GREMLIN Database
Q97VX2 - Succinyl-CoA ligase [ADP-forming] subunit alpha
UniProt: Q97VX2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 260 (240)
Sequences: 4855 (2896)
Seq/√Len: 186.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_K175_E5.0331.00
29_T32_D3.1601.00
229_G247_I3.1281.00
91_R158_G2.8961.00
28_D32_D2.8861.00
59_V88_R2.8391.00
56_Y84_Y2.7161.00
237_I247_I2.6531.00
31_K57_E2.5651.00
122_G146_S2.4631.00
146_S174_T2.3101.00
66_I90_A2.2941.00
20_Q23_S2.2651.00
248_A257_L2.2451.00
236_K240_F2.2241.00
74_P78_M2.2091.00
56_Y80_R2.1731.00
240_F245_I2.1711.00
33_A39_A2.1701.00
46_V54_A2.1251.00
131_T148_V2.0751.00
55_I66_I2.0291.00
42_S58_A2.0231.00
206_A240_F2.0211.00
52_V80_R1.9631.00
159_T164_V1.9371.00
31_K60_D1.9141.00
195_Y245_I1.8901.00
58_A63_I1.8601.00
122_G174_T1.8301.00
46_V50_Y1.8301.00
18_G26_V1.8231.00
10_A27_Y1.8161.00
169_D201_K1.8151.00
53_D57_E1.8051.00
177_I200_I1.8031.00
178_V254_I1.7741.00
13_T17_G1.7701.00
79_A83_K1.7611.00
56_Y60_D1.7391.00
186_T190_R1.7381.00
102_A105_E1.7211.00
171_D174_T1.7201.00
68_T81_A1.7181.00
149_I164_V1.7101.00
59_V90_A1.6981.00
136_E140_N1.6871.00
12_V33_A1.6761.00
206_A245_I1.6321.00
121_I176_K1.6271.00
85_A92_I1.5871.00
56_Y87_A1.5791.00
179_V206_A1.5581.00
178_V258_L1.5511.00
165_A177_I1.5061.00
191_L195_Y1.5001.00
11_G24_V1.4851.00
42_S63_I1.4621.00
30_V58_A1.4571.00
83_K87_A1.4411.00
193_E197_R1.4401.00
121_I258_L1.4091.00
97_C150_G1.4031.00
59_V84_Y1.3801.00
82_I86_R1.3791.00
40_D64_K1.3751.00
51_A68_T1.3741.00
38_E61_A1.3651.00
44_I54_A1.3531.00
68_T92_I1.3481.00
239_A243_A1.3441.00
190_R193_E1.3361.00
122_G168_F1.3271.00
51_A73_I1.3021.00
82_I85_A1.2881.00
13_T28_D1.2861.00
41_A108_V1.2661.00
211_M249_N1.2621.00
169_D198_G1.2431.00
176_K258_L1.2251.00
205_I248_A1.2231.00
124_V164_V1.2201.00
123_I145_Q1.2201.00
119_G144_G1.2191.00
21_V26_V1.2141.00
93_I164_V1.2121.00
84_Y88_R1.2091.00
161_T181_G1.2031.00
191_L197_R1.1961.00
147_T168_F1.1921.00
53_D56_Y1.1901.00
30_V61_A1.1891.00
238_R242_E1.1831.00
93_I100_I1.1811.00
91_R159_T1.1791.00
55_I84_Y1.1771.00
183_I224_A1.1421.00
19_T28_D1.1351.00
10_A24_V1.1321.00
195_Y204_I1.1161.00
149_I168_F1.1111.00
190_R197_R1.1091.00
102_A147_T1.1071.00
27_Y34_M1.0991.00
130_L251_P1.0881.00
166_K170_Q1.0871.00
82_I155_P1.0851.00
166_K197_R1.0791.00
29_T57_E1.0731.00
8_I35_K1.0681.00
147_T174_T1.0641.00
169_D200_I1.0331.00
13_T18_G1.0331.00
249_N253_D1.0321.00
41_A67_V1.0251.00
118_K173_E1.0231.00
67_V100_I1.0161.00
9_V24_V1.0141.00
154_D185_G1.0040.99
11_G26_V1.0020.99
33_A38_E0.9840.99
