GREMLIN Database
NPD - NAD-dependent protein deacetylase
UniProt: Q97VX5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (227)
Sequences: 5856 (4075)
Seq/√Len: 270.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_A231_E3.9281.00
28_S77_N3.2101.00
78_K235_P2.7471.00
94_V175_I2.6751.00
105_Q114_E2.6281.00
185_I230_V2.5401.00
228_E233_S2.5061.00
24_I79_A2.4871.00
85_E88_K2.4861.00
121_R158_D2.3471.00
51_E163_G2.3041.00
26_T32_D2.1391.00
192_Y196_L2.1281.00
228_E232_I2.1231.00
84_A88_K2.1051.00
18_A83_L2.1031.00
201_V206_G2.0831.00
192_Y195_N2.0591.00
229_P232_I2.0471.00
79_A234_L2.0441.00
87_E109_S2.0131.00
87_E111_N1.9831.00
124_C127_C1.9701.00
213_M229_P1.9411.00
148_R151_C1.9281.00
129_R150_D1.8981.00
15_Y93_K1.8741.00
131_Y155_I1.8691.00
15_Y178_E1.8581.00
79_A230_V1.8561.00
127_C151_C1.8321.00
18_A183_I1.7841.00
140_I143_G1.7821.00
83_L95_I1.7461.00
85_E89_M1.7381.00
75_Q106_K1.7371.00
129_R149_C1.7211.00
78_K81_Y1.7131.00
27_A229_P1.7041.00
94_V113_I1.6661.00
50_I54_E1.6571.00
82_S234_L1.6311.00
236_K239_E1.6221.00
82_S238_L1.6021.00
130_T158_D1.5681.00
17_I179_S1.5621.00
113_I171_E1.5131.00
49_S52_Y1.4941.00
95_I109_S1.4941.00
131_Y149_C1.4931.00
202_K223_D1.4811.00
15_Y180_D1.4761.00
20_T104_H1.4541.00
207_K223_D1.4371.00
174_S178_E1.4301.00
211_L233_S1.4261.00
123_Y158_D1.4091.00
58_K62_G1.4061.00
124_C151_C1.3941.00
216_T219_D1.3911.00
115_L194_A1.3811.00
82_S235_P1.3801.00
181_L209_I1.3611.00
32_D35_G1.3521.00
109_S112_V1.3451.00
118_T121_R1.3351.00
114_E118_T1.3221.00
87_E110_K1.3041.00
47_L52_Y1.2991.00
82_S86_L1.2871.00
123_Y130_T1.2831.00
75_Q81_Y1.2781.00
176_A197_I1.2771.00
37_Q41_K1.2691.00
226_V233_S1.2691.00
173_L200_T1.2651.00
20_T24_I1.2611.00
185_I234_L1.2551.00
177_Y200_T1.2501.00
15_Y175_I1.2411.00
176_A182_V1.2381.00
30_I74_A1.2311.00
210_I222_A1.2241.00
113_I175_I1.2181.00
207_K224_Y1.2091.00
210_I216_T1.2081.00
81_Y85_E1.2061.00
62_G66_L1.2041.00
181_L207_K1.2031.00
35_G41_K1.1991.00
210_I219_D1.1871.00
185_I211_L1.1801.00
86_L238_L1.1671.00
20_T83_L1.1631.00
53_F125_V1.1571.00
48_A52_Y1.1561.00
18_A92_I1.1541.00
20_T95_I1.1521.00
53_F156_R1.1491.00
85_E238_L1.1481.00
77_N231_E1.1431.00
102_G106_K1.1301.00
84_A107_A1.1291.00
34_R38_G1.1191.00
13_S181_L1.1161.00
121_R130_T1.1151.00
17_I96_I1.1041.00
82_S85_E1.1031.00
105_Q112_V1.0971.00
56_D59_N1.0811.00
60_F161_L1.0701.00
115_L166_V1.0681.00
125_V153_G1.0611.00
124_C148_R1.0541.00
