Q97VX1 - SULSO - GREMLIN Contacts

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Q97VX1 - Succinyl-CoA synthetase, beta subunit (SucC)

UniProt:	Q97VX1	Sequences: MKLYEYEGKSLFKRVGIPVPNGVVTSEPIRWQGKAVVKSQLLEGARGKRGLVRVTEDIYNTILELKKLGVEKFLVEEFVPHEKEIYASVLLDRETAEPMLVLSREGGIDVEQAKDVKKMIIPLERGVRSYDIVEAEKYLGVKGLGQIIQGLYKLFVDYDAELVEINPLALTNDGRILALDSKVILEDNALYRHEDLLKELGRQEVRDSYVELEGDIGIIGNGAGLTMASMDLVKLNGGNPANFLDVGGGANREHVKESVLKVGSNPRVKKIVINIYGGITRCDEVALGIIDALKEVKKPIFVRLLGTNEELGKKILRENGVNVYDDVLKMIGDAVRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	337 (334)
Sequences:	2433 (1253)
Seq/√Len:	68.5

ECOLI - SUCC
BACSU - SUCC
HALSA - SUCC
SULSO - Q97VX1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
314_K	318_E	5.454	1.00
290_I	315_I	5.381	1.00
21_N	77_E	3.848	1.00
199_E	202_R	3.443	1.00
202_R	207_D	3.387	1.00
199_E	207_D	3.237	1.00
153_K	157_D	3.159	1.00
234_K	239_N	3.038	1.00
202_R	206_R	2.941	1.00
129_S	149_Q	2.935	1.00
204_E	207_D	2.768	1.00
257_E	260_L	2.706	1.00
311_L	314_K	2.628	1.00
32_Q	62_I	2.450	1.00
80_P	172_N	2.442	1.00
199_E	204_E	2.407	1.00
15_V	157_D	2.368	1.00
119_M	131_D	2.364	1.00
102_L	135_A	2.344	1.00
34_K	78_F	2.339	1.00
199_E	205_V	2.316	1.00
3_L	185_L	2.308	1.00
203_Q	207_D	2.298	1.00
56_E	60_N	2.288	1.00
146_Q	150_G	2.263	1.00
198_K	203_Q	2.258	1.00
26_S	30_R	2.228	1.00
272_V	332_G	2.226	1.00
199_E	206_R	2.211	1.00
9_K	76_E	2.207	1.00
82_E	172_N	2.180	1.00
26_S	72_K	2.170	1.00
109_D	112_Q	2.145	1.00
201_G	204_E	2.125	1.00
85_I	170_L	2.112	1.00
117_K	138_Y	2.070	1.00
122_P	126_G	2.053	1.00
11_L	154_L	2.048	1.00
119_M	134_E	2.019	1.00
57_D	60_N	2.009	1.00
252_R	291_D	1.974	1.00
34_K	56_E	1.964	1.00
18_P	147_I	1.959	1.00
256_K	295_E	1.956	1.00
202_R	205_V	1.953	1.00
25_T	30_R	1.943	1.00
17_I	178_A	1.925	1.00
25_T	31_W	1.918	1.00
14_R	158_Y	1.863	1.00
201_G	207_D	1.830	1.00
87_A	148_I	1.827	1.00
130_Y	133_V	1.796	1.00
308_N	311_L	1.786	1.00
58_I	61_T	1.762	1.00
206_R	211_E	1.752	1.00
12_F	181_S	1.707	1.00
154_L	158_Y	1.704	1.00
10_S	14_R	1.703	1.00
12_F	154_L	1.686	1.00
100_L	148_I	1.684	1.00
252_R	287_L	1.669	0.99
185_L	196_L	1.648	0.99
236_N	330_M	1.642	0.99
13_K	21_N	1.635	0.99
220_G	226_T	1.631	0.99
37_V	73_F	1.618	0.99
64_E	67_K	1.612	0.99
330_M	334_A	1.603	0.99
328_L	331_I	1.598	0.99
203_Q	206_R	1.569	0.99
63_L	67_K	1.566	0.99
219_I	262_V	1.548	0.99
64_E	69_G	1.530	0.99
236_N	334_A	1.526	0.99
280_T	284_E	1.526	0.99
89_V	98_P	1.515	0.99
22_G	74_L	1.506	0.99
127_V	132_I	1.496	0.99
287_L	291_D	1.477	0.99
