GREMLIN Database
Q97VX1 - Succinyl-CoA synthetase, beta subunit (SucC)
UniProt: Q97VX1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (334)
Sequences: 2433 (1253)
Seq/√Len: 68.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_K318_E5.4541.00
290_I315_I5.3811.00
21_N77_E3.8481.00
199_E202_R3.4431.00
202_R207_D3.3871.00
199_E207_D3.2371.00
153_K157_D3.1591.00
234_K239_N3.0381.00
202_R206_R2.9411.00
129_S149_Q2.9351.00
204_E207_D2.7681.00
257_E260_L2.7061.00
311_L314_K2.6281.00
32_Q62_I2.4501.00
80_P172_N2.4421.00
199_E204_E2.4071.00
15_V157_D2.3681.00
119_M131_D2.3641.00
102_L135_A2.3441.00
34_K78_F2.3391.00
199_E205_V2.3161.00
3_L185_L2.3081.00
203_Q207_D2.2981.00
56_E60_N2.2881.00
146_Q150_G2.2631.00
198_K203_Q2.2581.00
26_S30_R2.2281.00
272_V332_G2.2261.00
199_E206_R2.2111.00
9_K76_E2.2071.00
82_E172_N2.1801.00
26_S72_K2.1701.00
109_D112_Q2.1451.00
201_G204_E2.1251.00
85_I170_L2.1121.00
117_K138_Y2.0701.00
122_P126_G2.0531.00
11_L154_L2.0481.00
119_M134_E2.0191.00
57_D60_N2.0091.00
252_R291_D1.9741.00
34_K56_E1.9641.00
18_P147_I1.9591.00
256_K295_E1.9561.00
202_R205_V1.9531.00
25_T30_R1.9431.00
17_I178_A1.9251.00
25_T31_W1.9181.00
14_R158_Y1.8631.00
201_G207_D1.8301.00
87_A148_I1.8271.00
130_Y133_V1.7961.00
308_N311_L1.7861.00
58_I61_T1.7621.00
206_R211_E1.7521.00
12_F181_S1.7071.00
154_L158_Y1.7041.00
10_S14_R1.7031.00
12_F154_L1.6861.00
100_L148_I1.6841.00
252_R287_L1.6690.99
185_L196_L1.6480.99
236_N330_M1.6420.99
13_K21_N1.6350.99
220_G226_T1.6310.99
37_V73_F1.6180.99
64_E67_K1.6120.99
330_M334_A1.6030.99
328_L331_I1.5980.99
203_Q206_R1.5690.99
63_L67_K1.5660.99
219_I262_V1.5480.99
64_E69_G1.5300.99
236_N334_A1.5260.99
280_T284_E1.5260.99
89_V98_P1.5150.99
22_G74_L1.5060.99
127_V132_I1.4960.99
287_L291_D1.4770.99
132_I136_E1.4680.99
305_L309_E1.4630.99
311_L315_I1.4560.99
80_P173_D1.4500.98
160_A163_V1.4480.98
287_L315_I1.4300.98
13_K19_V1.4260.98
91_L155_F1.4210.98
4_Y42_L1.4190.98
313_K327_V1.4110.98
8_G181_S1.4060.98
35_A61_T1.3930.98
28_P32_Q1.3910.98
199_E203_Q1.3780.98
65_L69_G1.3760.98
102_L139_L1.3750.98
158_Y195_D1.3740.98
100_L135_A1.3610.98
133_V137_K1.3610.98
36_V54_V1.3540.98
29_I62_I1.3470.98
32_Q61_T1.3440.98
81_H169_A1.3310.97
100_L121_I1.3200.97
34_K54_V1.3160.97
331_I335_V1.3000.97
128_R131_D1.2790.97
159_D192_R1.2730.97
48_K109_D1.2680.96
197_L207_D1.2660.96
14_R195_D1.2620.96
129_S133_V1.2580.96
201_G206_R1.2490.96
28_P58_I1.2440.96
50_G53_R1.2340.96
216_I238_G1.2300.96
314_K317_R1.2290.96
87_A102_L1.2170.95
201_G205_V1.2150.95
280_T309_E1.2090.95
324_Y335_V1.2060.95
260_L295_E1.1990.95
273_I289_I1.1950.95
49_R53_R1.1940.95
