Y1.5061.00
4_F103_V1.5011.00
180_A184_E1.4851.00
343_N387_P1.4841.00
108_S271_F1.4831.00
256_E286_E1.4831.00
103_V320_A1.4751.00
216_I318_L1.4561.00
69_I73_E1.4551.00
203_K288_Y1.4521.00
263_R266_K1.4431.00
98_E271_F1.4331.00
143_V184_E1.4291.00
148_K152_E1.4161.00
253_E256_E1.4151.00
308_G334_R1.4141.00
357_Y380_W1.4111.00
114_R124_I1.3991.00
115_I292_I1.3911.00
51_Y75_A1.3821.00
6_K49_E1.3711.00
411_N426_K1.3591.00
97_V104_F1.3521.00
95_E110_S1.3471.00
424_L428_I1.3361.00
31_V35_S1.3351.00
32_A43_H1.3351.00
262_I266_K1.3341.00
121_G125_A1.3301.00
123_M126_R1.3251.00
413_Y422_I1.3251.00
216_I273_L1.3251.00
148_K151_G1.3231.00
45_K376_E1.3221.00
149_I153_I1.3201.00
98_E109_A1.3121.00
151_G180_A1.2881.00
140_I149_I1.2851.00
119_L123_M1.2831.00
183_F199_I1.2741.00
22_A313_K1.2551.00
136_P152_E1.2501.00
224_V326_F1.2471.00
67_R70_D1.2441.00
98_E108_S1.2421.00
29_K49_E1.2411.00
7_V23_V1.2381.00
215_L265_G1.2361.00
95_E109_A1.2311.00
35_S39_K1.2311.00
147_L176_P1.2241.00
171_I186_S1.2221.00
54_G61_S1.2161.00
207_K282_P1.2091.00
105_I316_I1.2081.00
47_A50_A1.2061.00
113_N120_E1.2061.00
177_S181_E1.2031.00
147_L151_G1.2011.00
20_M46_Y1.1981.00
94_V104_F1.1951.00
213_T258_I1.1951.00
68_I97_V1.1931.00
136_P149_I1.1881.00
23_V81_H1.1881.00
163_G196_R1.1871.00
282_P285_R1.1861.00
31_V34_Y1.1781.00
30_A35_S1.1721.00
32_A35_S1.1711.00
150_A183_F1.1711.00
86_F91_A1.1691.00
181_E185_R1.1681.00
32_A36_D1.1661.00
406_G429_L1.1631.00
139_P198_E1.1631.00
266_K269_N1.1631.00
7_V316_I1.1621.00
69_I96_A1.1611.00
394_V406_G1.1601.00
126_R136_P1.1531.00
400_D404_Q1.1451.00
257_I260_A1.1421.00
143_V187_K1.1401.00
21_K25_E1.1381.00
110_S114_R1.1321.00
48_D51_Y1.1311.00
264_F267_E1.1271.00
124_I128_A1.1231.00
134_P153_I1.1191.00
34_Y37_A1.1181.00
407_L426_K1.1181.00
392_L413_Y1.1161.00
10_A93_F1.1151.00
124_I127_K1.1151.00
4_F79_A1.1151.00
349_N352_T1.1141.00
19_V81_H1.1131.00
143_V180_A1.1131.00
146_A179_L1.1101.00
309_I314_L1.1091.00
159_L199_I1.1061.00
31_V36_D1.1051.00
363_E413_Y1.1021.00
403_I407_L1.0951.00
220_Y269_N1.0921.00
408_R412_D1.0811.00
369_V394_V1.0761.00
230_E246_S1.0761.00
141_E145_E1.0731.00
7_V28_M1.0711.00
225_V258_I1.0661.00
49_E75_A1.0631.00
144_D148_K1.0571.00
340_F391_K1.0551.00
147_L184_E1.0531.00
396_G405_V1.0531.00
143_V147_L1.0521.00
250_K285_R1.0491.00
124_I267_E1.0491.00
140_I146_A1.0481.00
403_I429_L1.0431.00
171_I189_L1.0411.00
145_E148_K1.0331.00
28_M31_V1.0291.00
30_A34_Y1.0241.00
338_I402_A1.0201.00
255_K258_I1.0141.00
9_V23_V1.0131.00
122_K132_T1.0111.00
32_A47_A1.0101.00
248_S280_F1.0091.00
72_A97_V1.0091.00
328_Q331_L1.0031.00
228_E254_R1.0031.00
32_A39_K1.0001.00
65_I69_I0.9971.00
376_E379_S0.9951.00
407_L411_N0.9901.00
336_H339_Q0.9901.00
126_R134_P0.9861.00
155_Y175_N0.9831.00
