GREMLIN Database
LEUD - 3-isopropylmalate dehydratase small subunit
UniProt: Q97VY3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (146)
Sequences: 6768 (3300)
Seq/√Len: 273.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_E132_K3.7651.00
59_K85_E2.8041.00
57_A84_A2.6611.00
60_V63_M2.6331.00
121_D124_T2.4771.00
15_D18_I2.3851.00
74_L100_L2.2011.00
36_H39_E2.1941.00
81_A120_I2.1411.00
18_I41_L2.1061.00
126_E133_V2.0951.00
85_E110_K2.0831.00
5_G53_V2.0121.00
32_Y35_Q1.9991.00
95_A102_V1.9531.00
42_D45_F1.9361.00
8_I42_D1.9281.00
108_S111_E1.9021.00
12_D59_K1.9021.00
24_Y39_E1.8191.00
54_I81_A1.7261.00
13_K60_V1.7221.00
12_D58_G1.7211.00
95_A100_L1.6981.00
119_K128_L1.6901.00
12_D85_E1.6351.00
47_K50_S1.6131.00
71_A88_A1.5601.00
104_T137_K1.5351.00
6_P117_Y1.5171.00
96_I102_V1.4921.00
23_R40_P1.4611.00
43_P47_K1.4571.00
141_G145_E1.4531.00
37_V73_A1.4151.00
145_E149_A1.4091.00
142_M146_I1.4011.00
91_F95_A1.3981.00
144_L148_Q1.3421.00
113_D116_S1.3371.00
61_F91_F1.3351.00
37_V77_A1.3301.00
126_E135_K1.3231.00
140_T143_A1.3191.00
145_E148_Q1.2711.00
54_I83_V1.2711.00
71_A100_L1.2551.00
5_G54_I1.2501.00
44_E47_K1.2271.00
105_L109_T1.1691.00
25_L29_D1.1511.00
85_E108_S1.1391.00
116_S129_V1.1371.00
75_K80_K1.1341.00
55_I79_V1.1341.00
10_F58_G1.1311.00
96_I143_A1.1311.00
92_Y143_A1.1291.00
85_E109_T1.1281.00
53_V79_V1.1271.00
122_V125_G1.1181.00
138_G147_L1.1141.00
6_P115_N1.1141.00
56_V109_T1.1121.00
24_Y36_H1.1021.00
123_E148_Q1.1011.00
10_F14_I1.0941.00
43_P46_Y1.0921.00
128_L133_V1.0891.00
23_R39_E1.0871.00
75_K100_L1.0791.00
125_G144_L1.0781.00
48_K51_K1.0731.00
34_A76_A1.0531.00
47_K51_K1.0511.00
27_Y33_L1.0421.00
45_F49_A1.0411.00
25_L69_Q1.0411.00
113_D130_G1.0381.00
138_G144_L1.0361.00
20_I73_A1.0181.00
27_Y32_Y1.0151.00
27_Y36_H1.0111.00
42_D48_K1.0111.00
124_T130_G1.0011.00
31_Q76_A0.9881.00
59_K107_N0.9861.00
122_V127_I0.9831.00
75_K98_N0.9821.00
54_I118_V0.9711.00
53_V80_K0.9711.00
92_Y96_I0.9631.00
141_G144_L0.9571.00
107_N110_K0.9551.00
20_I37_V0.9541.00
96_I139_I0.9431.00
105_L108_S0.9421.00
123_E144_L0.9321.00
22_A66_S0.9151.00
22_A40_P0.9051.00
101_P147_L0.9051.00
71_A98_N0.8971.00
38_M41_L0.8951.00
58_G110_K0.8901.00
111_E134_L0.8901.00
121_D126_E0.8791.00
9_K109_T0.8761.00
46_Y49_A0.8751.00
83_V109_T0.8741.00
92_Y104_T0.8701.00
139_I144_L0.8581.00
103_I136_G0.8581.00
123_E127_I0.8581.00
146_I150_G0.8481.00
56_V83_V0.8321.00
44_E48_K0.8200.99
