GREMLIN Database
Q97VY1 - Deoxyribodipyrimidine photolyase (DNA photolyase) (Photoreactivating enzyme). (PhrB)
UniProt: Q97VY1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (420)
Sequences: 4506 (3421)
Seq/√Len: 166.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
218_H223_T3.9371.00
292_I313_L3.6371.00
276_N279_L3.5621.00
280_F328_I3.4541.00
301_N332_Y3.4501.00
321_V416_R3.3231.00
281_Q285_E3.3141.00
280_F284_L3.2621.00
263_P269_N3.1681.00
298_R386_E2.9991.00
282_A410_I2.8191.00
296_G310_V2.8161.00
63_N67_R2.7831.00
321_V413_W2.7331.00
58_S223_T2.6141.00
370_Q380_I2.5111.00
95_Y125_F2.5101.00
381_K392_A2.5001.00
418_N422_R2.4681.00
301_N336_K2.4571.00
63_N72_R2.4381.00
371_V397_N2.4291.00
14_D228_E2.3771.00
238_A241_R2.3631.00
96_L122_M2.3611.00
61_E183_R2.3251.00
7_F31_P2.2541.00
397_N400_K2.2531.00
96_L124_S2.2051.00
16_N97_N2.1971.00
274_E279_L2.1931.00
78_G83_V2.1691.00
290_Y317_F2.1651.00
249_Y348_N2.1611.00
310_V379_Y2.1301.00
189_G229_V2.1231.00
368_K372_T2.1201.00
94_V115_C2.1191.00
413_W416_R2.1081.00
302_R383_W2.0551.00
370_Q396_H2.0371.00
58_S181_G2.0131.00
5_F18_G2.0091.00
381_K395_I1.9941.00
184_G187_K1.9881.00
332_Y336_K1.9871.00
303_T383_W1.9741.00
417_V421_K1.9691.00
93_A123_K1.9421.00
298_R384_V1.9421.00
290_Y413_W1.9251.00
79_L82_E1.9231.00
394_I402_T1.8921.00
5_F16_N1.8741.00
376_E392_A1.8721.00
281_Q284_L1.8681.00
32_A87_L1.8551.00
232_S235_D1.8461.00
390_Y401_Y1.8251.00
412_D415_I1.8221.00
299_Q379_Y1.7721.00
315_A352_I1.7371.00
414_R418_N1.7341.00
81_E85_K1.7311.00
277_E328_I1.7241.00
318_L324_I1.7121.00
213_T239_I1.7101.00
31_P71_S1.6821.00
274_E423_L1.6751.00
249_Y347_G1.6641.00
7_F66_L1.6561.00
279_L410_I1.6491.00
299_Q303_T1.6441.00
146_Y241_R1.6261.00
334_A340_Y1.6251.00
207_V310_V1.6221.00
230_Y240_I1.6211.00
182_E228_E1.6171.00
215_L239_I1.6161.00
219_L229_V1.6121.00
76_Y90_D1.6011.00
185_G224_L1.5971.00
284_L335_S1.5951.00
146_Y244_Y1.5911.00
65_E182_E1.5821.00
86_N90_D1.5781.00
145_F251_L1.5721.00
391_D394_I1.5711.00
112_R124_S1.5641.00
193_I197_R1.5611.00
83_V86_N1.5601.00
142_F241_R1.5561.00
93_A121_I1.5561.00
363_V421_K1.5541.00
289_G294_D1.5521.00
61_E65_E1.5381.00
76_Y83_V1.5291.00
81_E110_R1.5201.00
282_A287_K1.5171.00
330_E346_N1.5161.00
181_G185_G1.5141.00
181_G184_G1.5031.00
85_K118_T1.5011.00
3_C95_Y1.5001.00
199_I203_R1.5001.00
4_L91_V1.5001.00
186_R228_E1.4911.00
323_I419_L1.4901.00
17_T127_D1.4771.00
20_I24_E1.4761.00
275_N328_I1.4721.00
189_G232_S1.4511.00
228_E232_S1.4421.00
66_L71_S1.4361.00
367_W399_Y1.4351.00
318_L329_G1.4311.00
14_D186_R1.4281.00
88_L91_V1.4271.00
204_K207_V1.4251.00
53_N57_N1.4231.00