327_S330_D0.9761.00
65_I93_F0.9761.00
181_E184_E0.9751.00
426_K430_Q0.9721.00
371_V390_S0.9691.00
20_M47_A0.9691.00
50_A53_I0.9671.00
241_I340_F0.9661.00
33_V53_I0.9651.00
110_S113_N0.9631.00
36_D40_Y0.9621.00
227_F306_I0.9571.00
258_I263_R0.9571.00
249_I253_E0.9561.00
215_L276_M0.9541.00
111_V271_F0.9541.00
145_E149_I0.9541.00
345_E356_G0.9511.00
222_N226_A0.9471.00
392_L409_A0.9471.00
227_F333_I0.9461.00
119_L139_P0.9461.00
70_D73_E0.9431.00
31_V39_K0.9431.00
410_L418_V0.9401.00
6_K78_D0.9361.00
411_N422_I0.9341.00
81_H315_Q0.9341.00
103_V219_K0.9331.00
252_E255_K0.9331.00
252_E256_E0.9321.00
49_E53_I0.9291.00
251_E254_R0.9281.00
126_R132_T0.9271.00
128_A267_E0.9211.00
220_Y323_Y0.9181.00
157_I201_I0.9141.00
146_A183_F0.9121.00
153_I157_I0.9111.00
203_K286_E0.9061.00
159_L183_F0.9051.00
114_R120_E0.9041.00
146_A201_I0.9021.00
334_R395_Y0.9021.00
32_A37_A0.9021.00
342_I422_I0.8981.00
26_M310_D0.8841.00
316_I320_A0.8821.00
227_F331_L0.8781.00
140_I145_E0.8771.00
34_Y50_A0.8771.00
348_L427_L0.8741.00
258_I262_I0.8691.00
343_N410_L0.8691.00
30_A36_D0.8681.00
377_L381_V0.8671.00
24_K48_D0.8671.00
26_M313_K0.8651.00
410_L420_T0.8631.00
54_G63_L0.8621.00
48_D52_W0.8611.00
405_V408_R0.8611.00
378_G381_V0.8571.00
222_N225_V0.8571.00
71_A77_A0.8561.00
185_R189_L0.8521.00
360_Y377_L0.8511.00
144_D147_L0.8491.00
150_A157_I0.8401.00
346_D417_G0.8401.00
276_M292_I0.8401.00
401_Y405_V0.8381.00
37_A40_Y0.8371.00
23_V312_V0.8361.00
244_A302_V0.8351.00
226_A307_T0.8331.00
377_L380_W0.8311.00
216_I226_A0.8311.00
233_I428_I0.8291.00
315_Q319_A0.8231.00
257_I263_R0.8231.00
117_D162_A0.8201.00
338_I403_I0.8201.00
335_G338_I0.8201.00
190_A197_A0.8181.00
93_F97_V0.8181.00
211_I246_S0.8181.00
92_S113_N0.8171.00
242_E302_V0.8161.00
53_I71_A0.8131.00
150_A154_G0.8131.00
7_V312_V0.8121.00
69_I102_M0.8111.00
222_N266_K0.8071.00
49_E52_W0.8031.00
270_Y294_K0.8021.00
301_T339_Q0.8021.00
218_D324_L0.8011.00
171_I182_A0.8011.00
157_I203_K0.7961.00
256_E259_E0.7951.00
408_R411_N0.7941.00
119_L200_Y0.7921.00
360_Y416_G0.7911.00
173_V182_A0.7891.00
33_V68_I0.7881.00
243_E399_R0.7821.00
151_G155_Y0.7801.00
94_V98_E0.7771.00
322_E326_F0.7751.00
6_K76_H0.7751.00
229_R243_E0.7751.00
407_L429_L0.7741.00
70_D100_A0.7741.00
17_I43_H0.7741.00
150_A201_I0.7741.00
136_P145_E0.7741.00
141_E198_E0.7731.00
241_I429_L0.7721.00
359_T416_G0.7711.00
224_V227_F0.7711.00
374_G379_S0.7701.00
159_L179_L0.7641.00
240_L421_T0.7641.00
256_E287_F0.7621.00
359_T414_K0.7621.00
223_Y262_I0.7611.00
306_I333_I0.7601.00
346_D353_P0.7581.00
376_E383_P0.7561.00
27_G313_K0.7551.00
375_I379_S0.7541.00
31_V37_A0.7531.00
225_V328_Q0.7511.00
92_S95_E0.7501.00
282_P286_E0.7481.00
6_K75_A0.7471.00
302_V305_F0.7471.00
314_L317_R0.7471.00
369_V409_A0.7451.00