309_E313_K1.1860.95
281_R307_T1.1850.95
12_F17_I1.1840.95
253_E257_E1.1830.95
65_L68_L1.1730.94
32_Q59_Y1.1650.94
200_L204_E1.1530.94
79_V179_L1.1480.94
71_E201_G1.1450.94
28_P31_W1.1360.93
31_W61_T1.1350.93
2_K184_I1.1250.93
198_K207_D1.1240.93
83_K170_L1.1180.93
134_E138_Y1.1170.93
160_A183_V1.1160.93
284_E287_L1.1130.93
289_I302_V1.1130.93
28_P61_T1.1110.93
144_L148_I1.1110.93
97_E123_L1.1100.93
27_E31_W1.1070.93
158_Y193_H1.1030.92
287_L311_L1.1030.92
101_V116_V1.0920.92
20_P76_E1.0870.92
95_T120_I1.0760.92
79_V169_A1.0700.91
48_K108_I1.0660.91
132_I145_G1.0440.90
63_L69_G1.0360.90
158_Y196_L1.0350.90
326_D331_I1.0340.90
121_I152_Y1.0160.89
76_E179_L1.0120.89
198_K202_R1.0040.88
215_D269_K1.0030.88
300_I323_V0.9940.88
163_V183_V0.9920.88
162_L184_I0.9910.88
232_L236_N0.9870.88
43_E68_L0.9870.88
20_P79_V0.9750.87
280_T285_V0.9700.87
27_E30_R0.9670.86
24_V72_K0.9620.86
150_G153_K0.9580.86
121_I126_G0.9550.86
99_M118_K0.9520.86
15_V158_Y0.9370.85
129_S145_G0.9350.85
270_K301_F0.9330.84
32_Q58_I0.9290.84
171_T177_L0.9280.84
200_L203_Q0.9280.84
37_V75_V0.9260.84
89_V100_L0.9250.84
24_V73_F0.9250.84
128_R133_V0.9230.84
326_D335_V0.9210.84
250_A280_T0.9190.84
99_M120_I0.9180.83
44_G47_G0.9170.83
49_R66_K0.9150.83
265_N268_V0.9150.83
55_T61_T0.8980.82
88_S101_V0.8970.82
310_E314_K0.8940.82
10_S13_K0.8880.81
171_T175_R0.8870.81
132_I149_Q0.8870.81
78_F179_L0.8870.81
218_I226_T0.8860.81
63_L68_L0.8860.81
316_L323_V0.8840.81
101_V118_K0.8790.81
28_P73_F0.8760.80
273_I285_V0.8740.80
119_M138_Y0.8690.80
127_V148_I0.8690.80
25_T32_Q0.8680.80
215_D238_G0.8640.80
131_D134_E0.8520.79
223_A243_F0.8500.78
259_V273_I0.8470.78
254_H280_T0.8460.78
256_K260_L0.8430.78
109_D113_A0.8410.78
35_A55_T0.8410.78
169_A179_L0.8390.78
130_Y134_E0.8360.77
309_E331_I0.8330.77
82_E174_G0.8320.77
329_K332_G0.8310.77
17_I150_G0.8310.77
107_G180_D0.8230.76
54_V60_N0.8190.76
102_L144_L0.8190.76
198_K206_R0.8120.75
198_K201_G0.8120.75
58_I62_I0.8070.75
281_R311_L0.8060.75
78_F81_H0.8030.74
255_V288_G0.8030.74
25_T75_V0.8010.74
221_N225_L0.8010.74
154_L163_V0.8000.74
17_I20_P0.7990.74
22_G76_E0.7980.74
291_D294_K0.7970.74
25_T28_P0.7970.74
272_V329_K0.7940.74
289_I316_L0.7880.73
141_V170_L0.7860.73
98_P155_F0.7850.73
74_L185_L0.7810.72
252_R295_E0.7800.72
55_T60_N0.7780.72
79_V177_L0.7770.72
33_G57_D0.7760.72
132_I148_I0.7690.71
125_R131_D0.7680.71
291_D295_E0.7670.71
213_E267_R0.7670.71
200_L207_D0.7650.71
211_E267_R0.7640.71
197_L206_R0.7640.71
56_E78_F0.7630.71
34_K80_P0.7630.71
85_I141_V0.7610.70
105_E108_I0.7590.70
43_E66_K0.7570.70
20_P74_L0.7530.70
130_Y137_K0.7470.69
281_R284_E0.7470.69
