GREMLIN Database
Q97VX6 - Metabolite permease, putative
UniProt: Q97VX6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 505 (456)
Sequences: 11635 (7384)
Seq/√Len: 345.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
438_T479_V5.8771.00
369_T372_G4.0681.00
427_F480_S3.8741.00
270_D273_R3.7821.00
19_F23_Y3.3881.00
177_A385_K3.3301.00
438_T475_L3.2551.00
361_I368_I3.2311.00
434_A483_G3.0261.00
208_V212_L3.0241.00
435_G480_S2.9811.00
483_G487_A2.9311.00
481_V485_L2.9261.00
365_N372_G2.8731.00
428_N487_A2.8701.00
479_V483_G2.8661.00
442_S475_L2.7561.00
210_V297_L2.7551.00
371_K375_T2.7521.00
431_A484_T2.6961.00
219_H222_S2.6611.00
116_K125_A2.6521.00
430_W487_A2.6021.00
420_L480_S2.5911.00
375_T379_W2.4871.00
173_F389_L2.4651.00
164_V167_I2.4181.00
379_W383_V2.3641.00
185_L267_S2.3461.00
36_H43_R2.2681.00
45_L189_A2.2631.00
12_A16_V2.2171.00
231_A236_L2.1751.00
298_V316_V2.1221.00
368_I372_G2.1201.00
69_S314_A2.1071.00
13_L17_F2.1031.00
269_D273_R2.0941.00
428_N431_A2.0761.00
281_L284_Y2.0481.00
114_F421_G2.0251.00
123_I433_T2.0051.00
424_T427_F1.9971.00
417_A432_L1.9961.00
434_A479_V1.9661.00
170_I174_I1.9591.00
428_N484_T1.9511.00
15_I19_F1.9251.00
40_L43_R1.9141.00
37_E42_G1.8971.00
204_I208_V1.8961.00
119_F427_F1.8921.00
431_A483_G1.8891.00
61_A146_G1.8731.00
430_W434_A1.8631.00
202_T336_G1.8631.00
386_F390_A1.8501.00
478_V482_I1.8471.00
120_N123_I1.8201.00
358_R362_K1.8151.00
219_H223_V1.8031.00
273_R276_Y1.8031.00
222_S226_S1.7801.00
361_I365_N1.7761.00
365_N368_I1.7601.00
176_L345_A1.7491.00
222_S225_N1.7471.00
272_N276_Y1.7461.00
49_L193_V1.7421.00
361_I376_L1.7401.00
424_T485_L1.7341.00
183_S187_G1.7191.00
272_N275_M1.7141.00
420_L477_L1.7081.00
431_A435_G1.6851.00
108_Y117_D1.6791.00
20_L194_F1.6761.00
441_I445_Y1.6481.00
424_T481_V1.6461.00
331_G335_L1.6451.00
375_T378_K1.6241.00
426_W485_L1.6191.00
302_P323_S1.6051.00
362_K373_E1.5941.00
249_L252_A1.5911.00
356_L380_I1.5641.00
349_A385_K1.5581.00
426_W488_N1.5541.00
47_T273_R1.5391.00
434_A438_T1.5321.00
148_K169_L1.5171.00
319_A323_S1.5141.00
356_L360_V1.5051.00
7_I11_I1.5011.00
218_T222_S1.4901.00
249_L253_L1.4901.00
372_G375_T1.4821.00
166_E393_F1.4781.00
232_R235_T1.4721.00
192_G264_G1.4711.00
116_K122_S1.4661.00
11_I15_I1.4641.00
174_I178_A1.4501.00
113_D359_N1.4501.00
438_T442_S1.4491.00
120_N429_P1.4351.00
52_F193_V1.4301.00
247_L251_S1.4261.00
