GREMLIN Database
Q97VX7 - Uncharacterized protein
UniProt: Q97VX7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (222)
Sequences: 9502 (6178)
Seq/√Len: 414.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_A107_I3.8711.00
29_S235_K3.5291.00
86_K89_E3.4891.00
179_F182_I3.3161.00
181_V184_S3.0951.00
30_H105_L3.0551.00
33_L103_H2.7561.00
18_I230_I2.6921.00
28_A231_S2.5471.00
75_T103_H2.5151.00
19_A34_L2.3151.00
2_E138_N2.2591.00
5_D136_D2.2311.00
26_L107_I2.1391.00
211_P229_E2.1351.00
215_E218_Y2.0811.00
208_V233_L1.9741.00
16_S46_V1.9021.00
20_Y43_L1.8981.00
25_T234_A1.8891.00
26_L105_L1.8861.00
187_N191_P1.8521.00
206_K209_K1.8261.00
76_V81_C1.7951.00
2_E137_Y1.7891.00
85_I88_V1.7621.00
29_S231_S1.7561.00
20_Y46_V1.7321.00
20_Y47_Y1.7151.00
84_K87_N1.7011.00
23_S107_I1.6991.00
185_V188_M1.6991.00
171_S175_D1.6391.00
224_L227_P1.6171.00
34_L43_L1.6101.00
67_F70_V1.5871.00
95_D99_G1.5841.00
171_S174_N1.5381.00
75_T101_S1.5331.00
46_V148_L1.5201.00
182_I186_I1.5041.00
196_D199_K1.5021.00
49_I76_V1.4481.00
178_N185_V1.4221.00
42_T152_E1.4191.00
91_K94_A1.4081.00
181_V186_I1.3941.00
197_I200_I1.3931.00
141_L157_M1.3681.00
33_L106_M1.3511.00
126_Y129_Y1.3321.00
141_L153_S1.3271.00
225_N228_M1.3251.00
93_I96_I1.3161.00
222_N227_P1.3101.00
53_L56_Y1.3051.00
125_A129_Y1.2941.00
18_I173_G1.2841.00
158_Q161_K1.2821.00
31_K102_D1.2811.00
25_T29_S1.2781.00
94_A98_S1.2751.00
181_V185_V1.2741.00
40_T115_S1.2731.00
215_E221_F1.2641.00
7_A110_N1.2611.00
127_Y130_L1.2611.00
85_I89_E1.2591.00
47_Y76_V1.2571.00
173_G233_L1.2561.00
154_L203_L1.2531.00
23_S34_L1.2531.00
228_M231_S1.2511.00
125_A128_T1.2481.00
171_S176_L1.2421.00
199_K203_L1.2391.00
5_D110_N1.2271.00
44_S80_G1.2231.00
83_R88_V1.2131.00
189_Y192_R1.2021.00
139_L160_F1.2011.00
63_S67_F1.1981.00
51_G54_L1.1961.00
60_G63_S1.1901.00
196_D201_K1.1831.00
83_R87_N1.1701.00
198_S201_K1.1671.00
57_L60_G1.1671.00
182_I185_V1.1651.00
186_I189_Y1.1541.00
18_I22_L1.1511.00
26_L32_I1.1461.00
58_T61_Q1.1371.00
37_K108_V1.1361.00
83_R86_K1.1261.00
223_Q228_M1.1201.00
197_I201_K1.1141.00
214_K218_Y1.1041.00
174_N177_V1.1021.00
200_I203_L1.0991.00
92_K96_I1.0941.00
77_V81_C1.0891.00
84_K88_V1.0891.00
18_I142_I1.0821.00
172_L176_L1.0821.00
103_H106_M1.0821.00
27_A74_L1.0791.00
3_R108_V1.0781.00
174_N178_N1.0751.00
176_L212_F1.0751.00
213_K226_T1.0681.00
184_S188_M1.0681.00
47_Y74_L1.0551.00