83_V105_L0.8100.99
129_V132_K0.8040.99
101_P122_V0.8020.99
120_I127_I0.8010.99
29_D36_H0.7970.99
7_V56_V0.7960.99
116_S130_G0.7880.99
69_Q72_I0.7870.99
61_F74_L0.7760.99
11_G41_L0.7750.99
85_E107_N0.7740.99
35_Q39_E0.7600.99
33_L73_A0.7560.99
9_K110_K0.7280.99
132_K135_K0.7280.99
96_I146_I0.7260.99
119_K131_N0.7160.99
30_P72_I0.7140.98
106_P135_K0.7140.98
15_D25_L0.7100.98
118_V129_V0.6980.98
56_V105_L0.6930.98
8_I46_Y0.6870.98
7_V118_V0.6850.98
14_I57_A0.6780.98
11_G14_I0.6760.98
123_E126_E0.6680.98
132_K137_K0.6680.98
13_K63_M0.6670.98
45_F48_K0.6670.98
33_L72_I0.6640.98
129_V134_L0.6610.97
121_D131_N0.6590.97
7_V112_I0.6540.97
23_R26_K0.6540.97
26_K69_Q0.6520.97
5_G52_G0.6500.97
65_S94_N0.6480.97
37_V74_L0.6430.97
72_I98_N0.6430.97
8_I49_A0.6420.97
139_I142_M0.6410.97
83_V103_I0.6410.97
22_A69_Q0.6400.97
61_F95_A0.6300.97
92_Y102_V0.6280.97
9_K56_V0.6280.97
55_I74_L0.6230.96
19_I38_M0.6230.96
10_F57_A0.6190.96
71_A95_A0.6170.96
20_I33_L0.6060.96
146_I149_A0.6040.96
8_I53_V0.6040.96
28_T69_Q0.6030.96
57_A82_V0.6030.96
124_T133_V0.6020.96
138_G143_A0.5960.95
56_V112_I0.5940.95
70_A94_N0.5930.95
120_I134_L0.5920.95
33_L79_V0.5870.95
22_A39_E0.5860.95
80_K101_P0.5820.95
109_T112_I0.5810.95
124_T128_L0.5780.95
118_V127_I0.5780.95
131_N135_K0.5780.95
33_L36_H0.5740.94
114_E122_V0.5730.94
6_P53_V0.5720.94
106_P117_Y0.5700.94
108_S134_L0.5690.94
143_A146_I0.5680.94
69_Q88_A0.5660.94
26_K76_A0.5650.94
106_P133_V0.5630.94
35_Q38_M0.5600.94
33_L69_Q0.5540.93
9_K113_D0.5530.93
108_S112_I0.5510.93
27_Y38_M0.5510.93
68_E88_A0.5440.93
20_I82_V0.5410.92
6_P51_K0.5380.92
83_V136_G0.5330.92
124_T127_I0.5330.92
67_R90_I0.5320.92
121_D125_G0.5310.92
72_I76_A0.5300.92
93_R96_I0.5290.92
125_G141_G0.5290.92
122_V126_E0.5270.91
116_S131_N0.5250.91
83_V134_L0.5160.91
139_I147_L0.5160.91
117_Y135_K0.5150.91
16_T67_R0.5140.90
29_D76_A0.5080.90
66_S90_I0.5080.90
30_P76_A0.5070.90
59_K86_S0.5040.90
120_I123_E0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vbaA 2 1 100 0.125 Contact Map
2pkpA 2 0.9879 100 0.13 Contact Map
1v7lA 6 0.9879 100 0.143 Contact Map
3q3wA 1 0.9394 100 0.215 Contact Map
2hcuA 1 0.9091 100 0.23 Contact Map
1l5jA 1 0.9879 100 0.235 Contact Map
3h5jA 1 0.9152 100 0.235 Contact Map
2b3yA 1 0.9455 100 0.308 Contact Map
1c96A 1 0.9818 100 0.322 Contact Map
3t05A 3 0.6182 70.1 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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