Q97VX2 - SULSO - GREMLIN Contacts

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Q97VX2 - Succinyl-CoA ligase [ADP-forming] subunit alpha

UniProt:	Q97VX2	Sequences: MLKYGTKIVAGVTPGKGGTQVNSVPVYDTVKDAMKEHEADASIIFVPARYAVDAIYEAVDAGIKLIVTITEHIPVLDMARAIKYARARGARIIGPNCPGIIAPEESLVGILPARAFKKGKIGIVSRSGTLTYEVSELLKNSGMGQSTVIGIGGDPIIGTSTLEVAKMFDQDPETEKIVVIGEIGGTMEERLAEAYKRGEIKKPIIAYIAGMTAPREKRMGHAGAVVYMGMGTFESKIRAFKEAGIPIANTPYDIPKLLLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	260 (240)
Sequences:	4855 (2896)
Seq/√Len:	186.9

ECOLI - PKA SUCD YAHF FDRA
BACSU - SUCD
HALSA - Q9HPP0 Q9HQZ0
SULSO - Q97VX2 Q97XD9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
120_K	175_E	5.033	1.00
29_T	32_D	3.160	1.00
229_G	247_I	3.128	1.00
91_R	158_G	2.896	1.00
28_D	32_D	2.886	1.00
59_V	88_R	2.839	1.00
56_Y	84_Y	2.716	1.00
237_I	247_I	2.653	1.00
31_K	57_E	2.565	1.00
122_G	146_S	2.463	1.00
146_S	174_T	2.310	1.00
66_I	90_A	2.294	1.00
20_Q	23_S	2.265	1.00
248_A	257_L	2.245	1.00
236_K	240_F	2.224	1.00
74_P	78_M	2.209	1.00
56_Y	80_R	2.173	1.00
240_F	245_I	2.171	1.00
33_A	39_A	2.170	1.00
46_V	54_A	2.125	1.00
131_T	148_V	2.075	1.00
55_I	66_I	2.029	1.00
42_S	58_A	2.023	1.00
206_A	240_F	2.021	1.00
52_V	80_R	1.963	1.00
159_T	164_V	1.937	1.00
31_K	60_D	1.914	1.00
195_Y	245_I	1.890	1.00
58_A	63_I	1.860	1.00
122_G	174_T	1.830	1.00
46_V	50_Y	1.830	1.00
18_G	26_V	1.823	1.00
10_A	27_Y	1.816	1.00
169_D	201_K	1.815	1.00
53_D	57_E	1.805	1.00
177_I	200_I	1.803	1.00
178_V	254_I	1.774	1.00
13_T	17_G	1.770	1.00
79_A	83_K	1.761	1.00
56_Y	60_D	1.739	1.00
186_T	190_R	1.738	1.00
102_A	105_E	1.721	1.00
171_D	174_T	1.720	1.00
68_T	81_A	1.718	1.00
149_I	164_V	1.710	1.00
59_V	90_A	1.698	1.00
136_E	140_N	1.687	1.00
12_V	33_A	1.676	1.00
206_A	245_I	1.632	1.00
121_I	176_K	1.627	1.00
85_A	92_I	1.587	1.00
56_Y	87_A	1.579	1.00
179_V	206_A	1.558	1.00
178_V	258_L	1.551	1.00
165_A	177_I	1.506	1.00
191_L	195_Y	1.500	1.00
11_G	24_V	1.485	1.00
42_S	63_I	1.462	1.00
30_V	58_A	1.457	1.00
83_K	87_A	1.441	1.00
193_E	197_R	1.440	1.00
121_I	258_L	1.409	1.00
97_C	150_G	1.403	1.00
59_V	84_Y	1.380	1.00
82_I	86_R	1.379	1.00
40_D	64_K	1.375	1.00
51_A	68_T	1.374	1.00
38_E	61_A	1.365	1.00
44_I	54_A	1.353	1.00
68_T	92_I	1.348	1.00
239_A	243_A	1.344	1.00
190_R	193_E	1.336	1.00
122_G	168_F	1.327	1.00