45_R151_D1.0501.00
6_I107_I1.0501.00
229_E232_E1.0491.00
35_I108_V1.0461.00
24_K28_A1.0371.00
232_E236_Y1.0351.00
31_K104_D1.0341.00
57_L61_Q1.0341.00
185_V189_Y1.0291.00
17_F216_A1.0191.00
186_I190_N1.0181.00
198_S209_K1.0081.00
7_A156_F1.0021.00
22_L237_V1.0021.00
232_E235_K1.0021.00
172_L175_D0.9991.00
228_M232_E0.9951.00
30_H104_D0.9871.00
23_S43_L0.9831.00
175_D178_N0.9781.00
90_P97_Y0.9751.00
69_E75_T0.9731.00
4_I168_L0.9701.00
22_L234_A0.9651.00
66_Y69_E0.9591.00
2_E30_H0.9581.00
199_K202_D0.9531.00
16_S43_L0.9501.00
59_V62_S0.9421.00
6_I140_I0.9391.00
180_D186_I0.9371.00
57_L62_S0.9371.00
186_I192_R0.9371.00
143_L149_L0.9331.00
180_D184_S0.9301.00
35_I106_M0.9121.00
55_S59_V0.9031.00
210_I226_T0.8961.00
6_I22_L0.8951.00
56_Y61_Q0.8911.00
188_M192_R0.8771.00
184_S192_R0.8761.00
168_L171_S0.8741.00
138_N166_N0.8711.00
183_S189_Y0.8701.00
214_K217_I0.8691.00
68_K71_D0.8661.00
182_I189_Y0.8641.00
79_V82_S0.8641.00
67_F71_D0.8591.00
225_N229_E0.8591.00
213_K216_A0.8591.00
90_P94_A0.8551.00
210_I229_E0.8511.00
91_K95_D0.8501.00
189_Y193_E0.8481.00
196_D200_I0.8441.00
185_V192_R0.8421.00
138_N168_L0.8391.00
84_K89_E0.8331.00
198_S202_D0.8261.00
110_N118_C0.8211.00
73_G77_V0.8121.00
21_F24_K0.8121.00
83_R89_E0.8061.00
194_R198_S0.8041.00
193_E196_D0.8011.00
177_V209_K0.8001.00
221_F224_L0.8001.00
195_I199_K0.7951.00
205_S236_Y0.7941.00
59_V63_S0.7901.00
165_K168_L0.7901.00
226_T229_E0.7831.00
91_K96_I0.7711.00
182_I188_M0.7711.00
56_Y59_V0.7681.00
179_F186_I0.7681.00
76_V79_V0.7671.00
24_K72_S0.7651.00
167_E171_S0.7631.00
78_N81_C0.7621.00
119_L159_L0.7571.00
25_T231_S0.7531.00
219_T222_N0.7481.00
51_G55_S0.7471.00
233_L237_V0.7431.00
187_N190_N0.7411.00
171_S205_S0.7361.00
231_S235_K0.7341.00
183_S187_N0.7331.00
22_L140_I0.7281.00
139_L165_K0.7271.00
93_I97_Y0.7221.00
181_V188_M0.7211.00
126_Y130_L0.7201.00
154_L158_Q0.7201.00
39_L117_V0.7191.00
70_V75_T0.7081.00
90_P93_I0.7081.00
216_A226_T0.7051.00
4_I138_N0.7041.00
7_A153_S0.7021.00
180_D183_S0.7021.00
92_K95_D0.7021.00
44_S78_N0.6991.00
42_T148_L0.6941.00
213_K224_L0.6871.00
190_N194_R0.6831.00
77_V100_F0.6811.00
181_V192_R0.6781.00
220_P223_Q0.6741.00
90_P96_I0.6710.99
226_T230_I0.6690.99
66_Y70_V0.6680.99
42_T151_D0.6680.99
188_M191_P0.6650.99
125_A130_L0.6650.99
32_I105_L0.6640.99
183_S192_R0.6630.99
230_I233_L0.6620.99
195_I198_S0.6580.99
194_R197_I0.6580.99