364_P409_A0.7441.00
44_V50_A0.7441.00
185_R188_R0.7431.00
285_R288_Y0.7431.00
65_I91_A0.7421.00
153_I203_K0.7421.00
404_Q408_R0.7401.00
223_Y227_F0.7371.00
217_G265_G0.7371.00
125_A289_F0.7371.00
362_K377_L0.7361.00
360_Y414_K0.7350.99
336_H397_Q0.7350.99
119_L162_A0.7350.99
48_D53_I0.7330.99
225_V262_I0.7270.99
257_I261_S0.7270.99
317_R320_A0.7260.99
143_V179_L0.7240.99
98_E104_F0.7230.99
159_L173_V0.7210.99
23_V316_I0.7180.99
206_I281_S0.7170.99
346_D349_N0.7170.99
307_T331_L0.7160.99
22_A26_M0.7160.99
403_I426_K0.7110.99
184_E188_R0.7070.99
33_V39_K0.7060.99
51_Y54_G0.7020.99
136_P140_I0.7020.99
314_L326_F0.7010.99
47_A52_W0.6960.99
154_G176_P0.6950.99
364_P368_G0.6930.99
122_K202_E0.6920.99
356_G416_G0.6920.99
24_K30_A0.6910.99
159_L201_I0.6900.99
411_N420_T0.6900.99
30_A37_A0.6890.99
362_K414_K0.6820.99
108_S269_N0.6820.99
47_A51_Y0.6820.99
159_L182_A0.6790.99
121_G289_F0.6770.99
177_S180_A0.6760.99
326_F330_D0.6760.99
368_G405_V0.6730.99
34_Y38_D0.6720.99
409_A412_D0.6690.99
133_S205_A0.6690.99
241_I428_I0.6680.99
114_R294_K0.6680.99
361_Y413_Y0.6680.99
42_P376_E0.6660.99
103_V271_F0.6620.99
140_I143_V0.6620.99
155_Y179_L0.6600.99
157_I173_V0.6600.99
334_R397_Q0.6590.99
192_S195_G0.6580.99
307_T333_I0.6580.99
31_V77_A0.6570.99
123_M135_G0.6550.99
240_L343_N0.6540.99
313_K401_Y0.6540.99
188_R192_S0.6530.99
103_V316_I0.6520.99
26_M316_I0.6520.99
53_I61_S0.6510.99
4_F7_V0.6500.99
91_A113_N0.6500.99
361_Y382_P0.6490.99
223_Y226_A0.6480.99
410_L422_I0.6480.99
371_V413_Y0.6480.99
354_Q419_K0.6480.99
217_G271_F0.6470.99
170_I237_N0.6460.99
421_T425_Y0.6450.99
182_A186_S0.6410.99
183_F187_K0.6390.99
108_S219_K0.6390.99
35_S38_D0.6380.99
66_E70_D0.6380.99
150_A179_L0.6380.99
82_P94_V0.6340.99
209_K248_S0.6340.99
422_I426_K0.6330.99
367_P405_V0.6330.99
158_M172_K0.6300.98
21_K371_V0.6280.98
5_N29_K0.6270.98
122_K200_Y0.6250.98
326_F331_L0.6240.98
93_F104_F0.6240.98
115_I268_I0.6220.98
15_I296_V0.6220.98
144_D180_A0.6220.98
85_G166_A0.6210.98
158_M170_I0.6190.98
214_Q273_L0.6170.98
316_I319_A0.6170.98
415_I420_T0.6170.98
339_Q403_I0.6160.98
221_G225_V0.6150.98
26_M317_R0.6130.98
224_V331_L0.6130.98
178_E181_E0.6110.98
35_S40_Y0.6100.98
168_V189_L0.6090.98
63_L91_A0.6090.98
330_D333_I0.6080.98
33_V36_D0.6080.98
384_Y415_I0.6050.98
80_V104_F0.6040.98
261_S265_G0.6040.98
30_A39_K0.6040.98
119_L198_E0.6030.98
194_F197_A0.6010.98
9_V81_H0.5990.98
335_G395_Y0.5980.98
82_P104_F0.5970.98
150_A153_I0.5960.98
376_E385_Y0.5940.98
400_D403_I0.5940.98
218_D222_N0.5940.98
131_P260_A0.5930.98
125_A130_V0.5900.98
171_I185_R0.5890.98
394_V409_A0.5870.98
28_M320_A0.5850.98
50_A54_G0.5840.97
41_A374_G0.5830.97
249_I254_R0.5830.97
155_Y172_K0.5800.97
354_Q385_Y0.5800.97
329_E333_I0.5800.97
14_E391_K0.5800.97
