GREMLIN Database
LEUC - 3-isopropylmalate dehydratase large subunit
UniProt: Q97VY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (404)
Sequences: 5865 (2260)
Seq/√Len: 112.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_V261_T5.0751.00
268_E284_N4.8351.00
407_E411_T4.0181.00
308_E339_R4.0091.00
263_Q266_E3.9501.00
231_Q235_R3.6561.00
161_K198_F3.4541.00
5_K13_S3.3371.00
165_E261_T3.2261.00
48_E89_S3.1671.00
294_V401_A2.9471.00
323_C350_C2.8181.00
375_V396_S2.7931.00
304_L335_E2.7291.00
174_G209_Y2.7221.00
232_E235_R2.6271.00
161_K259_E2.5781.00
183_G280_V2.5511.00
165_E200_K2.5371.00
163_V259_E2.4751.00
307_F336_A2.4711.00
315_K344_T2.4551.00
201_D264_L2.4151.00
343_Q347_D2.4031.00
288_G409_K2.3911.00
198_F259_E2.3781.00
184_D262_I2.3451.00
180_K184_D2.3431.00
377_T401_A2.2291.00
180_K270_L2.2061.00
296_I323_C2.1871.00
400_V404_S2.1671.00
30_V117_V2.1291.00
268_E282_V2.1151.00
8_T157_P2.1121.00
312_K315_K2.0421.00
167_K204_S2.0321.00
168_P177_V2.0211.00
164_L264_L1.9971.00
342_I346_V1.9921.00
296_I310_A1.9791.00
164_L181_L1.9421.00
193_M258_D1.9151.00
341_Y345_L1.9081.00
309_I399_A1.9001.00
167_K200_K1.8921.00
163_V198_F1.8471.00
9_E159_P1.8251.00
178_A213_V1.8201.00
294_V375_V1.8121.00
197_I217_G1.8111.00
158_Q257_V1.8101.00
162_V181_L1.8051.00
169_A172_I1.8031.00
368_A374_I1.7831.00
317_K406_L1.7761.00
282_V285_E1.7731.00
270_L280_V1.7731.00
304_L339_R1.7661.00
304_L308_E1.7291.00
206_P305_S1.6871.00
180_K183_G1.6851.00
164_L177_V1.6591.00
180_K267_M1.6421.00
308_E341_Y1.6401.00
213_V227_F1.6331.00
342_I352_V1.6221.00
194_T224_A1.6201.00
55_V92_I1.6121.00
307_F325_A1.6031.00
326_I358_G1.5961.00
291_V404_S1.5871.00
203_L231_Q1.5851.00
335_E339_R1.5681.00
48_E90_E1.5601.00
244_E247_L1.5591.00
177_V205_F1.5521.00
290_P409_K1.5451.00
77_A81_G1.5421.00
160_F258_D1.5281.00
162_V195_L1.5261.00
11_I226_M1.5221.00
180_K262_I1.5151.00
207_M232_E1.5091.00
134_F224_A1.5001.00
188_D258_D1.4961.00
337_L342_I1.4881.00
195_L220_M1.4851.00
293_Q372_E1.4831.00
173_T399_A1.4801.00
158_Q193_M1.4771.00
173_T309_I1.4741.00
10_K251_D1.4701.00
291_V294_V1.4611.00
396_S410_I1.4601.00
333_F337_L1.4551.00
29_K151_K1.4391.00
209_Y305_S1.4291.00
217_G225_L1.4231.00
314_M323_C1.4121.00
178_A216_M1.3991.00
94_N98_I1.3981.00
85_K89_S1.3901.00
62_V111_Y1.3871.00
229_P234_K1.3791.00
293_Q322_R1.3771.00
273_A281_K1.3721.00
368_A391_A1.3641.00
131_V207_M1.3571.00
333_F355_G1.3521.00
319_V323_C1.3501.00
326_I353_T1.3461.00
177_V201_D1.3371.00
283_V400_V1.3261.00
164_L202_P1.3241.00
174_G205_F1.3201.00