55_M221_F1.4181.00
259_V346_N1.4071.00
203_R209_E1.3931.00
9_R99_D1.3881.00
278_R282_A1.3881.00
94_V122_M1.3811.00
419_L423_L1.3751.00
190_I232_S1.3691.00
67_R72_R1.3671.00
33_F55_M1.3451.00
57_N180_Q1.3441.00
238_A242_Q1.3431.00
296_G379_Y1.3371.00
32_A84_I1.3351.00
8_R108_D1.3341.00
367_W370_Q1.3311.00
146_Y150_K1.3291.00
21_K24_E1.3261.00
262_E269_N1.3211.00
149_V244_Y1.3181.00
201_Y238_A1.3171.00
128_Y250_T1.3131.00
252_L357_T1.3021.00
30_I74_Y1.2961.00
32_A76_Y1.2941.00
54_F218_H1.2761.00
280_F324_I1.2761.00
25_D93_A1.2661.00
105_K254_Y1.2461.00
233_L240_I1.2391.00
299_Q305_D1.2351.00
7_F62_L1.2291.00
377_A381_K1.2031.00
23_L164_N1.2011.00
3_C26_C1.1991.00
242_Q344_V1.1981.00
131_T149_V1.1981.00
378_K381_K1.1961.00
203_R211_N1.1951.00
101_T104_S1.1931.00
329_G349_W1.1921.00
284_L332_Y1.1911.00
215_L229_V1.1881.00
89_K118_T1.1871.00
323_I420_A1.1841.00
258_R262_E1.1831.00
14_D182_E1.1831.00
37_P77_F1.1781.00
292_I370_Q1.1751.00
182_E186_R1.1681.00
328_I331_K1.1661.00
65_E183_R1.1641.00
33_F59_L1.1531.00
184_G188_E1.1521.00
105_K109_E1.1491.00
142_F145_F1.1481.00
85_K88_L1.1341.00
293_I313_L1.1341.00
253_A343_S1.1271.00
202_D205_D1.1251.00
13_L69_R1.1251.00
300_L337_L1.1191.00
101_T342_P1.1171.00
368_K371_V1.1091.00
6_I111_I1.1031.00
180_Q184_G1.1021.00
126_E132_S1.0991.00
34_I84_I1.0911.00
82_E86_N1.0901.00
3_C25_D1.0861.00
154_I157_P1.0851.00
322_L411_V1.0801.00
65_E69_R1.0711.00
415_I419_L1.0691.00
394_I401_Y1.0620.99
324_I328_I1.0620.99
181_G223_T1.0610.99
99_D104_S1.0600.99
36_D39_Q1.0590.99
283_W297_M1.0590.99
157_P161_N1.0590.99
214_F305_D1.0580.99
233_L239_I1.0560.99
342_P346_N1.0550.99
155_K227_R1.0510.99
290_Y321_V1.0360.99
280_F318_L1.0240.99
256_N264_L1.0230.99
38_R79_L1.0140.99
139_Y142_F1.0130.99
56_I60_N1.0090.99
50_F336_K1.0040.99
244_Y247_D0.9930.99
65_E68_K0.9870.99
35_L40_V0.9870.99
88_L120_K0.9860.99
96_L112_R0.9810.99
21_K125_F0.9800.99
129_L250_T0.9800.99
54_F217_P0.9790.99
179_R184_G0.9780.99
210_D214_F0.9760.99
54_F223_T0.9750.99
88_L115_C0.9650.99
35_L59_L0.9620.99
285_E301_N0.9620.99
191_K195_R0.9500.99
4_L88_L0.9490.99
138_N256_N0.9460.99
317_F410_I0.9450.99
252_L259_V0.9440.99
150_K237_Q0.9430.99
171_G175_E0.9420.99
380_I384_V0.9400.99
392_A395_I0.9380.99
111_I115_C0.9370.99
85_K114_Y0.9370.99
193_I233_L0.9340.99
30_I91_V0.9330.99
187_K191_K0.9330.99
60_N64_D0.9330.99
212_R305_D0.9280.99
34_I80_A0.9250.99
35_L75_V0.9240.99
23_L29_V0.9170.98
94_V111_I0.9160.98
279_L419_L0.9160.98
217_P338_I0.9140.98
348_N352_I0.9130.98
99_D107_R0.9120.98
309_R369_Q0.9110.98
54_F58_S0.9090.98
31_P66_L0.9090.98
25_D95_Y0.9080.98
98_E124_S0.9070.98