132_I	136_E	1.468	0.99
305_L	309_E	1.463	0.99
311_L	315_I	1.456	0.99
80_P	173_D	1.450	0.98
160_A	163_V	1.448	0.98
287_L	315_I	1.430	0.98
13_K	19_V	1.426	0.98
91_L	155_F	1.421	0.98
4_Y	42_L	1.419	0.98
313_K	327_V	1.411	0.98
8_G	181_S	1.406	0.98
35_A	61_T	1.393	0.98
28_P	32_Q	1.391	0.98
199_E	203_Q	1.378	0.98
65_L	69_G	1.376	0.98
102_L	139_L	1.375	0.98
158_Y	195_D	1.374	0.98
100_L	135_A	1.361	0.98
133_V	137_K	1.361	0.98
36_V	54_V	1.354	0.98
29_I	62_I	1.347	0.98
32_Q	61_T	1.344	0.98
81_H	169_A	1.331	0.97
100_L	121_I	1.320	0.97
34_K	54_V	1.316	0.97
331_I	335_V	1.300	0.97
128_R	131_D	1.279	0.97
159_D	192_R	1.273	0.97
48_K	109_D	1.268	0.96
197_L	207_D	1.266	0.96
14_R	195_D	1.262	0.96
129_S	133_V	1.258	0.96
201_G	206_R	1.249	0.96
28_P	58_I	1.244	0.96
50_G	53_R	1.234	0.96
216_I	238_G	1.230	0.96
314_K	317_R	1.229	0.96
87_A	102_L	1.217	0.95
201_G	205_V	1.215	0.95
280_T	309_E	1.209	0.95
324_Y	335_V	1.206	0.95
260_L	295_E	1.199	0.95
273_I	289_I	1.195	0.95
49_R	53_R	1.194	0.95
309_E	313_K	1.186	0.95
281_R	307_T	1.185	0.95
12_F	17_I	1.184	0.95
253_E	257_E	1.183	0.95
65_L	68_L	1.173	0.94
32_Q	59_Y	1.165	0.94
200_L	204_E	1.153	0.94
79_V	179_L	1.148	0.94
71_E	201_G	1.145	0.94
28_P	31_W	1.136	0.93
31_W	61_T	1.135	0.93
2_K	184_I	1.125	0.93
198_K	207_D	1.124	0.93
83_K	170_L	1.118	0.93
134_E	138_Y	1.117	0.93
160_A	183_V	1.116	0.93
284_E	287_L	1.113	0.93
289_I	302_V	1.113	0.93
28_P	61_T	1.111	0.93
144_L	148_I	1.111	0.93
97_E	123_L	1.110	0.93
27_E	31_W	1.107	0.93
158_Y	193_H	1.103	0.92
287_L	311_L	1.103	0.92
101_V	116_V	1.092	0.92
20_P	76_E	1.087	0.92
95_T	120_I	1.076	0.92
79_V	169_A	1.070	0.91
48_K	108_I	1.066	0.91
132_I	145_G	1.044	0.90
63_L	69_G	1.036	0.90
158_Y	196_L	1.035	0.90
326_D	331_I	1.034	0.90
121_I	152_Y	1.016	0.89
76_E	179_L	1.012	0.89
198_K	202_R	1.004	0.88
215_D	269_K	1.003	0.88
300_I	323_V	0.994	0.88
163_V	183_V	0.992	0.88
162_L	184_I	0.991	0.88
232_L	236_N	0.987	0.88
43_E	68_L	0.987	0.88
20_P	79_V	0.975	0.87
280_T	285_V	0.970	0.87
27_E	30_R	0.967	0.86
24_V	72_K	0.962	0.86
150_G	153_K	0.958	0.86
121_I	126_G	0.955	0.86
99_M	118_K	0.952	0.86
15_V	158_Y	0.937	0.85
129_S	145_G	0.935	0.85
270_K	301_F	0.933	0.84
32_Q	58_I	0.929	0.84
171_T	177_L	0.928	0.84
200_L	203_Q	0.928	0.84
37_V	75_V	0.926	0.84
89_V	100_L	0.925	0.84
24_V	73_F	0.925	0.84
128_R	133_V	0.923	0.84
326_D	335_V	0.921	0.84
250_A	280_T	0.919	0.84
99_M	120_I	0.918	0.83
44_G	47_G	0.917	0.83
49_R	66_K	0.915	0.83
265_N	268_V	0.915	0.83
55_T	61_T	0.898	0.82
88_S	101_V	0.897	0.82
310_E	314_K	0.894	0.82