51_A	73_I	1.302	1.00
82_I	85_A	1.288	1.00
13_T	28_D	1.286	1.00
41_A	108_V	1.266	1.00
211_M	249_N	1.262	1.00
169_D	198_G	1.243	1.00
176_K	258_L	1.225	1.00
205_I	248_A	1.223	1.00
124_V	164_V	1.220	1.00
123_I	145_Q	1.220	1.00
119_G	144_G	1.219	1.00
21_V	26_V	1.214	1.00
93_I	164_V	1.212	1.00
84_Y	88_R	1.209	1.00
161_T	181_G	1.203	1.00
191_L	197_R	1.196	1.00
147_T	168_F	1.192	1.00
53_D	56_Y	1.190	1.00
30_V	61_A	1.189	1.00
238_R	242_E	1.183	1.00
93_I	100_I	1.181	1.00
91_R	159_T	1.179	1.00
55_I	84_Y	1.177	1.00
183_I	224_A	1.142	1.00
19_T	28_D	1.135	1.00
10_A	24_V	1.132	1.00
195_Y	204_I	1.116	1.00
149_I	168_F	1.111	1.00
190_R	197_R	1.109	1.00
102_A	147_T	1.107	1.00
27_Y	34_M	1.099	1.00
130_L	251_P	1.088	1.00
166_K	170_Q	1.087	1.00
82_I	155_P	1.085	1.00
166_K	197_R	1.079	1.00
29_T	57_E	1.073	1.00
8_I	35_K	1.068	1.00
147_T	174_T	1.064	1.00
169_D	200_I	1.033	1.00
13_T	18_G	1.033	1.00
249_N	253_D	1.032	1.00
41_A	67_V	1.025	1.00
118_K	173_E	1.023	1.00
67_V	100_I	1.016	1.00
9_V	24_V	1.014	1.00
154_D	185_G	1.004	0.99
11_G	26_V	1.002	0.99
33_A	38_E	0.984	0.99
192_A	239_A	0.982	0.99
55_I	81_A	0.975	0.99
17_G	28_D	0.975	0.99
48_A	70_T	0.971	0.99
234_E	238_R	0.969	0.99
19_T	26_V	0.968	0.99
104_E	173_E	0.956	0.99
80_R	83_K	0.953	0.99
10_A	33_A	0.952	0.99
204_I	245_I	0.951	0.99
54_A	57_E	0.951	0.99
55_I	90_A	0.939	0.99
34_M	39_A	0.936	0.99
184_G	236_K	0.931	0.99
154_D	161_T	0.928	0.99
47_P	50_Y	0.928	0.99
237_I	241_K	0.924	0.99
181_G	206_A	0.920	0.99
68_T	85_A	0.919	0.99
124_V	168_F	0.912	0.99
65_L	91_R	0.907	0.99
246_P	257_L	0.907	0.99
162_L	194_A	0.898	0.99
169_D	197_R	0.895	0.99
229_G	237_I	0.889	0.99
135_S	148_V	0.887	0.99
169_D	194_A	0.887	0.99
78_M	153_G	0.886	0.99
44_I	51_A	0.885	0.99
10_A	35_K	0.879	0.99
72_H	75_V	0.878	0.99
98_P	132_Y	0.872	0.99
20_Q	24_V	0.871	0.99
145_Q	148_V	0.871	0.99
170_Q	197_R	0.870	0.99
138_L	145_Q	0.868	0.98
250_T	253_D	0.867	0.98
34_M	61_A	0.865	0.98
56_Y	59_V	0.862	0.98
117_K	139_K	0.860	0.98
60_D	88_R	0.858	0.98
66_I	85_A	0.853	0.98
221_H	224_A	0.852	0.98
83_K	86_R	0.850	0.98
104_E	118_K	0.846	0.98
41_A	109_G	0.841	0.98
31_K	61_A	0.841	0.98
59_V	81_A	0.838	0.98
78_M	82_I	0.834	0.98
21_V	24_V	0.829	0.98
177_I	198_G	0.829	0.98
98_P	129_T	0.826	0.98
124_V	151_I	0.825	0.98
220_G	224_A	0.824	0.98
182_E	221_H	0.822	0.98
85_A	88_R	0.821	0.98