105_E328_A1.3151.00
78_E82_Y1.3091.00
138_M143_I1.3081.00
84_R97_D1.2990.99
132_G229_P1.2980.99
8_T194_T1.2930.99
18_K24_D1.2890.99
113_N116_Q1.2890.99
396_S401_A1.2780.99
344_T347_D1.2770.99
310_A345_L1.2750.99
105_E329_S1.2700.99
8_T159_P1.2680.99
362_G367_I1.2650.99
169_A268_E1.2600.99
214_S227_F1.2540.99
119_L138_M1.2540.99
270_L282_V1.2240.99
112_A128_S1.2210.99
169_A267_M1.2200.99
61_L147_L1.2190.99
96_Y99_N1.2170.99
373_N392_K1.2170.99
184_D260_Y1.2140.99
334_K347_D1.2080.99
235_R238_K1.1990.99
105_E302_G1.1970.99
57_D60_K1.1970.99
32_L111_Y1.1930.99
131_V211_A1.1920.99
8_T224_A1.1900.99
291_V375_V1.1840.99
95_F98_I1.1840.99
338_E343_Q1.1820.99
207_M233_T1.1790.99
39_T121_A1.1760.99
81_G85_K1.1740.99
202_P213_V1.1660.99
238_K244_E1.1650.99
164_L201_D1.1630.99
292_D372_E1.1600.99
272_A280_V1.1550.99
185_F189_Y1.1530.99
243_Y246_E1.1450.99
181_L195_L1.1430.99
271_V286_L1.1420.99
168_P172_I1.1390.99
130_A207_M1.1370.99
334_K338_E1.1240.98
39_T361_L1.1200.98
46_V144_A1.1170.98
108_I211_A1.1040.98
203_L249_T1.1020.98
396_S400_V1.1000.98
34_A103_L1.0990.98
295_Y378_S1.0950.98
55_V147_L1.0950.98
307_F345_L1.0920.98
397_G400_V1.0830.98
343_Q346_V1.0820.98
9_E156_V1.0680.98
202_P205_F1.0670.98
264_L267_M1.0660.98
184_D266_E1.0630.98
112_A131_V1.0580.98
134_F194_T1.0550.98
271_V396_S1.0550.98
309_I312_K1.0540.98
404_S411_T1.0490.98
126_T217_G1.0490.98
295_Y358_G1.0470.98
276_S279_N1.0450.98
185_F195_L1.0440.98
313_I402_A1.0400.97
193_M257_V1.0390.97
315_K347_D1.0380.97
208_D305_S1.0360.97
206_P232_E1.0320.97
322_R351_I1.0310.97
200_K204_S1.0290.97
294_V377_T1.0260.97
206_P209_Y1.0250.97
346_V351_I1.0250.97
6_T159_P1.0220.97
168_P204_S1.0220.97
95_F99_N1.0180.97
251_D254_A1.0170.97
160_F193_M1.0120.97
119_L146_A1.0110.97
375_V404_S1.0100.97
281_K285_E1.0090.97
334_K337_L1.0050.97
370_P388_S1.0050.97
240_M331_R0.9980.97
184_D258_D0.9960.97
373_N394_Y0.9950.97
185_F220_M0.9920.97
234_K238_K0.9890.97
168_P264_L0.9840.96
375_V410_I0.9840.96
294_V405_A0.9830.96
35_F103_L0.9830.96
38_L41_Y0.9800.96
110_Q331_R0.9800.96
30_V146_A0.9780.96
372_E391_A0.9750.96
63_I83_I0.9750.96
228_I249_T0.9730.96
128_S135_A0.9720.96
112_A118_I0.9690.96
235_R239_E0.9630.96
287_E409_K0.9600.96
316_G347_D0.9560.96
165_E263_Q0.9540.96
201_D205_F0.9540.96
273_A286_L0.9510.96
300_T379_S0.9500.96
308_E312_K0.9490.96
32_L116_Q0.9470.96
112_A133_A0.9440.96
202_P227_F0.9390.95
63_I87_V0.9390.95
335_E338_E0.9370.95
371_G389_N0.9350.95
138_M146_A0.9290.95
169_A265_D0.9270.95
210_R230_D0.8950.94
341_Y344_T0.8950.94