192_A239_A0.9820.99
55_I81_A0.9750.99
17_G28_D0.9750.99
48_A70_T0.9710.99
234_E238_R0.9690.99
19_T26_V0.9680.99
104_E173_E0.9560.99
80_R83_K0.9530.99
10_A33_A0.9520.99
204_I245_I0.9510.99
54_A57_E0.9510.99
55_I90_A0.9390.99
34_M39_A0.9360.99
184_G236_K0.9310.99
154_D161_T0.9280.99
47_P50_Y0.9280.99
237_I241_K0.9240.99
181_G206_A0.9200.99
68_T85_A0.9190.99
124_V168_F0.9120.99
65_L91_R0.9070.99
246_P257_L0.9070.99
162_L194_A0.8980.99
169_D197_R0.8950.99
229_G237_I0.8890.99
135_S148_V0.8870.99
169_D194_A0.8870.99
78_M153_G0.8860.99
44_I51_A0.8850.99
10_A35_K0.8790.99
72_H75_V0.8780.99
98_P132_Y0.8720.99
20_Q24_V0.8710.99
145_Q148_V0.8710.99
170_Q197_R0.8700.99
138_L145_Q0.8680.98
250_T253_D0.8670.98
34_M61_A0.8650.98
56_Y59_V0.8620.98
117_K139_K0.8600.98
60_D88_R0.8580.98
66_I85_A0.8530.98
221_H224_A0.8520.98
83_K86_R0.8500.98
104_E118_K0.8460.98
41_A109_G0.8410.98
31_K61_A0.8410.98
59_V81_A0.8380.98
78_M82_I0.8340.98
21_V24_V0.8290.98
177_I198_G0.8290.98
98_P129_T0.8260.98
124_V151_I0.8250.98
220_G224_A0.8240.98
182_E221_H0.8220.98
85_A88_R0.8210.98
35_K38_E0.8190.98
253_D256_K0.8190.98
52_V81_A0.8160.98
103_P146_S0.8150.98
93_I159_T0.8120.98
125_S131_T0.8070.98
178_V205_I0.8040.98
165_A179_V0.8000.97
161_T179_V0.7970.97
11_G25_P0.7960.97
65_L93_I0.7940.97
160_S190_R0.7940.97
41_A65_L0.7800.97
176_K205_I0.7790.97
122_G147_T0.7760.97
62_G88_R0.7710.97
211_M237_I0.7690.97
52_V59_V0.7660.97
35_K61_A0.7610.97
217_K221_H0.7590.96
14_P17_G0.7570.96
73_I153_G0.7570.96
137_L255_P0.7540.96
71_E222_A0.7530.96
33_A61_A0.7490.96
165_A169_D0.7460.96
56_Y88_R0.7450.96
238_R241_K0.7380.96
218_R221_H0.7370.96
80_R84_Y0.7370.96
52_V56_Y0.7360.96
57_E60_D0.7350.96
11_G27_Y0.7300.96
116_F135_S0.7290.96
220_G225_V0.7290.96
241_K249_N0.7290.96
166_K190_R0.7280.96
59_V66_I0.7270.96
20_Q25_P0.7260.95
50_Y54_A0.7250.95
147_T167_M0.7210.95
205_I257_L0.7190.95
124_V179_V0.7150.95
235_S239_A0.7140.95
166_K194_A0.7110.95
248_A254_I0.7110.95
62_G90_A0.7100.95
228_M234_E0.7070.95
123_I138_L0.7050.95
169_D195_Y0.7040.95
215_R218_R0.7010.95
138_L255_P0.6970.94
8_I24_V0.6960.94
59_V85_A0.6950.94
159_T167_M0.6950.94
128_G223_G0.6800.94
151_I154_D0.6800.94
190_R195_Y0.6790.94
48_A73_I0.6770.93
59_V87_A0.6760.93
128_G182_E0.6730.93
218_R222_A0.6700.93
52_V84_Y0.6670.93
217_K223_G0.6670.93
30_V42_S0.6640.93
208_I247_I0.6630.93
221_H225_V0.6620.93
164_V168_F0.6600.93
19_T25_P0.6590.93
31_K35_K0.6590.93
57_E61_A0.6580.92
38_E63_I0.6510.92
141_S256_K0.6510.92
70_T97_C0.6490.92
125_S180_I0.6460.92
75_V153_G0.6440.92
151_I164_V0.6430.92