56_Y60_G0.6580.99
140_I173_G0.6570.99
27_A73_G0.6550.99
230_I234_A0.6460.99
210_I233_L0.6440.99
185_V190_N0.6420.99
93_I117_V0.6390.99
91_K100_F0.6380.99
2_E105_L0.6370.99
63_S68_K0.6360.99
178_N187_N0.6320.99
43_L76_V0.6320.99
179_F184_S0.6310.99
10_K13_V0.6280.99
24_K74_L0.6260.99
147_Q150_L0.6250.99
185_V209_K0.6250.99
61_Q67_F0.6230.99
179_F189_Y0.6200.99
66_Y71_D0.6200.99
96_I100_F0.6170.99
25_T28_A0.6150.99
138_N171_S0.6150.99
41_S80_G0.6140.99
233_L236_Y0.6140.99
58_T63_S0.6100.99
92_K99_G0.6090.99
144_P176_L0.6080.99
74_L78_N0.6080.99
184_S187_N0.6030.99
192_R196_D0.6020.99
193_E197_I0.6020.99
227_P231_S0.6020.99
52_N56_Y0.6010.99
5_D139_L0.5980.99
72_S75_T0.5980.99
77_V82_S0.5960.99
53_L58_T0.5960.99
184_S189_Y0.5940.99
95_D98_S0.5920.99
157_M161_K0.5910.99
18_I210_I0.5880.99
51_G59_V0.5850.99
41_S112_S0.5820.99
55_S58_T0.5780.98
227_P230_I0.5720.98
75_T78_N0.5720.98
143_L172_L0.5700.98
57_L63_S0.5690.98
45_R50_K0.5680.98
185_V193_E0.5650.98
45_R147_Q0.5630.98
192_R197_I0.5630.98
182_I190_N0.5620.98
185_V191_P0.5610.98
221_F227_P0.5610.98
62_S66_Y0.5600.98
3_R7_A0.5560.98
75_T79_V0.5560.98
183_S190_N0.5550.98
172_L177_V0.5540.98
143_L194_R0.5500.98
94_A99_G0.5490.98
151_D158_Q0.5450.98
17_F46_V0.5450.98
116_D119_L0.5430.98
34_L47_Y0.5430.98
107_I237_V0.5420.98
220_P226_T0.5420.98
92_K97_Y0.5420.98
63_S66_Y0.5410.98
4_I105_L0.5390.98
171_S177_V0.5360.98
6_I19_A0.5350.98
62_S67_F0.5340.98
156_F160_F0.5340.98
186_I193_E0.5330.97
144_P149_L0.5320.97
180_D185_V0.5310.97
90_P100_F0.5300.97
141_L156_F0.5290.97
73_G78_N0.5290.97
54_L57_L0.5260.97
206_K210_I0.5240.97
204_T208_V0.5230.97
183_S186_I0.5180.97
195_I200_I0.5180.97
173_G176_L0.5170.97
192_R195_I0.5140.97
90_P128_T0.5110.97
196_D202_D0.5060.97
151_D155_A0.5060.97
140_I233_L0.5060.97
195_I202_D0.5050.97
13_V149_L0.5030.96
28_A219_T0.5000.96
93_I100_F0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pg5A 2 0.8525 100 0.413 Contact Map
4rz3A 2 0.9139 100 0.425 Contact Map
3kjhA 2 0.8852 100 0.427 Contact Map
1wcv1 2 0.9057 100 0.44 Contact Map
4v03A 2 0.8893 100 0.444 Contact Map
1hyqA 1 0.8852 100 0.446 Contact Map
3ea0A 2 0.8893 100 0.45 Contact Map
4pfsA 1 0.8852 100 0.45 Contact Map
5aunB 2 0.8484 100 0.451 Contact Map
1g3qA 1 0.8975 100 0.453 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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