35_F40_G0.8940.94
7_L11_I0.8940.94
314_M350_C0.8930.94
162_V260_Y0.8930.94
337_L346_V0.8900.94
353_T358_G0.8860.94
247_L252_N0.8810.94
52_M148_I0.8800.93
308_E335_E0.8790.93
165_E264_L0.8780.93
183_G270_L0.8770.93
9_E13_S0.8760.93
200_K203_L0.8750.93
36_H103_L0.8730.93
58_K91_G0.8730.93
62_V94_N0.8730.93
289_T409_K0.8710.93
289_T410_I0.8700.93
33_V143_I0.8700.93
204_S232_E0.8650.93
177_V213_V0.8630.93
8_T226_M0.8630.93
375_V401_A0.8590.93
163_V200_K0.8590.93
177_V267_M0.8590.93
197_I225_L0.8580.93
217_G222_A0.8500.92
160_F257_V0.8480.92
314_M317_K0.8470.92
177_V264_L0.8460.92
45_E49_K0.8450.92
222_A225_L0.8440.92
293_Q391_A0.8440.92
182_L220_M0.8410.92
6_T254_A0.8370.92
28_A154_L0.8340.92
334_K343_Q0.8320.91
291_V373_N0.8320.91
405_A408_G0.8300.91
310_A399_A0.8280.91
231_Q246_E0.8280.91
14_R244_E0.8260.91
227_F264_L0.8250.91
333_F342_I0.8250.91
167_K265_D0.8230.91
310_A325_A0.8230.91
319_V405_A0.8210.91
119_L152_T0.8200.91
373_N410_I0.8190.91
55_V61_L0.8180.91
111_Y242_G0.8170.91
126_T218_I0.8130.90
318_K347_D0.8120.90
177_V202_P0.8120.90
65_F95_F0.8100.90
87_V94_N0.8090.90
32_L62_V0.8030.90
130_A211_A0.8020.90
21_S24_D0.8010.90
241_R331_R0.7970.90
192_G223_D0.7950.89
96_Y111_Y0.7940.89
7_L248_V0.7930.89
102_I302_G0.7930.89
371_G392_K0.7920.89
250_P253_G0.7870.89
200_K264_L0.7800.89
298_S378_S0.7760.88
326_I359_P0.7750.88
114_P237_I0.7730.88
314_M406_L0.7730.88
250_P256_Y0.7720.88
33_V146_A0.7710.88
13_S16_S0.7710.88
30_V33_V0.7660.88
72_P365_F0.7640.88
7_L226_M0.7630.87
203_L232_E0.7630.87
158_Q258_D0.7620.87
268_E285_E0.7620.87
307_F341_Y0.7610.87
304_L341_Y0.7600.87
19_D25_V0.7580.87
403_I407_E0.7580.87
374_I391_A0.7570.87
366_G370_P0.7570.87
35_F121_A0.7540.87
283_V410_I0.7480.86
12_L156_V0.7470.86
107_M112_A0.7470.86
249_T252_N0.7460.86
325_A350_C0.7450.86
69_A100_Y0.7430.86
30_V152_T0.7380.86
64_A103_L0.7320.85
369_G372_E0.7310.85
273_A394_Y0.7300.85
113_N241_R0.7290.85
78_E370_P0.7290.85
252_N255_K0.7280.85
160_F195_L0.7280.85
234_K237_I0.7250.85
65_F97_D0.7240.85
308_E336_A0.7230.85
35_F61_L0.7210.84
40_G83_I0.7210.84
201_D265_D0.7190.84
47_M90_E0.7170.84
234_K246_E0.7150.84
198_F256_Y0.7140.84
288_G410_I0.7100.83
82_Y85_K0.7070.83
346_V352_V0.7050.83
180_K266_E0.7040.83
11_I194_T0.7010.83
170_K312_K0.7000.83
111_Y116_Q0.7000.83
294_V404_S0.6990.82
314_M348_A0.6980.82
127_T211_A0.6970.82
74_V78_E0.6940.82
58_K116_Q0.6920.82
248_V251_D0.6910.82
290_P320_K0.6910.82
168_P209_Y0.6880.81
102_I328_A0.6870.81
214_S224_A0.6860.81
293_Q374_I0.6850.81
337_L352_V0.6850.81