130_L149_V0.9060.98
98_E126_E0.9000.98
298_R302_R0.8980.98
106_M110_R0.8960.98
98_E132_S0.8920.98
80_A85_K0.8900.98
54_F181_G0.8900.98
206_F209_E0.8890.98
419_L422_R0.8880.98
54_F180_Q0.8870.98
85_K89_K0.8860.98
64_D68_K0.8860.98
416_R419_L0.8850.98
174_H177_P0.8840.98
250_T344_V0.8800.98
6_I80_A0.8790.98
100_Y129_L0.8750.98
299_Q383_W0.8750.98
102_P106_M0.8730.98
78_G82_E0.8700.98
4_L87_L0.8690.98
182_E185_G0.8670.98
76_Y86_N0.8640.98
20_I158_V0.8610.98
34_I83_V0.8610.98
260_F342_P0.8600.98
3_C27_E0.8600.98
279_L282_A0.8590.98
97_N127_D0.8590.98
203_R206_F0.8550.98
323_I423_L0.8550.98
134_N255_Y0.8530.98
142_F146_Y0.8520.98
274_E419_L0.8500.97
415_I418_N0.8500.97
137_K140_R0.8450.97
112_R122_M0.8410.97
100_Y132_S0.8370.97
275_N324_I0.8350.97
84_I87_L0.8350.97
242_Q312_M0.8330.97
284_L328_I0.8320.97
35_L77_F0.8300.97
229_V239_I0.8290.97
66_L73_L0.8250.97
215_L224_L0.8240.97
15_D227_R0.8220.97
21_K25_D0.8210.97
259_V264_L0.8180.97
233_L236_S0.8170.97
74_Y87_L0.8160.97
279_L324_I0.8150.97
384_V406_Y0.8140.97
3_C93_A0.8130.97
95_Y123_K0.8070.97
3_C28_K0.8040.96
241_R245_W0.7980.96
204_K242_Q0.7980.96
61_E64_D0.7970.96
17_T21_K0.7960.96
250_T341_D0.7950.96
390_Y394_I0.7930.96
145_F149_V0.7840.96
4_L32_A0.7840.96
157_P231_Y0.7840.96
287_K384_V0.7810.96
266_R269_N0.7800.96
391_D401_Y0.7780.96
109_E113_K0.7770.96
5_F95_Y0.7760.96
80_A83_V0.7730.96
401_Y405_S0.7710.96
370_Q377_A0.7700.95
13_L66_L0.7680.95
291_P406_Y0.7650.95
34_I78_G0.7650.95
46_Y335_S0.7640.95
131_T244_Y0.7630.95
180_Q186_R0.7620.95
88_L94_V0.7600.95
132_S135_D0.7580.95
286_G297_M0.7570.95
351_W362_R0.7560.95
61_E180_Q0.7550.95
394_I400_K0.7510.95
224_L229_V0.7510.95
130_L230_Y0.7510.95
79_L110_R0.7510.95
71_S166_Y0.7490.95
109_E112_R0.7480.95
181_G186_R0.7460.95
61_E223_T0.7440.95
5_F31_P0.7430.95
169_S172_D0.7420.95
139_Y148_V0.7360.94
197_R233_L0.7310.94
154_I158_V0.7310.94
344_V348_N0.7300.94
34_I88_L0.7260.94
296_G306_M0.7240.94
113_K117_D0.7230.94
390_Y398_A0.7220.94
237_Q241_R0.7210.94
241_R244_Y0.7190.94
362_R369_Q0.7140.93
116_E119_G0.7140.93
380_I395_I0.7080.93
58_S180_Q0.7060.93
286_G384_V0.7030.93
180_Q185_G0.7020.93
6_I96_L0.7010.93
290_Y416_R0.7010.93
148_V151_N0.7000.93
291_P380_I0.6980.93
320_K358_D0.6970.92
181_G189_G0.6940.92
161_N164_N0.6940.92
21_K123_K0.6930.92
98_E134_N0.6900.92
273_W325_D0.6890.92
325_D328_I0.6860.92
197_R236_S0.6840.92
189_G224_L0.6840.92
387_L406_Y0.6840.92
112_R134_N0.6800.92
106_M109_E0.6790.91
277_E281_Q0.6780.91
259_V347_G0.6770.91
22_A95_Y0.6750.91
143_T147_N0.6730.91
142_F150_K0.6720.91
18_G97_N0.6720.91
145_F247_D0.6710.91
7_F13_L0.6710.91
234_L240_I0.6700.91
