NPD - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

NPD - NAD-dependent protein deacetylase

UniProt:	Q97VX5	Sequences: MIYEKVAEELISSSYTIAFTGAGISTASGIPDFRGPQGLWKKYSPELASIEYFEKDPKNFWGFYSLRMRGLFEAQPNKAHYSLAELEKMGIIKVIITQNIDGLHQKAGSKNVIELHGTMRRSYCVLCLRTYDSLNVLSMIEKGNLPPRCDCGGIIRPDVVLFGEPVKNIYEALSIAYESDLVISIGSSLTVYPANLIPQTVKERGGKLIILNMEETPLDSIADYVVREPVEISLPKILENVRQKILS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	247 (227)
Sequences:	5856 (4075)
Seq/√Len:	270.4

ECOLI - NPD
BACSU - NPD
SULSO - NPD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
27_A	231_E	3.928	1.00
28_S	77_N	3.210	1.00
78_K	235_P	2.747	1.00
94_V	175_I	2.675	1.00
105_Q	114_E	2.628	1.00
185_I	230_V	2.540	1.00
228_E	233_S	2.506	1.00
24_I	79_A	2.487	1.00
85_E	88_K	2.486	1.00
121_R	158_D	2.347	1.00
51_E	163_G	2.304	1.00
26_T	32_D	2.139	1.00
192_Y	196_L	2.128	1.00
228_E	232_I	2.123	1.00
84_A	88_K	2.105	1.00
18_A	83_L	2.103	1.00
201_V	206_G	2.083	1.00
192_Y	195_N	2.059	1.00
229_P	232_I	2.047	1.00
79_A	234_L	2.044	1.00
87_E	109_S	2.013	1.00
87_E	111_N	1.983	1.00
124_C	127_C	1.970	1.00
213_M	229_P	1.941	1.00
148_R	151_C	1.928	1.00
129_R	150_D	1.898	1.00
15_Y	93_K	1.874	1.00
131_Y	155_I	1.869	1.00
15_Y	178_E	1.858	1.00
79_A	230_V	1.856	1.00
127_C	151_C	1.832	1.00
18_A	183_I	1.784	1.00
140_I	143_G	1.782	1.00
83_L	95_I	1.746	1.00
85_E	89_M	1.738	1.00
75_Q	106_K	1.737	1.00
129_R	149_C	1.721	1.00
78_K	81_Y	1.713	1.00
27_A	229_P	1.704	1.00
94_V	113_I	1.666	1.00
50_I	54_E	1.657	1.00
82_S	234_L	1.631	1.00
236_K	239_E	1.622	1.00
82_S	238_L	1.602	1.00
130_T	158_D	1.568	1.00
17_I	179_S	1.562	1.00
113_I	171_E	1.513	1.00
49_S	52_Y	1.494	1.00
95_I	109_S	1.494	1.00
131_Y	149_C	1.493	1.00
202_K	223_D	1.481	1.00
15_Y	180_D	1.476	1.00
20_T	104_H	1.454	1.00
207_K	223_D	1.437	1.00
174_S	178_E	1.430	1.00
211_L	233_S	1.426	1.00
123_Y	158_D	1.409	1.00
58_K	62_G	1.406	1.00
124_C	151_C	1.394	1.00
216_T	219_D	1.391	1.00
115_L	194_A	1.381	1.00
82_S	235_P	1.380	1.00
181_L	209_I	1.361	1.00
32_D	35_G	1.352	1.00
109_S	112_V	1.345	1.00
118_T	121_R	1.335	1.00
114_E	118_T	1.322	1.00
87_E	110_K	1.304	1.00
47_L	52_Y	1.299	1.00
82_S	86_L	1.287	1.00
123_Y	130_T	1.283	1.00
75_Q	81_Y	1.278	1.00
176_A	197_I	1.277	1.00
37_Q	41_K	1.269	1.00
226_V	233_S	1.269	1.00
173_L	200_T	1.265	1.00
20_T	24_I	1.261	1.00
185_I	234_L	1.255	1.00
177_Y	200_T	1.250	1.00
15_Y	175_I	1.241	1.00
176_A	182_V	1.238	1.00
30_I	74_A	1.231	1.00
210_I	222_A	1.224	1.00
113_I	175_I	1.218	1.00
207_K	224_Y	1.209	1.00
210_I	216_T	1.208	1.00
81_Y	85_E	1.206	1.00
62_G	66_L	1.204	1.00
181_L	207_K	1.203	1.00
35_G	41_K	1.199	1.00
210_I	219_D	1.187	1.00
185_I	211_L	1.180	1.00
86_L	238_L	1.167	1.00
20_T	83_L	1.163	1.00
53_F	125_V	1.157	1.00
48_A	52_Y	1.156	1.00
18_A	92_I	1.154	1.00
20_T	95_I	1.152	1.00
53_F	156_R	1.149	1.00
85_E	238_L	1.148	1.00
77_N	231_E	1.143	1.00
102_G	106_K	1.130	1.00
84_A	107_A	1.129	1.00