32_L107_M0.6840.81
162_V262_I0.6800.81
400_V411_T0.6790.81
94_N99_N0.6790.81
396_S404_S0.6780.81
332_M335_E0.6750.80
311_A344_T0.6750.80
68_L76_S0.6750.80
142_D154_L0.6740.80
178_A181_L0.6730.80
190_F222_A0.6730.80
330_Y355_G0.6720.80
335_E341_Y0.6720.80
304_L336_A0.6680.80
126_T135_A0.6670.79
52_M144_A0.6650.79
35_F147_L0.6650.79
404_S409_K0.6640.79
157_P194_T0.6630.79
100_Y330_Y0.6610.79
314_M345_L0.6580.79
84_R88_K0.6570.78
65_F80_Q0.6570.78
181_L262_I0.6560.78
187_A278_D0.6550.78
108_I131_V0.6530.78
15_A31_D0.6520.78
138_M152_T0.6510.78
127_T215_N0.6500.78
14_R246_E0.6490.78
108_I128_S0.6460.77
208_D332_M0.6450.77
85_K88_K0.6450.77
164_L168_P0.6440.77
33_V61_L0.6440.77
286_L404_S0.6430.77
71_P324_I0.6400.77
404_S410_I0.6390.77
183_G187_A0.6370.76
106_V110_Q0.6370.76
175_K300_T0.6370.76
159_P194_T0.6360.76
20_V23_G0.6330.76
262_I266_E0.6330.76
110_Q113_N0.6330.76
16_S25_V0.6320.76
185_F260_Y0.6310.76
81_G369_G0.6300.76
201_D209_Y0.6290.75
20_V24_D0.6290.75
146_A152_T0.6280.75
247_L250_P0.6270.75
333_F352_V0.6260.75
353_T356_T0.6250.75
172_I269_P0.6230.75
177_V200_K0.6220.75
162_V184_D0.6220.75
205_F213_V0.6210.74
304_L332_M0.6210.74
283_V286_L0.6200.74
36_H39_T0.6200.74
295_Y359_P0.6200.74
56_F61_L0.6190.74
318_K321_S0.6190.74
37_D40_G0.6190.74
16_S28_A0.6170.74
174_G213_V0.6170.74
293_Q369_G0.6170.74
325_A345_L0.6140.74
38_L361_L0.6140.74
220_M225_L0.6140.74
322_R372_E0.6140.74
302_G307_F0.6100.73
144_A383_K0.6080.73
322_R369_G0.6070.73
169_A266_E0.6060.73
169_A284_N0.6060.73
38_L79_I0.6050.73
76_S361_L0.6050.73
289_T373_N0.6030.72
28_A117_V0.6020.72
118_I133_A0.6010.72
156_V159_P0.5990.72
314_M325_A0.5990.72
29_K57_D0.5930.71
234_K245_P0.5930.71
72_P322_R0.5930.71
159_P256_Y0.5920.71
47_M148_I0.5910.71
165_E203_L0.5910.71
119_L154_L0.5910.71
105_E332_M0.5890.71
214_S226_M0.5880.70
27_E153_W0.5880.70
200_K261_T0.5880.70
130_A214_S0.5870.70
267_M270_L0.5870.70
293_Q324_I0.5860.70
110_Q241_R0.5860.70
183_G282_V0.5850.70
12_L16_S0.5840.70
54_K169_A0.5830.70
353_T359_P0.5830.70
204_S238_K0.5820.70
185_F190_F0.5800.69
62_V242_G0.5800.69
86_F90_E0.5790.69
250_P254_A0.5790.69
281_K289_T0.5780.69
87_V92_I0.5770.69
329_S332_M0.5770.69
94_N111_Y0.5760.69
234_K247_L0.5730.68
326_I345_L0.5730.68
160_F260_Y0.5730.68
55_V90_E0.5730.68
207_M211_A0.5720.68
123_S139_G0.5710.68
319_V348_A0.5710.68
61_L92_I0.5710.68
369_G391_A0.5710.68
54_K90_E0.5700.68
403_I411_T0.5690.68
46_V49_K0.5690.68
168_P201_D0.5680.68
212_T398_P0.5680.68
166_G265_D0.5680.68
164_L200_K0.5670.68
375_V400_V0.5670.68
296_I302_G0.5660.68