185_G189_G0.6700.91
370_Q395_I0.6670.91
365_D368_K0.6660.91
139_Y145_F0.6650.91
173_E176_L0.6650.91
363_V420_A0.6620.90
150_K244_Y0.6600.90
22_A29_V0.6600.90
39_Q43_E0.6600.90
275_N280_F0.6590.90
86_N89_K0.6590.90
63_N73_L0.6550.90
172_D175_E0.6540.90
298_R301_N0.6530.90
21_K95_Y0.6520.90
4_L84_I0.6510.90
217_P305_D0.6490.90
178_P217_P0.6470.89
377_A398_A0.6460.89
358_D362_R0.6460.89
367_W371_V0.6450.89
297_M314_T0.6450.89
25_D28_K0.6450.89
36_D80_A0.6430.89
290_Y367_W0.6420.89
316_F352_I0.6410.89
204_K208_A0.6410.89
306_M333_F0.6400.89
253_A259_V0.6400.89
299_Q302_R0.6400.89
33_F39_Q0.6380.89
100_Y133_K0.6380.89
196_A210_D0.6370.89
203_R207_V0.6360.89
150_K241_R0.6350.89
391_D395_I0.6340.88
212_R307_P0.6330.88
199_I202_D0.6330.88
13_L182_E0.6320.88
274_E277_E0.6320.88
134_N254_Y0.6300.88
309_R362_R0.6300.88
390_Y395_I0.6290.88
84_I88_L0.6250.88
99_D220_K0.6220.87
231_Y235_D0.6220.87
131_T136_F0.6210.87
286_G298_R0.6190.87
11_L55_M0.6190.87
193_I232_S0.6150.87
263_P355_V0.6140.87
142_F149_V0.6130.87
207_V292_I0.6120.87
330_E334_A0.6120.87
64_D183_R0.6100.86
292_I310_V0.6090.86
418_N421_K0.6090.86
230_Y243_L0.6080.86
88_L114_Y0.6070.86
96_L108_D0.6070.86
170_L174_H0.6040.86
333_F337_L0.6040.86
124_S132_S0.6030.86
126_E135_D0.6020.86
290_Y410_I0.6020.86
394_I397_N0.6010.86
247_D357_T0.6010.86
225_S228_E0.6000.86
276_N328_I0.6000.86
297_M332_Y0.5990.85
36_D78_G0.5970.85
312_M373_Y0.5970.85
350_Q355_V0.5970.85
197_R200_N0.5960.85
263_P325_D0.5940.85
98_E133_K0.5930.85
300_L306_M0.5920.85
53_N180_Q0.5880.84
139_Y144_T0.5870.84
356_G369_Q0.5860.84
31_P34_I0.5860.84
110_R114_Y0.5860.84
301_N335_S0.5860.84
189_G193_I0.5850.84
186_R190_I0.5850.84
329_G337_L0.5840.84
387_L390_Y0.5820.84
323_I416_R0.5810.84
207_V382_R0.5810.84
6_I84_I0.5800.84
258_R261_H0.5800.84
386_E406_Y0.5800.84
79_L83_V0.5790.84
411_V416_R0.5790.84
362_R365_D0.5790.84
147_N151_N0.5780.83
3_C125_F0.5780.83
5_F22_A0.5770.83
308_N312_M0.5760.83
320_K362_R0.5740.83
402_T405_S0.5740.83
312_M364_F0.5740.83
312_M351_W0.5730.83
379_Y383_W0.5730.83
67_R71_S0.5720.83
290_Y411_V0.5720.83
405_S408_K0.5720.83
159_Q162_Y0.5700.83
251_L255_Y0.5700.83
391_D398_A0.5700.83
97_N125_F0.5690.82
172_D176_L0.5690.82
242_Q245_W0.5680.82
20_I159_Q0.5660.82
320_K351_W0.5660.82
351_W358_D0.5650.82
84_I115_C0.5640.82
245_W347_G0.5640.82
114_Y118_T0.5640.82
192_L213_T0.5630.82
208_A299_Q0.5630.82
29_V164_N0.5620.82
306_M314_T0.5610.82
202_D206_F0.5610.82
170_L177_P0.5610.82
115_C120_K0.5600.81
62_L73_L0.5600.81
26_C29_V0.5600.81
51_A220_K0.5590.81
348_N359_Y0.5590.81
308_N369_Q0.5580.81
154_I230_Y0.5580.81
5_F19_L0.5570.81