10_S	13_K	0.888	0.81
171_T	175_R	0.887	0.81
132_I	149_Q	0.887	0.81
78_F	179_L	0.887	0.81
218_I	226_T	0.886	0.81
63_L	68_L	0.886	0.81
316_L	323_V	0.884	0.81
101_V	118_K	0.879	0.81
28_P	73_F	0.876	0.80
273_I	285_V	0.874	0.80
119_M	138_Y	0.869	0.80
127_V	148_I	0.869	0.80
25_T	32_Q	0.868	0.80
215_D	238_G	0.864	0.80
131_D	134_E	0.852	0.79
223_A	243_F	0.850	0.78
259_V	273_I	0.847	0.78
254_H	280_T	0.846	0.78
256_K	260_L	0.843	0.78
109_D	113_A	0.841	0.78
35_A	55_T	0.841	0.78
169_A	179_L	0.839	0.78
130_Y	134_E	0.836	0.77
309_E	331_I	0.833	0.77
82_E	174_G	0.832	0.77
329_K	332_G	0.831	0.77
17_I	150_G	0.831	0.77
107_G	180_D	0.823	0.76
54_V	60_N	0.819	0.76
102_L	144_L	0.819	0.76
198_K	206_R	0.812	0.75
198_K	201_G	0.812	0.75
58_I	62_I	0.807	0.75
281_R	311_L	0.806	0.75
78_F	81_H	0.803	0.74
255_V	288_G	0.803	0.74
25_T	75_V	0.801	0.74
221_N	225_L	0.801	0.74
154_L	163_V	0.800	0.74
17_I	20_P	0.799	0.74
22_G	76_E	0.798	0.74
291_D	294_K	0.797	0.74
25_T	28_P	0.797	0.74
272_V	329_K	0.794	0.74
289_I	316_L	0.788	0.73
141_V	170_L	0.786	0.73
98_P	155_F	0.785	0.73
74_L	185_L	0.781	0.72
252_R	295_E	0.780	0.72
55_T	60_N	0.778	0.72
79_V	177_L	0.777	0.72
33_G	57_D	0.776	0.72
132_I	148_I	0.769	0.71
125_R	131_D	0.768	0.71
291_D	295_E	0.767	0.71
213_E	267_R	0.767	0.71
200_L	207_D	0.765	0.71
211_E	267_R	0.764	0.71
197_L	206_R	0.764	0.71
56_E	78_F	0.763	0.71
34_K	80_P	0.763	0.71
85_I	141_V	0.761	0.70
105_E	108_I	0.759	0.70
43_E	66_K	0.757	0.70
20_P	74_L	0.753	0.70
130_Y	137_K	0.747	0.69
281_R	284_E	0.747	0.69
216_I	252_R	0.747	0.69
160_A	185_L	0.747	0.69
39_S	70_V	0.745	0.69
7_E	42_L	0.744	0.69
95_T	99_M	0.742	0.68
20_P	177_L	0.741	0.68
163_V	181_S	0.740	0.68
43_E	220_G	0.739	0.68
41_L	70_V	0.739	0.68
197_L	203_Q	0.738	0.68
33_G	58_I	0.735	0.68
3_L	8_G	0.734	0.68
104_R	140_G	0.731	0.67
135_A	138_Y	0.727	0.67
18_P	175_R	0.726	0.67
252_R	284_E	0.720	0.66
284_E	309_E	0.720	0.66
280_T	304_L	0.720	0.66
34_K	77_E	0.718	0.66
227_M	276_Y	0.717	0.66
324_Y	331_I	0.716	0.66
29_I	32_Q	0.712	0.65
110_V	116_V	0.711	0.65
216_I	285_V	0.709	0.65
107_G	111_E	0.709	0.65
107_G	166_N	0.709	0.65
170_L	176_I	0.707	0.65
254_H	258_S	0.706	0.65
89_V	155_F	0.704	0.64
133_V	145_G	0.704	0.64
161_E	184_I	0.703	0.64
198_K	205_V	0.700	0.64
44_G	111_E	0.700	0.64
294_K	320_G	0.698	0.64
209_Y	261_K	0.697	0.64
88_S	163_V	0.697	0.64
92_D	120_I	0.697	0.64
283_D	308_N	0.696	0.63
12_F	183_V	0.694	0.63
2_K	49_R	0.692	0.63
254_H	284_E	0.691	0.63
31_W	75_V	0.691	0.63
218_I	233_V	0.690	0.63
221_N	274_N	0.689	0.63