35_K	38_E	0.819	0.98
253_D	256_K	0.819	0.98
52_V	81_A	0.816	0.98
103_P	146_S	0.815	0.98
93_I	159_T	0.812	0.98
125_S	131_T	0.807	0.98
178_V	205_I	0.804	0.98
165_A	179_V	0.800	0.97
161_T	179_V	0.797	0.97
11_G	25_P	0.796	0.97
65_L	93_I	0.794	0.97
160_S	190_R	0.794	0.97
41_A	65_L	0.780	0.97
176_K	205_I	0.779	0.97
122_G	147_T	0.776	0.97
62_G	88_R	0.771	0.97
211_M	237_I	0.769	0.97
52_V	59_V	0.766	0.97
35_K	61_A	0.761	0.97
217_K	221_H	0.759	0.96
14_P	17_G	0.757	0.96
73_I	153_G	0.757	0.96
137_L	255_P	0.754	0.96
71_E	222_A	0.753	0.96
33_A	61_A	0.749	0.96
165_A	169_D	0.746	0.96
56_Y	88_R	0.745	0.96
238_R	241_K	0.738	0.96
218_R	221_H	0.737	0.96
80_R	84_Y	0.737	0.96
52_V	56_Y	0.736	0.96
57_E	60_D	0.735	0.96
11_G	27_Y	0.730	0.96
116_F	135_S	0.729	0.96
220_G	225_V	0.729	0.96
241_K	249_N	0.729	0.96
166_K	190_R	0.728	0.96
59_V	66_I	0.727	0.96
20_Q	25_P	0.726	0.95
50_Y	54_A	0.725	0.95
147_T	167_M	0.721	0.95
205_I	257_L	0.719	0.95
124_V	179_V	0.715	0.95
235_S	239_A	0.714	0.95
166_K	194_A	0.711	0.95
248_A	254_I	0.711	0.95
62_G	90_A	0.710	0.95
228_M	234_E	0.707	0.95
123_I	138_L	0.705	0.95
169_D	195_Y	0.704	0.95
215_R	218_R	0.701	0.95
138_L	255_P	0.697	0.94
8_I	24_V	0.696	0.94
59_V	85_A	0.695	0.94
159_T	167_M	0.695	0.94
128_G	223_G	0.680	0.94
151_I	154_D	0.680	0.94
190_R	195_Y	0.679	0.94
48_A	73_I	0.677	0.93
59_V	87_A	0.676	0.93
128_G	182_E	0.673	0.93
218_R	222_A	0.670	0.93
52_V	84_Y	0.667	0.93
217_K	223_G	0.667	0.93
30_V	42_S	0.664	0.93
208_I	247_I	0.663	0.93
221_H	225_V	0.662	0.93
164_V	168_F	0.660	0.93
19_T	25_P	0.659	0.93
31_K	35_K	0.659	0.93
57_E	61_A	0.658	0.92
38_E	63_I	0.651	0.92
141_S	256_K	0.651	0.92
70_T	97_C	0.649	0.92
125_S	180_I	0.646	0.92
75_V	153_G	0.644	0.92
151_I	164_V	0.643	0.92
74_P	77_D	0.641	0.92
71_E	129_T	0.641	0.92
96_N	153_G	0.640	0.91
45_F	69_I	0.639	0.91
105_E	118_K	0.638	0.91
35_K	39_A	0.630	0.91
169_D	199_E	0.628	0.91
81_A	85_A	0.628	0.91
96_N	221_H	0.625	0.90
166_K	200_I	0.625	0.90
160_S	163_E	0.624	0.90
217_K	220_G	0.623	0.90
78_M	85_A	0.621	0.90
48_A	52_V	0.620	0.90
163_E	190_R	0.616	0.90
30_V	33_A	0.616	0.90
64_K	90_A	0.615	0.90
48_A	72_H	0.613	0.90
76_L	79_A	0.611	0.89
123_I	135_S	0.603	0.89
192_A	195_Y	0.602	0.89
10_A	34_M	0.601	0.89
50_Y	53_D	0.600	0.89
47_P	70_T	0.600	0.89
213_A	216_E	0.600	0.89
10_A	39_A	0.599	0.89