7_F11_L0.5570.81
102_P342_P0.5560.81
155_K158_V0.5560.81
131_T135_D0.5550.81
400_K403_L0.5550.81
308_N364_F0.5520.81
364_F369_Q0.5520.81
188_E196_A0.5520.81
278_R281_Q0.5520.81
102_P260_F0.5510.80
341_D344_V0.5510.80
333_F345_N0.5510.80
50_F304_G0.5490.80
188_E214_F0.5470.80
116_E121_I0.5460.80
127_D227_R0.5450.80
126_E129_L0.5450.80
416_R423_L0.5440.80
147_N150_K0.5440.80
57_N179_R0.5440.80
259_V357_T0.5440.80
263_P266_R0.5440.80
131_T154_I0.5440.80
10_D15_D0.5430.79
191_K196_A0.5430.79
39_Q42_N0.5420.79
114_Y117_D0.5420.79
40_V52_I0.5410.79
337_L349_W0.5400.79
250_T343_S0.5400.79
370_Q398_A0.5370.79
47_K51_A0.5360.79
249_Y252_L0.5360.79
308_N345_N0.5360.79
35_L56_I0.5350.78
112_R116_E0.5350.78
38_R81_E0.5340.78
306_M337_L0.5340.78
228_E231_Y0.5330.78
208_A211_N0.5330.78
63_N66_L0.5330.78
345_N349_W0.5320.78
23_L26_C0.5320.78
188_E191_K0.5320.78
356_G359_Y0.5310.78
181_G188_E0.5310.78
129_L251_L0.5300.78
378_K392_A0.5300.78
399_Y402_T0.5290.78
320_K361_F0.5290.78
321_V419_L0.5280.78
188_E224_L0.5270.77
81_E88_L0.5270.77
115_C122_M0.5260.77
219_L226_I0.5260.77
65_E160_N0.5260.77
296_G314_T0.5250.77
140_R256_N0.5240.77
367_W397_N0.5240.77
47_K52_I0.5230.77
416_R420_A0.5230.77
337_L345_N0.5230.77
58_S218_H0.5230.77
299_Q306_M0.5220.77
111_I114_Y0.5210.77
141_N144_T0.5210.77
307_P351_W0.5210.77
170_L173_E0.5200.77
389_S405_S0.5200.77
205_D211_N0.5180.76
50_F53_N0.5170.76
242_Q308_N0.5170.76
139_Y149_V0.5170.76
37_P40_V0.5170.76
242_Q351_W0.5170.76
352_I361_F0.5160.76
229_V233_L0.5160.76
309_R364_F0.5150.76
230_Y234_L0.5150.76
183_R187_K0.5150.76
268_Y424_Y0.5150.76
148_V152_K0.5130.76
362_R373_Y0.5120.75
273_W319_V0.5110.75
283_W322_L0.5110.75
356_G362_R0.5110.75
178_P338_I0.5110.75
230_Y233_L0.5110.75
351_W359_Y0.5110.75
319_V323_I0.5100.75
315_A349_W0.5100.75
207_V379_Y0.5090.75
64_D156_K0.5090.75
197_R213_T0.5080.75
104_S220_K0.5070.75
377_A395_I0.5060.75
76_Y87_L0.5060.75
142_F248_F0.5060.75
401_Y404_K0.5060.75
146_Y149_V0.5050.74
210_D299_Q0.5040.74
308_N351_W0.5040.74
141_N359_Y0.5030.74
265_K354_S0.5030.74
13_L31_P0.5020.74
240_I244_Y0.5010.74
32_A83_V0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u63A 1 0.9815 100 0.092 Contact Map
1owlA 1 0.9908 100 0.093 Contact Map
3fy4A 1 1 100 0.096 Contact Map
2e0iA 1 0.9746 100 0.096 Contact Map
1dnpA 1 0.9815 100 0.097 Contact Map
1np7A 1 0.9723 100 0.1 Contact Map
1u3dA 1 0.9908 100 0.101 Contact Map
4gu5A 1 0.9954 100 0.104 Contact Map
4k0rA 1 0.9376 100 0.107 Contact Map
4mlpC 1 0.9954 100 0.111 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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