50_V268_A1.4211.00
231_A235_T1.4041.00
149_S312_G1.3901.00
95_T419_F1.3871.00
121_S429_P1.3791.00
361_I372_G1.3781.00
474_V478_V1.3761.00
176_L342_L1.3681.00
83_P87_L1.3601.00
130_L360_V1.3581.00
50_V53_L1.3491.00
281_L285_G1.3371.00
173_F385_K1.3331.00
113_D358_R1.3291.00
127_L433_T1.3291.00
6_G328_W1.3291.00
352_A384_I1.3131.00
368_I373_E1.3131.00
131_T440_I1.3111.00
169_L389_L1.3041.00
118_R421_G1.2961.00
215_G219_H1.2951.00
428_N488_N1.2841.00
223_V226_S1.2831.00
16_V20_L1.2771.00
47_T51_W1.2691.00
167_I171_V1.2591.00
233_Y236_L1.2591.00
247_L252_A1.2471.00
124_L433_T1.2441.00
166_E170_I1.2431.00
34_L37_E1.2421.00
192_G346_A1.2411.00
426_W489_A1.2401.00
39_G377_A1.2291.00
356_L361_I1.2211.00
116_K363_E1.2131.00
374_T378_K1.2121.00
475_L479_V1.2071.00
191_T346_A1.2061.00
18_I21_G1.1991.00
214_Y220_A1.1901.00
477_L481_V1.1841.00
372_G376_L1.1771.00
147_M172_S1.1751.00
217_F221_F1.1721.00
110_T354_N1.1681.00
427_F431_A1.1681.00
125_A359_N1.1671.00
114_F118_R1.1651.00
233_Y237_P1.1651.00
167_I170_I1.1611.00
41_A45_L1.1521.00
128_I436_W1.1471.00
130_L134_V1.1441.00
235_T238_S1.1431.00
53_L347_I1.1421.00
124_L432_L1.1371.00
144_I173_F1.1361.00
41_A185_L1.1311.00
195_K346_A1.1311.00
122_S363_E1.1301.00
426_W490_L1.1291.00
402_N406_L1.1281.00
400_A404_Q1.1201.00
403_L407_G1.1141.00
163_L168_S1.1141.00
430_W483_G1.1131.00
231_A234_T1.1091.00
197_I201_I1.1031.00
13_L21_G1.1011.00
57_D347_I1.1011.00
218_T221_F1.0981.00
17_F194_F1.0931.00
223_V300_A1.0911.00
179_F342_L1.0901.00
428_N483_G1.0831.00
71_L78_Y1.0831.00
17_F21_G1.0821.00
127_L436_W1.0811.00
442_S479_V1.0811.00
16_V19_F1.0801.00
435_G439_G1.0781.00
247_L253_L1.0771.00
377_A381_S1.0711.00
445_Y449_T1.0711.00
141_A391_F1.0681.00
400_A407_G1.0661.00
427_F484_T1.0651.00
152_Q165_S1.0611.00
321_I333_M1.0571.00
435_G476_N1.0531.00
201_I205_S1.0531.00
295_G299_Y1.0511.00
176_L346_A1.0501.00
429_P433_T1.0491.00
357_V377_A1.0491.00
380_I383_V1.0481.00
303_N308_V1.0471.00
282_P285_G1.0451.00
390_A394_L1.0451.00
474_V477_L1.0441.00
403_L408_G1.0431.00
170_I389_L1.0401.00
105_N271_K1.0351.00
123_I127_L1.0351.00
8_I12_A1.0231.00
13_L342_L1.0221.00
205_S209_I1.0131.00
55_G284_Y1.0121.00
368_I376_L1.0101.00
413_Q476_N1.0091.00
421_G432_L1.0041.00
209_I213_Q1.0031.00
479_V482_I1.0011.00
244_Y251_S0.9991.00
471_I474_V0.9951.00
220_A224_I0.9931.00
96_M100_W0.9851.00
152_Q157_G0.9851.00