74_P77_D0.6410.92
71_E129_T0.6410.92
96_N153_G0.6400.91
45_F69_I0.6390.91
105_E118_K0.6380.91
35_K39_A0.6300.91
169_D199_E0.6280.91
81_A85_A0.6280.91
96_N221_H0.6250.90
166_K200_I0.6250.90
160_S163_E0.6240.90
217_K220_G0.6230.90
78_M85_A0.6210.90
48_A52_V0.6200.90
163_E190_R0.6160.90
30_V33_A0.6160.90
64_K90_A0.6150.90
48_A72_H0.6130.90
76_L79_A0.6110.89
123_I135_S0.6030.89
192_A195_Y0.6020.89
10_A34_M0.6010.89
50_Y53_D0.6000.89
47_P70_T0.6000.89
213_A216_E0.6000.89
10_A39_A0.5990.89
84_Y87_A0.5980.88
101_I116_F0.5980.88
59_V62_G0.5940.88
47_P128_G0.5940.88
64_K91_R0.5940.88
168_F177_I0.5910.88
198_G201_K0.5900.88
146_S175_E0.5890.88
10_A13_T0.5890.88
184_G191_L0.5860.87
218_R223_G0.5860.87
78_M155_P0.5860.87
194_A200_I0.5840.87
38_E62_G0.5820.87
162_L190_R0.5820.87
18_G28_D0.5810.87
73_I78_M0.5800.87
39_A62_G0.5790.87
221_H227_Y0.5780.87
218_R224_A0.5750.86
151_I161_T0.5750.86
211_M229_G0.5740.86
101_I110_I0.5680.86
103_P147_T0.5680.86
165_A198_G0.5670.86
128_G221_H0.5650.85
73_I77_D0.5610.85
139_K145_Q0.5600.85
91_R167_M0.5600.85
174_T202_K0.5560.85
112_P132_Y0.5540.84
165_A191_L0.5520.84
183_I223_G0.5510.84
217_K222_A0.5480.84
165_A194_A0.5480.84
236_K247_I0.5470.84
179_V204_I0.5450.83
122_G203_P0.5440.83
22_N26_V0.5440.83
207_Y254_I0.5430.83
55_I92_I0.5420.83
78_M81_A0.5400.83
87_A90_A0.5400.83
63_I90_A0.5390.83
131_T150_G0.5370.83
237_I249_N0.5360.82
39_A63_I0.5320.82
52_V55_I0.5290.82
51_A70_T0.5270.81
168_F174_T0.5250.81
85_A89_G0.5250.81
81_A84_Y0.5240.81
194_A242_E0.5240.81
109_G133_E0.5230.81
218_R226_V0.5210.81
34_M38_E0.5210.81
160_S186_T0.5200.80
166_K169_D0.5200.80
147_T173_E0.5180.80
33_A63_I0.5150.80
86_R158_G0.5140.80
97_C125_S0.5140.80
123_I134_V0.5130.80
98_P125_S0.5130.80
138_L258_L0.5130.80
174_T177_I0.5120.79
194_A197_R0.5110.79
193_E242_E0.5100.79
124_V161_T0.5070.79
196_K199_E0.5070.79
75_V78_M0.5060.79
150_G180_I0.5050.79
96_N223_G0.5050.79
13_T26_V0.5040.78
98_P131_T0.5030.78
10_A25_P0.5030.78
220_G223_G0.5020.78
180_I209_A0.5010.78
109_G112_P0.5010.78
190_R194_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pffA 2 0.9423 100 0.175 Contact Map
2csuA 2 0.8885 100 0.196 Contact Map
3mwdB 1 0.9423 100 0.221 Contact Map
2fp4A 1 1 100 0.273 Contact Map
2nu8A 1 0.9962 100 0.284 Contact Map
2yv1A 1 0.9192 100 0.285 Contact Map
1oi7A 1 0.9269 100 0.296 Contact Map
3dmyA 2 0.7962 100 0.305 Contact Map
2yv2A 1 0.9269 100 0.309 Contact Map
3ff4A 1 0.3692 99.8 0.729 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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