283_V411_T0.5650.67
32_L113_N0.5650.67
309_I313_I0.5630.67
118_I128_S0.5630.67
216_M300_T0.5630.67
311_A341_Y0.5620.67
402_A408_G0.5620.67
186_K278_D0.5610.67
231_Q234_K0.5600.67
8_T12_L0.5600.67
394_Y410_I0.5590.67
203_L264_L0.5590.67
94_N97_D0.5570.66
24_D153_W0.5570.66
64_A106_V0.5560.66
202_P228_I0.5550.66
39_T43_V0.5540.66
181_L260_Y0.5540.66
40_G63_I0.5530.66
45_E48_E0.5520.66
170_K313_I0.5520.66
37_D42_H0.5510.65
8_T117_V0.5490.65
79_I361_L0.5490.65
39_T140_A0.5470.65
15_A29_K0.5470.65
76_S79_I0.5470.65
226_M229_P0.5460.65
198_F250_P0.5450.65
203_L228_I0.5450.65
22_P158_Q0.5450.65
294_V319_V0.5450.65
132_G248_V0.5440.64
320_K406_L0.5430.64
238_K243_Y0.5430.64
339_R342_I0.5420.64
160_F185_F0.5420.64
12_L154_L0.5410.64
368_A372_E0.5410.64
228_I250_P0.5400.64
75_R78_E0.5390.64
41_Y44_I0.5390.64
379_S398_P0.5370.64
188_D191_N0.5360.63
117_V224_A0.5360.63
27_E151_K0.5350.63
22_P26_I0.5340.63
237_I241_R0.5340.63
293_Q368_A0.5330.63
369_G389_N0.5330.63
368_A388_S0.5320.63
127_T300_T0.5310.63
98_I334_K0.5310.63
249_T253_G0.5300.63
289_T394_Y0.5290.62
201_D204_S0.5280.62
33_V119_L0.5260.62
305_S309_I0.5250.62
202_P232_E0.5250.62
253_G256_Y0.5250.62
102_I106_V0.5230.61
46_V140_A0.5230.61
398_P408_G0.5230.61
356_T365_F0.5220.61
44_I86_F0.5210.61
165_E168_P0.5190.61
153_W391_A0.5190.61
275_H383_K0.5190.61
357_C360_C0.5180.61
181_L184_D0.5170.61
9_E21_S0.5160.60
167_K201_D0.5150.60
181_L185_F0.5150.60
323_C402_A0.5150.60
190_F220_M0.5140.60
106_V329_S0.5140.60
168_P267_M0.5130.60
286_L410_I0.5130.60
138_M142_D0.5130.60
376_S386_M0.5120.60
175_K379_S0.5120.60
35_F43_V0.5110.60
161_K256_Y0.5110.60
333_F354_Y0.5100.60
231_Q238_K0.5100.60
205_F209_Y0.5090.59
45_E82_Y0.5090.59
165_E262_I0.5070.59
54_K89_S0.5070.59
351_I354_Y0.5070.59
175_K216_M0.5060.59
291_V409_K0.5040.59
269_P283_V0.5040.59
174_G177_V0.5040.59
201_D213_V0.5040.59
336_A342_I0.5040.59
36_H363_G0.5030.59
350_C405_A0.5020.58
21_S338_E0.5020.58
328_A332_M0.5020.58
129_G214_S0.5010.58
68_L79_I0.5000.58
162_V197_I0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kp1A 1 0.9928 100 0.092 Contact Map
4kp2A 2 0.976 100 0.097 Contact Map
1c96A 1 0.9928 100 0.155 Contact Map
1l5jA 1 0.9736 100 0.208 Contact Map
2b3yA 1 0.9904 100 0.227 Contact Map
1p3y1 6 0.3798 75.7 0.973 Contact Map
1qzuA 3 0.3462 68.2 0.975 Contact Map
1mvlA 3 0.3702 65.2 0.975 Contact Map
3qjgA 5 0.3702 25.8 0.981 Contact Map
1sbzA 6 0.387 21.1 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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