417_A436_W0.9841.00
170_I393_F0.9841.00
32_L37_E0.9811.00
243_A247_L0.9801.00
401_I408_G0.9761.00
192_G347_I0.9751.00
205_S329_A0.9731.00
294_F298_V0.9721.00
469_A473_L0.9721.00
241_Q244_Y0.9701.00
475_L478_V0.9671.00
312_G315_L0.9671.00
51_W280_L0.9651.00
16_V194_F0.9631.00
39_G354_N0.9621.00
420_L427_F0.9611.00
36_H107_G0.9601.00
356_L384_I0.9561.00
370_P373_E0.9561.00
225_N228_N0.9541.00
122_S126_A0.9511.00
181_Y382_A0.9501.00
216_G219_H0.9491.00
48_V52_F0.9491.00
213_Q301_V0.9471.00
119_F421_G0.9461.00
50_V54_M0.9451.00
179_F346_A0.9451.00
318_P321_I0.9431.00
357_V376_L0.9411.00
53_L56_A0.9401.00
221_F225_N0.9381.00
404_Q407_G0.9371.00
57_D192_G0.9351.00
144_I169_L0.9351.00
430_W486_V0.9351.00
140_I388_A0.9331.00
404_Q408_G0.9321.00
406_L409_I0.9291.00
80_F84_Y0.9291.00
319_A322_T0.9281.00
8_I11_I0.9281.00
364_V368_I0.9261.00
115_V128_I0.9211.00
400_A403_L0.9171.00
376_L380_I0.9141.00
118_R424_T0.9141.00
90_A94_L0.9111.00
81_A84_Y0.9091.00
400_A408_G0.9091.00
401_I409_I0.9061.00
79_F83_P0.9051.00
445_Y448_F0.8991.00
21_G25_A0.8861.00
244_Y247_L0.8841.00
61_A341_G0.8841.00
350_I353_S0.8811.00
131_T436_W0.8781.00
115_V124_L0.8771.00
361_I364_V0.8761.00
439_G443_G0.8741.00
248_F251_S0.8741.00
310_K313_G0.8731.00
14_F17_F0.8721.00
195_K339_V0.8671.00
119_F480_S0.8651.00
353_S357_V0.8621.00
18_I22_F0.8621.00
240_L244_Y0.8611.00
234_T237_P0.8591.00
241_Q245_W0.8581.00
431_A434_A0.8571.00
231_A237_P0.8571.00
47_T276_Y0.8541.00
72_Y310_K0.8531.00
60_T139_Y0.8521.00
116_K121_S0.8521.00
106_R117_D0.8521.00
417_A476_N0.8521.00
386_F389_L0.8511.00
73_A313_G0.8481.00
179_F343_V0.8471.00
157_G164_V0.8471.00
56_A264_G0.8461.00
383_V387_L0.8461.00
191_T195_K0.8451.00
123_I429_P0.8431.00
51_W55_G0.8421.00
437_T441_I0.8411.00
10_F14_F0.8401.00
139_Y259_P0.8381.00
232_R237_P0.8361.00
424_T428_N0.8351.00
468_A472_A0.8351.00
294_F320_L0.8341.00
424_T431_A0.8311.00
32_L374_T0.8291.00
243_A249_L0.8281.00
401_I407_G0.8281.00
97_P275_M0.8261.00
308_V311_Y0.8231.00
71_L296_I0.8231.00
400_A405_L0.8221.00
295_G298_V0.8201.00
19_F22_F0.8191.00
53_L264_G0.8191.00
179_F195_K0.8181.00
221_F224_I0.8161.00
420_L481_V0.8151.00
52_F196_D0.8141.00
49_L189_A0.8131.00
343_V346_A0.8041.00
188_A191_T0.8021.00
214_Y300_A0.8001.00
212_L217_F0.7971.00
163_L171_V0.7951.00
402_N407_G0.7941.00
236_L239_N0.7921.00
53_L57_D0.7881.00
195_K343_V0.7871.00