216_I252_R0.7470.69
160_A185_L0.7470.69
39_S70_V0.7450.69
7_E42_L0.7440.69
95_T99_M0.7420.68
20_P177_L0.7410.68
163_V181_S0.7400.68
43_E220_G0.7390.68
41_L70_V0.7390.68
197_L203_Q0.7380.68
33_G58_I0.7350.68
3_L8_G0.7340.68
104_R140_G0.7310.67
135_A138_Y0.7270.67
18_P175_R0.7260.67
252_R284_E0.7200.66
284_E309_E0.7200.66
280_T304_L0.7200.66
34_K77_E0.7180.66
227_M276_Y0.7170.66
324_Y331_I0.7160.66
29_I32_Q0.7120.65
110_V116_V0.7110.65
216_I285_V0.7090.65
107_G111_E0.7090.65
107_G166_N0.7090.65
170_L176_I0.7070.65
254_H258_S0.7060.65
89_V155_F0.7040.64
133_V145_G0.7040.64
161_E184_I0.7030.64
198_K205_V0.7000.64
44_G111_E0.7000.64
294_K320_G0.6980.64
209_Y261_K0.6970.64
88_S163_V0.6970.64
92_D120_I0.6970.64
283_D308_N0.6960.63
12_F183_V0.6940.63
2_K49_R0.6920.63
254_H284_E0.6910.63
31_W75_V0.6910.63
218_I233_V0.6900.63
221_N274_N0.6890.63
230_M240_P0.6860.62
127_V131_D0.6850.62
147_I176_I0.6800.62
88_S109_D0.6800.62
128_R137_K0.6770.61
285_V304_L0.6770.61
243_F278_G0.6760.61
3_L74_L0.6720.61
119_M135_A0.6720.61
20_P179_L0.6720.61
293_L321_V0.6700.61
200_L205_V0.6680.60
84_E107_G0.6670.60
136_E148_I0.6660.60
12_F18_P0.6650.60
221_N245_D0.6640.60
245_D278_G0.6640.60
47_G108_I0.6630.60
104_R113_A0.6620.60
20_P77_E0.6600.59
216_I309_E0.6580.59
125_R130_Y0.6570.59
144_L176_I0.6570.59
278_G303_R0.6550.59
313_K325_D0.6550.59
317_R325_D0.6520.58
151_L163_V0.6490.58
11_L183_V0.6490.58
136_E144_L0.6480.58
190_L197_L0.6460.58
64_E68_L0.6430.57
87_A100_L0.6420.57
282_C302_V0.6410.57
77_E175_R0.6350.56
302_V325_D0.6340.56
88_S219_I0.6320.56
236_N258_S0.6300.56
227_M243_F0.6300.56
113_A116_V0.6290.56
16_G150_G0.6290.56
44_G182_K0.6280.56
223_A227_M0.6260.55
45_A66_K0.6260.55
100_L127_V0.6250.55
74_L160_A0.6240.55
331_I334_A0.6240.55
252_R256_K0.6230.55
288_G292_A0.6220.55
8_G183_V0.6200.55
164_E167_P0.6200.55
221_N244_L0.6170.54
183_V193_H0.6160.54
25_T73_F0.6150.54
91_L161_E0.6150.54
89_V148_I0.6140.54
4_Y7_E0.6110.54
243_F250_A0.6100.53
213_E239_N0.6080.53
246_V285_V0.6070.53
81_H179_L0.6070.53
279_I282_C0.6070.53
147_I168_L0.6060.53
200_L206_R0.6060.53
205_V257_E0.6050.53
12_F163_V0.6030.53
326_D329_K0.5980.52
305_L331_I0.5970.52
317_R327_V0.5960.52
106_G180_D0.5940.52
3_L183_V0.5940.52
92_D95_T0.5930.51
159_D193_H0.5910.51
244_L247_G0.5900.51
37_V59_Y0.5900.51
146_Q153_K0.5890.51
19_V154_L0.5880.51
122_P132_I0.5880.51
9_K74_L0.5870.51
82_E169_A0.5860.51
76_E79_V0.5850.50
97_E122_P0.5850.50
24_V28_P0.5840.50
142_K170_L0.5830.50
158_Y185_L0.5820.50
122_P125_R0.5800.50
184_I187_D0.5800.50
105_E109_D0.5790.50
221_N229_S0.5790.50
227_M247_G0.5760.49
208_S216_I0.5760.49