34_R	38_G	1.119	1.00
13_S	181_L	1.116	1.00
121_R	130_T	1.115	1.00
17_I	96_I	1.104	1.00
82_S	85_E	1.103	1.00
105_Q	112_V	1.097	1.00
56_D	59_N	1.081	1.00
60_F	161_L	1.070	1.00
115_L	166_V	1.068	1.00
125_V	153_G	1.061	1.00
124_C	148_R	1.054	1.00
156_R	164_E	1.051	1.00
169_I	197_I	1.045	1.00
15_Y	91_I	1.039	1.00
31_P	42_K	1.037	1.00
102_G	114_E	1.029	1.00
102_G	120_R	1.026	1.00
146_P	149_C	1.024	1.00
104_H	109_S	1.011	1.00
54_E	125_V	1.011	1.00
50_I	53_F	1.008	1.00
64_Y	67_R	1.007	1.00
49_S	53_F	1.007	1.00
84_A	109_S	0.999	1.00
228_E	236_K	0.998	1.00
16_T	91_I	0.989	1.00
132_D	135_N	0.986	1.00
19_F	194_A	0.975	1.00
115_L	172_A	0.975	1.00
31_P	70_G	0.973	1.00
126_L	153_G	0.973	1.00
122_S	155_I	0.959	1.00
14_S	180_D	0.956	1.00
137_L	143_G	0.954	1.00
208_L	222_A	0.953	1.00
232_I	236_K	0.953	1.00
137_L	140_I	0.944	1.00
219_D	225_V	0.944	1.00
235_P	238_L	0.937	1.00
183_I	209_I	0.929	1.00
215_E	227_R	0.928	1.00
171_E	174_S	0.923	1.00
59_N	62_G	0.915	1.00
46_E	55_K	0.913	1.00
125_V	154_I	0.909	1.00
88_K	110_K	0.891	1.00
102_G	118_T	0.885	1.00
53_F	161_L	0.882	1.00
102_G	105_Q	0.875	1.00
69_R	73_E	0.871	1.00
46_E	59_N	0.871	1.00
169_I	173_L	0.869	1.00
219_D	222_A	0.868	1.00
50_I	163_G	0.867	1.00
46_E	49_S	0.863	1.00
135_N	149_C	0.853	1.00
20_T	185_I	0.851	1.00
48_A	161_L	0.849	1.00
46_E	52_Y	0.845	1.00
171_E	175_I	0.844	1.00
63_F	67_R	0.836	1.00
216_T	222_A	0.828	0.99
79_A	229_P	0.826	0.99
17_I	182_V	0.824	0.99
111_N	171_E	0.820	0.99
48_A	53_F	0.815	0.99
79_A	185_I	0.814	0.99
123_Y	156_R	0.807	0.99
211_L	226_V	0.806	0.99
127_C	153_G	0.802	0.99
40_W	48_A	0.801	0.99
71_L	74_A	0.800	0.99
57_P	61_W	0.798	0.99
16_T	181_L	0.796	0.99
189_L	210_I	0.796	0.99
78_K	82_S	0.788	0.99
53_F	57_P	0.786	0.99
193_P	198_P	0.777	0.99
168_N	171_E	0.766	0.99
31_P	37_Q	0.766	0.99
16_T	180_D	0.766	0.99
13_S	16_T	0.765	0.99
19_F	182_V	0.764	0.99
60_F	64_Y	0.761	0.99
147_P	154_I	0.758	0.99
85_E	239_E	0.757	0.99
184_S	187_S	0.756	0.99
122_S	133_S	0.756	0.99
78_K	231_E	0.754	0.99
96_I	194_A	0.749	0.99
162_F	191_V	0.747	0.99
66_L	70_G	0.746	0.99
22_A	25_S	0.746	0.99
232_I	235_P	0.743	0.99
173_L	177_Y	0.743	0.99
48_A	67_R	0.741	0.99
188_S	191_V	0.737	0.99
70_G	74_A	0.736	0.99
52_Y	56_D	0.736	0.99
61_W	146_P	0.735	0.99
17_I	176_A	0.734	0.99
133_S	137_L	0.730	0.99
175_I	178_E	0.727	0.99
53_F	56_D	0.726	0.99
46_E	51_E	0.719	0.98
19_F	197_I	0.717	0.98
100_I	159_V	0.716	0.98
106_K	120_R	0.716	0.98
15_Y	94_V	0.713	0.98
72_F	120_R	0.712	0.98
201_V	207_K	0.712	0.98
69_R	72_F	0.710	0.98
47_L	50_I	0.699	0.98
64_Y	159_V	0.689	0.98
72_F	134_L	0.689	0.98
143_G	146_P	0.688	0.98
170_Y	173_L	0.688	0.98
64_Y	119_M	0.688	0.98
95_I	104_H	0.684	0.98
27_A	77_N	0.684	0.98
124_C	153_G	0.684	0.98
214_E	225_V	0.680	0.98
66_L	69_R	0.675	0.98
51_E	54_E	0.674	0.98
133_S	136_V	0.672	0.98
214_E	227_R	0.667	0.98
45_P	52_Y	0.666	0.98
234_L	238_L	0.666	0.98
46_E	50_I	0.665	0.98