381_S385_K0.7861.00
169_L392_V0.7861.00
23_Y190_L0.7851.00
133_V356_L0.7841.00
246_S251_S0.7841.00
89_F93_M0.7831.00
127_L437_T0.7821.00
97_P271_K0.7821.00
70_S74_K0.7821.00
268_A274_L0.7781.00
476_N480_S0.7781.00
321_I330_A0.7771.00
80_F83_P0.7741.00
22_F182_T0.7741.00
93_M279_A0.7721.00
247_L250_G0.7681.00
439_G476_N0.7671.00
64_F203_V0.7641.00
389_L393_F0.7631.00
156_L163_L0.7611.00
279_A283_I0.7601.00
315_L319_A0.7601.00
203_V291_I0.7581.00
297_L301_V0.7571.00
81_A85_V0.7561.00
94_L98_K0.7561.00
213_Q324_T0.7551.00
18_I178_A0.7551.00
47_T280_L0.7531.00
13_L339_V0.7521.00
188_A347_I0.7461.00
293_L296_I0.7451.00
439_G442_S0.7441.00
427_F435_G0.7421.00
442_S446_M0.7401.00
248_F252_A0.7401.00
41_A267_S0.7381.00
46_G273_R0.7381.00
442_S445_Y0.7350.99
56_A195_K0.7350.99
433_T437_T0.7350.99
477_L480_S0.7340.99
290_I294_F0.7340.99
206_V210_V0.7340.99
98_K423_Y0.7300.99
438_T483_G0.7300.99
179_F187_G0.7300.99
424_T484_T0.7280.99
12_A19_F0.7280.99
165_S169_L0.7270.99
143_Q344_P0.7250.99
432_L439_G0.7250.99
151_L168_S0.7240.99
195_K344_P0.7240.99
446_M471_I0.7230.99
235_T239_N0.7220.99
223_V227_A0.7220.99
291_I295_G0.7200.99
210_V213_Q0.7190.99
291_I294_F0.7190.99
243_A246_S0.7190.99
48_V51_W0.7180.99
400_A406_L0.7170.99
64_F333_M0.7170.99
149_S314_A0.7170.99
126_A129_A0.7150.99
79_F82_V0.7150.99
53_L189_A0.7110.99
220_A297_L0.7110.99
298_V320_L0.7110.99
428_N489_A0.7100.99
9_V328_W0.7080.99
390_A393_F0.7060.99
478_V481_V0.7050.99
168_S172_S0.7050.99
299_Y303_N0.7050.99
133_V352_A0.7040.99
20_L24_G0.7040.99
482_I485_L0.7030.99
96_M274_L0.7020.99
14_F18_I0.6990.99
200_W204_I0.6990.99
6_G330_A0.6980.99
405_L409_I0.6970.99
401_I406_L0.6960.99
244_Y248_F0.6960.99
420_L424_T0.6950.99
195_K342_L0.6950.99
362_K366_P0.6950.99
211_P216_G0.6950.99
362_K370_P0.6910.99
76_A296_I0.6900.99
60_T64_F0.6900.99
128_I414_T0.6890.99
94_L97_P0.6860.99
234_T238_S0.6860.99
120_N491_G0.6840.99
416_P477_L0.6830.99
430_W488_N0.6830.99
35_L39_G0.6830.99
53_L192_G0.6830.99
22_F25_A0.6820.99
8_I15_I0.6810.99
47_T50_V0.6800.99
126_A360_V0.6800.99
190_L193_V0.6790.99
473_L476_N0.6770.99
185_L189_A0.6760.99
440_I444_T0.6760.99
268_A273_R0.6750.99
287_G291_I0.6740.99
17_F25_A0.6730.99
344_P348_M0.6720.99
361_I366_P0.6710.99
21_G24_G0.6700.99
288_L291_I0.6700.99
296_I299_Y0.6690.99
315_L318_P0.6690.99
328_W332_I0.6680.99
246_S252_A0.6670.99
10_F338_F0.6660.99