249_G279_I0.5750.49
105_E113_A0.5750.49
309_E326_D0.5730.49
274_N282_C0.5730.49
145_G149_Q0.5730.49
37_V61_T0.5730.49
14_R175_R0.5730.49
76_E141_V0.5720.49
209_Y265_N0.5720.49
88_S98_P0.5720.49
278_G282_C0.5720.49
275_I278_G0.5710.49
212_L243_F0.5710.49
102_L138_Y0.5700.49
280_T312_G0.5690.49
283_D307_T0.5690.49
13_K76_E0.5690.49
140_G143_G0.5680.48
229_S274_N0.5680.48
98_P120_I0.5670.48
17_I154_L0.5640.48
136_E143_G0.5610.48
221_N243_F0.5600.47
88_S152_Y0.5600.47
87_A135_A0.5600.47
251_N254_H0.5600.47
146_Q149_Q0.5590.47
38_K46_R0.5580.47
82_E171_T0.5570.47
111_E166_N0.5570.47
101_V155_F0.5530.47
93_R278_G0.5520.47
3_L41_L0.5500.46
92_D99_M0.5490.46
43_E182_K0.5480.46
280_T300_I0.5480.46
329_K334_A0.5470.46
154_L157_D0.5460.46
106_G166_N0.5460.46
93_R303_R0.5450.46
170_L174_G0.5440.46
293_L322_N0.5440.46
133_V136_E0.5430.45
92_D159_D0.5420.45
52_V56_E0.5410.45
226_T230_M0.5400.45
121_I127_V0.5400.45
88_S99_M0.5400.45
104_R117_K0.5380.45
8_G18_P0.5370.45
227_M282_C0.5360.45
43_E284_E0.5360.45
86_Y166_N0.5350.45
111_E116_V0.5350.45
98_P233_V0.5330.44
28_P62_I0.5320.44
126_G152_Y0.5320.44
256_K291_D0.5320.44
59_Y125_R0.5320.44
257_E266_P0.5310.44
276_Y279_I0.5300.44
225_L244_L0.5290.44
24_V71_E0.5290.44
110_V276_Y0.5280.44
272_V326_D0.5280.44
27_E62_I0.5250.43
274_N278_G0.5250.43
218_I280_T0.5250.43
269_K294_K0.5240.43
225_L243_F0.5230.43
245_D282_C0.5230.43
5_E9_K0.5220.43
104_R187_D0.5210.43
151_L155_F0.5210.43
104_R139_L0.5200.43
12_F147_I0.5190.43
41_L51_L0.5190.43
284_E313_K0.5190.43
223_A244_L0.5180.42
262_V268_V0.5160.42
210_V223_A0.5150.42
208_S258_S0.5150.42
8_G14_R0.5150.42
275_I282_C0.5150.42
290_I319_N0.5140.42
3_L7_E0.5130.42
228_A282_C0.5120.42
291_D311_L0.5110.42
110_V113_A0.5110.42
223_A250_A0.5100.42
93_R268_V0.5100.42
49_R162_L0.5100.42
286_A289_I0.5090.41
280_T319_N0.5090.41
282_C304_L0.5080.41
141_V144_L0.5080.41
315_I321_V0.5080.41
93_R220_G0.5080.41
182_K225_L0.5070.41
9_K13_K0.5060.41
281_R300_I0.5060.41
131_D137_K0.5060.41
327_V332_G0.5050.41
33_G61_T0.5050.41
92_D192_R0.5030.41
54_V59_Y0.5030.41
223_A274_N0.5030.41
221_N226_T0.5000.40
223_A245_D0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pffA 2 0.9911 100 0.229 Contact Map
3mwdA 2 0.9881 100 0.371 Contact Map
2nu8B 2 1 100 0.371 Contact Map
2fp4B 1 1 100 0.38 Contact Map
3ufxB 2 0.9941 100 0.415 Contact Map
1wr2A 1 0.5401 100 0.767 Contact Map
2csuA 2 0.9288 100 0.782 Contact Map
3va7A 1 0.7804 99 0.902 Contact Map
3e5nA 2 0.5193 98.9 0.905 Contact Map
3tqtA 2 0.549 98.9 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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