230_M	240_P	0.686	0.62
127_V	131_D	0.685	0.62
147_I	176_I	0.680	0.62
88_S	109_D	0.680	0.62
128_R	137_K	0.677	0.61
285_V	304_L	0.677	0.61
243_F	278_G	0.676	0.61
3_L	74_L	0.672	0.61
119_M	135_A	0.672	0.61
20_P	179_L	0.672	0.61
293_L	321_V	0.670	0.61
200_L	205_V	0.668	0.60
84_E	107_G	0.667	0.60
136_E	148_I	0.666	0.60
12_F	18_P	0.665	0.60
221_N	245_D	0.664	0.60
245_D	278_G	0.664	0.60
47_G	108_I	0.663	0.60
104_R	113_A	0.662	0.60
20_P	77_E	0.660	0.59
216_I	309_E	0.658	0.59
125_R	130_Y	0.657	0.59
144_L	176_I	0.657	0.59
278_G	303_R	0.655	0.59
313_K	325_D	0.655	0.59
317_R	325_D	0.652	0.58
151_L	163_V	0.649	0.58
11_L	183_V	0.649	0.58
136_E	144_L	0.648	0.58
190_L	197_L	0.646	0.58
64_E	68_L	0.643	0.57
87_A	100_L	0.642	0.57
282_C	302_V	0.641	0.57
77_E	175_R	0.635	0.56
302_V	325_D	0.634	0.56
88_S	219_I	0.632	0.56
236_N	258_S	0.630	0.56
227_M	243_F	0.630	0.56
113_A	116_V	0.629	0.56
16_G	150_G	0.629	0.56
44_G	182_K	0.628	0.56
223_A	227_M	0.626	0.55
45_A	66_K	0.626	0.55
100_L	127_V	0.625	0.55
74_L	160_A	0.624	0.55
331_I	334_A	0.624	0.55
252_R	256_K	0.623	0.55
288_G	292_A	0.622	0.55
8_G	183_V	0.620	0.55
164_E	167_P	0.620	0.55
221_N	244_L	0.617	0.54
183_V	193_H	0.616	0.54
25_T	73_F	0.615	0.54
91_L	161_E	0.615	0.54
89_V	148_I	0.614	0.54
4_Y	7_E	0.611	0.54
243_F	250_A	0.610	0.53
213_E	239_N	0.608	0.53
246_V	285_V	0.607	0.53
81_H	179_L	0.607	0.53
279_I	282_C	0.607	0.53
147_I	168_L	0.606	0.53
200_L	206_R	0.606	0.53
205_V	257_E	0.605	0.53
12_F	163_V	0.603	0.53
326_D	329_K	0.598	0.52
305_L	331_I	0.597	0.52
317_R	327_V	0.596	0.52
106_G	180_D	0.594	0.52
3_L	183_V	0.594	0.52
92_D	95_T	0.593	0.51
159_D	193_H	0.591	0.51
244_L	247_G	0.590	0.51
37_V	59_Y	0.590	0.51
146_Q	153_K	0.589	0.51
19_V	154_L	0.588	0.51
122_P	132_I	0.588	0.51
9_K	74_L	0.587	0.51
82_E	169_A	0.586	0.51
76_E	79_V	0.585	0.50
97_E	122_P	0.585	0.50
24_V	28_P	0.584	0.50
142_K	170_L	0.583	0.50
158_Y	185_L	0.582	0.50
122_P	125_R	0.580	0.50
184_I	187_D	0.580	0.50
105_E	109_D	0.579	0.50
221_N	229_S	0.579	0.50
227_M	247_G	0.576	0.49
208_S	216_I	0.576	0.49
249_G	279_I	0.575	0.49
105_E	113_A	0.575	0.49
309_E	326_D	0.573	0.49
274_N	282_C	0.573	0.49
145_G	149_Q	0.573	0.49
37_V	61_T	0.573	0.49
14_R	175_R	0.573	0.49
76_E	141_V	0.572	0.49
209_Y	265_N	0.572	0.49
88_S	98_P	0.572	0.49
278_G	282_C	0.572	0.49
275_I	278_G	0.571	0.49
212_L	243_F	0.571	0.49
102_L	138_Y	0.570	0.49
280_T	312_G	0.569	0.49
283_D	307_T	0.569	0.49
13_K	76_E	0.569	0.49
140_G	143_G	0.568	0.48
229_S	274_N	0.568	0.48
98_P	120_I	0.567	0.48