180_T346_A0.6660.99
227_A299_Y0.6650.99
205_S208_V0.6640.99
406_L444_T0.6630.99
143_Q345_A0.6630.99
244_Y249_L0.6630.99
466_M470_V0.6620.99
482_I486_V0.6610.99
294_F299_Y0.6610.99
126_A130_L0.6600.99
38_W381_S0.6600.99
45_L50_V0.6590.99
135_A410_L0.6590.99
426_W429_P0.6580.99
357_V373_E0.6580.99
147_M341_G0.6560.99
17_F24_G0.6560.99
373_E377_A0.6560.99
209_I212_L0.6560.99
206_V317_V0.6560.99
356_L376_L0.6540.99
487_A490_L0.6540.99
6_G9_V0.6530.99
51_W54_M0.6510.99
149_S152_Q0.6510.99
379_W382_A0.6510.99
488_N491_G0.6490.99
224_I299_Y0.6480.99
18_I25_A0.6470.99
481_V484_T0.6470.99
121_S124_L0.6470.99
232_R236_L0.6470.99
292_A296_I0.6460.99
441_I444_T0.6460.99
87_L91_I0.6430.99
70_S78_Y0.6430.99
320_L324_T0.6420.99
48_V193_V0.6420.99
325_M329_A0.6420.99
486_V489_A0.6410.99
348_M351_A0.6400.99
88_T92_A0.6400.99
451_G454_R0.6390.99
256_Y259_P0.6370.99
406_L447_F0.6360.99
434_A437_T0.6360.99
353_S377_A0.6360.99
304_A310_K0.6350.99
289_A295_G0.6340.98
9_V331_G0.6340.98
294_F297_L0.6310.98
245_W252_A0.6310.98
207_I290_I0.6310.98
72_Y316_V0.6300.98
33_D37_E0.6290.98
148_K165_S0.6290.98
188_A264_G0.6270.98
245_W250_G0.6250.98
243_A253_L0.6240.98
25_A182_T0.6210.98
349_A381_S0.6180.98
113_D117_D0.6160.98
467_Y471_I0.6160.98
100_W271_K0.6140.98
112_A128_I0.6130.98
192_G343_V0.6120.98
13_L195_K0.6120.98
426_W430_W0.6110.98
14_F21_G0.6090.98
431_A479_V0.6080.98
177_A382_A0.6060.98
402_N408_G0.6060.98
206_V333_M0.6050.98
66_A139_Y0.6040.98
296_I300_A0.6030.98
248_F253_L0.6010.98
119_F420_L0.6010.98
470_V474_V0.6010.98
57_D260_H0.6000.98
442_S472_A0.6000.98
122_S125_A0.6000.98
109_V113_D0.5990.98
443_G472_A0.5970.98
37_E186_R0.5940.98
110_T359_N0.5930.98
132_G355_L0.5920.98
99_L262_I0.5920.98
139_Y348_M0.5910.98
483_G486_V0.5880.98
405_L408_G0.5870.98
436_W439_G0.5870.98
145_V149_S0.5870.98
169_L173_F0.5860.97
415_L419_F0.5840.97
227_A230_S0.5840.97
120_N124_L0.5830.97
290_I295_G0.5810.97
63_T288_L0.5800.97
69_S313_G0.5800.97
123_I126_A0.5800.97
353_S381_S0.5790.97
231_A238_S0.5790.97
401_I405_L0.5780.97
170_I386_F0.5770.97
224_I296_I0.5770.97
432_L435_G0.5770.97
404_Q409_I0.5760.97
36_H370_P0.5750.97
472_A476_N0.5740.97
79_F87_L0.5740.97
291_I299_Y0.5730.97
46_G49_L0.5730.97
186_R190_L0.5730.97
430_W433_T0.5730.97
211_P220_A0.5710.97
84_Y100_W0.5700.97
233_Y239_N0.5690.97
469_A476_N0.5670.97
214_Y219_H0.5660.97
449_T453_P0.5650.97