156_R164_E1.0511.00
169_I197_I1.0451.00
15_Y91_I1.0391.00
31_P42_K1.0371.00
102_G114_E1.0291.00
102_G120_R1.0261.00
146_P149_C1.0241.00
104_H109_S1.0111.00
54_E125_V1.0111.00
50_I53_F1.0081.00
64_Y67_R1.0071.00
49_S53_F1.0071.00
84_A109_S0.9991.00
228_E236_K0.9981.00
16_T91_I0.9891.00
132_D135_N0.9861.00
19_F194_A0.9751.00
115_L172_A0.9751.00
31_P70_G0.9731.00
126_L153_G0.9731.00
122_S155_I0.9591.00
14_S180_D0.9561.00
137_L143_G0.9541.00
208_L222_A0.9531.00
232_I236_K0.9531.00
137_L140_I0.9441.00
219_D225_V0.9441.00
235_P238_L0.9371.00
183_I209_I0.9291.00
215_E227_R0.9281.00
171_E174_S0.9231.00
59_N62_G0.9151.00
46_E55_K0.9131.00
125_V154_I0.9091.00
88_K110_K0.8911.00
102_G118_T0.8851.00
53_F161_L0.8821.00
102_G105_Q0.8751.00
69_R73_E0.8711.00
46_E59_N0.8711.00
169_I173_L0.8691.00
219_D222_A0.8681.00
50_I163_G0.8671.00
46_E49_S0.8631.00
135_N149_C0.8531.00
20_T185_I0.8511.00
48_A161_L0.8491.00
46_E52_Y0.8451.00
171_E175_I0.8441.00
63_F67_R0.8361.00
216_T222_A0.8280.99
79_A229_P0.8260.99
17_I182_V0.8240.99
111_N171_E0.8200.99
48_A53_F0.8150.99
79_A185_I0.8140.99
123_Y156_R0.8070.99
211_L226_V0.8060.99
127_C153_G0.8020.99
40_W48_A0.8010.99
71_L74_A0.8000.99
57_P61_W0.7980.99
16_T181_L0.7960.99
189_L210_I0.7960.99
78_K82_S0.7880.99
53_F57_P0.7860.99
193_P198_P0.7770.99
168_N171_E0.7660.99
31_P37_Q0.7660.99
16_T180_D0.7660.99
13_S16_T0.7650.99
19_F182_V0.7640.99
60_F64_Y0.7610.99
147_P154_I0.7580.99
85_E239_E0.7570.99
184_S187_S0.7560.99
122_S133_S0.7560.99
78_K231_E0.7540.99
96_I194_A0.7490.99
162_F191_V0.7470.99
66_L70_G0.7460.99
22_A25_S0.7460.99
232_I235_P0.7430.99
173_L177_Y0.7430.99
48_A67_R0.7410.99
188_S191_V0.7370.99
70_G74_A0.7360.99
52_Y56_D0.7360.99
61_W146_P0.7350.99
17_I176_A0.7340.99
133_S137_L0.7300.99
175_I178_E0.7270.99
53_F56_D0.7260.99
46_E51_E0.7190.98
19_F197_I0.7170.98
100_I159_V0.7160.98
106_K120_R0.7160.98
15_Y94_V0.7130.98
72_F120_R0.7120.98
201_V207_K0.7120.98
69_R72_F0.7100.98
47_L50_I0.6990.98
64_Y159_V0.6890.98
72_F134_L0.6890.98
143_G146_P0.6880.98
170_Y173_L0.6880.98
64_Y119_M0.6880.98
95_I104_H0.6840.98
27_A77_N0.6840.98
124_C153_G0.6840.98
214_E225_V0.6800.98
66_L69_R0.6750.98
51_E54_E0.6740.98
133_S136_V0.6720.98
214_E227_R0.6670.98
45_P52_Y0.6660.98
234_L238_L0.6660.98
46_E50_I0.6650.98
231_E235_P0.6640.97
79_A231_E0.6620.97
25_S101_D0.6600.97
33_F38_G0.6600.97
179_S206_G0.6590.97
209_I224_Y0.6540.97
156_R161_L0.6540.97
24_I104_H0.6510.97
51_E55_K0.6510.97