17_I	154_L	0.564	0.48
136_E	143_G	0.561	0.48
221_N	243_F	0.560	0.47
88_S	152_Y	0.560	0.47
87_A	135_A	0.560	0.47
251_N	254_H	0.560	0.47
146_Q	149_Q	0.559	0.47
38_K	46_R	0.558	0.47
82_E	171_T	0.557	0.47
111_E	166_N	0.557	0.47
101_V	155_F	0.553	0.47
93_R	278_G	0.552	0.47
3_L	41_L	0.550	0.46
92_D	99_M	0.549	0.46
43_E	182_K	0.548	0.46
280_T	300_I	0.548	0.46
329_K	334_A	0.547	0.46
154_L	157_D	0.546	0.46
106_G	166_N	0.546	0.46
93_R	303_R	0.545	0.46
170_L	174_G	0.544	0.46
293_L	322_N	0.544	0.46
133_V	136_E	0.543	0.45
92_D	159_D	0.542	0.45
52_V	56_E	0.541	0.45
226_T	230_M	0.540	0.45
121_I	127_V	0.540	0.45
88_S	99_M	0.540	0.45
104_R	117_K	0.538	0.45
8_G	18_P	0.537	0.45
227_M	282_C	0.536	0.45
43_E	284_E	0.536	0.45
86_Y	166_N	0.535	0.45
111_E	116_V	0.535	0.45
98_P	233_V	0.533	0.44
28_P	62_I	0.532	0.44
126_G	152_Y	0.532	0.44
256_K	291_D	0.532	0.44
59_Y	125_R	0.532	0.44
257_E	266_P	0.531	0.44
276_Y	279_I	0.530	0.44
225_L	244_L	0.529	0.44
24_V	71_E	0.529	0.44
110_V	276_Y	0.528	0.44
272_V	326_D	0.528	0.44
27_E	62_I	0.525	0.43
274_N	278_G	0.525	0.43
218_I	280_T	0.525	0.43
269_K	294_K	0.524	0.43
225_L	243_F	0.523	0.43
245_D	282_C	0.523	0.43
5_E	9_K	0.522	0.43
104_R	187_D	0.521	0.43
151_L	155_F	0.521	0.43
104_R	139_L	0.520	0.43
12_F	147_I	0.519	0.43
41_L	51_L	0.519	0.43
284_E	313_K	0.519	0.43
223_A	244_L	0.518	0.42
262_V	268_V	0.516	0.42
210_V	223_A	0.515	0.42
208_S	258_S	0.515	0.42
8_G	14_R	0.515	0.42
275_I	282_C	0.515	0.42
290_I	319_N	0.514	0.42
3_L	7_E	0.513	0.42
228_A	282_C	0.512	0.42
291_D	311_L	0.511	0.42
110_V	113_A	0.511	0.42
223_A	250_A	0.510	0.42
93_R	268_V	0.510	0.42
49_R	162_L	0.510	0.42
286_A	289_I	0.509	0.41
280_T	319_N	0.509	0.41
282_C	304_L	0.508	0.41
141_V	144_L	0.508	0.41
315_I	321_V	0.508	0.41
93_R	220_G	0.508	0.41
182_K	225_L	0.507	0.41
9_K	13_K	0.506	0.41
281_R	300_I	0.506	0.41
131_D	137_K	0.506	0.41
327_V	332_G	0.505	0.41
33_G	61_T	0.505	0.41
92_D	192_R	0.503	0.41
54_V	59_Y	0.503	0.41
223_A	274_N	0.503	0.41
221_N	226_T	0.500	0.40
223_A	245_D	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pffA	2	0.9911	100	0.229	Contact Map
3mwdA	2	0.9881	100	0.371	Contact Map
2nu8B	2	1	100	0.371	Contact Map
2fp4B	1	1	100	0.38	Contact Map
3ufxB	2	0.9941	100	0.415	Contact Map
1wr2A	1	0.5401	100	0.767	Contact Map
2csuA	2	0.9288	100	0.782	Contact Map
3va7A	1	0.7804	99	0.902	Contact Map
3e5nA	2	0.5193	98.9	0.905	Contact Map
3tqtA	2	0.549	98.9	0.906	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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