122_K133_S0.5800.97
311_L315_Q0.5800.97
53_I62_Y0.5780.97
68_I80_V0.5780.97
140_I183_F0.5770.97
211_I280_F0.5760.97
94_V109_A0.5760.97
30_A33_V0.5750.97
281_S285_R0.5710.97
64_N70_D0.5700.97
353_P417_G0.5700.97
149_I201_I0.5700.97
69_I80_V0.5690.97
158_M204_A0.5680.97
338_I429_L0.5680.97
117_D120_E0.5680.97
209_K246_S0.5670.97
35_S61_S0.5660.97
254_R258_I0.5660.97
403_I425_Y0.5650.97
120_E124_I0.5650.97
179_L183_F0.5630.97
411_N430_Q0.5620.97
150_A155_Y0.5600.97
301_T391_K0.5600.97
363_E373_S0.5590.97
8_L33_V0.5580.97
6_K77_A0.5570.97
336_H340_F0.5570.97
54_G62_Y0.5570.97
109_A113_N0.5570.97
112_M294_K0.5560.97
351_F424_L0.5550.97
361_Y365_T0.5540.97
20_M30_A0.5540.97
30_A49_E0.5540.97
214_Q228_E0.5540.97
211_I249_I0.5530.97
339_Q425_Y0.5530.97
390_S413_Y0.5520.96
97_V100_A0.5510.96
223_Y266_K0.5510.96
33_V40_Y0.5510.96
361_Y364_P0.5510.96
172_K206_I0.5500.96
264_F292_I0.5500.96
222_N325_P0.5500.96
280_F287_F0.5500.96
36_D41_A0.5490.96
401_Y404_Q0.5490.96
140_I201_I0.5480.96
415_I418_V0.5480.96
257_I287_F0.5460.96
221_G266_K0.5450.96
39_K42_P0.5430.96
346_D356_G0.5410.96
17_I42_P0.5400.96
352_T355_S0.5380.96
423_P426_K0.5380.96
273_L296_V0.5370.96
271_F318_L0.5370.96
305_F372_D0.5360.96
205_A208_P0.5360.96
94_V108_S0.5350.96
37_A41_A0.5350.96
32_A71_A0.5350.96
117_D198_E0.5340.96
33_V37_A0.5320.96
367_P371_V0.5310.96
156_P204_A0.5310.96
136_P139_P0.5300.96
6_K30_A0.5300.96
114_R127_K0.5290.96
78_D103_V0.5290.96
379_S382_P0.5280.95
34_Y44_V0.5280.95
42_P46_Y0.5260.95
67_R71_A0.5250.95
133_S290_L0.5240.95
28_M35_S0.5240.95
361_Y373_S0.5220.95
92_S96_A0.5210.95
289_F292_I0.5210.95
30_A38_D0.5200.95
205_A288_Y0.5200.95
246_S249_I0.5200.95
105_I319_A0.5180.95
134_P288_Y0.5140.95
103_V319_A0.5140.95
355_S383_P0.5140.95
240_L425_Y0.5140.95
279_V290_L0.5140.95
213_T261_S0.5130.95
213_T254_R0.5130.95
256_E263_R0.5120.95
226_A309_I0.5120.95
225_V255_K0.5110.95
339_Q342_I0.5100.95
363_E366_G0.5100.95
378_G383_P0.5080.94
356_G417_G0.5080.94
205_A279_V0.5070.94
37_A384_Y0.5060.94
69_I97_V0.5050.94
23_V28_M0.5050.94
35_S41_A0.5040.94
7_V30_A0.5030.94
19_V304_E0.5030.94
187_K199_I0.5030.94
95_E98_E0.5020.94
35_S42_P0.5020.94
178_E182_A0.5020.94
220_Y321_G0.5020.94
34_Y40_Y0.5010.94
345_E353_P0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6rA 1 0.8549 100 0.205 Contact Map
3u9tA 3 0.9667 100 0.216 Contact Map
2qf7A 4 0.9059 100 0.223 Contact Map
3hblA 4 0.9922 100 0.23 Contact Map
4qshA 4 0.8745 100 0.233 Contact Map
3jrxA 1 0.8255 100 0.239 Contact Map
3va7A 1 0.8431 100 0.25 Contact Map
4rcnA 6 0.8863 100 0.261 Contact Map
1w96A 1 0.8706 100 0.287 Contact Map
2dzdA 2 0.8843 100 0.288 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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