184_S189_L0.6510.97
199_Q221_I0.6510.97
199_Q218_L0.6490.97
24_I185_I0.6460.97
127_C148_R0.6450.97
43_Y46_E0.6430.97
61_W145_L0.6410.97
145_L154_I0.6390.97
33_F64_Y0.6370.97
184_S208_L0.6360.97
94_V111_N0.6360.97
51_E56_D0.6340.97
160_V164_E0.6320.97
83_L185_I0.6310.97
166_V193_P0.6290.97
17_I197_I0.6290.97
233_S237_I0.6240.96
209_I212_N0.6210.96
100_I119_M0.6210.96
182_V206_G0.6210.96
183_I237_I0.6210.96
49_S164_E0.6200.96
18_A93_K0.6190.96
157_P164_E0.6170.96
89_M238_L0.6150.96
96_I172_A0.6130.96
211_L237_I0.6130.96
114_E120_R0.6120.96
65_S68_M0.6110.96
200_T203_E0.6090.96
102_G119_M0.6070.96
46_E56_D0.6050.96
172_A197_I0.6050.96
17_I175_I0.6010.96
176_A179_S0.5960.95
49_S56_D0.5930.95
210_I225_V0.5860.95
84_A87_E0.5740.94
71_L120_R0.5720.94
157_P161_L0.5710.94
170_Y174_S0.5700.94
179_S182_V0.5690.94
31_P35_G0.5680.94
192_Y199_Q0.5670.94
26_T35_G0.5670.94
47_L63_F0.5650.94
93_K175_I0.5640.94
43_Y59_N0.5640.94
64_Y161_L0.5630.94
35_G214_E0.5630.94
122_S136_V0.5630.94
94_V112_V0.5620.94
213_M227_R0.5580.93
82_S185_I0.5580.93
45_P49_S0.5530.93
209_I237_I0.5490.93
217_P222_A0.5490.93
97_T114_E0.5450.93
13_S180_D0.5440.92
235_P239_E0.5440.92
215_E225_V0.5410.92
202_K221_I0.5380.92
209_I226_V0.5360.92
52_Y59_N0.5350.92
63_F68_M0.5330.92
16_T93_K0.5320.92
53_F61_W0.5310.92
40_W162_F0.5290.91
123_Y128_L0.5290.91
169_I172_A0.5290.91
72_F137_L0.5270.91
131_Y136_V0.5270.91
123_Y167_K0.5270.91
68_M72_F0.5270.91
125_V156_R0.5250.91
199_Q203_E0.5210.91
146_P154_I0.5200.91
137_L141_E0.5190.91
219_D227_R0.5190.91
56_D62_G0.5180.91
36_P41_K0.5170.91
161_L164_E0.5160.90
63_F66_L0.5150.90
128_L149_C0.5130.90
70_G73_E0.5120.90
229_P233_S0.5120.90
30_I71_L0.5110.90
158_D167_K0.5110.90
18_A185_I0.5090.90
31_P41_K0.5060.90
24_I77_N0.5060.90
64_Y68_M0.5060.90
127_C130_T0.5060.90
213_M228_E0.5050.89
176_A208_L0.5020.89
80_H98_Q0.5020.89
196_L199_Q0.5010.89
147_P152_G0.5000.89
45_P48_A0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yc5A 1 0.9393 100 0.101 Contact Map
1m2kA 1 0.9757 100 0.126 Contact Map
4iaoA 1 0.9838 100 0.127 Contact Map
5btrA 1 0.9838 100 0.127 Contact Map
4twjA 1 0.9312 100 0.128 Contact Map
3riyA 1 0.9676 100 0.134 Contact Map
2hjhA 2 0.9838 100 0.136 Contact Map
4kxqA 1 0.9838 100 0.138 Contact Map
3u31A 1 0.9919 100 0.142 Contact Map
1q14A 3 0.9352 100 0.155 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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