84_Y	87_A	0.598	0.88
101_I	116_F	0.598	0.88
59_V	62_G	0.594	0.88
47_P	128_G	0.594	0.88
64_K	91_R	0.594	0.88
168_F	177_I	0.591	0.88
198_G	201_K	0.590	0.88
146_S	175_E	0.589	0.88
10_A	13_T	0.589	0.88
184_G	191_L	0.586	0.87
218_R	223_G	0.586	0.87
78_M	155_P	0.586	0.87
194_A	200_I	0.584	0.87
38_E	62_G	0.582	0.87
162_L	190_R	0.582	0.87
18_G	28_D	0.581	0.87
73_I	78_M	0.580	0.87
39_A	62_G	0.579	0.87
221_H	227_Y	0.578	0.87
218_R	224_A	0.575	0.86
151_I	161_T	0.575	0.86
211_M	229_G	0.574	0.86
101_I	110_I	0.568	0.86
103_P	147_T	0.568	0.86
165_A	198_G	0.567	0.86
128_G	221_H	0.565	0.85
73_I	77_D	0.561	0.85
139_K	145_Q	0.560	0.85
91_R	167_M	0.560	0.85
174_T	202_K	0.556	0.85
112_P	132_Y	0.554	0.84
165_A	191_L	0.552	0.84
183_I	223_G	0.551	0.84
217_K	222_A	0.548	0.84
165_A	194_A	0.548	0.84
236_K	247_I	0.547	0.84
179_V	204_I	0.545	0.83
122_G	203_P	0.544	0.83
22_N	26_V	0.544	0.83
207_Y	254_I	0.543	0.83
55_I	92_I	0.542	0.83
78_M	81_A	0.540	0.83
87_A	90_A	0.540	0.83
63_I	90_A	0.539	0.83
131_T	150_G	0.537	0.83
237_I	249_N	0.536	0.82
39_A	63_I	0.532	0.82
52_V	55_I	0.529	0.82
51_A	70_T	0.527	0.81
168_F	174_T	0.525	0.81
85_A	89_G	0.525	0.81
81_A	84_Y	0.524	0.81
194_A	242_E	0.524	0.81
109_G	133_E	0.523	0.81
218_R	226_V	0.521	0.81
34_M	38_E	0.521	0.81
160_S	186_T	0.520	0.80
166_K	169_D	0.520	0.80
147_T	173_E	0.518	0.80
33_A	63_I	0.515	0.80
86_R	158_G	0.514	0.80
97_C	125_S	0.514	0.80
123_I	134_V	0.513	0.80
98_P	125_S	0.513	0.80
138_L	258_L	0.513	0.80
174_T	177_I	0.512	0.79
194_A	197_R	0.511	0.79
193_E	242_E	0.510	0.79
124_V	161_T	0.507	0.79
196_K	199_E	0.507	0.79
75_V	78_M	0.506	0.79
150_G	180_I	0.505	0.79
96_N	223_G	0.505	0.79
13_T	26_V	0.504	0.78
98_P	131_T	0.503	0.78
10_A	25_P	0.503	0.78
220_G	223_G	0.502	0.78
180_I	209_A	0.501	0.78
109_G	112_P	0.501	0.78
190_R	194_A	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pffA	2	0.9423	100	0.175	Contact Map
2csuA	2	0.8885	100	0.196	Contact Map
3mwdB	1	0.9423	100	0.221	Contact Map
2fp4A	1	1	100	0.273	Contact Map
2nu8A	1	0.9962	100	0.284	Contact Map
2yv1A	1	0.9192	100	0.285	Contact Map
1oi7A	1	0.9269	100	0.296	Contact Map
3dmyA	2	0.7962	100	0.305	Contact Map
2yv2A	1	0.9269	100	0.309	Contact Map
3ff4A	1	0.3692	99.8	0.729	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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