56_A196_D0.5640.97
6_G331_G0.5640.97
46_G50_V0.5630.97
435_G438_T0.5630.97
57_D264_G0.5620.97
204_I207_I0.5620.97
293_L297_L0.5620.97
58_L408_G0.5610.97
72_Y304_A0.5610.97
14_F22_F0.5600.97
211_P217_F0.5580.97
201_I204_I0.5580.97
144_I187_G0.5580.97
214_Y223_V0.5580.97
83_P86_S0.5560.97
220_A223_V0.5550.97
212_L216_G0.5550.97
353_S380_I0.5530.96
55_G196_D0.5530.96
357_V380_I0.5530.96
299_Y316_V0.5530.96
195_K340_G0.5510.96
225_N230_S0.5510.96
450_F454_R0.5510.96
240_L243_A0.5500.96
139_Y143_Q0.5500.96
81_A88_T0.5490.96
259_P263_N0.5490.96
342_L346_A0.5490.96
416_P480_S0.5490.96
310_K315_L0.5470.96
402_N405_L0.5450.96
444_T448_F0.5450.96
246_S249_L0.5450.96
79_F84_Y0.5440.96
115_V417_A0.5430.96
140_I345_A0.5430.96
303_N309_S0.5430.96
348_M414_T0.5430.96
45_L267_S0.5420.96
276_Y280_L0.5410.96
57_D180_T0.5410.96
325_M333_M0.5410.96
60_T143_Q0.5400.96
294_F317_V0.5400.96
152_Q164_V0.5380.96
188_A350_I0.5380.96
241_Q246_S0.5370.96
401_I404_Q0.5360.96
448_F453_P0.5360.96
276_Y279_A0.5350.96
242_I245_W0.5350.96
88_T91_I0.5340.96
302_P316_V0.5330.96
88_T95_T0.5330.96
364_V367_S0.5330.96
38_W378_K0.5320.96
149_S153_M0.5310.96
170_I173_F0.5310.96
264_G347_I0.5300.96
58_L84_Y0.5290.95
326_P329_A0.5290.95
64_F69_S0.5290.95
388_A392_V0.5270.95
177_A181_Y0.5270.95
173_F392_V0.5260.95
31_N37_E0.5250.95
125_A129_A0.5250.95
189_A192_G0.5240.95
246_S250_G0.5230.95
179_F183_S0.5230.95
369_T375_T0.5220.95
260_H351_A0.5220.95
124_L128_I0.5220.95
389_L392_V0.5200.95
340_G343_V0.5190.95
265_S278_T0.5180.95
111_A418_V0.5160.95
50_V55_G0.5160.95
174_I382_A0.5160.95
447_F468_A0.5160.95
143_Q146_G0.5150.95
304_A309_S0.5130.95
24_G190_L0.5120.95
426_W484_T0.5120.95
124_L429_P0.5120.95
378_K381_S0.5120.95
58_L285_G0.5070.94
243_A250_G0.5060.94
90_A252_A0.5060.94
327_D331_G0.5050.94
163_L167_I0.5030.94
112_A132_G0.5030.94
219_H300_A0.5010.94
310_K319_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9089 100 0.246 Contact Map
3dh4A 3 0.8653 100 0.29 Contact Map
3l1lA 2 0.8139 99.2 0.86 Contact Map
3giaA 1 0.8317 99 0.873 Contact Map
4wgvA 2 0.7386 99 0.874 Contact Map
4djkA 2 0.8059 98.8 0.881 Contact Map
2jlnA 1 0.8218 98.4 0.898 Contact Map
2wswA 3 0.7881 95.1 0.936 Contact Map
4c7rA 3 0.8495 94.2 0.939 Contact Map
4us3A 1 0.7822 90.4 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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