231_E	235_P	0.664	0.97
79_A	231_E	0.662	0.97
25_S	101_D	0.660	0.97
33_F	38_G	0.660	0.97
179_S	206_G	0.659	0.97
209_I	224_Y	0.654	0.97
156_R	161_L	0.654	0.97
24_I	104_H	0.651	0.97
51_E	55_K	0.651	0.97
184_S	189_L	0.651	0.97
199_Q	221_I	0.651	0.97
199_Q	218_L	0.649	0.97
24_I	185_I	0.646	0.97
127_C	148_R	0.645	0.97
43_Y	46_E	0.643	0.97
61_W	145_L	0.641	0.97
145_L	154_I	0.639	0.97
33_F	64_Y	0.637	0.97
184_S	208_L	0.636	0.97
94_V	111_N	0.636	0.97
51_E	56_D	0.634	0.97
160_V	164_E	0.632	0.97
83_L	185_I	0.631	0.97
166_V	193_P	0.629	0.97
17_I	197_I	0.629	0.97
233_S	237_I	0.624	0.96
209_I	212_N	0.621	0.96
100_I	119_M	0.621	0.96
182_V	206_G	0.621	0.96
183_I	237_I	0.621	0.96
49_S	164_E	0.620	0.96
18_A	93_K	0.619	0.96
157_P	164_E	0.617	0.96
89_M	238_L	0.615	0.96
96_I	172_A	0.613	0.96
211_L	237_I	0.613	0.96
114_E	120_R	0.612	0.96
65_S	68_M	0.611	0.96
200_T	203_E	0.609	0.96
102_G	119_M	0.607	0.96
46_E	56_D	0.605	0.96
172_A	197_I	0.605	0.96
17_I	175_I	0.601	0.96
176_A	179_S	0.596	0.95
49_S	56_D	0.593	0.95
210_I	225_V	0.586	0.95
84_A	87_E	0.574	0.94
71_L	120_R	0.572	0.94
157_P	161_L	0.571	0.94
170_Y	174_S	0.570	0.94
179_S	182_V	0.569	0.94
31_P	35_G	0.568	0.94
192_Y	199_Q	0.567	0.94
26_T	35_G	0.567	0.94
47_L	63_F	0.565	0.94
93_K	175_I	0.564	0.94
43_Y	59_N	0.564	0.94
64_Y	161_L	0.563	0.94
35_G	214_E	0.563	0.94
122_S	136_V	0.563	0.94
94_V	112_V	0.562	0.94
213_M	227_R	0.558	0.93
82_S	185_I	0.558	0.93
45_P	49_S	0.553	0.93
209_I	237_I	0.549	0.93
217_P	222_A	0.549	0.93
97_T	114_E	0.545	0.93
13_S	180_D	0.544	0.92
235_P	239_E	0.544	0.92
215_E	225_V	0.541	0.92
202_K	221_I	0.538	0.92
209_I	226_V	0.536	0.92
52_Y	59_N	0.535	0.92
63_F	68_M	0.533	0.92
16_T	93_K	0.532	0.92
53_F	61_W	0.531	0.92
40_W	162_F	0.529	0.91
123_Y	128_L	0.529	0.91
169_I	172_A	0.529	0.91
72_F	137_L	0.527	0.91
131_Y	136_V	0.527	0.91
123_Y	167_K	0.527	0.91
68_M	72_F	0.527	0.91
125_V	156_R	0.525	0.91
199_Q	203_E	0.521	0.91
146_P	154_I	0.520	0.91
137_L	141_E	0.519	0.91
219_D	227_R	0.519	0.91
56_D	62_G	0.518	0.91
36_P	41_K	0.517	0.91
161_L	164_E	0.516	0.90
63_F	66_L	0.515	0.90
128_L	149_C	0.513	0.90
70_G	73_E	0.512	0.90
229_P	233_S	0.512	0.90
30_I	71_L	0.511	0.90
158_D	167_K	0.511	0.90
18_A	185_I	0.509	0.90
31_P	41_K	0.506	0.90
24_I	77_N	0.506	0.90
64_Y	68_M	0.506	0.90
127_C	130_T	0.506	0.90
213_M	228_E	0.505	0.89
176_A	208_L	0.502	0.89
80_H	98_Q	0.502	0.89
196_L	199_Q	0.501	0.89
147_P	152_G	0.500	0.89
45_P	48_A	0.500	0.89

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yc5A	1	0.9393	100	0.101	Contact Map
1m2kA	1	0.9757	100	0.126	Contact Map
4iaoA	1	0.9838	100	0.127	Contact Map
5btrA	1	0.9838	100	0.127	Contact Map
4twjA	1	0.9312	100	0.128	Contact Map
3riyA	1	0.9676	100	0.134	Contact Map
2hjhA	2	0.9838	100	0.136	Contact Map
4kxqA	1	0.9838	100	0.138	Contact Map
3u31A	1	0.9919	100	0.142	Contact Map
1q14A	3	0.9352	100	0.155	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.