GREMLIN Database
Q97VX4 - Sugar phosphate nucleotydyl transferase
UniProt: Q97VX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (219)
Sequences: 22416 (13937)
Seq/√Len: 941.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_E181_P3.3371.00
34_R42_S3.1381.00
145_E153_D2.6991.00
38_E66_W2.6941.00
145_E152_I2.6651.00
51_S77_S2.5751.00
87_L91_G2.5421.00
5_H51_S2.4341.00
60_W64_I2.4161.00
179_Y197_E2.3311.00
147_K150_K2.3281.00
105_T173_R2.3261.00
51_S79_Y2.3031.00
147_K152_I2.3011.00
6_A49_I2.2941.00
6_A44_L2.2041.00
179_Y193_K2.0501.00
56_T60_W2.0121.00
94_R97_E1.9781.00
41_I52_F1.9471.00
130_M134_L1.8981.00
60_W82_I1.8781.00
193_K197_E1.8561.00
131_T134_L1.8331.00
81_S95_K1.8241.00
192_P196_K1.8171.00
61_E65_K1.8121.00
38_E42_S1.8051.00
153_D192_P1.7691.00
129_V133_S1.7501.00
44_L109_L1.7401.00
18_R22_D1.7051.00
93_L108_V1.7031.00
145_E162_N1.6941.00
10_A54_I1.6751.00
146_T164_W1.6681.00
70_N74_L1.6661.00
193_K196_K1.6551.00
200_L203_I1.6261.00
7_V96_V1.6211.00
24_R30_E1.5861.00
211_R221_E1.5731.00
64_I82_I1.5681.00
200_L204_K1.5621.00
53_V99_L1.5601.00
45_K76_I1.5531.00
62_V65_K1.5441.00
35_P38_E1.5401.00
24_R62_V1.5321.00
123_K131_T1.5291.00
105_T124_I1.4821.00
79_Y99_L1.4681.00
219_I223_S1.4611.00
28_L62_V1.4451.00
189_L192_P1.4401.00
53_V81_S1.4361.00
52_F76_I1.4251.00
135_V138_K1.4131.00
144_V151_I1.3841.00
105_T171_L1.3761.00
91_G95_K1.3611.00
129_V134_L1.3461.00
130_M133_S1.3411.00
104_N174_K1.3191.00
155_K161_E1.2981.00
215_T218_D1.2921.00
199_L202_G1.2871.00
209_Y225_D1.2831.00
110_N168_G1.2811.00
13_Y86_P1.2591.00
94_R181_P1.2461.00
100_L106_F1.2421.00
220_E224_E1.2341.00
178_K181_P1.2321.00
91_G94_R1.2241.00
105_T174_K1.2151.00
183_K187_E1.2121.00
145_E155_K1.2061.00
56_T64_I1.2001.00
175_E178_K1.2001.00
179_Y182_E1.1961.00
53_V96_V1.1941.00
56_T82_I1.1941.00
178_K182_E1.1661.00
107_I171_L1.1601.00
129_V173_R1.1571.00
218_D221_E1.1451.00
136_P163_Y1.1381.00
129_V199_L1.1371.00
49_I107_I1.1301.00
68_S80_F1.1291.00
106_F174_K1.1281.00
56_T80_F1.1251.00
116_N209_Y1.1141.00
38_E70_N1.1131.00
139_S157_K1.1121.00
201_I204_K1.1101.00
213_I222_V1.1071.00
59_K62_V1.0961.00
28_L66_W1.0961.00
188_K192_P1.0881.00
56_T63_L1.0761.00
211_R225_D1.0761.00
182_E197_E1.0681.00
142_G156_E1.0661.00
179_Y190_T1.0641.00
88_G188_K1.0511.00
34_R39_W1.0431.00
37_I54_I1.0401.00
17_L29_I1.0361.00
64_I80_F1.0261.00
182_E193_K1.0201.00
37_I67_L1.0191.00
36_I213_I1.0161.00
172_M191_F1.0091.00
46_Q117_L1.0031.00
11_G55_L0.9981.00
150_K200_L0.9851.00
140_P218_D0.9831.00
37_I63_L0.9771.00
5_H104_N0.9761.00
127_E173_R0.9711.00
53_V79_Y0.9701.00
126_N201_I0.9681.00
128_N131_T0.9681.00
108_V172_M0.9671.00
224_E227_I0.9661.00
130_M172_M0.9641.00
103_E175_E0.9571.00
7_V106_F0.9561.00
94_R180_L0.9561.00
122_L171_L0.9531.00
166_N170_Y0.9491.00
42_S45_K0.9451.00
35_P66_W0.9451.00
128_N201_I0.9441.00
164_W204_K0.9431.00
220_E223_S0.9431.00
81_S99_L0.9351.00
34_R38_E0.9341.00
221_E224_E0.9341.00
17_L21_T0.9241.00
211_R222_V0.9131.00
223_S227_I0.9111.00
4_M104_N0.9091.00
5_H53_V0.9011.00
129_V132_M0.8951.00
42_S74_L0.8821.00
41_I67_L0.8821.00
76_I79_Y0.8791.00
27_P111_G0.8781.00
118_D121_K0.8771.00
140_P157_K0.8741.00
134_L137_L0.8711.00
8_I111_G0.8701.00
119_I122_L0.8671.00
217_K221_E0.8501.00
123_K126_N0.8501.00
30_E35_P0.8491.00
5_H101_S0.8431.00
139_S159_I0.8431.00
47_F120_S0.8411.00
134_L164_W0.8281.00
36_I40_Q0.8261.00
97_E177_F0.8231.00
134_L144_V0.8231.00
113_I210_W0.8211.00
61_E64_I0.8181.00
54_I78_T0.8171.00
41_I78_T0.8171.00
128_N132_M0.8161.00
89_T110_N0.8141.00
128_N150_K0.8111.00
184_G187_E0.8101.00
45_K52_F0.8101.00
221_E225_D0.8091.00
117_L120_S0.8061.00
64_I68_S0.8001.00
143_I165_I0.8001.00
76_I80_F0.7961.00
190_T193_K0.7951.00
21_T29_I0.7951.00
9_L110_N0.7921.00
45_K75_G0.7911.00
29_I219_I0.7851.00
45_K50_T0.7801.00
123_K128_N0.7791.00
122_L133_S0.7791.00
123_K129_V0.7761.00
25_P62_V0.7751.00
32_A223_S0.7701.00
175_E179_Y0.7671.00
150_K202_G0.7651.00
128_N202_G0.7641.00
46_Q120_S0.7581.00
35_P39_W0.7431.00
43_W117_L0.7401.00
7_V55_L0.7391.00
65_K68_S0.7381.00
32_A39_W0.7331.00
220_E227_I0.7331.00
50_T77_S0.7261.00
152_I155_K0.7201.00
93_L176_I0.7181.00
5_H100_L0.7171.00
97_E106_F0.7161.00
81_S96_V0.7151.00
43_W47_F0.7131.00
128_N133_S0.7101.00
109_L119_I0.7091.00
85_E184_G0.7061.00
55_L92_A0.7051.00
75_G78_T0.7051.00
189_L193_K0.7021.00
20_L216_I0.7001.00
33_G39_W0.7001.00
154_F166_N0.6981.00
45_K70_N0.6961.00
103_E174_K0.6961.00
6_A52_F0.6921.00
39_W226_L0.6921.00
79_Y82_I0.6861.00
101_S174_K0.6831.00
67_L78_T0.6781.00
38_E67_L0.6761.00
54_I67_L0.6731.00
30_E33_G0.6711.00
139_S160_L0.6681.00
97_E100_L0.6681.00
20_L24_R0.6681.00
155_K158_P0.6651.00
8_I109_L0.6621.00
14_G26_K0.6611.00
150_K201_I0.6581.00
39_W42_S0.6561.00
100_L177_F0.6551.00
55_L96_V0.6541.00
123_K133_S0.6541.00
122_L131_T0.6511.00
5_H106_F0.6501.00
41_I54_I0.6471.00
28_L63_L0.6441.00
86_P91_G0.6411.00
128_N200_L0.6411.00
41_I76_I0.6391.00
44_L107_I0.6341.00
194_L198_S0.6331.00
134_L163_Y0.6321.00
216_I220_E0.6311.00
212_S218_D0.6301.00
20_L29_I0.6271.00
89_T166_N0.6261.00
7_V53_V0.6251.00
151_I202_G0.6231.00
150_K199_L0.6231.00
109_L169_V0.6201.00
194_L199_L0.6181.00
98_R101_S0.6161.00
97_E101_S0.6151.00
97_E178_K0.6131.00
88_G189_L0.6101.00
124_I127_E0.6091.00
123_K127_E0.6081.00
114_I222_V0.6051.00
57_G86_P0.6051.00
43_W169_V0.6041.00
43_W46_Q0.6031.00
145_E161_E0.5981.00
8_I40_Q0.5931.00
137_L140_P0.5921.00
16_R26_K0.5891.00
9_L89_T0.5821.00
153_D196_K0.5811.00
185_D188_K0.5791.00
217_K220_E0.5781.00
175_E197_E0.5761.00
149_D204_K0.5731.00
31_V223_S0.5711.00
83_E92_A0.5711.00
13_Y18_R0.5671.00
55_L81_S0.5651.00
110_N113_I0.5621.00
192_P195_A0.5621.00
127_E131_T0.5611.00
140_P215_T0.5591.00
88_G185_D0.5581.00
129_V175_E0.5581.00
60_W63_L0.5581.00
39_W43_W0.5551.00
42_S70_N0.5551.00
134_L202_G0.5551.00
96_V99_L0.5541.00
176_I194_L0.5531.00
84_E95_K0.5531.00
132_M144_V0.5511.00
20_L23_D0.5491.00
50_T75_G0.5461.00
179_Y194_L0.5461.00
40_Q43_W0.5431.00
174_K177_F0.5401.00
125_S128_N0.5351.00
115_T169_V0.5331.00
175_E198_S0.5301.00
145_E163_Y0.5281.00
126_N131_T0.5261.00
91_G186_M0.5261.00
190_T194_L0.5261.00
27_P63_L0.5251.00
136_P162_N0.5241.00
137_L163_Y0.5231.00
41_I45_K0.5221.00
124_I129_V0.5211.00
66_W69_E0.5201.00
93_L177_F0.5201.00
25_P59_K0.5181.00
110_N169_V0.5171.00
43_W119_I0.5161.00
85_E91_G0.5091.00
40_Q109_L0.5081.00
175_E199_L0.5071.00
32_A226_L0.5061.00
141_Y156_E0.5051.00
115_T167_A0.5051.00
7_V93_L0.5031.00
87_L186_M0.5021.00
42_S46_Q0.5021.00
188_K191_F0.5001.00
94_R186_M0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tzfA 4 0.9578 100 0.326 Contact Map
3jukA 3 0.9536 100 0.327 Contact Map
2e3dA 3 0.9873 100 0.328 Contact Map
2ux8A 4 0.9916 100 0.329 Contact Map
2pa4A 3 0.9916 100 0.343 Contact Map
1iimA 3 0.9916 100 0.349 Contact Map
3brkX 2 0.9705 100 0.359 Contact Map
1yp2A 4 0.9831 100 0.359 Contact Map
4ecmA 3 0.9662 100 0.364 Contact Map
1lvwA 3 0.9873 100 0.367 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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